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WO1998013715B1 - Microscope generating a three-dimensional representation of an object - Google Patents

Microscope generating a three-dimensional representation of an object

Info

Publication number
WO1998013715B1
WO1998013715B1 PCT/FR1997/001695 FR9701695W WO9813715B1 WO 1998013715 B1 WO1998013715 B1 WO 1998013715B1 FR 9701695 W FR9701695 W FR 9701695W WO 9813715 B1 WO9813715 B1 WO 9813715B1
Authority
WO
WIPO (PCT)
Prior art keywords
wave
page
image
mcrcroscope
illuminating
Prior art date
Application number
PCT/FR1997/001695
Other languages
French (fr)
Other versions
WO1998013715A1 (en
Filing date
Publication date
Priority claimed from FR9611773A external-priority patent/FR2754069A1/en
Priority claimed from FR9615255A external-priority patent/FR2754070A1/en
Priority claimed from FR9707469A external-priority patent/FR2757278A1/en
Application filed filed Critical
Priority to US09/254,869 priority Critical patent/US6249349B1/en
Priority to EP97943004A priority patent/EP0928433A1/en
Publication of WO1998013715A1 publication Critical patent/WO1998013715A1/en
Publication of WO1998013715B1 publication Critical patent/WO1998013715B1/en

Links

Abstract

The invention concerns a microscope comprising an optical part for generating interference figures between a reference light wave and a light wave diffracted by the observed object, sensors for digitising these interference figures, actuators for operating the optical system, and a computer for receiving the digitised interference figures, controlling the actuators, and provided with a memory and computing means for computing the three-dimensional images from the interference figures, based on a principle analogous to holography. The optical part enables the recording on a sensing surface (116) interference figures generated by a reference beam (Fr) and a beam (Fe) passing through a sample (109). The interference figures can differ from one another by the reference wave phase controlled by the piezoelectric actuator (120) or the spatial distribution of the illuminating beam controlled by the positioning device (106). This microscope can be used in biology or metrology.

