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WO1998019701B1 - Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations - Google Patents

Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations

Info

Publication number
WO1998019701B1
WO1998019701B1 PCT/US1997/020388 US9720388W WO9819701B1 WO 1998019701 B1 WO1998019701 B1 WO 1998019701B1 US 9720388 W US9720388 W US 9720388W WO 9819701 B1 WO9819701 B1 WO 9819701B1
Authority
WO
WIPO (PCT)
Prior art keywords
inos
graft
wound
region
cells
Prior art date
Application number
PCT/US1997/020388
Other languages
English (en)
Other versions
WO1998019701A1 (fr
Filing date
Publication date
Priority claimed from US08/745,375 external-priority patent/US5830461A/en
Application filed filed Critical
Priority to CA002270619A priority Critical patent/CA2270619A1/fr
Priority to EP97946907A priority patent/EP0963204A1/fr
Priority to JP52181598A priority patent/JP2001503432A/ja
Priority to AU51992/98A priority patent/AU5199298A/en
Publication of WO1998019701A1 publication Critical patent/WO1998019701A1/fr
Publication of WO1998019701B1 publication Critical patent/WO1998019701B1/fr

Links

Abstract

Cette invention se rapporte à un procédé permettant de promouvoir la fermeture d'une plaie dans le corps d'un patient. Ce procédé consiste à transférer l'enzyme sous forme exogène oxyde nitrique synthase inductible (ONSi) dans la région de la plaie, pour qu'un produit de cette enzyme ONSi soit généré dans la région de la plaie, afin de promouvoir sa fermeture. Cette invention se rapporte également à un procédé permettant de transplanter une greffe dans le corps d'un patient, ce procédé consistant à transférer un vecteur comprenant une cassette d'expression d'ONSi dans des cellules associées à la greffe et à incorporer par voie chirurgicale les tissus de la greffe dans le corps du patient. Après expression de l'enzyme ONSi dans le corps du patient, un produit de cette enzyme est généré dans la région de la greffe, de façon à atténuer la vasculopathie dans la région de la greffe. Pour réaliser ce procédé, cette invention présente également des compositions pharmaceutiques permettant d'acheminer l'enzyme ONSi et/ou la bioptérine BH4 dans les cellules associées aux plaies ou aux greffes.
PCT/US1997/020388 1996-11-08 1997-11-07 Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations WO1998019701A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002270619A CA2270619A1 (fr) 1996-11-08 1997-11-07 Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations
EP97946907A EP0963204A1 (fr) 1996-11-08 1997-11-07 Promotion de la cicatrisation et traitement des vasculopathies associees a des transplantations
JP52181598A JP2001503432A (ja) 1996-11-08 1997-11-07 創傷治癒の促進方法および移植に関連する血管症の治療方法
AU51992/98A AU5199298A (en) 1996-11-08 1997-11-07 Methods for promoting wound healing and treating transplant-associated vasculopathy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/745,375 US5830461A (en) 1992-11-25 1996-11-08 Methods for promoting wound healing and treating transplant-associated vasculopathy
US08/745,375 1996-11-08

Publications (2)

Publication Number Publication Date
WO1998019701A1 WO1998019701A1 (fr) 1998-05-14
WO1998019701B1 true WO1998019701B1 (fr) 1998-07-23

Family

ID=24996422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/020388 WO1998019701A1 (fr) 1996-11-08 1997-11-07 Procedes pour promouvoir la cicatrisation et pour traiter les vasculopathies associees a des transplantations

Country Status (6)

Country Link
US (2) US5830461A (fr)
EP (1) EP0963204A1 (fr)
JP (1) JP2001503432A (fr)
AU (1) AU5199298A (fr)
CA (1) CA2270619A1 (fr)
WO (1) WO1998019701A1 (fr)

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