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WO1998008535A3 - Procede permettant de provoquer une immuno-suppression selective au moyen de lectines associees aux hl-60 - Google Patents

Procede permettant de provoquer une immuno-suppression selective au moyen de lectines associees aux hl-60 Download PDF

Info

Publication number
WO1998008535A3
WO1998008535A3 PCT/US1997/015016 US9715016W WO9808535A3 WO 1998008535 A3 WO1998008535 A3 WO 1998008535A3 US 9715016 W US9715016 W US 9715016W WO 9808535 A3 WO9808535 A3 WO 9808535A3
Authority
WO
WIPO (PCT)
Prior art keywords
lectin
treating
causing selective
tumor
administering
Prior art date
Application number
PCT/US1997/015016
Other languages
English (en)
Other versions
WO1998008535A2 (fr
Inventor
Linda G Baum
Nancy L Perillo
Jeffrey J Seilhamer
Original Assignee
Incyte Pharma Inc
Univ California
Linda G Baum
Nancy L Perillo
Jeffrey J Seilhamer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Univ California, Linda G Baum, Nancy L Perillo, Jeffrey J Seilhamer filed Critical Incyte Pharma Inc
Priority to AU40913/97A priority Critical patent/AU4091397A/en
Publication of WO1998008535A2 publication Critical patent/WO1998008535A2/fr
Publication of WO1998008535A3 publication Critical patent/WO1998008535A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention se rapporte à des procédés de traitement de maladies néoplasiques caractérisées par la prolifération de lymphocytes. Lesdits procédés consistent à administrer des compositions pharmaceutiques contenant une lectine soluble possédant un poids moléculaire d'environ 14 kilodaltons. L'invention se rapporte en outre à des procédés de traitement de tumeurs productrices de lectine qui consistent à administrer une quantité efficace d'un anticorps qui se lie de manière spécifique à la lectine, aux antagonistes de la lectine, à des saccharides inhibiteurs ou à des inhibiteurs de glycosylation dans le but de prévenir l'apoptose induite par les lectines des lymphocytes T infiltrés dans la tumeur.
PCT/US1997/015016 1996-08-26 1997-08-26 Procede permettant de provoquer une immuno-suppression selective au moyen de lectines associees aux hl-60 WO1998008535A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40913/97A AU4091397A (en) 1996-08-26 1997-08-26 Method of causing selective immunosuppression using hl-60-related lectins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70480296A 1996-08-26 1996-08-26
US08/704,802 1996-08-26

Publications (2)

Publication Number Publication Date
WO1998008535A2 WO1998008535A2 (fr) 1998-03-05
WO1998008535A3 true WO1998008535A3 (fr) 1998-05-28

Family

ID=24830917

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/015016 WO1998008535A2 (fr) 1996-08-26 1997-08-26 Procede permettant de provoquer une immuno-suppression selective au moyen de lectines associees aux hl-60

Country Status (2)

Country Link
AU (1) AU4091397A (fr)
WO (1) WO1998008535A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1122311A4 (fr) 1998-07-31 2002-04-17 Kirin Brewery Medicaments permettant de soigner la neuropathie contenant de la galectine-1 ou ses derives comme substance active
TW200617393A (en) * 2004-11-22 2006-06-01 Univ Nat Cheng Kung Method for testing lectin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337799A2 (fr) * 1988-04-14 1989-10-18 Incyte Pharmaceuticals, Inc. Lectines 14-bêta-gal de mammifères
WO1992019239A1 (fr) * 1991-05-01 1992-11-12 University Of New Mexico Traitement d'etats cellulaires aberrants a l'aide de biomodulateurs
WO1994011497A1 (fr) * 1992-11-16 1994-05-26 Incyte Pharmaceuticals, Inc. Procede d'obtention d'une immunosuppression selective a l'aide de lectines apparentees a hl-60

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337799A2 (fr) * 1988-04-14 1989-10-18 Incyte Pharmaceuticals, Inc. Lectines 14-bêta-gal de mammifères
WO1992019239A1 (fr) * 1991-05-01 1992-11-12 University Of New Mexico Traitement d'etats cellulaires aberrants a l'aide de biomodulateurs
WO1994011497A1 (fr) * 1992-11-16 1994-05-26 Incyte Pharmaceuticals, Inc. Procede d'obtention d'une immunosuppression selective a l'aide de lectines apparentees a hl-60

Also Published As

Publication number Publication date
WO1998008535A2 (fr) 1998-03-05
AU4091397A (en) 1998-03-19

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