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WO1997038662A3 - Pulverisateur ou capsule polaire d'aerosols buccaux - Google Patents

Pulverisateur ou capsule polaire d'aerosols buccaux Download PDF

Info

Publication number
WO1997038662A3
WO1997038662A3 PCT/US1997/002793 US9702793W WO9738662A3 WO 1997038662 A3 WO1997038662 A3 WO 1997038662A3 US 9702793 W US9702793 W US 9702793W WO 9738662 A3 WO9738662 A3 WO 9738662A3
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
polar solvent
invention comprises
buccal
flavoring agent
Prior art date
Application number
PCT/US1997/002793
Other languages
English (en)
Other versions
WO1997038662A2 (fr
Inventor
Harry A Dugger Iii
Original Assignee
Flemington Pharmaceutical Corp
Harry A Dugger Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24525609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1997038662(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Flemington Pharmaceutical Corp, Harry A Dugger Iii filed Critical Flemington Pharmaceutical Corp
Priority to DE69732412T priority Critical patent/DE69732412T2/de
Priority to AT97914779T priority patent/ATE288255T1/de
Priority to AU21906/97A priority patent/AU2190697A/en
Priority to DK97914779T priority patent/DK0910339T3/da
Priority to EP97914779A priority patent/EP0910339B1/fr
Priority to CA002252038A priority patent/CA2252038C/fr
Publication of WO1997038662A2 publication Critical patent/WO1997038662A2/fr
Publication of WO1997038662A3 publication Critical patent/WO1997038662A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un pulvérisateur ou une capsule d'aérosols buccaux utilisant un solvant polaire. Ce pulvérisateur ou cette capsule fournissent des composés biologiquement actifs en vue de leur absorption rapide par les muqueuses buccales, ce qui permet d'obtenir un effet très rapidement. Le pulvérisateur d'aérosol buccal selon l'invention comprend 5-50 % de solvant polaire, 0,0025-40 % d'un composé actif, 0,05-5 % d'un agent aromatisant. La capsule de gélatine molle selon l'invention comprend comme composition de remplissage: 75-99 % d'un solvant polaire, 0-20 % d'émulsifiant, 0,0003-35 % de composé actif, et 0,05-60 % d'un agent aromatisant.
PCT/US1997/002793 1996-04-12 1997-02-21 Pulverisateur ou capsule polaire d'aerosols buccaux WO1997038662A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE69732412T DE69732412T2 (de) 1996-04-12 1997-02-21 Bukales, polares spray
AT97914779T ATE288255T1 (de) 1996-04-12 1997-02-21 Polares bukkales spray
AU21906/97A AU2190697A (en) 1996-04-12 1997-02-21 Buccal polar spray or capsule
DK97914779T DK0910339T3 (da) 1996-04-12 1997-02-21 Polært buccalt spray
EP97914779A EP0910339B1 (fr) 1996-04-12 1997-02-21 Aerosol buccal polaire
CA002252038A CA2252038C (fr) 1996-04-12 1997-02-21 Pulverisateur ou capsule polaire d'aerosols buccaux

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63006596A 1996-04-12 1996-04-12
US08/630,065 1996-04-12

Publications (2)

Publication Number Publication Date
WO1997038662A2 WO1997038662A2 (fr) 1997-10-23
WO1997038662A3 true WO1997038662A3 (fr) 1998-02-12

Family

ID=24525609

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/002793 WO1997038662A2 (fr) 1996-04-12 1997-02-21 Pulverisateur ou capsule polaire d'aerosols buccaux

Country Status (8)

