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WO1997031655A3 - Modified cytokines for therapeutic use - Google Patents

Modified cytokines for therapeutic use Download PDF

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Publication number
WO1997031655A3
WO1997031655A3 PCT/EP1997/000704 EP9700704W WO9731655A3 WO 1997031655 A3 WO1997031655 A3 WO 1997031655A3 EP 9700704 W EP9700704 W EP 9700704W WO 9731655 A3 WO9731655 A3 WO 9731655A3
Authority
WO
WIPO (PCT)
Prior art keywords
component
cytokines
therapeutic use
modified cytokines
modified
Prior art date
Application number
PCT/EP1997/000704
Other languages
French (fr)
Other versions
WO1997031655A2 (en
Inventor
Angelo Corti
Antonio Siccardi
Paolo Dellabona
Giulia Casorati
Micaela Pelagi
Original Assignee
San Raffaele Centro Fond
Angelo Corti
Antonio Siccardi
Paolo Dellabona
Giulia Casorati
Micaela Pelagi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by San Raffaele Centro Fond, Angelo Corti, Antonio Siccardi, Paolo Dellabona, Giulia Casorati, Micaela Pelagi filed Critical San Raffaele Centro Fond
Priority to EP97903285A priority Critical patent/EP0885015A2/en
Priority to AU17694/97A priority patent/AU1769497A/en
Priority to JP9530545A priority patent/JP2000506835A/en
Publication of WO1997031655A2 publication Critical patent/WO1997031655A2/en
Publication of WO1997031655A3 publication Critical patent/WO1997031655A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
    • A61K47/6898—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The object of the present invention is a new method and new products for the therapeutic use of cytokines. The method is based on the sequential administration of a component A (e.g. a biotinylated antibody) able to deliver onto a particular pathologic target a second component B (e.g. avidin), followed by a component able to bind the component B (component C) (e.g. biotin), conjugated with the cytokines. The method permits to increase the local concentration of the modified cytokines (C-cytokines) through the interaction with the 'artificial' receptor B and to cause a local biologic response mediated by 'natural' receptors.
PCT/EP1997/000704 1996-02-27 1997-02-14 Modified cytokines for therapeutic use WO1997031655A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP97903285A EP0885015A2 (en) 1996-02-27 1997-02-14 Modified cytokines for therapeutic use
AU17694/97A AU1769497A (en) 1996-02-27 1997-02-14 Modified cytokines for therapeutic use
JP9530545A JP2000506835A (en) 1996-02-27 1997-02-14 Modified cytokines for therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI000358A IT1282692B1 (en) 1996-02-27 1996-02-27 CYTOKINES MODIFIED FOR THERAPY USE
ITMI96A000358 1996-02-27

Publications (2)

Publication Number Publication Date
WO1997031655A2 WO1997031655A2 (en) 1997-09-04
WO1997031655A3 true WO1997031655A3 (en) 1997-11-13

Family

ID=11373397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/000704 WO1997031655A2 (en) 1996-02-27 1997-02-14 Modified cytokines for therapeutic use

Country Status (6)

