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WO1997035194A3 - Procede de criblage enantiomere et compositions pour ce procede - Google Patents

Procede de criblage enantiomere et compositions pour ce procede Download PDF

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Publication number
WO1997035194A3
WO1997035194A3 PCT/US1997/004176 US9704176W WO9735194A3 WO 1997035194 A3 WO1997035194 A3 WO 1997035194A3 US 9704176 W US9704176 W US 9704176W WO 9735194 A3 WO9735194 A3 WO 9735194A3
Authority
WO
WIPO (PCT)
Prior art keywords
target molecule
compounds
molecule
enantiomeric
screening process
Prior art date
Application number
PCT/US1997/004176
Other languages
English (en)
Other versions
WO1997035194A2 (fr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to AU25313/97A priority Critical patent/AU2531397A/en
Publication of WO1997035194A2 publication Critical patent/WO1997035194A2/fr
Publication of WO1997035194A3 publication Critical patent/WO1997035194A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention rend possible une approche dirigée puissante pour identifier les composés énantiosélectifs qui se fixent à des cibles biologiques. D'une façon générale, cette invention se rapporte, dans l'un de ses aspects, à un procédé pour identifier les composés qui interagissent avec une molécule cible (i) en plaçant une molécule de criblage en contact avec une banque de composés panachés, cette molécule de criblage comprenant une molécule cible solide ou l'énantiomère de cette molécule si la molécule cible est chirale; (ii) à sélectionner, dans cette banque de composés, les composés qui ont une interaction désirée avec la molécule cible; et (iii) à tester la capacité de l'énantiomère d'un composé sélectionné dans l'étape (ii) à interagir avec la molécule cible.
PCT/US1997/004176 1996-03-21 1997-03-21 Procede de criblage enantiomere et compositions pour ce procede WO1997035194A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU25313/97A AU2531397A (en) 1996-03-21 1997-03-21 Enantiomeric screening process, and compositions therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62233896A 1996-03-21 1996-03-21
US08/622,338 1996-03-21

Publications (2)

Publication Number Publication Date
WO1997035194A2 WO1997035194A2 (fr) 1997-09-25
WO1997035194A3 true WO1997035194A3 (fr) 1997-12-18

Family

ID=24493816

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/004176 WO1997035194A2 (fr) 1996-03-21 1997-03-21 Procede de criblage enantiomere et compositions pour ce procede

Country Status (2)

Country Link
AU (1) AU2531397A (fr)
WO (1) WO1997035194A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0647266B1 (fr) * 1992-06-05 1999-04-07 The Scripps Research Institute Compositions d'enzymes d et methodes d'utilisation de ces compositions
JP2002537562A (ja) * 1999-02-17 2002-11-05 グリコマインズ リミテッド コンビナトリアル複合糖質ライブラリーならびにその製造および使用方法
FR2818648B1 (fr) * 2000-12-22 2003-10-10 Aventis Pasteur Antigenes proteiques inducteurs d'anticorps neutralisant le virus vih
WO2002051865A2 (fr) * 2000-12-22 2002-07-04 Aventis Pasteur Antigenes proteiques inducteurs d'anticorps neutralisant le virus vih
AU2002250155A1 (en) * 2001-02-22 2002-09-12 The Scripps Research Institute Selection by mirror image display
GB2433505A (en) * 2005-12-20 2007-06-27 Sharp Kk Capture agents for binding a ligand
ES2304315B1 (es) 2007-03-27 2009-07-28 Proyecto De Biomedicina Cima, S.L. Peptidos con capacidad para unirse a la interleuquina 10 (il-10).
AU2016344716B2 (en) 2015-10-30 2021-10-21 Janssen Vaccines & Prevention B.V. Structure based design of D-protein ligands
WO2025042899A2 (fr) * 2023-08-24 2025-02-27 X-Chem, Inc. Procédés d'identification de composés se liant à une molécule cible à l'aide d'une imagerie miroir de la molécule cible

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009690A2 (fr) * 1990-12-03 1992-06-11 Genentech, Inc. Methode d'enrichissement pour des variantes de l'hormone de croissance avec des proprietes de liaison modifiees
WO1994016332A1 (fr) * 1993-01-13 1994-07-21 Yeda Research And Development Co. Ltd. Procede de criblage de polypeptides et de proteines non enzymatiques catalytiques
WO1995027072A1 (fr) * 1994-04-05 1995-10-12 Pharmagenics, Inc. Determination et identification de composes actifs dans une bibliotheque de composes
WO1996034879A1 (fr) * 1995-05-03 1996-11-07 Whitehead Institute For Biomedical Research Identification de ligands enantiomeres

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009690A2 (fr) * 1990-12-03 1992-06-11 Genentech, Inc. Methode d'enrichissement pour des variantes de l'hormone de croissance avec des proprietes de liaison modifiees
WO1994016332A1 (fr) * 1993-01-13 1994-07-21 Yeda Research And Development Co. Ltd. Procede de criblage de polypeptides et de proteines non enzymatiques catalytiques
WO1995027072A1 (fr) * 1994-04-05 1995-10-12 Pharmagenics, Inc. Determination et identification de composes actifs dans une bibliotheque de composes
WO1996034879A1 (fr) * 1995-05-03 1996-11-07 Whitehead Institute For Biomedical Research Identification de ligands enantiomeres

Also Published As

Publication number Publication date
WO1997035194A2 (fr) 1997-09-25
AU2531397A (en) 1997-10-10

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