WO1997039122A3 - PHOSPHOPROTEINE DE 78 kDa ISOLEE ET CLONEE DE MASTOCYTES (AGENT INHIBITEUR DE LA DEGRANULATION DES MASTOCYTES) ET SON UTILISATION - Google Patents
PHOSPHOPROTEINE DE 78 kDa ISOLEE ET CLONEE DE MASTOCYTES (AGENT INHIBITEUR DE LA DEGRANULATION DES MASTOCYTES) ET SON UTILISATION Download PDFInfo
- Publication number
- WO1997039122A3 WO1997039122A3 PCT/US1997/006042 US9706042W WO9739122A3 WO 1997039122 A3 WO1997039122 A3 WO 1997039122A3 US 9706042 W US9706042 W US 9706042W WO 9739122 A3 WO9739122 A3 WO 9739122A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mast cell
- moesin
- protein
- mast
- cell degranulation
- Prior art date
Links
- 210000003630 histaminocyte Anatomy 0.000 title abstract 10
- 102000007982 Phosphoproteins Human genes 0.000 title abstract 2
- 108010089430 Phosphoproteins Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 102100027869 Moesin Human genes 0.000 abstract 3
- 108010071525 moesin Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108010044467 Isoenzymes Proteins 0.000 abstract 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 abstract 2
- 239000002299 complementary DNA Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 abstract 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 abstract 1
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960000265 cromoglicic acid Drugs 0.000 abstract 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229930003935 flavonoid Natural products 0.000 abstract 1
- 150000002215 flavonoids Chemical class 0.000 abstract 1
- 235000017173 flavonoids Nutrition 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004305 lodoxamide Drugs 0.000 abstract 1
- RVGLGHVJXCETIO-UHFFFAOYSA-N lodoxamide Chemical compound OC(=O)C(=O)NC1=CC(C#N)=CC(NC(=O)C(O)=O)=C1Cl RVGLGHVJXCETIO-UHFFFAOYSA-N 0.000 abstract 1
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 abstract 1
- 229960004398 nedocromil Drugs 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 229960001285 quercetin Drugs 0.000 abstract 1
- 235000005875 quercetin Nutrition 0.000 abstract 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
On a cloné une protéine de mastocyte de 78 kDa (moesine) depuis le rat et on a déterminé son ADNc et sa séquence d'acides aminés. Cette protéine est phosphorylée sur des résidus spécifiques de serine et de threonine sous l'effet exercé dans les mastocytes par un ou plusieurs isozymes de protéine kinase C, en particulier, l'isozyme κ, ce qui permet d'obtenir une phosphoprotéine qui inhibe la dégranulation des mastocytes (agent inhibiteur de la dégranulation des mastocytes). On peut stimuler la phosphorylation in vivo de cette protéine dans les mastocytes au moyen de médicaments, tels que cromolyne, nedocromil, de flavonoïdes, tels que quercetine et kaempherol, et de lodoxamide, On peut inhiber la dégranulation des mastocytes au moyen de l'administration d'inhibiteurs de phosphomoesine phosphatase. On peut identifier des tissus déficients en moesine de mastocytes au moyen d'un anticorps marqué anti-moesine ou anti-phosphomoesine et les traiter au moyen de la transfection de ces mastocytes par de l'ADNc de moesine dans un vecteur viral, tel que le vecteur du virus de la grippe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU24563/97A AU2456397A (en) | 1996-04-12 | 1997-04-11 | Isolated and cloned mast cell 78 kda phosphoprotein (mast cell degranulation inhibitory agent) and use thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63118496A | 1996-04-12 | 1996-04-12 | |
| US08/631,184 | 1996-04-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997039122A2 WO1997039122A2 (fr) | 1997-10-23 |
| WO1997039122A3 true WO1997039122A3 (fr) | 1997-12-24 |
| WO1997039122A9 WO1997039122A9 (fr) | 1998-03-26 |
Family
ID=24530125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/006042 WO1997039122A2 (fr) | 1996-04-12 | 1997-04-11 | PHOSPHOPROTEINE DE 78 kDa ISOLEE ET CLONEE DE MASTOCYTES (AGENT INHIBITEUR DE LA DEGRANULATION DES MASTOCYTES) ET SON UTILISATION |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2456397A (fr) |
| WO (1) | WO1997039122A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6280739B1 (en) * | 1996-04-18 | 2001-08-28 | Genetics Institute, Inc. | Method of inhibiting angiogenesis using secreted proteins |
| US5872234A (en) | 1997-06-27 | 1999-02-16 | Incyte Pharmaceuticals, Inc. | Human extracellular matrix proteins |
| EP1557426A3 (fr) * | 1998-02-09 | 2005-08-03 | Human Genome Sciences, Inc. | 45 Protéines humaines secrétées |
| KR20010043090A (ko) * | 1998-04-28 | 2001-05-25 | 우에노 도시오 | 신규인 폴리펩티드, 그 폴리펩티드를 코드화하는 ｃＤＮＡ및 그 용도 |
| US8410248B2 (en) | 1999-03-12 | 2013-04-02 | Human Genome Sciences Inc. | HWBAO62 polypeptides |
| CA2374412A1 (fr) * | 1999-05-28 | 2000-12-07 | Zymogenetics, Inc. | Proteine-31 a helice alpha secretee |
| US7893218B2 (en) * | 2003-06-16 | 2011-02-22 | Stowers Institute For Medical Research | Antibodies that specifically bind SOST peptides |
| RU2380100C1 (ru) * | 2008-08-27 | 2010-01-27 | Научно-исследовательский институт гриппа Северо-Западного отделения Российской академии медицинских наук (НИИ гриппа СЗО РАМН) | Средство для профилактики и лечения гриппа а и в |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0613945A2 (fr) * | 1993-02-25 | 1994-09-07 | The General Hospital Corporation | Merlin, gène suppresseur de tumeurs, et ses utilisations |
-
1997
- 1997-04-11 WO PCT/US1997/006042 patent/WO1997039122A2/fr active Application Filing
- 1997-04-11 AU AU24563/97A patent/AU2456397A/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0613945A2 (fr) * | 1993-02-25 | 1994-09-07 | The General Hospital Corporation | Merlin, gène suppresseur de tumeurs, et ses utilisations |
Non-Patent Citations (4)
| Title |
|---|
| LANKES WT ET AL: "Moesin: a member of the protein 4.1-talin-ezrin family of proteins.", PROC NATL ACAD SCI U S A, OCT 1 1991, 88 (19) P8297-301, UNITED STATES, XP002045604 * |
| NAKAMURA F ET AL: "Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets.", J BIOL CHEM, DEC 29 1995, 270 (52) P31377-85, UNITED STATES, XP002045605 * |
| SATO N ET AL: "A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.", J CELL SCI, SEP 1992, 103 ( PT 1) P131-43, ENGLAND, XP002045603 * |
| SCHWARTZ-ALBIEZ R ET AL: "Differential expression of the microspike-associated protein moesin in human tissues.", EUR J CELL BIOL, JUL 1995, 67 (3) P189-98, GERMANY, XP002045606 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997039122A2 (fr) | 1997-10-23 |
| AU2456397A (en) | 1997-11-07 |
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