WO1998010825A1 - Utilisation de l'ozone pour la fabrication de medicaments gazeux - Google Patents
Utilisation de l'ozone pour la fabrication de medicaments gazeux Download PDFInfo
- Publication number
- WO1998010825A1 WO1998010825A1 PCT/IL1997/000303 IL9700303W WO9810825A1 WO 1998010825 A1 WO1998010825 A1 WO 1998010825A1 IL 9700303 W IL9700303 W IL 9700303W WO 9810825 A1 WO9810825 A1 WO 9810825A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- orifice
- gas
- electrode
- tubular
- housing
- Prior art date
Links
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 239000003814 drug Substances 0.000 title claims description 5
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 238000011282 treatment Methods 0.000 claims abstract description 37
- 206010052428 Wound Diseases 0.000 claims abstract description 14
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 14
- 208000004760 Tenosynovitis Diseases 0.000 claims abstract description 9
- 206010003246 arthritis Diseases 0.000 claims abstract description 9
- 230000006872 improvement Effects 0.000 claims abstract description 8
- 206010006811 Bursitis Diseases 0.000 claims abstract description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 6
- 201000009890 sinusitis Diseases 0.000 claims abstract description 6
- 241001465754 Metazoa Species 0.000 claims abstract description 5
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims abstract description 4
- 206010018691 Granuloma Diseases 0.000 claims abstract description 4
- 208000009889 Herpes Simplex Diseases 0.000 claims abstract description 4
- 208000007514 Herpes zoster Diseases 0.000 claims abstract description 4
- 206010021531 Impetigo Diseases 0.000 claims abstract description 4
- 201000004681 Psoriasis Diseases 0.000 claims abstract description 4
- 206010040943 Skin Ulcer Diseases 0.000 claims abstract description 4
- 208000000260 Warts Diseases 0.000 claims abstract description 4
- 206010000496 acne Diseases 0.000 claims abstract description 4
- 201000008937 atopic dermatitis Diseases 0.000 claims abstract description 4
- 238000005469 granulation Methods 0.000 claims abstract description 4
- 230000003179 granulation Effects 0.000 claims abstract description 4
- 201000010153 skin papilloma Diseases 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 28
- 238000001914 filtration Methods 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 14
- 238000011144 upstream manufacturing Methods 0.000 claims description 9
- 239000011343 solid material Substances 0.000 claims description 6
- 239000012811 non-conductive material Substances 0.000 claims description 3
- 238000006385 ozonation reaction Methods 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000007789 gas Substances 0.000 description 26
- 239000004020 conductor Substances 0.000 description 7
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitrogen oxide Inorganic materials O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000034309 Bacterial disease carrier Diseases 0.000 description 1
- 206010016228 Fasciitis Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000010891 electric arc Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 238000002169 hydrotherapy Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/105—Filters
- A61M16/106—Filters in a path
- A61M16/1065—Filters in a path in the expiratory path
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/30—Gas therapy for therapeutic treatment of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H33/00—Bathing devices for special therapeutic or hygienic purposes
- A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
- A61H2033/141—Devices for gas baths with ozone, hydrogen, or the like with ionised gas, e.g. ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H33/00—Bathing devices for special therapeutic or hygienic purposes
- A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0216—Ozone
Definitions
- the invention relates to a method for treating certain body ailments with ozone.
- Another object is regulation of the amount of ozone contained in the air stream by simple manipulation, by the administering personnel or by the patient himself.
- the apparatus described herein is safe and designed to prevent neither the patient nor the administering personnel from being exposed to the danger of contact with parts carrying high voltage.
- a further object is to provide as a means for carrying the method of the invention into effect, a relatively simple and economical apparatus which could readily be used by any clinic, medical office or center, or veterinary clinic, or even by a patient.
- U S Patent No 5,137,697 (Lathan).
