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WO1998006438A3 - Composition for pharmaceutical applications - Google Patents

Composition for pharmaceutical applications Download PDF

Info

Publication number
WO1998006438A3
WO1998006438A3 PCT/US1997/013988 US9713988W WO9806438A3 WO 1998006438 A3 WO1998006438 A3 WO 1998006438A3 US 9713988 W US9713988 W US 9713988W WO 9806438 A3 WO9806438 A3 WO 9806438A3
Authority
WO
WIPO (PCT)
Prior art keywords
component
composition
responsive
polymer network
structural component
Prior art date
Application number
PCT/US1997/013988
Other languages
French (fr)
Other versions
WO1998006438A9 (en
WO1998006438A2 (en
Inventor
Eyal S Ron
Lev Bromberg
Michal Orkisz
Marie Kearney
Scott Luczak
Mary J Timm
Stanley J Wrobel
Original Assignee
Gel Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gel Sciences Inc filed Critical Gel Sciences Inc
Priority to EP97937165A priority Critical patent/EP0920338A2/en
Priority to CA002263411A priority patent/CA2263411A1/en
Priority to JP10509898A priority patent/JP2000516614A/en
Publication of WO1998006438A2 publication Critical patent/WO1998006438A2/en
Publication of WO1998006438A3 publication Critical patent/WO1998006438A3/en
Publication of WO1998006438A9 publication Critical patent/WO1998006438A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer network. The polymer network includes at least one responsive polymer component, said responsive component capable of aggregation in solution in response to an environmental stimulus and at least one structural component, said structural component exhibiting self-repulsive interactions over use conditions. The responsive component is randomly bonded to said structural component and the polymer network characterized in that it viscosifies in response to said environmental stimulus. The composition further includes a pharmaceutically active agent which imparts a pharmaceutic effect, said carrier and said agent disposed within an aqueous-based medium. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.
PCT/US1997/013988 1996-08-12 1997-08-12 Composition for pharmaceutical applications WO1998006438A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP97937165A EP0920338A2 (en) 1996-08-12 1997-08-12 Composition for pharmaceutical applications
CA002263411A CA2263411A1 (en) 1996-08-12 1997-08-12 Composition for pharmaceutical applications
JP10509898A JP2000516614A (en) 1996-08-12 1997-08-12 Compositions for pharmaceutical applications

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US2399696P 1996-08-12 1996-08-12
US60/023,996 1996-08-12
US2597496P 1996-09-16 1996-09-16
US60/025,974 1996-09-16
US2818396P 1996-10-15 1996-10-15
US60/028,183 1996-10-15
US3079896P 1996-11-14 1996-11-14
US60/030,798 1996-11-14
US3445497P 1997-01-02 1997-01-02
US3417497P 1997-01-02 1997-01-02
US60/034,174 1997-01-02
US60/034,454 1997-01-02

Publications (3)

Publication Number Publication Date
WO1998006438A2 WO1998006438A2 (en) 1998-02-19
WO1998006438A3 true WO1998006438A3 (en) 1998-06-25
WO1998006438A9 WO1998006438A9 (en) 1998-07-23

Family

ID=27556028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/013988 WO1998006438A2 (en) 1996-08-12 1997-08-12 Composition for pharmaceutical applications

Country Status (4)

Country Link
EP (1) EP0920338A2 (en)
JP (1) JP2000516614A (en)
CA (1) CA2263411A1 (en)
WO (1) WO1998006438A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007603A2 (en) * 1998-08-04 2000-02-17 Madash Llp End modified thermal responsive hydrogels
CA2355598C (en) * 1998-12-14 2010-02-02 Rhodia Inc. Polymers which exhibit thermothickening properties and process making same
US7767197B2 (en) 2000-06-22 2010-08-03 Endo Pharmaceuticals Colorado LLC Delivery vehicle composition and methods for delivering antigens and other drugs
DE10031741A1 (en) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Externally applied oxygen carrier preparation for treating oxygen deficiency states of the skin, comprises active agent, specifically hemoglobin or its mixture with myoglobin, incorporated in a gel carrier
US7138133B2 (en) 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
AU2002335077B2 (en) * 2001-10-19 2006-09-07 Idexx Laboratories, Inc. Injectable compositions for the controlled delivery of pharmacologically active compound
FR2833268B1 (en) * 2001-12-12 2005-07-08 Fabre Pierre Dermo Cosmetique NOVEL ASSOCIATION CONTAINING POLOXAMER AND CHONDROID SULFURIC ACID AND / OR GLYCOPROTEIN AND USE THEREOF
US7273891B1 (en) 2002-01-17 2007-09-25 B L Partnership Stable copolymers
AU2003225516A1 (en) 2002-03-26 2003-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Responsive biomedical composites
DE10360847A1 (en) * 2003-12-20 2005-07-28 Cord Contract Research And Development Gmbh Medical lubricant gel, useful in ear, nose and throat medicine, urology and gynecology, comprising gel former, care component and antimicrobial
US20070048288A1 (en) * 2005-08-30 2007-03-01 Lyu Suping Shear thinning polymer cell delivery compositions
US20070077302A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for stabilizing ophthalmic compositions
AU2006320538B2 (en) 2005-11-30 2013-07-04 Endo Pharmaceuticals Inc. Treatment of xerostomia with a sulfur-containing antioxidant
GB0704709D0 (en) * 2007-03-12 2007-04-18 Croda Singapore P L Dispersion, gel and emulsification system
FR2932070B1 (en) 2008-06-10 2012-08-17 Oreal MAKE-UP AND / OR CARE OF LASHES
FR2940761B1 (en) 2009-01-07 2012-12-28 Polymerexpert Sa ANTI-ROUNDER COMPOSITION CONTAINING A THERMOGELIFYING POLYMER
US10413496B2 (en) 2012-10-15 2019-09-17 L'oreal Aqueous wax dispersions
US10626294B2 (en) 2012-10-15 2020-04-21 L'oreal Aqueous wax dispersions containing volatile solvents
US9408785B2 (en) 2012-10-15 2016-08-09 L'oreal Hair styling compositions containing aqueous wax dispersions
US10561596B2 (en) 2014-04-11 2020-02-18 L'oreal Compositions and dispersions containing particles comprising a polymer
FR3091996B1 (en) 2019-01-24 2021-01-29 Les Laboratoires Brothier HEALING COMPOSITION
CN115400219B (en) * 2021-05-26 2024-09-17 博唯弘展生技股份有限公司 Temperature-sensitive composition for preventing tissue adhesion and application thereof
CN119896636B (en) * 2025-04-01 2025-07-08 浙江大学 Lomefloxacin hydrochloride ear drop composition, product, preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000275A2 (en) * 1995-06-16 1997-01-03 Gel Sciences, Inc. Responsive polymer networks and methods of their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000275A2 (en) * 1995-06-16 1997-01-03 Gel Sciences, Inc. Responsive polymer networks and methods of their use

Also Published As

Publication number Publication date
WO1998006438A2 (en) 1998-02-19
JP2000516614A (en) 2000-12-12
EP0920338A2 (en) 1999-06-09
CA2263411A1 (en) 1998-02-19

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