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WO1997019178A3 - Autoantigenic metal proteases and methods of diagnosing autoimmune diseases - Google Patents

Autoantigenic metal proteases and methods of diagnosing autoimmune diseases Download PDF

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Publication number
WO1997019178A3
WO1997019178A3 PCT/DE1996/002094 DE9602094W WO9719178A3 WO 1997019178 A3 WO1997019178 A3 WO 1997019178A3 DE 9602094 W DE9602094 W DE 9602094W WO 9719178 A3 WO9719178 A3 WO 9719178A3
Authority
WO
WIPO (PCT)
Prior art keywords
autoantigenic
polypeptide
autoimmune diseases
methods
diagnosing autoimmune
Prior art date
Application number
PCT/DE1996/002094
Other languages
German (de)
French (fr)
Other versions
WO1997019178A2 (en
Inventor
Ulrich Krawinkel
Simon Mauch
Radislav Sedlacek
Original Assignee
Univ Konstanz
Ulrich Krawinkel
Simon Mauch
Radislav Sedlacek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Konstanz, Ulrich Krawinkel, Simon Mauch, Radislav Sedlacek filed Critical Univ Konstanz
Publication of WO1997019178A2 publication Critical patent/WO1997019178A2/en
Publication of WO1997019178A3 publication Critical patent/WO1997019178A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rehabilitation Therapy (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention concerns nucleic acids which contain at least one nucleic acid sequence coding for a polypeptide, the polypeptide containing at least one autoantigenic determinant originating from a metallic protease. The invention also concerns the polypeptide itself, antibodies directed at the polypeptide and specific inhibitors directed at the polypeptide. The invention further concerns methods and kits for detecting autoantigenic metallic proteases and autoimmune diseases, such as rheumatoid arthritis.
PCT/DE1996/002094 1995-11-20 1996-11-04 Autoantigenic metal proteases and methods of diagnosing autoimmune diseases WO1997019178A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19543265.7 1995-11-20
DE19543265A DE19543265A1 (en) 1995-11-20 1995-11-20 Autoantigens and methods for diagnosing autoimmune diseases

Publications (2)

Publication Number Publication Date
WO1997019178A2 WO1997019178A2 (en) 1997-05-29
WO1997019178A3 true WO1997019178A3 (en) 1997-09-25

Family

ID=7777951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/002094 WO1997019178A2 (en) 1995-11-20 1996-11-04 Autoantigenic metal proteases and methods of diagnosing autoimmune diseases

Country Status (2)

Country Link
DE (1) DE19543265A1 (en)
WO (1) WO1997019178A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69736227D1 (en) 1996-04-25 2006-08-10 Takeda Pharmaceutical Matrix-metalloprotease
WO1998040475A1 (en) 1997-03-11 1998-09-17 Abbott Laboratories Human matrix metalloprotease gene, proteins encoded therefrom and methods of using same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0522169A1 (en) * 1991-01-21 1993-01-13 Fuji Yakuhin Kogyo Kabushiki Kaisha Antihuman stromelysin monoclonal antibody and diagnosis of rheumatoid arthritis by enzyme immunoassay
WO1994010208A1 (en) * 1992-10-29 1994-05-11 Miles Inc. Diagnostic assay for latent matrix metalloproteinase no. 9

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69412466T2 (en) * 1993-11-30 1999-04-29 Fuji Yakuhin Kogyo K.K., Takaoka, Toyama NEW METALOPROTEASE AND ENCODING DNA FOR IT
DK0750672T3 (en) * 1994-03-17 2002-03-18 Max Delbrueck Centrum DNA sequences for matrix metal proteases, their generation and use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0522169A1 (en) * 1991-01-21 1993-01-13 Fuji Yakuhin Kogyo Kabushiki Kaisha Antihuman stromelysin monoclonal antibody and diagnosis of rheumatoid arthritis by enzyme immunoassay
WO1994010208A1 (en) * 1992-10-29 1994-05-11 Miles Inc. Diagnostic assay for latent matrix metalloproteinase no. 9

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COSSINS J ET AL: "Identification of MMP-18, a putative novel human matrix metalloproteinase.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 228 (2). 1996. 494-498. ISSN: 0006-291X, XP002036483 *
SIRUM K L ET AL: "CLONING OF THE GENES FOR HUMAN STROMELYSIN AND STROMELYSIN 2: DIFFERENTIAL EXPRESSION IN RHEUMATOID SYNOVIAL FIBROBLASTS", BIOCHEMISTRY, vol. 28, no. 22, 1989, pages 8691 - 8698, XP002029122 *

Also Published As

Publication number Publication date
DE19543265A1 (en) 1997-06-05
WO1997019178A2 (en) 1997-05-29

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