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WO1997018323A3 - Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity - Google Patents

Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity Download PDF

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Publication number
WO1997018323A3
WO1997018323A3 PCT/US1996/019337 US9619337W WO9718323A3 WO 1997018323 A3 WO1997018323 A3 WO 1997018323A3 US 9619337 W US9619337 W US 9619337W WO 9718323 A3 WO9718323 A3 WO 9718323A3
Authority
WO
WIPO (PCT)
Prior art keywords
pik
cycle checkpoint
cell cycle
phosphatidylinositol
assaying
Prior art date
Application number
PCT/US1996/019337
Other languages
French (fr)
Other versions
WO1997018323A2 (en
Inventor
Merl F Hoekstra
Doug A Holtzman
Kathleen S Keegan
Original Assignee
Icos Corp
Merl F Hoekstra
Doug A Holtzman
Kathleen S Keegan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp, Merl F Hoekstra, Doug A Holtzman, Kathleen S Keegan filed Critical Icos Corp
Priority to FI973005A priority Critical patent/FI973005L/en
Priority to MX9705466A priority patent/MX9705466A/en
Priority to HU0002207A priority patent/HUP0002207A2/en
Priority to SK1115-97A priority patent/SK111597A3/en
Priority to IL12130696A priority patent/IL121306A0/en
Priority to EP96945181A priority patent/EP0807169A3/en
Priority to AU14611/97A priority patent/AU1461197A/en
Priority to JP51918097A priority patent/JP2002515732A/en
Publication of WO1997018323A2 publication Critical patent/WO1997018323A2/en
Priority to NO973279A priority patent/NO973279L/en
Publication of WO1997018323A3 publication Critical patent/WO1997018323A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention generally relates to genes encoding cell cycle checkpoint phosphatidylinositol kinase (PIK)-related proteins essential to DNA damage responses in cells. These PIK-related kinases are required in regulatory pathways that arrest the cell cycle following DNA damage to allow DNA repair prior to mitosis or initiation of DNA replication. More particularly, the invention provides a novel human cell cycle checkpoint PIK-related kinase, MCCS1, and polynucleotide sequences encoding the MCSS1. Assays for identifying modulators of MCCS1 useful as, for example, chemotherapy and radiation adjuvants, are also provided by the invention. Further, assays for identifying modulators of the cell cycle checkpoint phosphatidylinositol kinase (PIK)-related protein identified as ATM are provided.
PCT/US1996/019337 1995-11-16 1996-11-18 Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity WO1997018323A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FI973005A FI973005L (en) 1995-11-16 1996-11-18 Cell cycle checkpoint PIK-related kinase materials and methods
MX9705466A MX9705466A (en) 1995-11-16 1996-11-18 Cell cycle checkpoint pik-related kinase materials and methods.
HU0002207A HUP0002207A2 (en) 1996-10-21 1996-11-18 Cell cycle checkpoint pik-related kinase materials and methods
SK1115-97A SK111597A3 (en) 1995-11-16 1996-11-18 Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity
IL12130696A IL121306A0 (en) 1995-11-16 1996-11-18 Cell cycle checkpoint pik-related kinase materials and methods
EP96945181A EP0807169A3 (en) 1995-11-16 1996-11-18 Cell cycle checkpoint pik-related kinase materials and methods
AU14611/97A AU1461197A (en) 1995-11-16 1996-11-18 Cell cycle checkpoint pik-related kinase materials and methods
JP51918097A JP2002515732A (en) 1995-11-16 1996-11-18 Cell cycle checkpoint PIK-related kinase substances and methods
NO973279A NO973279L (en) 1995-11-16 1997-07-15 PIK-related kinase materials and cell cycle checkpoint methods

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US55866695A 1995-11-16 1995-11-16
US08/558,666 1995-11-16
US73129696A 1996-02-27 1996-02-27
US08/007,312 1996-02-27
US72530496A 1996-10-21 1996-10-21
US08/725,304 1996-10-21