Country Link
US (1) US6110486A (fr)
EP (1) EP0910339B1 (fr)
AT (1) ATE288255T1 (fr)
AU (1) AU2190697A (fr)
DE (1) DE69732412T2 (fr)
ES (1) ES2234010T3 (fr)
PT (1) PT910339E (fr)
WO (1) WO1997038662A2 (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
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GB9523833D0 (en) * 1995-11-22 1996-01-24 Boots Co Plc Medical treatment
AU8107998A (en) * 1997-05-22 1998-12-11 Boots Company Plc, The Pharmaceutical compositions
US20090162300A1 (en) * 1997-10-01 2009-06-25 Dugger Iii Harry A Buccal, polar and non-polar spray containing alprazolam
US20030095925A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders
US20030095927A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders
AU4894697A (en) 1997-10-01 1999-04-23 Flemington Pharmaceutical Corporation Buccal, polar and non-polar spray or capsule
US20030190286A1 (en) * 1997-10-01 2003-10-09 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating allergies or asthma
US20040136914A1 (en) 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
US20030082107A1 (en) * 1997-10-01 2003-05-01 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer
US20050002867A1 (en) * 1997-10-01 2005-01-06 Novadel Pharma Inc. Buccal, polar and non-polar sprays containing propofol
US20050287075A1 (en) * 1997-10-01 2005-12-29 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating pain
US20040136915A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing atropine
US20050281752A1 (en) * 1997-10-01 2005-12-22 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
US20050180923A1 (en) * 1997-10-01 2005-08-18 Dugger Harry A.Iii Buccal, polar and non-polar spray containing testosterone
US20050163719A1 (en) * 1997-10-01 2005-07-28 Dugger Harry A.Iii Buccal, polar and non-polar spray containing diazepam
US20040141923A1 (en) * 1997-10-01 2004-07-22 Dugger Harry A. Buccal, polar and non-polar spray containing alprazolam
US20030095926A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract
US20030185761A1 (en) * 1997-10-01 2003-10-02 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating pain
US20030077229A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs
US20040136913A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing sumatriptan
US20030077228A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating endocrine disorders
US7632517B2 (en) * 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
US20030077227A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US7087215B2 (en) * 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6846495B2 (en) 1999-01-11 2005-01-25 The Procter & Gamble Company Compositions having improved delivery of actives
GB9911037D0 (en) * 1999-05-13 1999-07-14 Micap Limited Nicotine delivery service
US20060073174A1 (en) * 2001-08-16 2006-04-06 Access Pharmaceuticals, Inc. Adherent and erodible film to treat a moist surface of a body tissue
US6585997B2 (en) 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US7138133B2 (en) 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
US20030159702A1 (en) * 2002-01-21 2003-08-28 Lindell Katarina E.A. Formulation and use manufacture thereof
EP1496873B2 (fr) * 2002-04-25 2011-08-10 Banner Pharmacaps, Inc. Gelule molle a macher
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
EP1444976A1 (fr) * 2003-02-10 2004-08-11 Novadel Pharma Inc. Pulvérisation ou capsule buccale, polaire et non polaire
AU2004212989A1 (en) * 2003-02-20 2004-09-02 Teva Pharmaceutical Industries Ltd. Menthol solutions of drugs
US20060062812A1 (en) * 2003-03-11 2006-03-23 Calvin Ross Novel compositions
US9241902B2 (en) 2003-12-17 2016-01-26 R.P. Scherer Technologies, Llc Chewable soft capsules containing ungelatinized starch
JP5179757B2 (ja) * 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ， インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
US7850987B2 (en) * 2004-04-08 2010-12-14 Micronutrient, Llc Nutrient composition(s) and system(s) for individualized, responsive dosing regimens
CA2563609C (fr) * 2004-04-22 2012-11-06 Duocort Ab Compositions pharmaceutiques pour therapie aux glucocorticoides aigue
US7972621B2 (en) * 2004-06-03 2011-07-05 R.P. Scherer Technologies, Llc Process for formulating fast dispersing dosage forms comprising at least one fish gelatin selected on the basis of molecular weight
EP2767163A1 (fr) 2005-02-17 2014-08-20 Abbott Laboratories Administration par voie transmuqueuse de compositions médicamenteuses pour le traitement et la prévention de troubles chez les animaux
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
MX2007014679A (es) * 2005-05-25 2008-03-11 Transcept Pharmaceuticals Inc Composiciones solidas y metodos para tratar insomnio de medianoche.
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
WO2007123955A2 (fr) * 2006-04-19 2007-11-01 Novadel Pharma Inc. Formulations hydroalcooliques stables à pulvériser dans la cavité buccale et procédés associés
WO2007146805A2 (fr) 2006-06-08 2007-12-21 Warner Chilcott Company, Inc. Procédés destinés à l'administration de formes posologiques solides d'éthinyl estradiol et de ses promédicaments présentant une biodisponibilité améliorée
TW200840595A (en) * 2006-12-12 2008-10-16 Organon Nv Oral contraceptive spray
WO2008079295A1 (fr) * 2006-12-22 2008-07-03 Novadel Pharma Inc. Préparations antinauséeuses à pulvériser, à usage oral, stables, et méthodes associées
US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
WO2008091592A1 (fr) 2007-01-22 2008-07-31 Targacept, Inc. Administration intranasale, buccale et sublinguale d'analogues de métanicotine
EP2152247A4 (fr) * 2007-05-10 2012-12-26 Novadel Pharma Inc Compositions et procédés anti-insomnie
US20110293535A1 (en) * 2009-02-11 2011-12-01 Heglund, A.S. Composition for buccal absorption of nicotine for the purpose of smoking cessation
CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
GB2482868A (en) 2010-08-16 2012-02-22 Franciscus Wilhelmus Henricus Maria Merkus A testosterone liquid spray formulation for oromucosal administration
GB201200062D0 (en) * 2012-01-04 2012-02-15 Innotesto Bvba Estradiol oromucosal liquid compositions
RU2699674C1 (ru) * 2015-09-30 2019-09-09 Фуджифилм Корпорэйшн Композиция для чрескожной абсорбции
WO2019018338A1 (fr) 2017-07-17 2019-01-24 Northriver Pharm, LLC Composition nasale comprenant un polymère mucoadhésif
WO2025090448A1 (fr) * 2023-10-23 2025-05-01 R.P. Scherer Technologies, Llc Capsules pour administration orale et nasale de produits pharmaceutiques

