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WO1998017193A1 - Systeme et procede pour mesures hemodynamiques non invasives dans des pontages en hemodialyse - Google Patents

Systeme et procede pour mesures hemodynamiques non invasives dans des pontages en hemodialyse Download PDF

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Publication number
WO1998017193A1
WO1998017193A1 PCT/US1997/019511 US9719511W WO9817193A1 WO 1998017193 A1 WO1998017193 A1 WO 1998017193A1 US 9719511 W US9719511 W US 9719511W WO 9817193 A1 WO9817193 A1 WO 9817193A1
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WO
WIPO (PCT)
Prior art keywords
time
hematocrit
blood flow
measuring
period
Prior art date
Application number
PCT/US1997/019511
Other languages
English (en)
Inventor
Robert R. Steuer
David R. Miller
Original Assignee
In-Line Diagnostics Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by In-Line Diagnostics Corporation filed Critical In-Line Diagnostics Corporation
Priority to AU50920/98A priority Critical patent/AU5092098A/en
Priority to EP97913824A priority patent/EP0944362A4/fr
Priority to JP51971898A priority patent/JP3622984B2/ja
Priority to CA002268519A priority patent/CA2268519A1/fr
Publication of WO1998017193A1 publication Critical patent/WO1998017193A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring haematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6866—Extracorporeal blood circuits, e.g. dialysis circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1613—Profiling or modelling of patient or predicted treatment evolution or outcome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607—Regulation parameters
    • A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
    • A61M1/361—Physical characteristics of the blood, e.g. haematocrit, urea before treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607—Regulation parameters
    • A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
    • A61M1/3612—Physical characteristics of the blood, e.g. haematocrit, urea after treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3613—Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
    • A61M1/3655—Arterio-venous shunts or fistulae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
    • A61M1/3656—Monitoring patency or flow at connection sites; Detecting disconnections
    • A61M1/3658—Indicating the amount of purified blood recirculating in the fistula or shunt
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3663—Flow rate transducers; Flow integrators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/207—Blood composition characteristics hematocrit

