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WO1997018238A3 - Crf analogs - Google Patents

Crf analogs Download PDF

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Publication number
WO1997018238A3
WO1997018238A3 PCT/EP1996/005010 EP9605010W WO9718238A3 WO 1997018238 A3 WO1997018238 A3 WO 1997018238A3 EP 9605010 W EP9605010 W EP 9605010W WO 9718238 A3 WO9718238 A3 WO 9718238A3
Authority
WO
WIPO (PCT)
Prior art keywords
crf analogs
crf
analogs
lipophilic
pharmaceutical
Prior art date
Application number
PCT/EP1996/005010
Other languages
French (fr)
Other versions
WO1997018238A2 (en
Inventor
Joachim Spiess
Andreas Ruehmann
Original Assignee
Max Planck Gesellschaft
Joachim Spiess
Andreas Ruehmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Joachim Spiess, Andreas Ruehmann filed Critical Max Planck Gesellschaft
Publication of WO1997018238A2 publication Critical patent/WO1997018238A2/en
Publication of WO1997018238A3 publication Critical patent/WO1997018238A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to lipophilic CRF analogs which are useful as active ingredients in pharmaceutical or diagnostic compositions.
PCT/EP1996/005010 1995-11-14 1996-11-14 Crf analogs WO1997018238A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95117940.7 1995-11-14
EP95117940 1995-11-14

Publications (2)

Publication Number Publication Date
WO1997018238A2 WO1997018238A2 (en) 1997-05-22
WO1997018238A3 true WO1997018238A3 (en) 1997-07-03

Family

ID=8219816

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/005010 WO1997018238A2 (en) 1995-11-14 1996-11-14 Crf analogs

Country Status (1)

Country Link
WO (1) WO1997018238A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0516450A2 (en) * 1991-05-31 1992-12-02 The Salk Institute For Biological Studies CRF analogs
WO1996019499A2 (en) * 1994-12-12 1996-06-27 The Salk Institute For Biological Studies Improved cyclic crf antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0516450A2 (en) * 1991-05-31 1992-12-02 The Salk Institute For Biological Studies CRF analogs
WO1996019499A2 (en) * 1994-12-12 1996-06-27 The Salk Institute For Biological Studies Improved cyclic crf antagonists

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHROUSOS E.A.: "CRF: basic studies and clinical applications", PROG.NEURO-PSYCHOPHARMACOL.&BIOL.PSYCHIATRY, vol. 9, no. 4, 1985, pages 349 - 359, XP000673256 *
GULYAS E.A.: "Potent, structurally constrained agonists and competitive antagonists of CRF", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 92, no. 23, 7 November 1995 (1995-11-07), WASHINGTON US, pages 10575 - 10579, XP000566934 *
KORNREICH E.A: "Alanine series of oCRF; a structure-activity relationship study", JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, no. 10, 1992, WASHINGTON US, pages 1870 - 1876, XP002030859 *
MARTINS E.A.: "Unidirectional specific and modulated brain to blood transport of CRF", NEUROENDOCRINOLOGY, vol. 63, no. 4, April 1996 (1996-04-01), pages 338 - 348, XP000673299 *
RUEHMANN E.A.: "Design of new CRF analogues and molecular characterization of functional CRF receptors", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 21, no. 1-3, 1995, pages 1845, XP000671597 *
W.A.BANKS E.A: "peptides and the blood-brain barrier: lipophilicity as a predictor of permeability", BRAIN RESEARCH BULLETIN, vol. 15, no. 3, September 1985 (1985-09-01), pages 287 - 292, XP000673506 *

Also Published As

Publication number Publication date
WO1997018238A2 (en) 1997-05-22

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