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WO1998032469A3 - Polymers - Google Patents

Polymers Download PDF

Info

Publication number
WO1998032469A3
WO1998032469A3 PCT/GB1998/000270 GB9800270W WO9832469A3 WO 1998032469 A3 WO1998032469 A3 WO 1998032469A3 GB 9800270 W GB9800270 W GB 9800270W WO 9832469 A3 WO9832469 A3 WO 9832469A3
Authority
WO
WIPO (PCT)
Prior art keywords
linked
polymer backbone
compounds
polymers
therapeutic
Prior art date
Application number
PCT/GB1998/000270
Other languages
French (fr)
Other versions
WO1998032469A2 (en
Inventor
Henry Wolfe
Kenneth Kellar
Original Assignee
Nycomed Imaging As
Golding Louise
Henry Wolfe
Kenneth Kellar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9701813.9A external-priority patent/GB9701813D0/en
Application filed by Nycomed Imaging As, Golding Louise, Henry Wolfe, Kenneth Kellar filed Critical Nycomed Imaging As
Priority to EP98902085A priority Critical patent/EP1011736A2/en
Priority to AU58717/98A priority patent/AU5871798A/en
Priority to CA002278200A priority patent/CA2278200A1/en
Priority to JP53176198A priority patent/JP2001509796A/en
Publication of WO1998032469A2 publication Critical patent/WO1998032469A2/en
Publication of WO1998032469A3 publication Critical patent/WO1998032469A3/en
Priority to NO993662A priority patent/NO993662L/en
Priority to US10/057,943 priority patent/US20020076378A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)

Abstract

The invention provides compounds comprising a linear, branched or dendrimeric polymer backbone with linked thereto at least one reporter moiety, said polymer backbone comprising a plurality of amine-containing acids. Such compounds may be linked to one or more targeting agents and are useful as therapeutic and diagnostic agents, in particular in medical imaging techniques.
PCT/GB1998/000270 1997-01-29 1998-01-29 Polymers WO1998032469A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP98902085A EP1011736A2 (en) 1997-01-29 1998-01-29 Polymers
AU58717/98A AU5871798A (en) 1997-01-29 1998-01-29 Polymers
CA002278200A CA2278200A1 (en) 1997-01-29 1998-01-29 Polymers
JP53176198A JP2001509796A (en) 1997-01-29 1998-01-29 Polymer
NO993662A NO993662L (en) 1997-01-29 1999-07-28 polymers
US10/057,943 US20020076378A1 (en) 1997-01-29 2002-01-29 Polymers

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9701813.9 1997-01-29
GBGB9701813.9A GB9701813D0 (en) 1997-01-29 1997-01-29 Polymers
US5707497P 1997-08-27 1997-08-27
US60/057,074 1997-08-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US36271199A Continuation 1997-01-29 1999-07-29

Publications (2)

Publication Number Publication Date
WO1998032469A2 WO1998032469A2 (en) 1998-07-30
WO1998032469A3 true WO1998032469A3 (en) 1998-11-05

Family

ID=26310882

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/000270 WO1998032469A2 (en) 1997-01-29 1998-01-29 Polymers

Country Status (8)

