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WO1998001159A3 - Composition for enhanced uptake of polar drugs from mucosal surfaces - Google Patents

Composition for enhanced uptake of polar drugs from mucosal surfaces Download PDF

Info

Publication number
WO1998001159A3
WO1998001159A3 PCT/GB1997/001852 GB9701852W WO9801159A3 WO 1998001159 A3 WO1998001159 A3 WO 1998001159A3 GB 9701852 W GB9701852 W GB 9701852W WO 9801159 A3 WO9801159 A3 WO 9801159A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
mucosal surfaces
enhanced uptake
polar drugs
metabolisable
Prior art date
Application number
PCT/GB1997/001852
Other languages
French (fr)
Other versions
WO1998001159A2 (en
Inventor
Lisbeth Illum
Peter James Watts
Original Assignee
Danbiosyst Uk
Lisbeth Illum
Peter James Watts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danbiosyst Uk, Lisbeth Illum, Peter James Watts filed Critical Danbiosyst Uk
Priority to AU34539/97A priority Critical patent/AU722724B2/en
Priority to GB9900050A priority patent/GB2330533B/en
Priority to EP97930663A priority patent/EP0993305A2/en
Priority to JP10504949A priority patent/JP2000515503A/en
Publication of WO1998001159A2 publication Critical patent/WO1998001159A2/en
Publication of WO1998001159A3 publication Critical patent/WO1998001159A3/en
Priority to NO985956A priority patent/NO985956D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A composition for administration to a mucosal surface of a mammal comprising a non-metabolisable bile salt analogue and a therapeutic agent. Preferably the non-metabolisable bile salt analogue is a non-naturally occurring conjugate of cholic acid and an amino acid, and in particular cholylsarcosine. Preferably the therapeutic agent is a polar molecule.
PCT/GB1997/001852 1996-07-06 1997-07-07 Composition for enhanced uptake of polar drugs from mucosal surfaces WO1998001159A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU34539/97A AU722724B2 (en) 1996-07-06 1997-07-07 Composition for enhanced uptake of polar drugs from mucosal surfaces
GB9900050A GB2330533B (en) 1996-07-06 1997-07-07 Composition for enhanced uptake of polar drugs from mucosal surfaces
EP97930663A EP0993305A2 (en) 1996-07-06 1997-07-07 Composition for enhanced uptake of polar drugs from mucosal surfaces
JP10504949A JP2000515503A (en) 1996-07-06 1997-07-07 Compositions for enhancing uptake of polar drugs from mucosal surfaces
NO985956A NO985956D0 (en) 1996-07-06 1998-12-18 Mixture for improved uptake of polar drugs from mucosal surfaces

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9614235.1A GB9614235D0 (en) 1996-07-06 1996-07-06 Composition for enhanced uptake of polar drugs from mucosal surfaces
GB9614235.1 1996-07-06

Publications (2)

Publication Number Publication Date
WO1998001159A2 WO1998001159A2 (en) 1998-01-15
WO1998001159A3 true WO1998001159A3 (en) 1998-03-26

Family

ID=10796483

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/001852 WO1998001159A2 (en) 1996-07-06 1997-07-07 Composition for enhanced uptake of polar drugs from mucosal surfaces

Country Status (8)

Country Link
EP (1) EP0993305A2 (en)
JP (1) JP2000515503A (en)
KR (1) KR20000023583A (en)
AU (1) AU722724B2 (en)
CA (1) CA2257563A1 (en)
GB (2) GB9614235D0 (en)
NO (1) NO985956D0 (en)
WO (1) WO1998001159A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6572874B1 (en) * 1998-05-15 2003-06-03 Umd, Inc. Vaginal delivery of bisphosphonates
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
ATE386508T1 (en) * 1999-02-22 2008-03-15 Merrion Res I Ltd SOLID ORAL DOSAGE FORM CONTAINING AN ABSORPTION ENHANCER
GB2355009A (en) 1999-07-30 2001-04-11 Univ Glasgow Peptides conjugated to bile acids/salts
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
EP1572244A1 (en) * 2002-12-11 2005-09-14 Chong Kun Dang Pharmaceutical Corp. Oral formulations for poorly absorptive hydrophilic drugs
DE102004027924A1 (en) * 2004-06-09 2005-12-29 Röhm GmbH & Co. KG Pharmaceutical form containing the active ingredient cholylsarcosine
ES2426445T3 (en) 2006-04-07 2013-10-23 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
BRPI0912384A2 (en) 2008-05-07 2015-10-13 Merrion Res Iii Ltd composition and method for preparing a composition
RU2569756C2 (en) 2009-06-18 2015-11-27 Эллерген, Инк. Safe application of desmopressinum
WO2011120033A1 (en) 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
US8802114B2 (en) 2011-01-07 2014-08-12 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
US10265384B2 (en) 2015-01-29 2019-04-23 Novo Nordisk A/S Tablets comprising GLP-1 agonist and enteric coating
CN108201531A (en) * 2016-12-19 2018-06-26 湖南尔康湘药制药有限公司 Segmented intestine targeted starch capsule of highly dissoluble sulbenicillin sodium and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007923A1 (en) * 1989-01-19 1990-07-26 California Biotechnology Inc. Transmembrane formulations for drug administration
DE4222647A1 (en) * 1991-07-15 1993-01-21 Sandoz Ag PEPTIDE PREPARATIONS
WO1995001183A1 (en) * 1993-06-29 1995-01-12 Ferring B.V. Compositions for nasal administration of desmopressin
WO1997006813A1 (en) * 1995-08-15 1997-02-27 Asahi Kasei Kogyo Kabushiki Kaisha Mucosal preparation containing physiologically active peptide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007923A1 (en) * 1989-01-19 1990-07-26 California Biotechnology Inc. Transmembrane formulations for drug administration
DE4222647A1 (en) * 1991-07-15 1993-01-21 Sandoz Ag PEPTIDE PREPARATIONS
WO1995001183A1 (en) * 1993-06-29 1995-01-12 Ferring B.V. Compositions for nasal administration of desmopressin
WO1997006813A1 (en) * 1995-08-15 1997-02-27 Asahi Kasei Kogyo Kabushiki Kaisha Mucosal preparation containing physiologically active peptide