Definitions

  • This invention relates to systems and methods for noninvasively measuring
  • the present invention relates to noninvasive
  • Hemodialysis is a process wherein
  • an artificial kidney is required to function in the place of the patient's normal kidney in
  • This "access site” is typically located in the arm, leg, or neck of the patient.
  • Blood flow, Q measured by
  • One method of measuring access blood flow utilizes color coded duplex
  • Another method involves injection of a saline solution intravenously and
  • Another technique involves injecting saline boluses into the arterial and venous
  • the present standard measurement for access recirculation requires three blood
  • Another object of the present invention is to provide a means and method of
  • Another object of the present invention is to present the dilutional concentration-
  • Still another object of the present invention is to provide a system and method
  • access recirculation in a shunt is
  • Electronic circuitry receives signals from the
  • ultrafiltration rate (UFR) is changed and the corresponding change in concentration of
  • a blood constituent is measured.
  • concentration of a blood constituent is measured as a function of dialyzer blood flow rate or UFR and electronic
  • circuitry converts these measurements into quantitative determinations of access
  • the measured blood constituent is red blood cells.
  • FIG. 1 shows a typical dialysis tubing connection circuit.
  • FIG. 2 illustrates a plot of % ⁇ Hematocrit (or % ⁇ blood volume (BV)) versus Time
  • FIG. 3 shows a single injection dilutional curve when access recirculation is present
  • FIG. 4 shows a single injection dilutional curve with the arterial and venous tubing lines
  • FIG. 5 diagrammatically represents the dialysis circuit in terms of mass flow, in normal
  • FIG. 6 diagrammatically represents the dialysis circuit in terms of mass flow with arterial
  • measurements are conducted using the apparatus
  • hematocrit is measured through blood in a flow through cuvette located in the access line.
  • blood is taken out of a patient 200 by an intake catheter means,
  • Input catheter 122 is
  • the blood filter is also called a dialyzer 130.
  • the unclean blood flows from an artery in
  • pump 140 an example of which is pump 140.
  • Dialyzer 130 has an input port 230 and an output port 240.
  • the pump 140 performs the function of moving the unclean blood from patient 200 into
  • dialyzer 130 input port 230, through dialyzer 130, and out of dialyzer 130 at output port 240.
  • unclean blood in input catheter 122 is transported to input port 230
  • hemodialysis related component may receive further processing, such as heparin drip, in hemodialysis related component
  • the hemodialysis process uses a blood filter or dialyzer 130 to clean the blood of patient 200. As blood passes through dialyzer 130, it travels in
  • the straw-like tubes remove poisons and excess fluids through
  • BUN blood urea nitrogen
  • potassium potassium
  • dialyzer 130 enters dialyzer 130 at an input tube 210 from a combined controller and tank 170.
  • dialysate surrounds the straw-like tubes in dialyzer 130 as the dialysate flows down
  • dialyzer 130 The clean dialysate picks up the excess fluids and poisons passing
  • Dialysate exiting at output tube 220 after cleansing the blood may be discarded.
  • unclean blood flows from an artery in patient 200 to pump 140 and then
  • dialyzer 130 Unclean blood flows into dialyzer 130 from input catheter 122 and clean
  • a blood flow path for emitting radiation into the blood in the flow path, and for detecting
  • the means includes a cuvette means for defining the blood flow path, and an emitter/detector
  • emitter/detector means for emitting and detecting radiation.
  • emitter/detector means for emitting and detecting radiation.
  • Emitter/detector apparatus 100 also has a
  • detection means an example of which is depicted as a photodetector 104.
  • An example is depicted as a photodetector 104.
  • FIG. 1 A diagram of the cuvette means is shown in FIG. 1 as cuvette 10.
  • Emitter/detector apparatus 100 enables the detection by photodetector 104 of the
  • a cuvette 10 is installed at either end of dialyzer 130.
  • cuvette 10 has a photoemitter 102 and a photodetector 104 thereon.
  • a photoemitter 102 and a photodetector 104 thereon.
  • photoemitter 102 and photodetector 104 are shown as being
  • the emitter/detector means is electrically connected to a calculation means.
  • FIG. 1 as computer 150 which is electrically connected to photoemitter 102 and
  • Intake catheter 122 takes blood to cuvette 10 situated before input port 230 of
  • dialyzer 130 Emitter/detector apparatus 100 at input port 230 of dialyzer 130 subjects
  • port 240 of the dialyzer 130 communicates the detected radiation via cable 120 or 128 to computer 150.
  • Computer 150 calculates both before dialysis (via cable 120) and after dialysis
  • Computer 150 then displays, respectively, at a first display 152 and a second display 154,
  • the measuring disposable blood chamber 10 is immediately
  • hematocrit instantly occurs due to the dilution of the whole blood by the saline.
  • FIG. 2 (the Ficke principle), the dialyzer blood flow (Q,), access recirculation (AR), and
  • access blood flow (Q a ) are determined in the following manner.
  • K a conversion factor, determined empirically to convert percent
  • V Volume of saline injected (typically 10 ml)
  • FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present, FIG. 3 is obtained. In order to determine AR the access recirculation (AR) is present.
  • the area under the dilution curve 1 the "calibration area”
  • the area under dilution curve 2 represents the "measuring area”.
  • the priming dialyzer circuit volume (PDCV) can be calculated with the PDCV
  • RAR reversed access recirculation
  • RAR J(% ⁇ H) 2 dt/J(% ⁇ H),dt (4)
  • the second injection is the measuring injection.
  • the single saline injection technique utilizing a single detector is a major
  • injections must be the exact same volume each time and given at the same rate of
  • the actual rate of saline injection can be calculated from time basg
  • the injection rate-induced transients can thusly be compensated for resulting in
  • H 0 (Q,/(Q, - UFR))H 1 (10)
  • H,/H a (1 - R)[l - R (Q (Q, - UFR))] "1 (11)
  • the value of Q a is determined in the following manner.
  • a blood volume monitor (a relative measure of hematocrit) to measure AR and Q a
  • ⁇ BV hematocrit
  • circuitry and algorithms may be adapted for analysis of other rheologic parameters.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Fluid Mechanics (AREA)
  • Optics & Photonics (AREA)
  • External Artificial Organs (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