- This device has an ozone generator which generates a plasma field in the ultraviolet region It utilizes a pair of electrodes in the form of plates that are separated by an insulator The plates are connected to a high-voltage transformer through diodes in such a way that only a negative and less positive charges appear on the plates
- the generator is provided with a self-cleaning system in which the circulating air fan that is provided for normally forcing air through the electrostatic plates may be turned off for a period of time and the ozone generated by the plates at that point in time will tend to combine with the contaminants and oxidize the same
- a medical treatment apparatus using ozone for blowing ozone gas onto an affected body part is disclosed in WO 91/06275 (Hashimoto)
- a hood is connected to a flow path tube having a delivery flow path and a withdrawal flow path for the ozone gas and a blow-out member is disposed in the hood, whereby the ozone gas is blown onto the affected part while being delivered and withdrawn.
- This apparatus is characterized in that an ozone generator is positioned in a housing located on the floor and via a solid conduit having a fixed hood firmly attached thereto. This arrangement permits an arm, a hand or a leg to be placed thereunder for treatment, but it as not mobile and hand-held like the apparatus of the present invention.
- the Hashimoto apparatus includes a special sealing device which may have various shapes and sizes, adapted to fit various parts of the human body to be treated.
- French Patents Nos. 80 1227 and 60 1228 describe a beauty treatment apparatus delivering flow of steam containing ozone onto the face or other body parts.
- the apparatus is firmly positioned on the floor and requires that the body part to be treated be placed in front of a spout delivering the steam flow.
- DE 3214355 discloses a hydrotherapy device for hand or face which includes jets of air and ozone bubbles blown onto the hand or the face.
- the apparatus includes special containers which sealingly surround the face or the hand, while the jets are blown onto the skin. This apparatus is immobile and specifically designed for treatment of the hand or face alone.
- the present invention accordingly provides a method for improving the condition of a subject selected from human and non-human mammals suffering from an ailment as defined below, wherein the method comprises treating the subject by directing a flow of gas containing ozone towards a predesignated skin area, for a period of time sufficient until an improvement in the patient's condition is observable, the ailment being defined as a human ailment selected from Acne, Psoriasis, Planter facitis, Impetigo, Ulcus Cruris, Wounds in diabetic patients, Arthritis, Bursitis, Burns, Tendovaginitis, Herpes simplex, Tendosinovitis, Herpes Zoster, Sinusitis, Warts and Atopic dermatitis, or an animal ailment selected from Arthritis, Tendovaginitis, Wounds, Lick granuloma, and Excessive granulation.
- the present invention does not relate to a method wherein it is necessary to insert an ozone dispensing means into a body cavity, the present treatment being external.
- the ozonized gas is directed to a skin area near to the affected internal body part, and it is believed that ozone penetrates the skin in order to contact and improve the condition of the internal body part. This belief is supported by the experiments described in the Examples, below.
- the flow of ozonized gas will of course be directed towards the area where such an ailment is manifest.
- the term 'predesignated skin area as used herein will be understood accordingly.
- the treatment according to the present invention will be subject to safety margins with respect e.g. to the concentration of ozone in the ozonized gas and to the duration of a single treatment period or a succession of treatment periods, ands such phrases as "for a period of time sufficient until an improvement in the patient's condition is observable" should be interpreted accordingly.
- the observable improvement in the patient's condition by applying the method of the invention, could be e.g., healing of external wounds, relief from or lessening of pain, or/and improvement in the subject's mobility
- an apparatus which includes: means adapted for delivery of said flow of ozonized gas to said skin area; means for generating said flow of ozonized gas and conduit means for transferring said ozonized gas to said delivery means; and means for providing unozonized gas and conduit means for transferring said unozonized gas to said generating - means, said providing means being adapted, for example by use of an electrically driven compressor or pump, to supply gas at a pressure sufficient to drive said flow of gas after ozonization through said delivery means and towards said skin area.
- the delivery means referred to above does not necessarily constitute an inventive part of the apparatus described herein. It may be, e.g., of a generally conical configuration as shown in the drawings herein, but this is not critical. In the alternative, there may be used as delivery means any device known for this purpose in the art for known methods of superficial treatments with gaseous medicaments.
