WO1998014577B1 - Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation - Google Patents
Sequence nucleotique et de proteique de mammastatine et procedes d'utilisationInfo
- Publication number
- WO1998014577B1 WO1998014577B1 PCT/US1997/018026 US9718026W WO9814577B1 WO 1998014577 B1 WO1998014577 B1 WO 1998014577B1 US 9718026 W US9718026 W US 9718026W WO 9814577 B1 WO9814577 B1 WO 9814577B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mammastatin
- kda
- composition
- dna sequence
- nucleic acid
- Prior art date
Links
- 108010016172 mammastatin Proteins 0.000 title claims abstract 30
- 208000020600 Mammastatin Diseases 0.000 title claims abstract 29
- 238000000034 method Methods 0.000 title claims 4
- 108090000623 proteins and genes Chemical group 0.000 title claims 2
- 102000004169 proteins and genes Human genes 0.000 title claims 2
- 239000002773 nucleotide Substances 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract 11
- 210000004216 mammary stem cell Anatomy 0.000 claims abstract 8
- 150000007523 nucleic acids Chemical group 0.000 claims abstract 6
- 230000012010 growth Effects 0.000 claims abstract 4
- 206010006187 Breast cancer Diseases 0.000 claims abstract 3
- 208000026310 Breast neoplasm Diseases 0.000 claims abstract 3
- 210000004027 cell Anatomy 0.000 claims abstract 2
- 230000010261 cell growth Effects 0.000 claims abstract 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 8
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 201000009030 Carcinoma Diseases 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 108091026890 Coding region Proteins 0.000 claims 2
- 238000009007 Diagnostic Kit Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 239000013610 patient sample Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
Abstract
L'invention concerne une séquence nucléotidique codant pour la mammastatine, un inhibiteur de croissance spécifique de cellule mammaire. La mammastatine est codée par une seule séquence nucléotidique, et possède un poids moléculaire approximatif de 44 kDa dans sa forme inactive, non phosphorylée. Les cellules mammaires normales expriment des formes phosphorylées fonctionnelles possédant des poids moléculaires approximatifs de 53 kDa et 49 kDa. Des cellules mammaires métastatiques, ou n'expriment pas du tout la mammastatine, ou n'expriment pas les formes phosphorylées à 53 kDa ou 49 kDa. L'administration de mammastatine phosphorylée permet d'inhiber la croissance de cellules mammaires cancéreuses.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9713248-9A BR9713248A (pt) | 1996-10-03 | 1997-10-03 | Sequência de nucleotìdeos e de proteìnas de mamastatina e processos de uso |
| CA2267095A CA2267095C (fr) | 1996-10-03 | 1997-10-03 | Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation |
| IL12924197A IL129241A0 (en) | 1996-10-03 | 1997-10-03 | Nucleotide and protein sequence of mammastatin and methods of use |
| JP51695598A JP4452331B2 (ja) | 1996-10-03 | 1997-10-03 | ママスタチンのヌクレオチドおよびタンパク質配列およびその使用法 |
| AU46709/97A AU733380B2 (en) | 1996-10-03 | 1997-10-03 | Nucleotide and protein sequence of mammastatin and methods of use |
| EA199900256A EA199900256A1 (ru) | 1996-10-03 | 1997-10-03 | Нуклеотидная и белковая последовательность маммастатина и способы применения |
| EP97945531A EP0929675A2 (fr) | 1996-10-03 | 1997-10-03 | Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2731596P | 1996-10-03 | 1996-10-03 | |
| US60/027,315 | 1996-10-03 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| WO1998014577A2 WO1998014577A2 (fr) | 1998-04-09 |