On évalue quantitativement la recirculation d'accès dans un pontage au moyen d'un procédé selon lequel on injecte à un patient une solution de référence, telle qu'une solution saline, qui se mêle à l'écoulement sanguin en amont du pontage. Au niveau d'un point de la ligne d'accès, on effectue une mesure photométrique de la variation temporelle de l'hématocrite (delta H). Un circuit électronique (150) reçoit des signaux du détecteur (100), compare l'aire d'intégration par rapport au temps du delta H de la solution de référence s'écoulant initialement à travers le pontage, à celle de la solution en recirculation, et produit un affichage de cette recirculation (152).
PCT/US1997/019511 1996-10-23 1997-10-22 Systeme et procede pour mesures hemodynamiques non invasives dans des pontages en hemodialyse WO1998017193A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU50920/98A AU5092098A (en) 1996-10-23 1997-10-22 System and method for noninvasive hemodynamic measurements in hemodialysis shunts
EP97913824A EP0944362A4 (fr) 1996-10-23 1997-10-22 Systeme et procede pour mesures hemodynamiques non invasives dans des pontages en hemodialyse
JP51971898A JP3622984B2 (ja) 1996-10-23 1997-10-22 血液透析シャント内の血行動態の不侵襲測定システム
CA002268519A CA2268519A1 (fr) 1996-10-23 1997-10-22 Systeme et procede pour mesures hemodynamiques non invasives dans des pontages en hemodialyse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2958796P 1996-10-23 1996-10-23
US60/029,587 1996-10-23

Publications (1)

Publication Number Publication Date
WO1998017193A1 true WO1998017193A1 (fr) 1998-04-30

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PCT/US1997/019511 WO1998017193A1 (fr) 1996-10-23 1997-10-22 Systeme et procede pour mesures hemodynamiques non invasives dans des pontages en hemodialyse

Country Status (6)

Country Link
EP (1) EP0944362A4 (fr)
JP (1) JP3622984B2 (fr)
KR (1) KR100498628B1 (fr)
AU (1) AU5092098A (fr)
CA (1) CA2268519A1 (fr)
WO (1) WO1998017193A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210591B1 (en) 1994-09-16 2001-04-03 Transonic Systems, Inc. Method to measure blood flow rate in hemodialysis shunts
US6868739B1 (en) 1999-10-19 2005-03-22 Transonic Systems, Inc. Method and apparatus to measure blood flow by an introduced volume change
US7172570B2 (en) 2003-01-28 2007-02-06 Gambro Lundia Ab Apparatus and method for monitoring a vascular access of a patient subjected to an extracorporeal blood treatment
US7297280B2 (en) 1994-09-16 2007-11-20 Transonic Systems, Inc. Method and apparatus to measure blood flow in hemodialysis shunts
JP2008161703A (ja) * 1998-01-07 2008-07-17 Fresenius Medical Care Holdings Inc 血液透析パラメータを決定する方法および装置
US7500958B2 (en) 1998-10-23 2009-03-10 Gambro Lundia Ab Switch valve for an extracorporeal blood circuit and circuit including such a switch valve
US7704213B2 (en) 2002-12-19 2010-04-27 Fresenius Medical Care Deutschland Gmbh Method and device for determining the blood flow in a blood-conducting tube
WO2011131358A3 (fr) * 2010-04-20 2011-12-22 Up-Med Gmbh Procédé et dispositif de détermination du débit dans une fistule pour le traitement dialytique
WO2014161771A1 (fr) * 2013-04-03 2014-10-09 B. Braun Avitum Ag Système pour détecter un état d'un dispositif de dialyse, et dispositif de détection utilisable à cet effet
CN112004569A (zh) * 2018-04-26 2020-11-27 日机装株式会社 血液净化装置
US11389576B2 (en) * 2018-12-03 2022-07-19 Fresenius Medical Care Holdings, Inc. Determination of patient blood volume at start of a dialysis treatment

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060211947A1 (en) * 2005-03-07 2006-09-21 Nikolai Krivitski System and method for determining cardiac output
JP4573231B2 (ja) * 2006-11-01 2010-11-04 日機装株式会社 血液浄化装置
JP4573860B2 (ja) * 2007-08-22 2010-11-04 日機装株式会社 血液浄化装置
JP6559484B2 (ja) * 2015-07-06 2019-08-14 日機装株式会社 血液浄化装置及びその血液浄化装置によるアクセス血管の流量算出方法
JP7686400B2 (ja) * 2021-01-25 2025-06-02 日機装株式会社 血液浄化装置
WO2025173751A1 (fr) * 2024-02-14 2025-08-21 日機装株式会社 Dispositif de purification du sang

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US4446871A (en) * 1980-01-25 1984-05-08 Minolta Kabushiki Kaisha Optical analyzer for measuring a construction ratio between components in the living tissue
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KR20000052728A (ko) 2000-08-25
EP0944362A1 (fr) 1999-09-29
JP2001506873A (ja) 2001-05-29
AU5092098A (en) 1998-05-15
CA2268519A1 (fr) 1998-04-30
JP3622984B2 (ja) 2005-02-23
EP0944362A4 (fr) 2001-11-21

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