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WO1998003205A3 - Renforcement des contrastes d'echographie par utilisation de gaz inhales - Google Patents

Renforcement des contrastes d'echographie par utilisation de gaz inhales Download PDF

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Publication number
WO1998003205A3
WO1998003205A3 PCT/US1997/012354 US9712354W WO9803205A3 WO 1998003205 A3 WO1998003205 A3 WO 1998003205A3 US 9712354 W US9712354 W US 9712354W WO 9803205 A3 WO9803205 A3 WO 9803205A3
Authority
WO
WIPO (PCT)
Prior art keywords
ultrasound contrast
contrast agent
contrast imaging
enhanced ultrasound
inhaled gases
Prior art date
Application number
PCT/US1997/012354
Other languages
English (en)
Other versions
WO1998003205A2 (fr
Inventor
Steven C Quay
Original Assignee
Sonus Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sonus Pharma Inc filed Critical Sonus Pharma Inc
Priority to AU36652/97A priority Critical patent/AU3665297A/en
Publication of WO1998003205A2 publication Critical patent/WO1998003205A2/fr
Publication of WO1998003205A3 publication Critical patent/WO1998003205A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

La présente invention concerne le renforcement des contrastes d'échographie des cavités cardiaques gauches par inhalation d'un gaz ou d'un mélange gazeux pendant l'injection intraveineuse d'un agent de contraste d'échographie. La concentration accrue du gaz inhalé dans les poumons supprime le dégazage de l'agent de contraste dans les poumons, ce qui maintient des concentrations élevées de l'agent de contraste dans le sang irriguant le coeur gauche et d'autres tissus.
PCT/US1997/012354 1996-07-19 1997-07-16 Renforcement des contrastes d'echographie par utilisation de gaz inhales WO1998003205A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU36652/97A AU3665297A (en) 1996-07-19 1997-07-16 Enhanced ultrasound contrast imaging using inhaled gases

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2252896P 1996-07-19 1996-07-19
US60/022,528 1996-07-19
US89308197A 1997-07-15 1997-07-15
US08/893,081 1997-07-15

Publications (2)

Publication Number Publication Date
WO1998003205A2 WO1998003205A2 (fr) 1998-01-29
WO1998003205A3 true WO1998003205A3 (fr) 1998-03-05

Family

ID=26696032

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012354 WO1998003205A2 (fr) 1996-07-19 1997-07-16 Renforcement des contrastes d'echographie par utilisation de gaz inhales

Country Status (2)

Country Link
AU (1) AU3665297A (fr)
WO (1) WO1998003205A2 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005819A1 (fr) * 1991-09-17 1993-04-01 Sonus Pharmaceuticals, Inc Milieux de contraste gazeux ultrasonore et procede de selection de gaz utilises comme milieux de contraste ultrasonore
WO1993006869A1 (fr) * 1991-10-04 1993-04-15 Mallinckrodt Medical, Inc. Agents gazeux de contraste a ultrasons
WO1995023615A1 (fr) * 1994-03-01 1995-09-08 Holmes, Michael, John Microcapsules contenant un gaz, utiles comme agents de contraste pour imagerie diagnostique
WO1996035457A1 (fr) * 1995-05-12 1996-11-14 Board Of Regents Of The University Of Nebraska Imagerie a cavitation de microbulles induite par signal ultrasonique retarde
WO1996038181A1 (fr) * 1995-05-31 1996-12-05 Board Of Regents Of The University Of Nebraska Agent de contraste ultrasonique sonifie a base de dextrose et d'albumine et contenant du perfluorobutane
WO1996038180A1 (fr) * 1995-05-30 1996-12-05 Board Of Regents Of The University Of Nebraska Agent de contraste pour echographie ultrasonique, de type destrose-albumine contenant un perfluorocarbone dans des microbulles
WO1996040288A1 (fr) * 1995-06-07 1996-12-19 Mallinckrodt Medical, Inc. Agents de contraste ultrasonore gazeux et procede associe

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005819A1 (fr) * 1991-09-17 1993-04-01 Sonus Pharmaceuticals, Inc Milieux de contraste gazeux ultrasonore et procede de selection de gaz utilises comme milieux de contraste ultrasonore
WO1993006869A1 (fr) * 1991-10-04 1993-04-15 Mallinckrodt Medical, Inc. Agents gazeux de contraste a ultrasons
WO1995023615A1 (fr) * 1994-03-01 1995-09-08 Holmes, Michael, John Microcapsules contenant un gaz, utiles comme agents de contraste pour imagerie diagnostique
WO1996035457A1 (fr) * 1995-05-12 1996-11-14 Board Of Regents Of The University Of Nebraska Imagerie a cavitation de microbulles induite par signal ultrasonique retarde
WO1996038180A1 (fr) * 1995-05-30 1996-12-05 Board Of Regents Of The University Of Nebraska Agent de contraste pour echographie ultrasonique, de type destrose-albumine contenant un perfluorocarbone dans des microbulles
WO1996038181A1 (fr) * 1995-05-31 1996-12-05 Board Of Regents Of The University Of Nebraska Agent de contraste ultrasonique sonifie a base de dextrose et d'albumine et contenant du perfluorobutane
WO1996040288A1 (fr) * 1995-06-07 1996-12-19 Mallinckrodt Medical, Inc. Agents de contraste ultrasonore gazeux et procede associe

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHORTKOFF BS ET AL: "Pharmacokinetics do not explain the absence of an anesthetic effect of perfluoropropane or perfluoropentane.", ANESTH ANALG, AUG 1994, VOL. 79, NO. 2, PAGE(S) 234-7, XP002050883 *
EGER, E. I II ET AL.: "Molecular properties of the "ideal" inhaled anesthetic: Studies of fluorinated methanes, ethanes, propanes, and butanes", ANESTH. ANALG. (N. Y.), 1994, VOL. 79, NO. 2, PAGES 245-51, XP002050882 *
FANG Z ET AL: "Convulsant activity of nonanesthetic gas combinations.", ANESTH ANALG, MAR 1997, VOL. 84, NO. 3, PAGE(S) 634-40, XP002050886 *
FENG XIE ET AL: "PERFLUOROPROPANE ENHANCED SONICATED DEXTROSE ALBUMIN PRODUCES VISUALLY APPARENT CONSISTENT MYOCARDIAL OPACIFICATION WITH PHYSIOLOGIC WASHOUT AND MINIMAL HEMODYNAMIC CHANGES FOLLOWING VENOUS INJECTION", CIRCULATION, vol. 90, no. 4, PART 02, 14 November 1994 (1994-11-14), pages I-69, XP000577055 *
J.H. WIBLE JR. ET AL.: "Effects of inspired gas on the efficacy of Albunex(R) in dogs", CIRCULATION, vol. 88, no. 4, PART 02, October 1993 (1993-10-01), pages I-401, XP002050884 *
KANDEL L ET AL: "Nonanesthetics can suppress learning.", ANESTH ANALG, FEB 1996, VOL. 82, NO. 2, PAGE(S) 321-6, XP002050885 *
PORTER T R ET AL: "NONINVASIVE IDENTIFICATION OF ACUTE MYOCARDIAL ISCHEMIA AND REPERFUSION WITH CONTRAST ULTRASOUND USING INTRAVENOUS PERFLUOROPROPANE-EXPOSED SONICATED DEXTROSE ALBUMIN", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 26, no. 1, 1 July 1995 (1995-07-01), pages 33 - 40, XP000590865 *

Also Published As

Publication number Publication date
WO1998003205A2 (fr) 1998-01-29
AU3665297A (en) 1998-02-10

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