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784684A (en) * 1971-08-24 1974-01-08 Bayer Ag Coronary dilator in a pharmaceutical dosage unit form
US4232002A (en) * 1977-12-01 1980-11-04 The Welsh National School Of Medicine Procedures and pharmaceutical products for use in the administration of antihistamines
DE3338978A1 (de) * 1982-10-29 1984-05-03 Basf Ag, 6700 Ludwigshafen Verapamil und gallopamil und ihre physiologisch vertraeglichen salze zur resorptiven anwendung auf den schleimhaeuten des mundes, des nasen-rachen-raums und des rektums
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
EP0315960A1 (fr) * 1987-11-11 1989-05-17 Euro-Celtique S.A. Capsule à libération orale instantanée contenant de la nifédipine
DE3922650A1 (de) * 1988-07-08 1990-01-11 Egyt Gyogyszervegyeszeti Gyar Nitroglycerinhaltige, treibgasfreie aerosolpraeparate und verfahren zu deren herstellung
US4935243A (en) * 1988-12-19 1990-06-19 Pharmacaps, Inc. Chewable, edible soft gelatin capsule
US5135753A (en) * 1991-03-12 1992-08-04 Pharmetrix Corporation Method and therapeutic system for smoking cessation
EP0557129A1 (fr) * 1992-02-20 1993-08-25 Johannes Louw Kotze Von Wielligh Produit pour assister un fumeur à cesser cet habitude
WO1994013280A1 (fr) * 1992-12-04 1994-06-23 Mayor Pharmaceutical Laboratories, Inc. Composition analgesique pulverisable
US5456677A (en) * 1994-08-22 1995-10-10 Spector; John E. Method for oral spray administration of caffeine
EP0719549A1 (fr) * 1994-12-29 1996-07-03 McNEIL-PPC, INC. Forme pharmaceutique malle à base de gélatine contenant un gel translucide
US5593684A (en) * 1993-08-04 1997-01-14 Pharmacia Ab Method and therapeutic system for smoking cessation

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784684A (en) * 1971-08-24 1974-01-08 Bayer Ag Coronary dilator in a pharmaceutical dosage unit form
US4232002A (en) * 1977-12-01 1980-11-04 The Welsh National School Of Medicine Procedures and pharmaceutical products for use in the administration of antihistamines
DE3338978A1 (de) * 1982-10-29 1984-05-03 Basf Ag, 6700 Ludwigshafen Verapamil und gallopamil und ihre physiologisch vertraeglichen salze zur resorptiven anwendung auf den schleimhaeuten des mundes, des nasen-rachen-raums und des rektums
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
EP0315960A1 (fr) * 1987-11-11 1989-05-17 Euro-Celtique S.A. Capsule à libération orale instantanée contenant de la nifédipine
DE3922650A1 (de) * 1988-07-08 1990-01-11 Egyt Gyogyszervegyeszeti Gyar Nitroglycerinhaltige, treibgasfreie aerosolpraeparate und verfahren zu deren herstellung
US4935243A (en) * 1988-12-19 1990-06-19 Pharmacaps, Inc. Chewable, edible soft gelatin capsule
US5135753A (en) * 1991-03-12 1992-08-04 Pharmetrix Corporation Method and therapeutic system for smoking cessation
EP0557129A1 (fr) * 1992-02-20 1993-08-25 Johannes Louw Kotze Von Wielligh Produit pour assister un fumeur à cesser cet habitude
WO1994013280A1 (fr) * 1992-12-04 1994-06-23 Mayor Pharmaceutical Laboratories, Inc. Composition analgesique pulverisable
US5593684A (en) * 1993-08-04 1997-01-14 Pharmacia Ab Method and therapeutic system for smoking cessation
US5456677A (en) * 1994-08-22 1995-10-10 Spector; John E. Method for oral spray administration of caffeine
EP0719549A1 (fr) * 1994-12-29 1996-07-03 McNEIL-PPC, INC. Forme pharmaceutique malle à base de gélatine contenant un gel translucide

Also Published As

Publication number Publication date
US6110486A (en) 2000-08-29
EP0910339A2 (fr) 1999-04-28
DE69732412T2 (de) 2006-01-05
DE69732412D1 (de) 2005-03-10
EP0910339B1 (fr) 2005-02-02
ES2234010T3 (es) 2005-06-16
AU2190697A (en) 1997-11-07
ATE288255T1 (de) 2005-02-15
WO1997038662A2 (fr) 1997-10-23
PT910339E (pt) 2005-05-31

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