WO1997030085B1 - Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese - Google Patents
Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogeneseInfo
- Publication number
- WO1997030085B1 WO1997030085B1 PCT/US1997/002439 US9702439W WO9730085B1 WO 1997030085 B1 WO1997030085 B1 WO 1997030085B1 US 9702439 W US9702439 W US 9702439W WO 9730085 B1 WO9730085 B1 WO 9730085B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fact
- troponin subunit
- peptide
- subunit
- human
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title claims abstract 7
- 229940121369 angiogenesis inhibitor Drugs 0.000 title claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 title claims 2
- 230000033115 angiogenesis Effects 0.000 claims abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 5
- 206010028980 Neoplasm Diseases 0.000 claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
- 241000282414 Homo sapiens Species 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 241000283690 Bos taurus Species 0.000 claims 5
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 3
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 230000004663 cell proliferation Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 210000002889 endothelial cell Anatomy 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- LQRJAEQXMSMEDP-XCHBZYMASA-N peptide a Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)NCCCC[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C/C=1C=CC=CC=1)C(N)=O)C(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C\C1=CC=CC=C1 LQRJAEQXMSMEDP-XCHBZYMASA-N 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 206010003645 Atopy Diseases 0.000 abstract 1
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
Abstract
Des procédés permettent d'inhiber l'angiogénèse atopique à l'aide de sous-unités de troponine et de leurs fragments peptidiques. On décrit aussi des compositions pharmaceutiques comprenant une sous-unité de troponine ou un de ses fragments. Ces compositions et procédés permettent de traiter des tumeurs solides, particulièrement celles du système nerveux central et de l'oeil.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52953997A JP3990456B2 (ja) | 1996-02-16 | 1997-02-14 | 血管形成の阻害剤として有用なトロポニンのサブユニットおよびフラグメント |
DE69729125T DE69729125T2 (de) | 1996-02-16 | 1997-02-14 | Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese |
AT97905992T ATE266675T1 (de) | 1996-02-16 | 1997-02-14 | Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese |
CA2247247A CA2247247C (fr) | 1996-02-16 | 1997-02-14 | Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese |
EP97905992A EP1007556B1 (fr) | 1996-02-16 | 1997-02-14 | Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese |
AU22753/97A AU707262B2 (en) | 1996-02-16 | 1997-02-14 | Troponin subunits and fragments useful as angiogenesis inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/602,941 US5837680A (en) | 1996-02-16 | 1996-02-16 | Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis |
US08/602,941 | 1996-02-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997030085A1 WO1997030085A1 (fr) | 1997-08-21 |
WO1997030085B1 true WO1997030085B1 (fr) | 1997-09-25 |
Family
ID=24413387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/002439 WO1997030085A1 (fr) | 1996-02-16 | 1997-02-14 | Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese |
Country Status (8)
Country | Link |
---|---|
US (4) | US5837680A (fr) |
EP (1) | EP1007556B1 (fr) |
JP (1) | JP3990456B2 (fr) |
AT (1) | ATE266675T1 (fr) |
AU (1) | AU707262B2 (fr) |
CA (1) | CA2247247C (fr) |
DE (1) | DE69729125T2 (fr) |
WO (1) | WO1997030085A1 (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6586401B1 (en) | 1996-02-16 | 2003-07-01 | Children's Medical Center Corporation | Troponin subunit I fragment and homologs thereof |
US5837680A (en) | 1996-02-16 | 1998-11-17 | Children's Medical Center Corporation | Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis |
US6589936B1 (en) | 1996-02-16 | 2003-07-08 | Children's Medical Center Corporation | Pharmaceutical compositions comprising recombinant troponin subunits |
US6465431B1 (en) * | 1999-11-17 | 2002-10-15 | Boston Life Sciences, Inc. | Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis |
US7220557B2 (en) | 1997-04-24 | 2007-05-22 | Human Genome Sciences, Inc. | METH1 polynucleotides |
US20030166065A1 (en) * | 1997-04-24 | 2003-09-04 | Human Genome Sciences, Inc. | Novel integrin ligand ITGL-TSP |
US6248869B1 (en) * | 1997-05-29 | 2001-06-19 | Medical Analysis Systems, Inc. | Troponin I forms and use of the same |
US6468519B1 (en) * | 1997-09-10 | 2002-10-22 | Rutgers, The State University Of New Jersey | Polyanhydrides with biologically active degradation products |