Claims

REVENDICATIONS MODIFIEES MODIFIED CLAIMS
[reçues par le Bureau international le 24 avril 1998 (24 04 98); revendications originales 1-12 remplacées par les revendications 1-9 modifiées (1 page)][received by the International Bureau on 24 April 1998 (24 04 98); original claims 1-12 replaced by modified claims 1-9 (1 page)]
1 -Microscope calculant numériquement une représentation tridimensionnelle d'un objet observe, caractérisé par le fait que ladite represntation tridimensionnelle est calculée a partir de la représentation complexe d'une onde diffractee par l'objet et reçue sur une surface de réception, par le fait que ladite représentation complexe est elle-même obtenue a partir de plusieurs figures d'interférences formées sur ladite surface de réception par l'onde diffractee par l'objet et par une onde de référence, et par le fait que lesdites figures d'interférences diffèrent entre elles par la différence de phase entre l'onde éclairant l'objet et l'onde de référence1-Microscope numerically calculating a three-dimensional representation of an observed object, characterized in that said three-dimensional representation is calculated from the complex representation of a wave diffracted by the object and received on a receiving surface, thereby that said complex representation is itself obtained from several interference patterns formed on said receiving surface by the wave diffracted by the object and by a reference wave, and by the fact that said interference patterns differ between them by the phase difference between the wave illuminating the object and the reference wave
2-Mιcroscope selon la revendication 1, caractérisé par le fait que ladite onde de référence est approximativement sphéπque et centrée, réellement ou virtuellement, en un point central de la zone observée de l'objet2-Mcrcroscope according to claim 1, characterized in that said reference wave is approximately spherical and centered, actually or virtually, at a central point of the observed area of the object
3-Mιcroscope selon une des revendications 1 ou 2, caractérisé par le fait que ladite différence de phase entre l'onde de référence et l'onde éclairant l'objet est décalée de 120 degrés entre chacune desdites figures d'interférences3-Mcrcroscope according to one of claims 1 or 2, characterized in that said phase difference between the reference wave and the wave illuminating the object is offset by 120 degrees between each of said interference figures
4-Mιcroscope selon une des revendications 1 à 3, caractérisé par le fait qu'une image intermédiaire est formée optiquement et filtrée spatialement par un diaphragme, et par le fait que des lentilles sont utilisées pour former à partir de cette image intermédiaire une figure de diffraction sur la surface de réception4-Mιcroscope according to one of claims 1 to 3, characterized in that an intermediate image is formed optically and spatially filtered by a diaphragm, and in that lenses are used to form from the intermediate image a figure of diffraction on the receiving surface
5-Mιcroscope selon une des revendications 1 à 4, caractérisé par le fait qu'en l'abscence d'onde de référence une onde plane provenant de l'objet produit sur la surface de réception une image ponctuelle 6-Mιcroscope selon une des revendications 1 à 5, caractérisé par le fait que l'onde éclairant l'objet est obtenue par utilisation d'un condenseur formant sur l'objet l'image d'un élément diffusant éclairé par le faisceau laser5-microscope according to one of claims 1 to 4, characterized in that in the absence of a reference wave a plane wave from the object produced on the receiving surface a point image 6-Mcrcroscope according to one of the claims 1 to 5, characterized by the fact that the wave illuminating the object is obtained by using a condenser forming on the object the image of a diffusing element illuminated by the laser beam
7-Mιcroscope suivant une des revendications 1 à 6, caractérisé par le fait que plusieurs desdites représentations tridimensionnelles, différant entre elles par des modifications de l'onde éclairant l'objet, sont utilisées pour obtemr une représentation tridimensionnelle améliorée7-Mcrcroscope according to one of claims 1 to 6, characterized in that several of said three-dimensional representations, differing from each other by changes in the light illuminating the object, are used to obtemr an improved three-dimensional representation
8-Mιcroscope selon les revendications 6 et 7, caractérise par le fait que lesdites modifications de l'onde éclairant l'objet sont obtenues en déplaçant l'élément diffusant8-Mcrcroscope according to claims 6 and 7, characterized in that said modifications of the wave illuminating the object are obtained by moving the diffusing element
9-Mιcroscope selon une de revendications 7 ou 8, caractérisé par le fait que ladite représentation tridimensionnelle améliorée de l'objet observe est obtenue par moyennage en intensité desdites représentations tridimensionnelles différant entre elles par des modifications de l'onde éclairant l'objet -17-9-Mcrcroscope according to one of claims 7 or 8, characterized in that said improved three-dimensional representation of the object observed is obtained by averaging intensity said three-dimensional representations differing from each other by changes in the wave illuminating the object -17-
DECLARATION SELON L'ARTICLE 19DECLARATION UNDER ARTICLE 19
Les antériorités opposées concernent des méthodes numéπques simulant la reconstruction holographique optique L'antériorité « Tmg-Chung Poon et Al » en diffère cependant comme explique page 1341 du document cité l'enregistrement holographique traditionnel comprend les termesOpposite antecedents concern numerical methods simulating optical holographic reconstruction. The prior art "Tmg-Chung Poon et Al" differs however as explained on page 1341 of the document cited. The traditional holographic recording includes the terms
|0| +|R| + OR* +0*R Les deux premiers termes qui constituent le terme du second ordre ou spatially varying bias sont supprimés dans la méthode indiquée par l'auteur et l'enregistrement est réalise sous la forme d'une fonction de transmission réelle / (x, v) représentant la quantité OR +0 R Une reconstruction holographique classique est réalisée à partir de cette grandeur| 0 | + | R | + OR * +0 * R The first two terms constituting the second order term or spatially variable bias are removed in the method indicated by the author and the record is made as a real transmission function / ( x, v) representing the quantity OR +0 R A conventional holographic reconstruction is carried out from this quantity
