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WO1998031810A3 - Chemokines de mammiferes, recepteurs, reactifs, utilisations - Google Patents

Chemokines de mammiferes, recepteurs, reactifs, utilisations Download PDF

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Publication number
WO1998031810A3
WO1998031810A3 PCT/US1998/000218 US9800218W WO9831810A3 WO 1998031810 A3 WO1998031810 A3 WO 1998031810A3 US 9800218 W US9800218 W US 9800218W WO 9831810 A3 WO9831810 A3 WO 9831810A3
Authority
WO
WIPO (PCT)
Prior art keywords
reagents
receptors
chemokines
mammalian chemokines
mammalian
Prior art date
Application number
PCT/US1998/000218
Other languages
English (en)
Other versions
WO1998031810A2 (fr
Inventor
Constance F Huffine
Devora L Rossi
Myriam Capone
Joseph A Hedrick
Alain Vicari
Daniel M Gorman
Albert Zlotnik
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU60170/98A priority Critical patent/AU6017098A/en
Publication of WO1998031810A2 publication Critical patent/WO1998031810A2/fr
Publication of WO1998031810A3 publication Critical patent/WO1998031810A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des chémokines et sept récepteurs transmembranaires extraits de mammifères, ainsi que des réactifs associés, notamment des protéines purifiées, des anticorps spécifiques et des acides nucléiques codant pour lesdites chémokines ou lesdits récepteurs. Elle concerne également des méthodes permettant d'utiliser lesdits réactifs et des trousses diagnostiques.
PCT/US1998/000218 1997-01-21 1998-01-20 Chemokines de mammiferes, recepteurs, reactifs, utilisations WO1998031810A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60170/98A AU6017098A (en) 1997-01-21 1998-01-20 Mammalian chemokines; receptors; reagents; uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78662497A 1997-01-21 1997-01-21
US08/786,624 1997-01-21

Publications (2)

Publication Number Publication Date
WO1998031810A2 WO1998031810A2 (fr) 1998-07-23
WO1998031810A3 true WO1998031810A3 (fr) 1998-11-19

Family

ID=25139136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000218 WO1998031810A2 (fr) 1997-01-21 1998-01-20 Chemokines de mammiferes, recepteurs, reactifs, utilisations

Country Status (2)

Country Link
AU (1) AU6017098A (fr)
WO (1) WO1998031810A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176283B1 (en) 1996-10-30 2007-02-13 The Regents Of The University Of California Protease-activated receptor 3 and uses thereof

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1056854A2 (fr) * 1998-02-27 2000-12-06 The Regents of the University of California Recepteur 4 active par la protease et ses utilisations
ATE396400T1 (de) * 1998-11-20 2008-06-15 Arena Pharm Inc Menschliche, an ein g-protein gekoppelte rezeptor rup3 ohne bekannte ligand
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
AU783994B2 (en) * 1999-08-19 2006-01-12 Curagen Corporation Novel hematopoietic regulatory factors and methods of use thereof
GB0219303D0 (en) * 2002-08-19 2002-09-25 Ares Trading Sa Protein

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Database EMBL EMEST12, entry MM83035 Accession number W75830. 23 June 1996. 95% identity with Seq.ID:3 nt.927-1085 and99% identity with Seq.ID:3 nt.2083-2561. *
Database EMBL EMEST5, entry HS172327 Accession number W15172. 4 May 1996. 94% identity with Seq.ID:7 nt.1-205. *
Database EMBL, entry MM1251145 Accession number AA451142. 11 June 1997. 100% identity between nt.125-375 and Seq.ID:1. *
HEIBER M. ET AL.: "Isolation of three novel human genes encoding G protein-coupled receptors", DNA AND CELL BIOLOGY, vol. 14, no. 1, 1995, pages 25 - 35, XP002066093 *
MILLER M.D. ET AL.: "Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines", CRITICAL REVIEWS IN IMMUNOLOGY, vol. 12, no. 1/02, 1992, pages 17 - 46, XP002050850 *
NAKAGAWA H. ET AL.: "Identification of cytokine-induced neutrophil chemoattractants (CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by granulation tissue in culture: purification, complete amino acid sequences and characterization", BIOCHEMICAL JOURNAL, vol. 301, no. 2, 15 July 1994 (1994-07-15), pages 545 - 550, XP002063520 *
POWER C.A. ET AL.: "Cloning and characterization of human chemokine receptors", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 6, no. 17, June 1996 (1996-06-01), pages 209-213, XP004034558 *
XU Y. AND CASEY G.: "Identification od human OGR1, a novel G protein-coupled receptor that maps to chromosome 14", GENOMICS, vol. 35, no. 2, 15 July 1996 (1996-07-15), pages 397 - 402, XP002070730 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176283B1 (en) 1996-10-30 2007-02-13 The Regents Of The University Of California Protease-activated receptor 3 and uses thereof

Also Published As

Publication number Publication date
AU6017098A (en) 1998-08-07
WO1998031810A2 (fr) 1998-07-23

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