AU9673998A (en) * | 1997-10-01 | 1999-04-23 | G.D. Searle & Co. | Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment |
KR100335397B1 (ko) * | 1998-05-25 | 2002-09-05 | 주식회사 하이닉스반도체 | 센스앰프순차구동장치 |
EP1098971B1 (fr) | 1998-07-17 | 2006-08-30 | Licentia Ltd. | Myotiline, une proteine organisant l'actine |
US6378526B1 (en) * | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
WO2000023585A1 (fr) * | 1998-10-21 | 2000-04-27 | Spectral Diagnostics, Inc. | Fragments de polypeptides de troponine i cardiaque et utilisations pour diagnostic |
WO2000054770A1 (fr) * | 1999-03-15 | 2000-09-21 | Boston Life Sciences, Inc. | Compositions pharmaceutiques renfermant des sous-unites de troponine, ou des fragments ou des homologues desdites sous-unites, et leur utilisation pour inhiber l'angiogenese |
CA2382774A1 (fr) * | 1999-05-25 | 2000-11-30 | Human Genome Sciences, Inc. | Polynucleotides et polypeptides meth1 et meth2 |
US20020142982A1 (en) * | 1999-09-02 | 2002-10-03 | Timothy Hla | Method for regulating angiogenesis |
PT1299727E (pt) | 2000-07-12 | 2009-07-09 | Agensys Inc | Novo antigénio tumoral útil em diagnóstico e terapia de cancros da bexiga, do ovário, do pulmão e do rim |
US20030236188A1 (en) * | 2001-05-03 | 2003-12-25 | Spytek Kimberly A. | Novel human proteins, polynucleotides encoding them and methods of using the same |
ATE471371T1 (de) * | 2002-02-04 | 2010-07-15 | Yoshida Hideo | Antikrebsmittel mit verotoxinvarianten |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
EP2014310B8 (fr) | 2002-03-01 | 2012-12-26 | Dyax Corp. | Peptides de liaison KDR et VEGF/KDR et leur utilisation pour le diagnostic et la thérapie |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US8623822B2 (en) * | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
CA2513044A1 (fr) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques |
WO2003080116A1 (fr) * | 2002-03-21 | 2003-10-02 | University Of Florida | Modulation de l'angiogenese |
US20060189519A1 (en) * | 2002-09-26 | 2006-08-24 | Karl Volz | Anti-angiogenic fragments fo pigment epithelium-derived factor (pedf) |
WO2004078778A2 (fr) | 2003-03-03 | 2004-09-16 | Dyax Corp. | Peptides presentant une fixation specifique avec le recepteur de hgf (cmet) et ses utilisations |
CN1294987C (zh) * | 2003-04-15 | 2007-01-17 | 刘凤鸣 | 心肌肌钙蛋白i在制备抑制肿瘤药物中的应用 |
ES2737835T3 (es) | 2003-04-23 | 2020-01-16 | Valeritas Inc | Bomba accionada hidráulicamente para la administración de medicamentos de larga duración |
WO2006014425A1 (fr) | 2004-07-02 | 2006-02-09 | Biovalve Technologies, Inc. | Procedes et dispositifs pour l'administration du glp-1 et leurs utilisations |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
US7265248B1 (en) | 2005-04-29 | 2007-09-04 | Technology Innovations, Llc | Compositions and methods for the treatment of malaria |
US20070130009A1 (en) * | 2005-06-01 | 2007-06-07 | Chad Steelberg | System and method for media play pricing |
WO2007067611A2 (fr) * | 2005-12-07 | 2007-06-14 | The Brigham And Women's Hospital, Inc. | Méthodes pour traiter une maladie de reperfusion cardiaque |
EP2005309B1 (fr) | 2006-03-30 | 2016-02-17 | Valeritas, Inc. | Dispositief d'acheminement de fluide a cartouches multiples |
US8468561B2 (en) | 2006-08-09 | 2013-06-18 | Google Inc. | Preemptible station inventory |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991011193A1 (fr) * | 1990-01-25 | 1991-08-08 | Children's Hospital | Procede et compositions destines a inhiber l'angiogenese |
FR2701954B1 (fr) * | 1993-02-23 | 1995-07-07 | Pasteur Sanofi Diagnostics | Composition stabilisée de troponine pour immunoessais et procédé de stabilisation de troponine pour immunoessais. |
US5837680A (en) * | 1996-02-16 | 1998-11-17 | Children's Medical Center Corporation | Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis |
-
1996
- 1996-02-16 US US08/602,941 patent/US5837680A/en not_active Expired - Lifetime
-
1997
- 1997-02-14 AT AT97905992T patent/ATE266675T1/de not_active IP Right Cessation
- 1997-02-14 JP JP52953997A patent/JP3990456B2/ja not_active Expired - Fee Related
- 1997-02-14 AU AU22753/97A patent/AU707262B2/en not_active Ceased
- 1997-02-14 WO PCT/US1997/002439 patent/WO1997030085A1/fr active IP Right Grant
- 1997-02-14 EP EP97905992A patent/EP1007556B1/fr not_active Expired - Lifetime
- 1997-02-14 CA CA2247247A patent/CA2247247C/fr not_active Expired - Fee Related
- 1997-02-14 DE DE69729125T patent/DE69729125T2/de not_active Expired - Lifetime
- 1997-10-30 US US08/961,264 patent/US6025331A/en not_active Expired - Lifetime
-
1999
- 1999-08-04 US US09/368,214 patent/US6403558B1/en not_active Expired - Fee Related
-
2000
- 2000-11-28 US US09/724,401 patent/US6653283B1/en not_active Expired - Fee Related
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