- the apparatus useful in the treatment method of the invention may be characterized additionally by at least one of the following features:
- a tubular housing having a tapering and conductive front end with the apex thereof forming an orifice and said housing having an open rear end, a coronizing electrode concentrically mounted in said housing upstream of said tapering front end and with its pointed front end extending towards said orifice, and a high voltage source having a potential of at least 2200 volts having a first terminal connected to said electrode and a second terminal connected to said conductive front end of said housing;
- said apparatus is adapted to deliver to said skin area gas containing about 1 to about 50 p. p.m. ozone.
- such apparatus includes: a tubular housing of a solid material having a tapering front end of a conductive and anti-corrosive material with its apex open in the form of orifice which is sufficiently small so that said orifice constitutes said delivery means; a coronizing electrode concentrically positioned in said tube close behind the tapered front with its pointed front end extending towards said orifice, thus allowing flow of ozonized gas to be driven through said orifice thereby to contact the affected cavity tissue, and an electric high-voltage generating means attached to said apparatus characterized by a potential of at least 2200 volts, said high-voltage generating means having its high-voltage terminal connected to said electrode and its zero terminal to said tapered front end.
- the apparatus just described may be characterized additionally by at least one of the following features: (i) a filtering means and means for withdrawing used ozonized gas from said skin area and for passing said withdrawn ozonized gas through said filtering means; (ii) the rear end of said tubular housing is of smaller or larger or of substantially equal diameter to that of said orifice, said rear end being optionally partly or completely open, in order to allow ingress of air as said unozonized gas; (iii) said apparatus is adapted to deliver to said skin area gas containing about 1 to about 50 p. p.m.
- the entire tubular housing is made of a conductive and anti-corrosive material;
- said coronizing electrode is mounted inside said tubular housing by means of a cylindrical perforated support of a non-conductive material, permitting air to flow therethrough,
- an motor-driven fan mounted inside said tubular housing and so disposed that it directs a flow of unozonized air in the direction of said electrode,
- the described apparatus may be still further characterized by at least one of the following features
- a soft frusto-conical sleeve is removably mounted on the front end of said housing in order that it may be removed after each treatment
- the present invention enables ozone to be used in the manufacture of a gaseous medicament, for treating one of the ailment specified herein. Such use also constitutes a part of the present invention
- Figure 1 is a longitudinal section of a first embodiment of the apparatus useful in the method of the invention
- Figure 2 is a longitudinal section of a second embodiment of apparatus useful in the method of, characterized by ozone flow issuing from the central tube towards the diseased area;
- Figure 3 is a longitudinal section of the second embodiment showing a reversed air and ozone flow, issuing from the annular channel towards the diseased area;
- Figure 4 is a plan view of the soft removable sleeve to be attached to the apparatus illustrated in Figures 2 and 3;
- Figure 5 is a section along line 5-5 of Figure 4
- a first embodiment of the apparatus useful in the invention includes a tube of a solid material having a tapering front end of a conductive and anti-corrosive material with its apex open in the form of a small-diameter orifice, and having a rear end partly or completely open, but of larger cross section than that of the orifice
- An electrode is concentrically positioned close behind the tapered front with its pointed front end extending towards the orifice.
- An electric high- voltage generator e.g a transformer is attached to the apparatus and is characterized by a potential of at least 2,200 volts; it has its high-voltage terminal connected to the electrode and its earth terminal to the tapered front end which thus forms the second electrode
- the generator is supplied energy from the domestic supply by means of a flexible cable
- the motion of the ions creates a certain pressure causing the air and the ozone molecules to emerge out of the orifice which may have a diameter of between 2 to 10 mm.
- the tube For treatment of a disease the tube is held with the orifice sufficiently close to the skin of the patient for a predesignated period of time, the air and the ozone particles emerge out of the orifice and impinge on the diseased area and improve and accelerate the healing process.
- the apparatus is preferably provided with a hollow handle which carries the generator inside and which enables the operator to position the apparatus in a correct position for treating the ailment.
- a hollow handle which carries the generator inside and which enables the operator to position the apparatus in a correct position for treating the ailment.
