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WO1997034594A3 - Use of allosteric haemoglobin modifier for treating solid tumors and inhibiting tumor metastases - Google Patents

Use of allosteric haemoglobin modifier for treating solid tumors and inhibiting tumor metastases Download PDF

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Publication number
WO1997034594A3
WO1997034594A3 PCT/US1997/003465 US9703465W WO9734594A3 WO 1997034594 A3 WO1997034594 A3 WO 1997034594A3 US 9703465 W US9703465 W US 9703465W WO 9734594 A3 WO9734594 A3 WO 9734594A3
Authority
WO
WIPO (PCT)
Prior art keywords
allosteric
haemoglobin
modifier
solid tumors
inhibiting tumor
Prior art date
Application number
PCT/US1997/003465
Other languages
French (fr)
Other versions
WO1997034594A2 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to AU26575/97A priority Critical patent/AU2657597A/en
Publication of WO1997034594A2 publication Critical patent/WO1997034594A2/en
Publication of WO1997034594A3 publication Critical patent/WO1997034594A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for treating neoplastic growth and/or metastases is described. This involves using allosteric effectors, preferably fibric acid derivatives. In one embodiment, these compounds are used in a subject having a tumor experiencing rapid growth and at risk for metastases. In another embodiment, these compounds are used with a second antineoplastic agent such as radiation or a chemotherapeutic agent.
PCT/US1997/003465 1996-03-21 1997-03-21 Use of allosteric haemoglobin modifier for treating solid tumors and inhibiting tumor metastases WO1997034594A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU26575/97A AU2657597A (en) 1996-03-21 1997-03-21 Use of allosteric haemoglobin modifier for treating solid tumors and inhibiting tumor metastases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1381896P 1996-03-21 1996-03-21
US60/013,818 1996-03-21

Publications (2)

Publication Number Publication Date
WO1997034594A2 WO1997034594A2 (en) 1997-09-25
WO1997034594A3 true WO1997034594A3 (en) 1997-12-24

Family

ID=21761928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/003465 WO1997034594A2 (en) 1996-03-21 1997-03-21 Use of allosteric haemoglobin modifier for treating solid tumors and inhibiting tumor metastases

Country Status (2)

Country Link
AU (1) AU2657597A (en)
WO (1) WO1997034594A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2439298A1 (en) 2001-02-23 2002-09-06 Allos Therapeutics, Inc. Methods and reagents to acquire mri signals and images
EP1745012A4 (en) 2004-04-22 2010-11-03 Univ Virginia Commonwealth ALLOSTERIC HEMOGLOBIN MODIFIER COMPOSITIONS AND METHODS OF MAKING SAME
WO2015100235A1 (en) * 2013-12-27 2015-07-02 Virginia Commonwealth University Allosteric hemoglobin modifiers with nitric oxide releasing moiety

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020335A1 (en) * 1991-05-20 1992-11-26 Center For Innovative Technology Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood
US5432191A (en) * 1990-02-12 1995-07-11 The Center For Innovative Technology Allosteric hemoglobin modifiers to decrease oxygen affinity in blood

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432191A (en) * 1990-02-12 1995-07-11 The Center For Innovative Technology Allosteric hemoglobin modifiers to decrease oxygen affinity in blood
WO1992020335A1 (en) * 1991-05-20 1992-11-26 Center For Innovative Technology Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CALAIS ET AL: "In situ tumour radiosensitization induce by ....", RADIOTHERAPY AND ONCOLOGY, vol. 22, 1991, pages 99 - 103, XP002039429 *
KHANDELWAL ET AL: "Enhanced oxygenation in vivo .....", AM. J. PHYSIOL., vol. 265, 1993, pages H1450 - 53, XP002039428 *
TEICHER ET AL: "RSR13: Effects on tumor....", DRUG DEV. RES., vol. 38, May 1996 (1996-05-01), pages 1 - 11, XP002039430 *

Also Published As

Publication number Publication date
AU2657597A (en) 1997-10-10
WO1997034594A2 (en) 1997-09-25

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