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WO1997039793A1 - Dispositif electrochimique de traitement contre le cancer - Google Patents

Dispositif electrochimique de traitement contre le cancer Download PDF

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Publication number
WO1997039793A1
WO1997039793A1 PCT/CN1997/000032 CN9700032W WO9739793A1 WO 1997039793 A1 WO1997039793 A1 WO 1997039793A1 CN 9700032 W CN9700032 W CN 9700032W WO 9739793 A1 WO9739793 A1 WO 9739793A1
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Prior art keywords
circuit
current
computer
bus
current output
Prior art date
Application number
PCT/CN1997/000032
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English (en)
French (fr)
Inventor
Yajun Ma
Runqiu Chen
Qingtai Guo
Original Assignee
Beijing Haidian Dadi Electronic Technology Development Corp.
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Publication date
Application filed by Beijing Haidian Dadi Electronic Technology Development Corp. filed Critical Beijing Haidian Dadi Electronic Technology Development Corp.
Publication of WO1997039793A1 publication Critical patent/WO1997039793A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents

Definitions

  • the present invention relates to a medical instrument, in particular an electrochemical cancer treatment instrument that uses direct current as a treatment means to make a biochemical reaction of a diseased tissue, thereby destroying the diseased tissue (such as a tumor).
  • the purpose of the present invention is to provide an improved electrochemical cancer treatment instrument, which has good treatment effect, safety and reliability.
  • the electrochemical cancer treatment instrument includes a computer; a display and a keyboard supporting the computer; a bus conversion circuit board is inserted into the computer, and the bus conversion circuit is connected to the computer bus and the treatment host bus;
  • a treatment host and an electrode needle the treatment host includes: a DC current output unit composed of a multi-route D / A conversion circuit and a constant current output circuit; a multi-channel DC voltage stabilization unit, which is composed of a filter, a transformer, and a DC voltage regulator A plurality of negative current sharing circuits matching the constant current output circuit; an A / D conversion circuit, the constant current output circuit including an operational amplifier and a driver, and the current sharing circuit including three poles A tube, an upper bias resistor, an emitter resistor, and two diodes connected in series between the base and ground in a forward direction, the electrode needle includes a positive electrode A and a plurality of negative electrodes C.
  • Figure 1 Block diagram of the working principle of the therapeutic apparatus of the present invention
  • FIG. 2 is a circuit schematic diagram of a DC current output unit of the therapeutic apparatus of the present invention
  • Figure 3 Circuit schematic of the negative current sharing circuit of the therapeutic device of the present invention.
  • FIG. 1 is a computer, and 1 and 2 are a display and a keyboard supporting the computer.
  • a bus conversion circuit board 4 is inserted into the computer, which transmits signals between the computer and the treatment host, and is connected through the computer bus and the instrument bus 12. Between the computer and the treatment unit.
  • the treatment unit 5 includes: a DC current output unit composed of a D / A conversion circuit 6 and a constant current output circuit 7.
  • the output unit is multi-channel and can be selected according to needs; the host also includes Multi-channel DC voltage stabilizing unit 10, which includes a filter, a transformer, and a DC voltage stabilizer, can output a safety voltage below 36 V, and the current (milliampere level) under the safety voltage is regulated by the circuit of each part of the instrument and converted into the required treatment Current is drawn out; 9 in FIG. 1 is a negative current sharing circuit, which constitutes a treatment unit with the constant current output circuit 7 (see FIG. 3 for details), and FIG. 1 also includes an electrode needle 8 which adopts corrosion resistance and good conductivity. Made of metal materials, preferably a platinum group metal, the subject to be treated is connected in series between the positive and negative electrodes, and the host also includes an A / D conversion circuit.
  • Multi-channel DC voltage stabilizing unit 10 which includes a filter, a transformer, and a DC voltage stabilizer, can output a safety voltage below 36 V, and the current (milliampere level) under the safety voltage is regulated by the circuit of each
  • the above bus conversion circuit includes: an address latch, a write data latch, an address buffer, a data write buffer, a read data buffer, a data read buffer, and a control signal generator.
  • the control signal generator is used to generate the control signals required by the treatment unit, and these control signals are transmitted to the treatment unit via the control signal driver.
  • a control signal generator which is used for buffers and registers in the bus conversion circuit, etc. Provide chip select signal.
  • the A / D conversion circuit includes: a channel selection controller connected to the data bus, a multi-way conversion switch, an A / D conversion chip, and a digital data output end of the output terminal connected to the data bus and the input terminal of the A / D conversion chip.
  • the data receiver, the output end of the multiplexer is connected to the input end of the A / D conversion chip, and the channel controller is used to select the channel of the multiplexer.
  • 6 is a D / A conversion circuit, and the circuit includes a data buffer, an address decoder, a D / A conversion chip, and an operational amplifier 13. Among them, there are multiple D / A conversion chips and operational amplifiers, depending on the output The number of groups depends.
  • the output of the D / A conversion chip is connected to an operational amplifier.
  • the reference voltage VREF of the chip is directly provided by the voltage regulator of the voltage stabilization unit.
  • the model of the operational amplifier is ⁇ A741.
  • the operational amplifier 13 is connected to another operational amplifier. 14 (shared ⁇ A741), the output of the operational amplifier 14 is connected to the driver (S8050) 15, where the collector of the triode is connected to + 24V adjustable voltage.
  • the positive current of each constant current output circuit is between 20mA-100mA, which is lower than 20mA. The effect is not obvious, higher than 100mA is not conducive to patient treatment and safety.
  • the triode collector of driver 15 of the therapy device is connected with an adjustable voltage of + 24V, and an adjustable potentiometer is used, and the potentiometer is fixed on the front panel of the treatment host.
  • the potentiometer can be Adjust to zero to make the positive output current close to zero to ensure patient safety.
  • the positive treatment current la enters the tumor.
  • the negative current Iki of a certain path increases to make the
  • the negative current sharing circuit of this circuit works in a saturated state. In this state, the increase of Vci is large and the increase of I w is small, so the increased therapeutic current flowing to the negative electrode of this channel will pass through the cancer tissue between the negative electrodes. Flow to the negative electrode with a lower V ci value, so that the treatment current is evenly distributed among the various negative electrodes.
  • the constant current circuit satisfies the following formula
  • VREF Reference voltage for D / A conversion circuit 6, provided by the regulator.
  • the working process of the therapeutic instrument After the computer is set by the software, the therapeutic data representing the treatment channel number, the therapeutic current intensity and the corresponding control commands are sent to the instrument bus through the bus conversion unit, which is converted into simulation by D / A on the treatment host. The voltage is then output from the positive pole of the corresponding channel through constant current. The voltage presented at the output end is returned to the computer via A / D, conversion bus conversion, and computer bus. The computer processes and displays these data, and the remaining channels proceed in sequence. During the treatment process, the size of the treatment current is adjusted and controlled by the computer. Generally, the treatment current can be changed in a trapezoidal wave shape, that is, it gradually rises from a small value to a set current value. After maintaining for a period of time, it slowly decreases to zero. The computer regulates, controls and manages the entire process of treatment.
  • the therapy device adopts direct current as the main control parameter, which is beneficial to the treatment, and the current value is controlled in the range of 20mA-100mA, which greatly improves the treatment effect.
  • the therapy device is also provided with a treatment device in an emergency state (0 ⁇ + 24V output adjustable voltage), so that the output treatment current is close to zero, the safety and reliability of the therapy device is improved, and personal safety is guaranteed.
  • the use of metal materials such as platinum as electrodes also ensures the reliability of the instrument and extends Service life.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)