Publications (2)

Publication Number Publication Date
WO1997018323A2 WO1997018323A2 (en) 1997-05-22
WO1997018323A3 true WO1997018323A3 (en) 1997-10-09

Family

ID=27415779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/019337 WO1997018323A2 (en) 1995-11-16 1996-11-18 Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity

Country Status (6)

Country Link
CN (1) CN1199420A (en)
AU (1) AU1461197A (en)
IL (1) IL121306A0 (en)
NO (1) NO973279L (en)
PL (1) PL322876A1 (en)
WO (1) WO1997018323A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858661A (en) * 1995-05-16 1999-01-12 Ramot-University Authority For Applied Research And Industrial Development Ataxia-telangiectasia gene and its genomic organization
US5777093A (en) * 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
GB9518220D0 (en) * 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
WO1999002653A1 (en) * 1997-07-11 1999-01-21 Trustees Of The University Of Pennsylvania Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use
GB9714971D0 (en) 1997-07-16 1997-09-24 Cancer Res Campaign Tech Assays,therapeutic methods and means
GB9718952D0 (en) * 1997-09-05 1997-11-12 Medical Res Council Mammalian chk1 effector cell cycle checkpoint protein kinase materials and methods
CA2216559A1 (en) * 1997-09-25 1999-03-25 Michel Roberge G2 checkpoint inhibitors and assay
GB9722320D0 (en) * 1997-10-22 1997-12-17 Janssen Pharmaceutica Nv Human cell cycle checkpoint proteins
US6071691A (en) * 1998-04-27 2000-06-06 Oregon Health Science University Materials and methods for modulating differentiation
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
US6348311B1 (en) 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6670167B1 (en) 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
US20040142894A1 (en) * 2002-10-25 2004-07-22 Stein Gary S. Modulation of cellular proliferation
GB2420781B (en) 2003-08-13 2008-07-09 Kudos Pharm Ltd Aminopyrones and their use as ATM inhibitors
TW200616986A (en) 2004-09-20 2006-06-01 Kudos Pharm Ltd DNA-pk inhibitors
EP1848712A1 (en) 2005-02-09 2007-10-31 Kudos Pharmaceuticals Ltd Atm inhibitors
AR054438A1 (en) 2005-04-15 2007-06-27 Kudos Pharm Ltd DNA INHIBITORS -PK

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009433A1 (en) * 1995-09-06 1997-03-13 Icos Corporation Cell-cycle checkpoint genes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009433A1 (en) * 1995-09-06 1997-03-13 Icos Corporation Cell-cycle checkpoint genes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BENTLEY, N.J. ET AL.: "The Schizosaccharomyces pombe rad3 checkpoint gene", EMBO JOURNAL, vol. 15, no. 23, 1996, pages 6641 - 6651, XP002023634 *
CIMPRICH, K.A. ET AL.: "cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 93, April 1996 (1996-04-01), pages 2850 - 2855, XP002023632 *
HOEKSTRA, M.F.: "Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family", CURRENT OPINION GENET. DEV., vol. 7, no. 2, 1997, pages 170 - 175, XP002036687 *
SAVITSKY, K. ET AL.: "A single ataxia telangiectasia gene with a product similar to PI-3 kinase", SCIENCE, vol. 268, 23 June 1995 (1995-06-23), pages 1749 - 1753, XP002036686 *
SEATON, B.L. ET AL.: "Isolation and characterization of the Schizosaccharomyces pombe rad3 gene, involved in the DNA damage and DNA synthesis checkpoints", GENE, vol. 119, 1992, pages 83 - 89, XP002023633 *

Also Published As

Publication number Publication date
NO973279D0 (en) 1997-07-15
WO1997018323A2 (en) 1997-05-22
PL322876A1 (en) 1998-03-02
AU1461197A (en) 1997-06-05
IL121306A0 (en) 1998-01-04
NO973279L (en) 1997-09-16
CN1199420A (en) 1998-11-18

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