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WO1998009951B1 - Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease - Google Patents

Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease

Info

Publication number
WO1998009951B1
WO1998009951B1 PCT/US1997/015468 US9715468W WO9809951B1 WO 1998009951 B1 WO1998009951 B1 WO 1998009951B1 US 9715468 W US9715468 W US 9715468W WO 9809951 B1 WO9809951 B1 WO 9809951B1
Authority
WO
WIPO (PCT)
Prior art keywords
group
formula
compound
aryl
alkyl
Prior art date
Application number
PCT/US1997/015468
Other languages
English (en)
Other versions
WO1998009951A2 (fr
WO1998009951A3 (fr
Filing date
Publication date
Priority to UA99041906A priority Critical patent/UA67727C2/uk
Priority to APAP/P/1999/001497A priority patent/AP1322A/en
Priority to SK90-2005A priority patent/SK285278B6/sk
Priority to AU43317/97A priority patent/AU740369B2/en
Priority to EA199900257A priority patent/EA002051B1/ru
Priority to JP51283198A priority patent/JP4149000B2/ja
Priority to SK282-99A priority patent/SK284899B6/sk
Priority to NZ334909A priority patent/NZ334909A/en
Priority to DK97941402T priority patent/DK0927165T3/da
Priority to PL331801A priority patent/PL198408B1/pl
Priority to SI9730719T priority patent/SI1361216T1/sl
Priority to EEP199900109A priority patent/EE04465B1/xx
Priority to DE69726298T priority patent/DE69726298T2/de
Priority to EP97941402A priority patent/EP0927165B1/fr
Application filed filed Critical
Priority to CA002264756A priority patent/CA2264756A1/fr
Priority to BR9713192-0A priority patent/BR9713192A/pt
Priority to APAP/P/2003/002938A priority patent/AP2003002938A0/en
Priority to IL12856797A priority patent/IL128567A/en
Priority to AT97941402T priority patent/ATE254603T1/de
Priority to SI9730605T priority patent/SI0927165T1/xx
Publication of WO1998009951A2 publication Critical patent/WO1998009951A2/fr
Publication of WO1998009951A3 publication Critical patent/WO1998009951A3/fr
Publication of WO1998009951B1 publication Critical patent/WO1998009951B1/fr
Priority to IS4982A priority patent/IS2030B/is
Priority to NO19991072A priority patent/NO313287B1/no
Priority to BG103305A priority patent/BG64793B1/bg
Priority to AU14736/02A priority patent/AU766155B2/en
Priority to JP2007280974A priority patent/JP2008056693A/ja

Links

Abstract

L'invention concerne des inhibiteurs de la VIH-protéase inhibant ou bloquant l'activité biologique de l'enzyme VIH-protéase, ce qui provoque la fin de la réplication du virus de l'immunodéficience humaine. On peut préparer ces composés grâce aux nouveaux procédés selon la présente invention, en utilisant les nouveaux composés et intermédiaires de l'invention.
PCT/US1997/015468 1995-09-26 1997-09-04 Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease WO1998009951A2 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
UA99041906A UA67727C2 (uk) 1996-09-05 1997-04-09 Проміжні сполуки для одержання інгібіторів віл-протеази і способи одержання інгібіторів віл-протеази
EP97941402A EP0927165B1 (fr) 1996-09-05 1997-09-04 Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease
AU43317/97A AU740369B2 (en) 1995-09-26 1997-09-04 Intermediates for making HIV-protease inhibitors and methods of making HIV-protease inhibitors
EA199900257A EA002051B1 (ru) 1996-09-05 1997-09-04 Способ получения ингибиторов вич-протеазы
CA002264756A CA2264756A1 (fr) 1996-09-05 1997-09-04 Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease
SK282-99A SK284899B6 (sk) 1996-09-05 1997-09-04 Medziprodukty na výrobu inhibítorov HIV-proteázy a spôsoby výroby inhibítorov HIV-proteázy
NZ334909A NZ334909A (en) 1996-09-05 1997-09-04 Intermediates for making HIV protease inhibitors
DK97941402T DK0927165T3 (da) 1996-09-05 1997-09-04 Mellemprodukter til fremstilling af HIV-protease inhibitorer og fremgangsmåde til fremstilling af HIV-protease inhibitorer
PL331801A PL198408B1 (pl) 1996-09-05 1997-09-04 Chlorek kwasu 3-acetoksy-2-metylobenzoesowego, sposób wytwarzania chlorku kwasu 3-acetoksy-2-metylobenzoesowego, sposób wytwarzania nelfinaviru i sposób wytwarzania mesylanu nelfinaviru
SI9730719T SI1361216T1 (sl) 1996-09-05 1997-09-04 Postopek za pripravo zaviralca proteaze hiv
EEP199900109A EE04465B1 (et) 1996-09-05 1997-09-04 Vaheühendid HIV-proteaasi inhibiitorite valmistamiseks ja HIV-proteaasi inhibiitorite valmistamismeetodid
DE69726298T DE69726298T2 (de) 1996-09-05 1997-09-04 Zwischenprodukte zur herstellung von hiv-protease-inhibitoren und verfharen zur herstellung hiv-protease-inhibitoren
SI9730605T SI0927165T1 (en) 1996-09-05 1997-09-04 Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors
APAP/P/1999/001497A AP1322A (en) 1996-09-05 1997-09-04 Intermediates for making HIV- protease inhibitors and methods of making HIV protease inhibitors.
JP51283198A JP4149000B2 (ja) 1996-09-05 1997-09-04 Ｈｉｖ―プロテアーゼ阻害剤製造の中間体及びｈｉｖ―プロテアーゼ阻害剤の製造方法
BR9713192-0A BR9713192A (pt) 1996-09-05 1997-09-04 Intermediários para fabricação de inibidores da protease de hiv e métodos de fabricação de inibidores para protease de hiv
APAP/P/2003/002938A AP2003002938A0 (en) 1996-09-05 1997-09-04 Intermediates for making HIV- protease inhibitors and methods of making HIV protease inhibitors.
IL12856797A IL128567A (en) 1996-09-05 1997-09-04 Intermediates used to prepare Neplinavir HIV protease inhibitor, process for their preparation and methods for preparing naplinavir
AT97941402T ATE254603T1 (de) 1996-09-05 1997-09-04 Zwischenprodukte zur herstellung von hiv-protease-inhibitoren und verfharen zur herstellung hiv- protease-inhibitoren
SK90-2005A SK285278B6 (sk) 1996-09-05 1997-09-04 Spôsob výroby inhibítora HIV-proteázy
IS4982A IS2030B (is) 1996-09-05 1999-02-19 Milliefni til smíða á HIV-próteasatálmum og aðferðir til að smíða HIV-próteasatálma
NO19991072A NO313287B1 (no) 1996-09-05 1999-03-04 Fremgangsmåter for fremstilling av HIV-protease inhibitorer
BG103305A BG64793B1 (bg) 1996-09-05 1999-04-02 Междинни съединения за получаване на инхибитори на нiv-протеазата и методи за получаването на инхибитори на нiv-протеазата
AU14736/02A AU766155B2 (en) 1995-09-26 2002-01-31 Intermediates for making HIV-protease inhibitors and methods of making HIV-protease inhibitors
JP2007280974A JP2008056693A (ja) 1996-09-05 2007-10-29 Ｈｉｖ−プロテアーゼ阻害剤製造の中間体及びｈｉｖ−プロテアーゼ阻害剤の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70841196A 1996-09-05 1996-09-05
US08/708,411 1996-09-05