Description

电化学癌肿治疗仪 技术领域
本发明涉及一种医疗仪器， 特别是一种利用直流电作为治疗手段， 使 病体组织发生生物化学反应， 从而破坏病体組织（如肿瘤） 的电化学癌肿 治疗仪.
背景技术
已有的电化学癌肿治疗仪一般是采用可调电压输出方式， 这种选择电 压为首要的受控治疗参数， 从电化学治癌机理上看是不太合适的. 同时， 在治疗中， 流过肿瘤组织各部分电流分配不均匀， 直接影响疗效， 甚至可 使某一部分的肿瘤加速增长.
本专利申请人曽于 1993年 12月 3日向中国专利局申请了一项名称为 "电化学癌肿治疗仪" ， 申请号为 93120059.8的专利申请. 在上述的申请 中介绍了一种以治疗电流为主、 可予置治疗参数的电化学癌肿治疗仪， 其 主要特点是能够提供多路恒定的正极治疗电流， 并且为多路负极提供均匀 分配的电流. 在该申请中， 虽提供了作为治疗信号产生装置的恒流装置电 路原理图， 但未提供达到最佳治疗效果的参数. 因此有必要提供一种性能 突出的电化学癌肿治疗仪.
发明内容
本发明目的是提供一种改进的电化学癌肿治疗仪， 该治疗仪治疗效果 好， 安全可靠.
为达到上述目的， 本发明采用以下技术方案： 电化学癌肿治疗仪包括 计算机； 与计算机配套的显示器、 键盘； 计算机内插入一块总线转换电路 板， 总线转换电路与计算机总线、 治疗主机总线连接； 治疗主机以及电极 针， 所述治疗主机包括： 多路由 D/A转换电路、 恒流输出电路组成的直流 电流输出单元； 多路直流稳压单元， 它由滤波器、 变压器、 直流稳压器构 成； 与恒流输出电路相配套的多个负极均流电路； A/D转换电路， 所述恒 流输出电路包括一个运算放大器和一个驱动器， 所述的均流电路包括三极 管、 上偏流电阻、 射极电阻以及基极与地之间正向串接的两个二极管， 所 述的电极针包括正极 A和多个负极 C .
以下结合附图对本发明作进一步说明：
附图概述
图 1 : 本发明治疗仪的工作原理方框图；
图 2 : 本发明治疗仪的直流电流输出单元的电路原理图；
图 3 : 本发明治疗仪负极均流电路的电路原理图.
本发明的最佳实施方式
图 1中， 3为计算机， 1、 2为与计算机配套的显示器、 键盘， 计算 机内插入一块总线转换电路板 4， 它传递计算机和治疗主机之间的信号， 它通过计算机总线和仪器总线 12连接于计算机和治疗主机之间.治疗主机 5包括： 由 D/A转换电路 6、 恒流输出电路 7构成的直流电流榆出单元， 该输出单元为多路， 可根据需要选用； 主机中还包括多路直流稳压单元 10， 它含有滤波器、 变压器、 直流稳压器， 可输出 36V以下安全电压， 安 全电压下的电流（毫安级）经仪器各部分电路调控， 转换为所需要的治疗 电流揄出； 图 1中， 9为负极的均流电路， 它与恒流输出电路 7构成治疗 单元（详见图 3 ) ， 图 1中还包括电极针 8， 它采用耐腐蚀、 导电性能好 的金属材料做成， 最好是铂族金属， 被治疗对象串接在正、 负极之间， 主 机中还包括 A/D转换电路.
上述的总线转换电路包括： 地址锁存器， 写数据锁存器、 地址緩冲器、 数据写緩冲器， 读数据緩冲器， 数据读緩冲器， 还有控制信号发生器， 其 中， 控制信号发生器用于产生治疗单元所需的控制信号， 这些控制信号经 控制信号驱动器传递到治疗单元， 另外， 还有一控制信号发生器， 它是为 总线转换电路中緩冲器和销存器等提供片选信号.