Country Link
EP (1) EP0885015A2 (en)
JP (1) JP2000506835A (en)
AU (1) AU1769497A (en)
CA (1) CA2247308A1 (en)
IT (1) IT1282692B1 (en)
WO (1) WO1997031655A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012554A1 (en) * 1998-08-28 2000-03-09 Commissariat A L'energie Atomique Method for marked chemokine synthesis, marked chemokine and analysis kit
FR2783528A1 (en) * 1998-08-28 2000-03-24 Commissariat Energie Atomique Synthesis of labeled chemokine, useful for developing anti-inflammatory and antiviral agents uses conventional peptide synthesis with label attached to sidechain at predetermined position
DE19845798A1 (en) * 1998-09-29 2000-04-13 Schering Ag Use of neoangiogenesis markers for diagnosis and therapy of tumors, agents containing them, and methods for their production
US9358307B2 (en) * 2008-01-25 2016-06-07 Gavish-Galilee Bio Applications Ltd. Targeting of innate immune response to tumor site
EA201892619A1 (en) * 2011-04-29 2019-04-30 Роше Гликарт Аг IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS
UA125575C2 (en) 2014-03-21 2022-04-27 Еббві Інк. Conjugate containing an antibody against egfr and a medicine
US20200002421A1 (en) 2016-06-08 2020-01-02 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
CA3027045A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
CN109641962A (en) 2016-06-08 2019-04-16 艾伯维公司 Anti-B7-H3 Antibodies and Antibody Drug Conjugates
CN109562169A (en) 2016-06-08 2019-04-02 艾伯维公司 Anti-CD98 Antibody and Antibody Drug Conjugate
CN118562004A (en) 2016-12-16 2024-08-30 蓝鳍生物医药公司 Anti-CUB domain-containing protein 1 (CDCP 1) antibodies, antibody drug conjugates, and methods of use thereof
US11932694B2 (en) 2017-04-19 2024-03-19 Bluefin Biomedicine, Inc. Anti-VTCN1 antibodies and antibody drug conjugates
CN110997725B (en) 2017-06-12 2024-08-09 蓝鳍生物医药公司 Anti-IL1RAP Antibodies and Antibody Drug Conjugates
AR124681A1 (en) 2021-01-20 2023-04-26 Abbvie Inc ANTI-EGFR ANTIBODY-DRUG CONJUGATES
WO2025027529A1 (en) 2023-07-31 2025-02-06 Advesya Anti-il-1rap antibody drug conjugates and methods of use thereof
WO2025126157A1 (en) 2023-12-15 2025-06-19 Advesya Anti-il-1rap binding domains and antibody-drug conjugates thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018325A1 (en) * 1993-02-03 1994-08-18 N.V. Innogenetics S.A. Tnf-alpha muteins and a process for preparing them
WO1995014493A1 (en) * 1993-11-23 1995-06-01 Neorx Corporation Three-step pretargeting methods and compounds
WO1995015979A1 (en) * 1993-12-07 1995-06-15 Neorx Corporation Pretargeting methods and compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018325A1 (en) * 1993-02-03 1994-08-18 N.V. Innogenetics S.A. Tnf-alpha muteins and a process for preparing them
WO1995014493A1 (en) * 1993-11-23 1995-06-01 Neorx Corporation Three-step pretargeting methods and compounds
WO1995015979A1 (en) * 1993-12-07 1995-06-15 Neorx Corporation Pretargeting methods and compounds

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
6TH INT. TUMOR NECROSIS FACTOR CONGRESS, 8 May 1996 (1996-05-08) - 12 May 1996 (1996-05-12), RHODES (GREECE) *
CHEMICAL ABSTRACTS, vol. 124, no. 11, 11 March 1996, Columbus, Ohio, US; abstract no. 142954, VODYANIK, M. A. ET AL: "Flow cytometric detection of two types of tumor necrosis factor alpha (TNF) receptors by biotinamidocaproyl-TNF in human tumor cells" XP002040778 *
CORTI A. ET AL.: "TUMOR CELL TARGETING WITH ANTIBODY-AVIDIN COMPLEXES AND BIOTINYLATED TNF.", EUROPEAN CYTOKINE NETWORK, vol. 7, no. 2, 1996, pages 289 *
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; XP002040779 *
EKSP. ONKOL. (1995), 17(1), 11-17 CODEN: EKSODD;ISSN: 0204-3564, 1995 *
STONE D. ET AL.: "Pretargeting as a delivery system for tumor-specific localization of TNF-alpha.", PROCEEDINGS OF THE AMERICAN ASSOC. FOR CANCER RES., vol. 37, March 1996 (1996-03-01), pages 484, XP002040787 *

Also Published As

Publication number Publication date
ITMI960358A1 (en) 1997-08-27
JP2000506835A (en) 2000-06-06
CA2247308A1 (en) 1997-09-04
IT1282692B1 (en) 1998-03-31
EP0885015A2 (en) 1998-12-23
AU1769497A (en) 1997-09-16
WO1997031655A2 (en) 1997-09-04
ITMI960358A0 (en) 1996-02-27

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