Country Link
EP (1) EP1011736A2 (en)
JP (1) JP2001509796A (en)
KR (1) KR20000070544A (en)
CN (1) CN1246059A (en)
AU (1) AU5871798A (en)
CA (1) CA2278200A1 (en)
NO (1) NO993662L (en)
WO (1) WO1998032469A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69912827T2 (en) * 1998-09-29 2004-10-21 Loke Diagnostics Aps Aarhus "LIGAND PRESENTING ASSEMBLY" (LPA), METHOD FOR THE PRODUCTION AND USE THEREOF
EP1192465A1 (en) * 1999-06-29 2002-04-03 Dako A/S Detection using dendrimers bearing labels and probes
ITFO990015A1 (en) * 1999-07-23 2001-01-23 Verdini Antonio "POLYPEPTIDE DENDRIMERS AS UNIMOLECULAR CARRIERS OF DRUGS AND BIOLOGICALLY ACTIVE SUBSTANCES".
KR100379720B1 (en) * 2000-10-14 2003-04-11 주식회사 마크로젠 Supporter containing drimer monolayer and manufacturing method of same
CA2586621A1 (en) * 2004-11-22 2006-05-26 Ge Healthcare As Contrast agents to target extracellular matrix
JP4870941B2 (en) * 2005-05-09 2012-02-08 公立大学法人大阪府立大学 High molecular compound
KR101334780B1 (en) * 2010-08-13 2013-12-02 한국생명공학연구원 Iodine-containing radial-shape macromolecular compounds, preparation method thereof and contrast medium compositions for CT comprising the same
US20200215198A1 (en) * 2019-01-03 2020-07-09 Ionpath, Inc. Compositions and reagents for ion beam imaging
CN113307863B (en) * 2021-05-25 2022-12-16 华南农业大学 Preparation method and application of polyaspartic acid and salt antibody thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002611A1 (en) * 1983-12-12 1985-06-20 Scripps Clinic And Research Foundation Synthetic polypeptide corresponding to a portion of the heat-labile enterotoxin of escherichia coli, compositions and methods therewith
EP0331616A2 (en) * 1988-02-29 1989-09-06 Schering Aktiengesellschaft Polymer-bonded complexe builders, their complexes, process for their preparation and pharmaceutical agents containing the same
EP0481526A1 (en) * 1989-04-07 1992-04-22 Nycomed Salutar, Inc. Chelants
WO1993006868A1 (en) * 1991-10-07 1993-04-15 COCKBAIN, Jilian, Roderick, Michaelson Dendrimeric polychelants
WO1993010824A1 (en) * 1991-12-04 1993-06-10 Guerbet S.A. Novel macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent
WO1994005203A1 (en) * 1992-09-04 1994-03-17 The General Hospital Corporation Biocompatible polymers containing diagnostic or therapeutic moieties
WO1996040760A2 (en) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Iodine-containing peptides and their use as x-ray contrast media
WO1996040816A1 (en) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Iodine-containing linear polyamines and polyamides

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002611A1 (en) * 1983-12-12 1985-06-20 Scripps Clinic And Research Foundation Synthetic polypeptide corresponding to a portion of the heat-labile enterotoxin of escherichia coli, compositions and methods therewith
EP0331616A2 (en) * 1988-02-29 1989-09-06 Schering Aktiengesellschaft Polymer-bonded complexe builders, their complexes, process for their preparation and pharmaceutical agents containing the same
EP0481526A1 (en) * 1989-04-07 1992-04-22 Nycomed Salutar, Inc. Chelants
WO1993006868A1 (en) * 1991-10-07 1993-04-15 COCKBAIN, Jilian, Roderick, Michaelson Dendrimeric polychelants
WO1993010824A1 (en) * 1991-12-04 1993-06-10 Guerbet S.A. Novel macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent
WO1994005203A1 (en) * 1992-09-04 1994-03-17 The General Hospital Corporation Biocompatible polymers containing diagnostic or therapeutic moieties
WO1996040760A2 (en) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Iodine-containing peptides and their use as x-ray contrast media
WO1996040816A1 (en) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Iodine-containing linear polyamines and polyamides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RANGANATHAN, DARSHAN ET AL: "Synthesis of totally chiral, multiple armed, poly Glu and poly Asp scaffoldings on bifunctional adamantane core", TETRAHEDRON LETT., 1997, 38, 1265-1268, XP004034251 *

Also Published As

Publication number Publication date
CA2278200A1 (en) 1998-07-30
WO1998032469A2 (en) 1998-07-30
NO993662D0 (en) 1999-07-28
KR20000070544A (en) 2000-11-25
JP2001509796A (en) 2001-07-24
CN1246059A (en) 2000-03-01
NO993662L (en) 1999-09-28
EP1011736A2 (en) 2000-06-28
AU5871798A (en) 1998-08-18

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