上述 A/D转换电路包括： 输入与数据总线相连的通道选择控制器， 多 路转换开关， A/D转换芯片， 以及输出端接数据总线且输入端接 A/D转换 芯片的数字数据输出端的数据接收器， 多路转换开关的输出端接 A/D转换 芯片的输入端， 通道控制器用于选择多路转换开关的通道. 图 2中， 6为 D/A转换电路， 该电路包括数据緩冲器、 地址译码器、 D/A转换芯片、 运算放大器 13， 其中 D/A转换芯片和运算放大器为多个， 视输出组数多少而定. D/A转换芯片输出接运算放大器， 芯片的参考电压 VREF由稳压单元的稳压管直接提供， 运算放大器的型号为 μΑ741， 运算放 大器 13的榆出接另一运算放大器 14 (共用 μΑ741 ) , 运算放大器 14的输 出接驱动器（ S8050 ) 15 , 其中三极管的集电极接 + 24V可调电压. 每路恒流输出电路的正极电流为 20mA - 100mA之间，低于 20mA治 疗效果不明显， 高于 100mA不利于病人治疗和安全.
为适应紧急情况，在本治疗仪的驱动器 15的三极管集电极上接 + 24V 可调电压， 用可调电位器， 电位器固定在治疗主机的前面板上. 出现紧急 状态时， 可将电位器调至零值， 使正极输出电流接近为零， 以确保患者的 安全.
图 3中， 由某一路正极输出的直流电流 la通入病灶后， 经均流电路中 的三极管1\ 电阻 R9、 接地， 其中三极管的基极和集电极之间接电阻 ， 在基极和地之间串接二个二极管 D1 .
正极治疗电流 la进入瘤体， 当某路负极电流 Iki增加到使该路的
Vci«1.7V时， 该路负极均流电路工作在饱和状态， 在此状态， Vci增加较 大而 Iw增加很小， 于是流到该路负极增加的治疗电流会通过负极之间的癌 组织流向 Vci值较低的负极， 这样治疗电流在各路负极之间得到均匀分配. 恒流电路满足下列公式
Figure imgf000005_0001
其中 R3=R4 R5=¾+R7
式中： la : 流经正极的治疗电流
D : D/A转换电路 6的数字数据输入
其数值取在 0 - 255之间
VREF : D/A转换电路 6的参考电压， 由稳压管提供.
根据实际应用， 该电路中 R3 = Rt = R5 = 10ΚΩ， R6 = 9.95ΚΩ， R7 = 50Ω , 满度值的揄出电流为 99.86mA . 改变 D的取值， 以便使恒流 输出控制在 20mA - 100mA之间， 在该电流值内， 本治疗仪即可获得很好 治疗效果.
本治疗仪的工作过程： 计算机由软件设置后， 通过总线转换单元将表 征治疗通道号、 治疗电流强度的治疗数据及相应控制命令送至仪器总线 上， 经治疗主机上的 D/A转换成模拟量， 再经恒流从对应路的正极输出. 输出端呈现的电压经 A/D、 转换总线转换和计算机总线回到计算机， 计算 机对这些数据进行处理、 显示， 其余各通道依次进行。 治疗过程中， 治疗 电流的大小由计算机自行调节、 控制， 一般情况下可以使治疗电流呈梯形 波状变动， 即从小緩慢上升到设定的电流值， 经保持一段时间后， 再緩慢 下降至零， 由计算机调节、 控制和管理治疗的全部过程.
作用机理： 通过电化学治疗仪， 给肿瘤或病体组织施以治疗电流， 肌 体组织产生一系列生物电解、 电离、 电渗透反应， 并由此产生更为复杂的 生物化学反应， 其结果是： （ 1 )肿瘤或其他病体组织， 正极区 PH值降 至 1 - 2， 呈强酸性， 负极区 PH值上升至 12 - 14呈强碱性， 病体细胞 赖以生存的酸、 碱平衡环境彻底破坏. （ 2 )病体组织细胞膜破溃， 线粒 体消失， 核蛋白凝固坏死. （ 3 )病体组织内剧烈的酸、 碱反应和细胞蛋 白质凝固坏死， 又造成病体组织内血液和体液微循环的停滞. （ 4 )在上 迷病体细胞赖以生存的基础条件遭到彻底破坏情况下， 肿瘤或其他病体组 织细胞死亡， 从而导致肿瘤或其他病体组织彻底破坏.
本发明优点： 本治疗仪采用直流电流为主要控制参数， 有利于治疗， 且电流值控制在 20mA - 100mA范围之内， 大大提高了治疗效果， 治疗仪 还设有紧急状态下的处理装置（ 0 ~ + 24V的输出可调电压） ， 使输出治 疗电流接近零， 治疗仪的安全性、 可靠性提高， 保证了人身安全. 采用铂 等金属材料作为电极， 也保证了仪器的可靠性， 并延长使用寿命.