- the apparatus Owing to the small orifice the apparatus is suitable for treatment of small areas, but it is feasible to provide it with a larger orifice while increasing the voltage potential, if larger body areas are to be treated simultaneously.
- the air flow is recirculated by a motor-driven fan positioned inside the apparatus.
- the tube containing the electrode has two open ends and is enclosed in a housing in the form of a larger tube having its rear end closed, whereby an annular channel is formed between the two tubes.
- An axial fan mounted inside the inner tube sucks in air from the front end of the channel and blows it across the corona discharge generated by the electrode to the front onto the afflicted body portion.
- An annular filter positioned in the annular channel serves to filter the air returned from the afflicted area and to permit clean air to reach the fan and the electrode.
- the apparatus is provided with a handle and a high-voltage generator enclosed in the handle.
- the inner tube is either made completely of a conductive and non-corrosive material or is composed of two parts, a conductive portion surrounding the corona and the remaining portion of any other material.
- the air-flow is reversed, i.e. air is sucked in through the inner tube, filtered by a circular filter positioned in this tube before reaching the electrode, and is ejected through the annular channel to the front onto the afflicted portion.
- a soft resilient sleeve is mounted on the front of the apparatus which is disposed of after each session of treatment in order to prevent infectious transfer from one patient to another
- High- voltage charge on the electrode is generated by a transformer provided with rectifier and attenuating means to effect one side, connected to the electrode, to produce high voltage connected to the electrode and the other, zero, side, connected to the inner tube and to earth
- Figure 1 shows the principle of the working of a therapeutic ozone treating apparatus It includes a tubular oblong housing 1 of a conductive material which is open at its rear end 2 defining an air inlet, and has a tapering front end 3 closing the housing, except for a small orifice defining the air-ozone outlet 4 It further includes a centrally positioned coronizing electrode 6 which is provided with a pointed front end pointing towards the orifice in concentric alignment therewith and being held in position by an annular perforated support 5 of an inert material It is important that the housing is anti- corrosive, at least in the tapering portion which is exposed to the oxidizing action of the ozone
- a handle 10 is attached to the outside of the housing, facilitating operation of the apparatus and contains a high-voltage generator or transformer 7 in its hollow interior.
- the high-potential terminal of the transformer is connected to electrode 6 by conductor 9, and its low-potential terminal to the housing 1 at point 9
- the high voltage - at least 2200 volts - generates, in a known manner, a corona discharge 1 1 towards the tapering front end of the housing which splits and combines a small portion of the oxygen molecules in the surrounding air, whereby atoms 0 combine with O 2 to form ozone molecules O 3 .
- the corona exerts a very small pressure towards the orifice thereby driving the air and ozone out of the housing onto the patient's skin.
- the apparatus illustrated in Figure 2 is composed of tubular housing 20 of a solid material which has an open front end and a rear end closed by a hemispherical cover 22 and of an inner concentrically positioned tube 21 of a conductive and anti-corrosive, material, having two open ends. Both tubes are in concentric alignment, forming an annular channel 23 therebetween which contains a highly absorbing annular filter 24 in its front.
- a coronizing sharp-pointed electrode 25 is positioned in the center of the inner tube by means of a circular perforated support 26 with its sharp point extending towards the open front of the apparatus. It is connected to the high-potential terminal of a transformer or other high-voltage generator 27 which is mounted inside a handle 30, the low potential terminal being connected to the conductive tube 21.
- An axial blower 28 is mounted inside the inner tube 21 , configured to blow clean air towards the electrode and out through the open front; its electric motor is supplied domestic current through wiring 29 extending through the housing 20 and the handle 30.
- a frusto-conical sleeve 31 of a soft and resilient material - as shown in Figures 4 and 5 - is removably attached to the front of the housing and is disposed of after each treatment.
- the electrode being supplied with high voltage creates a corona discharge towards the inner, earthed tube generating a certain small amount of ozone which is driven towards the patient's body by the force of the axial fan.
- the used air is returned into the apparatus by suction action of the axial fan; it passes the filter 24 where all remaining ozone molecules are absorbed and is recirculated through annular channel 23 into the inner tube as shown by arrows, thereby preventing ozone from being dispersed into the surrounding space.