La présente invention, selon la nouvelle revendication 1, permet l'obtention de la quantité complexe O seule qui sert ensuite de base à une reconstruction simulant le retour inverse de la lumière et non la reconstruction holographique optique Dans la description de l'invention, page 2 lignes 26 à 29, il est indique que la méthode de reconstruction holographique traditionnelle, utilisée dans les antériorités « Karpov V B » « Bianco B et Al » et « Beltrame F et Al » , mène à des défauts qui sont l'apparition d'une image parasite et d'écarts du second ordre Dans le cas de l'antériorité « Ting-Chung Poon et Al » les écarts du second ordre sont suppπmes mais l'image parasite reste L'enseignement de la présente demande, ainsi qu'indique page 2 lignes 29 à 33, est que l'ensemble de ces défauts peuvent être supprimés en calculant la valeur complexe de l'onde sur la surface de réception La nouvelle revendication 1 se limite à un microscope utilisant cette valeur complexe de l'onde Elle se limite également en précisant le mode d'obtention de cette valeur complexe comme indique dans la description, page 2 lignes 33 à 35 Cette revendication n'est donc anténoπsee par aucune des références citées dans le rapport de rechercheThe present invention, according to the new claim 1, makes it possible to obtain the complex quantity O only which then serves as a basis for a reconstruction simulating the inverse return of light and not the optical holographic reconstruction. In the description of the invention, page 2 lines 26 to 29, it is indicated that the traditional holographic reconstruction method, used in the references "Karpov VB" "Bianco B and Al" and "Beltrame F and Al", leads to defects that are the appearance of a parasitic image and second-order deviations In the case of the "Ting-Chung Poon and Al" anteriority, the second-order deviations are eliminated but the parasite image remains the teaching of the present application, as indicated by page 2 lines 29 to 33, is that all of these defects can be eliminated by calculating the complex value of the wave on the receiving surface. The new claim 1 is limited to a microscope using this value wave complex It is also limited in specifying the manner of obtaining this complex value as indicated in the description, page 2 lines 33 to 35 This claim is therefore anténoπsee by none of the references cited in the research report
Les indications données dans la description du mode préféré de réalisation, page 5 lignes 5 à 7 signifient que l'onde de référence est centrée virtuellement au centre de l'objet observé Ce mode de réalisation correspond a la nouvelle revendication 1 L'ancienne revendication 2 couvrait également le mode de réalisation décπt de la page 12 ligne 32 à la page 13 ligne 27, qui n'est plus revendique, cette partie de la description devenant donc inutile La nouvelle revendication 2 limite l'ancienne revendication 2 en la restreignant au cas de la nouvelle revendication 1 et en restreignant le domaine dans lequel l'onde peut être centrée à la zone centrale de l'objet conformément au mode préféré de réalisationThe indications given in the description of the preferred embodiment, page 5 lines 5 to 7, mean that the reference wave is centered virtually in the center of the object being viewed. This embodiment corresponds to the new claim 1 The former claim 2 also covered the decedent embodiment of page 12 line 32 to page 13 line 27, which is no longer claimed, this part of the description thus becoming unnecessary The new claim 2 limits the former claim 2 by restricting it to the case of the new claim 1 and restricting the range in which the wave may be centered to the central area of the object in accordance with the preferred embodiment
L'antériorité « Karpov V B » concerne une reconstruction holographiqe traditionnelle dans laquelle l'onde de référence doit être centrée hors de l'objet observe, faute de quoi l'image parasite se superpose a l'image observée. La nouvelle revendication 2 n'est donc pas antéπonsee, d'une part parce que cette revendication est placée sous la revendication 1, d'autre part parce que dans « Karpov B V » 1 onde de référence n'est pas centrée en un point central de l'objet observé mais en un point proche dudit objetThe "Karpov V B" anteriority concerns a traditional holographic reconstruction in which the reference wave must be centered out of the observed object, otherwise the parasite image is superimposed on the observed image. The new claim 2 is therefore not prejudiced, on the one hand because this claim is placed under claim 1, on the other hand because in "Karpov BV" 1 reference wave is not centered at a central point of the observed object but at a point close to said object
Les revendications suivantes reprennent avec quelques modifications des revendications non anteπoπsees déjà présentes dans le texte initialement déposé The following claims reproduce with some modifications of the non-anteπoπsees claims already present in the text initially deposited
PCT/FR1997/001695 1996-09-27 1997-09-26 Microscope generating a three-dimensional representation of an object WO1998013715A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US09/254,869 US6249349B1 (en) 1996-09-27 1997-09-26 Microscope generating a three-dimensional representation of an object
EP97943004A EP0928433A1 (en) 1996-09-27 1997-09-26 Microscope generating a three-dimensional representation of an object

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR96/11773 1996-09-27
FR9611773A FR2754069A1 (en) 1996-09-27 1996-09-27 Three Dimensional Image Microscope for Biology
FR96/15255 1996-12-12
FR9615255A FR2754070A1 (en) 1996-09-27 1996-12-12 Three Dimensional Image Microscope for Biology
FR9707469A FR2757278A1 (en) 1996-12-12 1997-06-17 Three Dimensional Image Microscope for Biology
FR97/07469 1997-06-17

Publications (2)

Publication Number Publication Date
WO1998013715A1 WO1998013715A1 (en) 1998-04-02
WO1998013715B1 true WO1998013715B1 (en) 1998-06-04

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US (1) US6249349B1 (en)
EP (1) EP0928433A1 (en)
WO (1) WO1998013715A1 (en)

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