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WO1998000119A3 - Applications of active substances affecting the functions of non neuronal acetylcholine - Google Patents

Applications of active substances affecting the functions of non neuronal acetylcholine Download PDF

Info

Publication number
WO1998000119A3
WO1998000119A3 PCT/EP1997/003415 EP9703415W WO9800119A3 WO 1998000119 A3 WO1998000119 A3 WO 1998000119A3 EP 9703415 W EP9703415 W EP 9703415W WO 9800119 A3 WO9800119 A3 WO 9800119A3
Authority
WO
WIPO (PCT)
Prior art keywords
applications
functions
neuronal acetylcholine
active substances
non neuronal
Prior art date
Application number
PCT/EP1997/003415
Other languages
German (de)
French (fr)
Other versions
WO1998000119A2 (en
Inventor
Ignaz Wessler
Original Assignee
Boehringer Ingelheim Kg
Boehringer Ingelheim Int
Ignaz Wessler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg, Boehringer Ingelheim Int, Ignaz Wessler filed Critical Boehringer Ingelheim Kg
Priority to AU32632/97A priority Critical patent/AU3263297A/en
Publication of WO1998000119A2 publication Critical patent/WO1998000119A2/en
Publication of WO1998000119A3 publication Critical patent/WO1998000119A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a process for determining the functional state of non-neuronal acetylcholine in human tissue or cells which are accessible either directly or by endoscopy. It also relates to the use of active ingredients which can affect the synthesis, release, inactivation and function of non-neuronal acetylcholine.
PCT/EP1997/003415 1996-07-02 1997-07-01 Applications of active substances affecting the functions of non neuronal acetylcholine WO1998000119A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU32632/97A AU3263297A (en) 1996-07-02 1997-07-01 New use of active ingredients which affect non-neuronal acetylcholine functions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19626373.5 1996-07-02
DE19626373A DE19626373A1 (en) 1996-07-02 1996-07-02 Novel use of active ingredients that affect the function of non-neuronal acetylcholine

Publications (2)

Publication Number Publication Date
WO1998000119A2 WO1998000119A2 (en) 1998-01-08
WO1998000119A3 true WO1998000119A3 (en) 1998-04-02

Family

ID=7798569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/003415 WO1998000119A2 (en) 1996-07-02 1997-07-01 Applications of active substances affecting the functions of non neuronal acetylcholine

Country Status (4)

Country Link
AU (1) AU3263297A (en)
DE (1) DE19626373A1 (en)
WO (1) WO1998000119A2 (en)
ZA (1) ZA975804B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8742198A (en) * 1997-08-15 1999-03-08 Shire International Licensing B.V. Use of cholinesterase inhibitor for treating diseases associated with pro teolytic enzyme activity
GB9918760D0 (en) * 1999-08-09 1999-10-13 Darwin Discovery Ltd Topical treatment
US6277855B1 (en) * 2000-04-21 2001-08-21 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with nicotinic acetylcholine receptor agonists
DE10111843A1 (en) 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Compounds for the treatment of inflammatory diseases
US20050142088A1 (en) * 2002-02-07 2005-06-30 Mitsuru Mizuno Hair growth stimulants, percutaneous preparations and method of stimulating hair growth
WO2005072713A2 (en) * 2004-01-27 2005-08-11 The Feinstein Institute For Medical Research Cholinesterase inhibitors for treating inflammation
GB2419093A (en) * 2004-10-12 2006-04-19 Ernir Snorrason Acetylcholinesterase inhibitors for the treatment of skin
EP2008660A1 (en) * 2004-10-12 2008-12-31 Ernir Snorrason Inhibitors of acetylcholinesterase for treating skin diseases
TR201802725T4 (en) 2013-03-15 2018-03-21 Verona Pharma Plc Drug combination.
US20190125734A1 (en) * 2016-05-09 2019-05-02 Nanoegg Research Laboratories, Inc. Composition for treating or preventing atopic dermatitis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1243729A1 (en) * 1984-06-01 1986-07-15 Киевский государственный институт усовершенствования врачей Method of treatment of neurodermite
US5084281A (en) * 1989-02-14 1992-01-28 Dillon Richard S Method and solution for treating tissue wounds
EP0534343A1 (en) * 1991-09-23 1993-03-31 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments
WO1994015623A1 (en) * 1992-12-30 1994-07-21 Patent Biopharmaceutics Inc. Hyaluronic acid-urea pharmaceutical compositions and uses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1243729A1 (en) * 1984-06-01 1986-07-15 Киевский государственный институт усовершенствования врачей Method of treatment of neurodermite
US5084281A (en) * 1989-02-14 1992-01-28 Dillon Richard S Method and solution for treating tissue wounds
EP0534343A1 (en) * 1991-09-23 1993-03-31 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments
WO1994015623A1 (en) * 1992-12-30 1994-07-21 Patent Biopharmaceutics Inc. Hyaluronic acid-urea pharmaceutical compositions and uses

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE Dialog Information Services; XP002047242 *
DATABASE WPI Section Ch Week 8710, Derwent World Patents Index; Class B05, AN 87-071007, XP002047243 *
EVANS S. ET AL: "Synthesis and release of acetylcholine in the rabbit kidney cortex", LIFE SCI. (ENGLAND), vol. 51, no. 22, 1992, pages 1699 - 1703, XP002047239 *
GAJEWAKI W.: "Disappeareance of psoriatic skin rashes in the course of atropine therapy", POL TYG LEK, vol. 25, no. 47, November 1970 (1970-11-01), pages 1815 - 1816 *
KLAPPROTH H. ET AL: "Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man", NAUNYN-SCHMIEDEBERG'S ARCH. PHARMACOL., vol. 355, no. 4, April 1997 (1997-04-01), pages 515 - 523, XP002047241 *
KLAPPROTH H. ET AL: "Non-neuronal acetylcholine, a widespread signalling molecule in man", BRITISH JOURNAL OF PHARMACOLOGY, vol. 120, March 1997 (1997-03-01), pages 61P, XP002047240 *
REINHEIMER T. ET AL: "Acetylcholine in isolated airways of rat, guinea pig, and human: species differences in role of airway mucosa", AM. J. PHYSIOL. (UNITED STATES), vol. 14, no. 5, May 1996 (1996-05-01), pages L722 - L728, XP002047238 *

Also Published As

Publication number Publication date
WO1998000119A2 (en) 1998-01-08
AU3263297A (en) 1998-01-21
ZA975804B (en) 1998-01-02
DE19626373A1 (en) 1998-01-08

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