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WO1997022972A3 - Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule - Google Patents

Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule Download PDF

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Publication number
WO1997022972A3
WO1997022972A3 PCT/US1996/019129 US9619129W WO9722972A3 WO 1997022972 A3 WO1997022972 A3 WO 1997022972A3 US 9619129 W US9619129 W US 9619129W WO 9722972 A3 WO9722972 A3 WO 9722972A3
Authority
WO
WIPO (PCT)
Prior art keywords
neutralizing antibody
molecule
disease state
therapeutic target
simultaneous detection
Prior art date
Application number
PCT/US1996/019129
Other languages
French (fr)
Other versions
WO1997022972A2 (en
Inventor
Paul K Tomich
David A Jones
Howard D Fischer
Original Assignee
Upjohn Co
Paul K Tomich
David A Jones
Howard D Fischer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Paul K Tomich, David A Jones, Howard D Fischer filed Critical Upjohn Co
Priority to AU11270/97A priority Critical patent/AU1127097A/en
Priority to EP96942111A priority patent/EP0880703A2/en
Priority to JP9522826A priority patent/JP2000502896A/en
Publication of WO1997022972A2 publication Critical patent/WO1997022972A2/en
Publication of WO1997022972A3 publication Critical patent/WO1997022972A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The specification discloses combinatorial libraries of recombinant antibody-like molecules used to identify both potential therapeutic targets and their corresponding neutralizing antibody(ies). The identification can be done either by in vitro (biochemical) means or in situ with established cell lines. No prior knowledge of either the antigen target or its corresponding antibody is required.
PCT/US1996/019129 1995-12-15 1996-12-04 Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule WO1997022972A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU11270/97A AU1127097A (en) 1995-12-15 1996-12-04 Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule
EP96942111A EP0880703A2 (en) 1995-12-15 1996-12-04 Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule
JP9522826A JP2000502896A (en) 1995-12-15 1996-12-04 Simultaneous detection of therapeutic targets for disease states and their neutralizing antibody-like molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US868595P 1995-12-15 1995-12-15
US60/008,685 1995-12-15

Publications (2)

Publication Number Publication Date
WO1997022972A2 WO1997022972A2 (en) 1997-06-26
WO1997022972A3 true WO1997022972A3 (en) 1997-08-21

Family

ID=21733088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/019129 WO1997022972A2 (en) 1995-12-15 1996-12-04 Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule

Country Status (4)

Country Link
EP (1) EP0880703A2 (en)
JP (1) JP2000502896A (en)
AU (1) AU1127097A (en)
WO (1) WO1997022972A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9700291D0 (en) 1997-01-31 1997-01-31 Pharmacia & Upjohn Ab Selection method and prodcts resulting therefrom
WO2000014215A1 (en) * 1998-09-07 2000-03-16 Eberhard-Karls-Universität Tübingen Method for selecting peptides for the targeted transport of drugs and markers, and peptides discovered using said method
WO2000061790A1 (en) * 1999-04-14 2000-10-19 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High sensitivity phage display biomolecule detection
GB2360282A (en) * 2000-03-17 2001-09-19 Bioinvent Int Ab Making and using micro-arrays of biological materials
EP1394550A1 (en) * 2002-08-30 2004-03-03 Plant Research International B.V. A method of analysing relative epitope appearance in a plurality of samples

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011236A1 (en) * 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
US5264563A (en) * 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
WO1994026787A1 (en) * 1993-05-07 1994-11-24 The Board Of Trustees Of The Leland Stanford Junior University Method for generating cell type specific phage antibody libraries
WO1997006435A1 (en) * 1995-08-05 1997-02-20 Medical Research Council Improvements in or relating to methods of screening substances

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264563A (en) * 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
WO1993011236A1 (en) * 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
WO1994026787A1 (en) * 1993-05-07 1994-11-24 The Board Of Trustees Of The Leland Stanford Junior University Method for generating cell type specific phage antibody libraries
WO1997006435A1 (en) * 1995-08-05 1997-02-20 Medical Research Council Improvements in or relating to methods of screening substances

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D. A. DANIELS ET AL.: "Phage peptide libraries.", METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, vol. 9, no. 3, June 1996 (1996-06-01), NEW YORK, US., pages 494 - 507, XP000671255 *
F. FELICI ET AL.: "Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector.", JOURNAL OF MOLECULAR BIOLOGY, vol. 222, no. 2, 1991, LONDON, GB., pages 301 - 310, XP000373977 *
R. S. AMES ET AL.: "Neutralizing murine monoclonal antibodies to human IL-5 isolated from hybridomas and a filamentous phage Fab display library", THE JOURNAL OF IMMUNOLOGY, vol. 154, no. 12, 15 June 1995 (1995-06-15), BETHESDA, US, pages 6355 - 6364, XP002032743 *

Also Published As

Publication number Publication date
AU1127097A (en) 1997-07-14
WO1997022972A2 (en) 1997-06-26
EP0880703A2 (en) 1998-12-02
JP2000502896A (en) 2000-03-14

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