Publications (3)

Publication Number Publication Date
WO1998009951A2 WO1998009951A2 (fr) 1998-03-12
WO1998009951A3 WO1998009951A3 (fr) 1998-07-09
WO1998009951B1 true WO1998009951B1 (fr) 1998-08-13

Family

ID=24845703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/015468 WO1998009951A2 (fr) 1995-09-26 1997-09-04 Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease

Country Status (32)

Country Link
EP (2) EP0927165B1 (fr)
JP (3) JP4149000B2 (fr)
KR (1) KR100563289B1 (fr)
CN (2) CN1305854C (fr)
AP (2) AP2003002938A0 (fr)
AT (2) ATE254603T1 (fr)
AU (2) AU740369B2 (fr)
BG (2) BG64793B1 (fr)
BR (1) BR9713192A (fr)
CA (1) CA2264756A1 (fr)
CZ (2) CZ298175B6 (fr)
DE (2) DE69734689T2 (fr)
DK (2) DK0927165T3 (fr)
EA (1) EA002051B1 (fr)
EE (1) EE04465B1 (fr)
ES (2) ES2252586T3 (fr)
GE (1) GEP20022799B (fr)
HU (1) HUP0000028A3 (fr)
IL (1) IL128567A (fr)
IS (1) IS2030B (fr)
NO (1) NO313287B1 (fr)
NZ (1) NZ334909A (fr)
OA (1) OA10988A (fr)
PL (2) PL198408B1 (fr)
PT (1) PT927165E (fr)
SG (1) SG94780A1 (fr)
SI (2) SI1361216T1 (fr)
SK (2) SK284899B6 (fr)
TR (1) TR199900473T2 (fr)
UA (1) UA67727C2 (fr)
WO (1) WO1998009951A2 (fr)
YU (1) YU11599A (fr)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0641038A (ja) * 1992-07-17 1994-02-15 Mitsubishi Kasei Corp カルボン酸誘導体
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
JPH07248183A (ja) * 1994-03-11 1995-09-26 Osaka Gas Co Ltd 浴室兼用衣類乾燥室
JP3298293B2 (ja) * 1994-03-14 2002-07-02 松下電器産業株式会社 厨芥処理機
WO1996028423A1 (fr) * 1995-03-15 1996-09-19 Sankyo Company, Limited Composes dipeptidiques de structure ahpba
AU717710B2 (en) * 1995-09-26 2000-03-30 Agouron Pharmaceuticals, Inc. Production of amide derivatives and intermediate compounds therefor
US5962704A (en) * 1995-09-26 1999-10-05 Japan Tobacco Inc. Production of amide derivatives and intermediate compounds therefor
JP3566968B2 (ja) * 1995-09-26 2004-09-15 日本たばこ産業株式会社 アミド誘導体の製造方法及び中間体
BR9707635A (pt) * 1996-02-24 1999-07-27 Basf Ag Composto derivado de pirazol-4-IL-hetaroila processo para a preparação do mesmo composição herbicida e processo para controlar vegetação indesejável

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