- FIG 3 shows an apparatus similar to that shown in Figure 2, and the same numerals are employed in both figures to denote identical components, even if they are in a different position in both cases.
- the housing 20, the handle 30 and the inner tube 21 are completely identical with those illustrated in Figure 2, the difference lying in the reversed air flow.
- Air is sucked in by action of fan 28 and is conveyed through a cylindrical filter 124 - inside tube 21 - to electrode 25 which points towards the rear of the housing.
- the ozone-containing air now passes through the annular channel 23 and the soft sleeve 31 onto the patient's skin.
- the air from the patient's body is returned to the electrode after having passed the highly efficient filter 124 mounted in the front end of the inner tube, the filter preferably containing activated carbon for absorbing the remaining ozone molecules.
- This apparatus is adapted to cover a large circular area of the patient's skin, i.e. large wounds and or diseases can be treated simultaneously.
- the inner tube has been mentioned as being preferably of a conductive and anti-corrosive material. It should however be mentioned that only that portion of the tube which is in contact with the corona discharge may be made of this material, while the remaining portion may be of any suitable solid material, whether conductive or not.
- the apparatus described herein may be subject to modifications, e.g. the hand-held apparatus may be mounted on a stand by means of adjustable clamps so that the flow of ozonized gas may be more readily directed at a desired body part undergoing treatment, and the apparatus may incorporate a timer for automatically limiting the time of treatment, and it may be linked to a monitoring system for continuosly checking the concentration of ozone in the issuing flow of gas.
- the invention will be illustrated by the following non-limiting Examples of clinical treatment in accordance with the method of the invention and using the apparatus described herein, The treatment was carried out at the Carmel Hospital, Haifa, Israel.
- EXAMPLE 1 Three hospitalized diabetic patients, aged 47, 82 and 86, having 2-4 week old wounds were treated with ozonized air for 10-15 minutes per day, for 5-15 successive days. In all cases, the condition of the patients' wounds was sufficiently improved for them to be discharged from hospital. EXAMPLE 2
- a patient aged 44 who had suffered for two years from planter fascitis was treated as described in Example 4, as a result of which moderate relief from pain was reported.
- Another patient aged 28 who had suffered for three weeks from sinusitis was treated similarly, as a result of which pronounced relief from pain was reported.
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Oxygen, Ozone, And Oxides In General (AREA)
Abstract
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU42178/97A AU4217897A (en) | 1996-09-12 | 1997-09-11 | Use of ozone for the manufacture of gaseous medicaments |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11924996A IL119249A0 (en) | 1996-09-12 | 1996-09-12 | Therapeutic ozone treating apparatus |
| IL119249 | 1996-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1998010825A1 true WO1998010825A1 (fr) | 1998-03-19 |
Family
ID=11069299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IL1997/000303 WO1998010825A1 (fr) | 1996-09-12 | 1997-09-11 | Utilisation de l'ozone pour la fabrication de medicaments gazeux |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU4217897A (fr) |
| IL (1) | IL119249A0 (fr) |
| WO (1) | WO1998010825A1 (fr) |
| ZA (1) | ZA978253B (fr) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005120429A1 (fr) * | 2004-06-08 | 2005-12-22 | Shenzhen Jingrui Industry Co., Ltd. | Dispositif portable pour soins de la peau et du visage |