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
AUNGST, BRUCE J. ET AL: "Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promoter", J. PHARMACOL. EXP. THER. (1988), 244(1), 23-8 CODEN: JPETAB;ISSN: 0022-3565, 1988, XP002049338 *
BIOCHEM. PHARMACOL. (1983), 32(5), 773-6 CODEN: BCPCA6;ISSN: 0006-2952, 1983 *
CHEMICAL ABSTRACTS, vol. 112, no. 6, 5 February 1990, Columbus, Ohio, US; abstract no. 42406, NAGAI, T. ET AL: "Absorption of fibroblast interferon -.beta. in powder dosage form from nasal mucosa in rabbits" XP002049341 *
CHEMICAL ABSTRACTS, vol. 95, no. 13, 28 September 1981, Columbus, Ohio, US; abstract no. 109081, ZIV, EHUD ET AL: "Bile salts promote the absorption of insulin from the rat colon" XP002049343 *
CHEMICAL ABSTRACTS, vol. 98, no. 23, 6 June 1983, Columbus, Ohio, US; abstract no. 191258, ZIV, E. ET AL: "Bile salts facilitate the absorption of heparin from the intestine" XP002049342 *
CONGR. INT. TECHNOL. PHARM., 5TH (1989), VOLUME 1, 91-8 PUBLISHER: ASSOC. PHARM. GALENIQUE IND., CHATENAY MALABRY, FR. CODEN: 56SEA5, 1989 *
GORDON, G. S. ET AL: "Nasal absorption of insulin: enhancement by hydrophobic bile salts", PROC. NATL. ACAD. SCI. U. S. A. (1985), 82(21), 7419-23 CODEN: PNASA6;ISSN: 0027-8424, 1985, XP002049334 *
KRAMER W ET AL: "MODIFIED BILE ACIDS AS CARRIERS FOR PEPTIDES AND DRUGS", JOURNAL OF CONTROLLED RELEASE, vol. 46, no. 1/02, 5 May 1997 (1997-05-05), pages 17 - 30, XP000680749 *
LIFE SCI. (1981), 29(8), 803-9 CODEN: LIFSAK;ISSN: 0024-3205, 1981 *
LONGENECKER, JOHN P. ET AL: "Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep", J. PHARM. SCI. (1987), 76(5), 351-5 CODEN: JPMSAE;ISSN: 0022-3549, 1987, XP002049340 *
NAKADA, YUICHIRO ET AL: "The effect of additives on the oral mucosal absorption of human calcitonin in rats", J. PHARMACOBIO-DYN. (1988), 11(6), 395-401 CODEN: JOPHDQ;ISSN: 0386-846X, 1988, XP002049337 *
NAKADA, YUICHIRO ET AL: "The effect of bile salts on the oral mucosal absorption of human calcitonin in rats", J. PHARMACOBIO-DYN. (1989), 12(12), 736-43 CODEN: JOPHDQ;ISSN: 0386-846X, 1989, XP002049336 *
SCOTT-MONCRIEFF, J. CATHARINE ET AL: "Enhancement of Intestinal Insulin Absorption by Bile Salt Fatty Acid Mixed Micelles in Dogs", J. PHARM. SCI. (1994), 83(10), 1465-9 CODEN: JPMSAE;ISSN: 0022-3549, 1994, XP002049335 *
UCHIDA, NAOKI ET AL: "Influence of bile salts on the permeability of insulin through the nasal mucosa of rabbits in comparison with dextran derivatives", INT. J. PHARM. (1991), 74(2-3), 95-103 CODEN: IJPHDE;ISSN: 0378-5173, 1991, XP002049339 *

Also Published As

Publication number Publication date
NO985956L (en) 1998-12-18
GB2330533A (en) 1999-04-28
GB2330533B (en) 2000-10-25
KR20000023583A (en) 2000-04-25
AU3453997A (en) 1998-02-02
CA2257563A1 (en) 1998-01-15
AU722724B2 (en) 2000-08-10
EP0993305A2 (en) 2000-04-19
NO985956D0 (en) 1998-12-18
WO1998001159A2 (en) 1998-01-15
GB9900050D0 (en) 1999-02-24
GB9614235D0 (en) 1996-09-04
JP2000515503A (en) 2000-11-21

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