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WO1998019708A3 - Method for enhancing the solubility of substantially water-insoluble compounds - Google Patents

Method for enhancing the solubility of substantially water-insoluble compounds Download PDF

Info

Publication number
WO1998019708A3
WO1998019708A3 PCT/US1997/019831 US9719831W WO9819708A3 WO 1998019708 A3 WO1998019708 A3 WO 1998019708A3 US 9719831 W US9719831 W US 9719831W WO 9819708 A3 WO9819708 A3 WO 9819708A3
Authority
WO
WIPO (PCT)
Prior art keywords
solubility
water
enhancing
compounds
substantially water
Prior art date
Application number
PCT/US1997/019831
Other languages
French (fr)
Other versions
WO1998019708A2 (en
Inventor
David H Donabedian
Lawrence Marlin
Elke M A Clark
Original Assignee
Union Carbide Chem Plastic
David H Donabedian
Lawrence Marlin
Elke M A Clark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Carbide Chem Plastic, David H Donabedian, Lawrence Marlin, Elke M A Clark filed Critical Union Carbide Chem Plastic
Priority to EP97950577A priority Critical patent/EP0891190A2/en
Publication of WO1998019708A2 publication Critical patent/WO1998019708A2/en
Publication of WO1998019708A3 publication Critical patent/WO1998019708A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)

Abstract

Methods for enhancing the water-solubility of substantially water-insoluble compounds are disclosed by combining such compounds with a water-soluble polymer, e.g., polyalkylene oxide polymer or a cellulose ether, having a molecular weight of from about 50,000 to 7,000,000 grams/per gram in an amount effective to enhance the water-solubility of the compound in an acidic environment, e.g., pH less than about 5. Compositions comprising the compounds having enhanced water solubility are also disclosed.
PCT/US1997/019831 1996-11-04 1997-10-31 Method for enhancing the solubility of substantially water-insoluble compounds WO1998019708A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97950577A EP0891190A2 (en) 1996-11-04 1997-10-31 Method for enhancing the solubility of substantially water-insoluble compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3028296 1996-11-04
US60/030,282 1996-11-05

Publications (2)

Publication Number Publication Date
WO1998019708A2 WO1998019708A2 (en) 1998-05-14
WO1998019708A3 true WO1998019708A3 (en) 1998-08-20

Family

ID=21853450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019831 WO1998019708A2 (en) 1996-11-04 1997-10-31 Method for enhancing the solubility of substantially water-insoluble compounds

Country Status (3)

Country Link
EP (1) EP0891190A2 (en)
CN (1) CN1211928A (en)
WO (1) WO1998019708A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0008058A (en) 1999-12-08 2002-03-26 Pharmacia Corp Solid-state form of celecoxib having improved bioavailability
US6818566B2 (en) 2002-10-18 2004-11-16 The Boc Group, Inc. Thermal activation of fluorine for use in a semiconductor chamber
EP2838564A4 (en) 2012-04-19 2015-12-02 Purdue Research Foundation ALPHA-D-GLUCANES HIGHLY RAMIFIED

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (en) * 1978-11-20 1980-06-25 American Home Products Corporation Therapeutic compositions with enhanced bioavailability and process for their preparation
EP0315964A1 (en) * 1987-11-11 1989-05-17 Laboratoires Pharmascience A novel pharmaceutical composition comprising exifone and water-soluble polymer
WO1996032097A1 (en) * 1995-04-14 1996-10-17 Pharma Pass Solid compositions containing polyethyleneoxide and a non-amorphous active principle
WO1998011879A1 (en) * 1996-09-19 1998-03-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (en) * 1978-11-20 1980-06-25 American Home Products Corporation Therapeutic compositions with enhanced bioavailability and process for their preparation
EP0315964A1 (en) * 1987-11-11 1989-05-17 Laboratoires Pharmascience A novel pharmaceutical composition comprising exifone and water-soluble polymer
WO1996032097A1 (en) * 1995-04-14 1996-10-17 Pharma Pass Solid compositions containing polyethyleneoxide and a non-amorphous active principle
WO1998011879A1 (en) * 1996-09-19 1998-03-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter

Also Published As

Publication number Publication date
WO1998019708A2 (en) 1998-05-14
EP0891190A2 (en) 1999-01-20
CN1211928A (en) 1999-03-24

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