| WO2006018731A3 (fr) * | 2004-08-18 | 2006-06-01 | Jean Clement Edouart Gui Malak | Procede d'oxygenotherapie percutanee hyperbare par projection de fluorocarbones |
| CN100356995C (zh) * | 2001-12-04 | 2007-12-26 | 佛山市顺德区安医仕医疗科技有限公司 | 一种妇女生殖器疾病治疗装置 |
| CN107374938A (zh) * | 2017-08-11 | 2017-11-24 | 河南省宇安医疗科技开发有限公司 | 便携式三氧伤口治疗仪 |
| WO2018108373A1 (fr) * | 2016-12-14 | 2018-06-21 | Lohmann & Rauscher Gmbh | Système pour le traitement médical d'un être humain et d'un animal et dispositif d'application pour ce système |
| EP3809914A4 (fr) * | 2018-06-25 | 2022-04-20 | Booker Holdings, LLC | Fluide améliorant la tension superficielle et applications sur des tissus vivants |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US695657A (en) * | 1901-05-10 | 1902-03-18 | Electric Ozone Syndicate Ltd | Ozonizer for wounds, &c. |
| GB436257A (en) * | 1934-03-09 | 1935-10-08 | Carl Ronzi | Improvements in means for treating human skin |
| US2054367A (en) * | 1933-04-12 | 1936-09-15 | Fisch Edmondo | Apparatus for the production and use of ozone in therapeutics |
| US2132539A (en) * | 1936-01-27 | 1938-10-11 | Gen Patents Ltd | Production of ions |
| US5052382A (en) * | 1988-04-29 | 1991-10-01 | Wainwright Basil E | Apparatus for the controlled generation and administration of ozone |
-
1996
- 1996-09-12 IL IL11924996A patent/IL119249A0/xx unknown
-
1997
- 1997-09-11 AU AU42178/97A patent/AU4217897A/en not_active Abandoned
- 1997-09-11 WO PCT/IL1997/000303 patent/WO1998010825A1/fr active Application Filing
- 1997-09-12 ZA ZA978253A patent/ZA978253B/xx unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US695657A (en) * | 1901-05-10 | 1902-03-18 | Electric Ozone Syndicate Ltd | Ozonizer for wounds, &c. |
| US2054367A (en) * | 1933-04-12 | 1936-09-15 | Fisch Edmondo | Apparatus for the production and use of ozone in therapeutics |
| GB436257A (en) * | 1934-03-09 | 1935-10-08 | Carl Ronzi | Improvements in means for treating human skin |
| US2132539A (en) * | 1936-01-27 | 1938-10-11 | Gen Patents Ltd | Production of ions |
| US5052382A (en) * | 1988-04-29 | 1991-10-01 | Wainwright Basil E | Apparatus for the controlled generation and administration of ozone |
Non-Patent Citations (1)
| Title |
|---|
| LIFE SCIENCE FOUNDATION, 1994, SARTORI H.E. et al., "Ozone, The Eternal Purifier of the Earth and Cleanser of all Living Beings, The Future of Ozone in Medicine Environment and Society or 21 Century Medicine and Technology Now", pages 19, 22, 23, 32, 211 and 212. * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100356995C (zh) * | 2001-12-04 | 2007-12-26 | 佛山市顺德区安医仕医疗科技有限公司 | 一种妇女生殖器疾病治疗装置 |
| WO2005120429A1 (fr) * | 2004-06-08 | 2005-12-22 | Shenzhen Jingrui Industry Co., Ltd. | Dispositif portable pour soins de la peau et du visage |
| WO2006018731A3 (fr) * | 2004-08-18 | 2006-06-01 | Jean Clement Edouart Gui Malak | Procede d'oxygenotherapie percutanee hyperbare par projection de fluorocarbones |
| WO2018108373A1 (fr) * | 2016-12-14 | 2018-06-21 | Lohmann & Rauscher Gmbh | Système pour le traitement médical d'un être humain et d'un animal et dispositif d'application pour ce système |
| CN107374938A (zh) * | 2017-08-11 | 2017-11-24 | 河南省宇安医疗科技开发有限公司 | 便携式三氧伤口治疗仪 |
| CN107374938B (zh) * | 2017-08-11 | 2023-04-28 | 河南省宇安医疗科技开发有限公司 | 便携式三氧伤口治疗仪 |
| EP3809914A4 (fr) * | 2018-06-25 | 2022-04-20 | Booker Holdings, LLC | Fluide améliorant la tension superficielle et applications sur des tissus vivants |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA978253B (en) | 1999-06-14 |
| IL119249A0 (en) | 1996-12-05 |
| AU4217897A (en) | 1998-04-02 |
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