Claims

权 利 要 求
1. 一种电化学癌肿治疗仪， 它包括计算机（ 3 ) ; 与计算机配套的显 示器（ 1 ) 、 键盘（ 2 )； 计算机内插入一块总线转换电路板（ 4 ) , 总 线转换电路与计算机总线、 治疗主机总线（ 12 )连接； 治疗主机（ 5 )以 及电极针（ 8 )， 其特征在于所迷治疗主机包括： 多路由 D/A转换电路
( 6 ) 、 恒流输出电路（ 7 )組成的直流电流输出单元； 多路直流稳压单 元（ 10 ) , 它由滤波器、 变压器、 直流稳压器构成； 与恒流输出电路 ( 7 ) 相配套的多个负极均流电路（ 9 )； A/D转换电路（ 11 )， 所述的恒流输 出电路包括一个运算放大器（ 14 )和一个驱动器（ 15 ) , 所述的均流电 路包括三极管、 上倘流电阻 R8、 射极电阻 R9以及基极与地之间正向串接 的两个二极管， 所述的电极针包括正极 A和多个负极 C .
2. 根据权利要求 1所述的电化学癌肿治疗仪， 其特征在于： 所述的每 路恒流榆出电路的正极电流为 20mA - 100mA之间.
3. 根据权利要求 1或 2所述的电化学癌肿治疗仪， 其特征在于： 所述的 恒流输出电路（ 7 ) 中的参数为 R3 = R4 = R5 = 10ΚΏ , R6 = 9.95ΚΩ, R7=50Q .
4. 根据权利要求 1或 2所述的电化学癌肿治疗仪， 其特征在于： 所述的 驱动器（ 15 )采用三极管， 三极管的集电极接 + 24V可调电压.
5. 根据权利要求 1或 2所述的电化学癌肿治疗仪， 其特征在于： 所述的 电极针最好选用铂族材料.
PCT/CN1997/000032 1996-04-22 1997-04-22 Dispositif electrochimique de traitement contre le cancer WO1997039793A1 (fr)

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CN1086444A (zh) * 1993-06-12 1994-05-11 北京市海淀区大地电子技术开发公司 电化学癌肿治疗仪
CN1103319A (zh) * 1993-12-03 1995-06-07 北京市海淀区大地电子技术开发公司 电化学癌肿治疗仪
US5470347A (en) * 1994-12-13 1995-11-28 Somatics, Inc. Safety monitor circuit for an ECT device and method

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US6712840B2 (en) 1999-04-23 2004-03-30 Caijin Sun Tumor electrochemical-therapeutic device using electrothermal needles
KR100503882B1 (ko) * 2001-07-16 2005-07-29 주식회사 솔고 바이오메디칼 전기화학적 치료기

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