| WO1998014577A3 WO1998014577A3 (fr) | 1998-04-09 |
| WO1998014577B1 true WO1998014577B1 (fr) | 1998-07-30 |
| WO1998014577A9 WO1998014577A9 (fr) | 1998-08-27 |
Family
ID=21836977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/018026 WO1998014577A2 (fr) | 1996-10-03 | 1997-10-03 | Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US6451765B1 (fr) |
| EP (2) | EP0929675A2 (fr) |
| JP (2) | JP4452331B2 (fr) |
| AU (1) | AU733380B2 (fr) |
| BR (1) | BR9713248A (fr) |
| CA (1) | CA2267095C (fr) |
| EA (1) | EA199900256A1 (fr) |
| WO (1) | WO1998014577A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0929675A2 (fr) * | 1996-10-03 | 1999-07-21 | Biotherapies, Inc. | Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation |
| US6500937B1 (en) | 1996-10-03 | 2002-12-31 | University Of Michigan | Nucleotide sequence encoding a mammary cell growth inhibitor |
| JP2003513615A (ja) * | 1999-06-18 | 2003-04-15 | バイオセラピーズ・インコーポレイテッド | 上皮細胞増殖インヒビター |
| US6939714B2 (en) | 1999-06-18 | 2005-09-06 | Biotherapies, Inc. | Epithelial cell growth inhibitors |
| KR100674528B1 (ko) | 1999-06-28 | 2007-01-29 | 제넨테크, 인크. | 2가 금속 이온을 사용한 Ａｐｏ-2 리간드 제조 방법 |
| US20030212263A1 (en) * | 2000-06-19 | 2003-11-13 | The University Of Michigan | Mammastatin sequence variant C |
| WO2001098496A1 (fr) * | 2000-06-19 | 2001-12-27 | The University Of Michigan | Allele c de sequence de mammastatine |
| CN112888451A (zh) * | 2018-10-19 | 2021-06-01 | 川斯勒佰尔公司 | 信使rna的无泵包封 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4379839A (en) | 1977-05-23 | 1983-04-12 | The Trustees Of Columbia University In The City Of New York | Method for detecting cancer |
| US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
| JPH05506351A (ja) * | 1988-05-20 | 1993-09-22 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | ヒト乳房細胞成長インヒビターに対する抗体ならびにその製造方法および使用 |
| WO1989011492A1 (fr) * | 1988-05-20 | 1989-11-30 | The Regents Of The University Of Michigan | Inhibiteur de croissance de cellules mammaires humaines et procedes de production et d'utilisation |
| EP0929675A2 (fr) * | 1996-10-03 | 1999-07-21 | Biotherapies, Inc. | Sequence nucleotique et de proteique de mammastatine et procedes d'utilisation |
| US6500937B1 (en) * | 1996-10-03 | 2002-12-31 | University Of Michigan | Nucleotide sequence encoding a mammary cell growth inhibitor |
-
1997
- 1997-10-03 EP EP97945531A patent/EP0929675A2/fr not_active Ceased
- 1997-10-03 WO PCT/US1997/018026 patent/WO1998014577A2/fr active Application Filing
- 1997-10-03 BR BR9713248-9A patent/BR9713248A/pt not_active Application Discontinuation
- 1997-10-03 JP JP51695598A patent/JP4452331B2/ja not_active Expired - Fee Related
- 1997-10-03 AU AU46709/97A patent/AU733380B2/en not_active Ceased
- 1997-10-03 CA CA2267095A patent/CA2267095C/fr not_active Expired - Fee Related
- 1997-10-03 EA EA199900256A patent/EA199900256A1/ru unknown
- 1997-10-03 EP EP07019672A patent/EP1935899A1/fr not_active Withdrawn
-
1999
- 1999-04-02 US US09/285,379 patent/US6451765B1/en not_active Expired - Fee Related
- 1999-08-06 US US09/369,912 patent/US6492504B2/en not_active Expired - Fee Related
-
2002
- 2002-07-09 US US10/193,524 patent/US7323173B2/en not_active Expired - Fee Related
- 2002-07-09 US US10/192,915 patent/US7332287B2/en not_active Expired - Fee Related
-
2008
- 2008-02-07 US US12/027,799 patent/US20090011434A1/en not_active Abandoned
-
2009
- 2009-08-14 JP JP2009188028A patent/JP2010031013A/ja active Pending
-
2010
- 2010-09-22 US US12/888,214 patent/US20110039279A1/en not_active Abandoned
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