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WO1998000539A3 - Proteine d'interaction mkk3 (mip) - Google Patents

Proteine d'interaction mkk3 (mip) Download PDF

Info

Publication number
WO1998000539A3
WO1998000539A3 PCT/US1997/010866 US9710866W WO9800539A3 WO 1998000539 A3 WO1998000539 A3 WO 1998000539A3 US 9710866 W US9710866 W US 9710866W WO 9800539 A3 WO9800539 A3 WO 9800539A3
Authority
WO
WIPO (PCT)
Prior art keywords
kinase
mip
mkk3
protein
mitogen
Prior art date
Application number
PCT/US1997/010866
Other languages
English (en)
Other versions
WO1998000539A2 (fr
Inventor
Venkatakrishna Shyamala
Michael W Kavanaugh
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to AU43260/97A priority Critical patent/AU4326097A/en
Publication of WO1998000539A2 publication Critical patent/WO1998000539A2/fr
Publication of WO1998000539A3 publication Critical patent/WO1998000539A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur un nouveau gène humain codant une protéine appelée protéine d'interaction MKK3 (MIP) dont l'expression est propre à un tissu sélectionné dans un groupe comprenant le cerveau, les reins, le foie, le pancréas et la rate. La MIP, qui se fixe à un mutant interférant dominant de la MAPK kinase-3 (MKK3) peut jouer un rôle dans la transduction de signaux extracellulaires à l'intérieur du noyau, ce qui entraîne l'activation de la p38 kinase.
PCT/US1997/010866 1996-07-03 1997-07-02 Proteine d'interaction mkk3 (mip) WO1998000539A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43260/97A AU4326097A (en) 1996-07-03 1997-07-02 (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US2122496P 1996-07-03 1996-07-03
US60/021,224 1996-07-03
US2164196P 1996-07-12 1996-07-12
US60/021,641 1996-07-12
US88657297A 1997-07-01 1997-07-01
US08/886,572 1997-07-01

Publications (2)

Publication Number Publication Date
WO1998000539A2 WO1998000539A2 (fr) 1998-01-08
WO1998000539A3 true WO1998000539A3 (fr) 1998-03-26

Family

ID=27361599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/010866 WO1998000539A2 (fr) 1996-07-03 1997-07-02 Proteine d'interaction mkk3 (mip)

Country Status (2)

Country Link
AU (1) AU4326097A (fr)
WO (1) WO1998000539A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756332A (en) * 1996-12-26 1998-05-26 Incyte Pharmaceuticals, Inc. Guanosine monophosphate reductase
US6372473B1 (en) 1997-05-28 2002-04-16 Human Genome Sciences, Inc. Tissue plasminogen activator-like protease
US6165461A (en) * 1998-04-14 2000-12-26 Board Of Regents, University Of Texas System Tao protein kinases and methods of use therefor
WO2002058695A1 (fr) 2000-12-20 2002-08-01 Merck & Co., Inc. Agents inhibiteurs de p38 kinase (halo-benzo carbonyl)heterocyclo- fusionnes phenyl

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
B. DÉRIJARD ET AL.: "Independent Human MAP kinase signal transduction pathways defined by MEK and MKK isoforms.", SCIENCE, vol. 267, 3 February 1995 (1995-02-03), pages 682 - 685, XP002054336 *
H. KANNO ET AL.: "Two structural genes on different chromosomes are required for encoding the major subunit of human cell glucose-6-phosphate dehydrogenase.", CELL, vol. 58, 11 August 1989 (1989-08-11), pages 595 - 606, XP002054262 *
S. HENIKOFF ET AL.: "The human mRNA that provides the N-terminus of chimeric G6PD encodes GMP reductase.", CELL, vol. 58, 22 September 1989 (1989-09-22), pages 1021 - 1022, XP002054263 *
T. KONDOH ET AL.: "Genomic structure and expression of human guanosine monophosphate reductase.", HUMAN GENETICS, vol. 88, 1991, pages 219 - 224, XP002054264 *
Z. XIA ET AL.: "Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis.", SCIENCE, vol. 270, 24 November 1995 (1995-11-24), pages 1326 - 1331, XP002054337 *

Also Published As

Publication number Publication date
WO1998000539A2 (fr) 1998-01-08
AU4326097A (en) 1998-01-21

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