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WO1998036260A1 - Microtube individuel avec bouchon a cloison et procede - Google Patents

Microtube individuel avec bouchon a cloison et procede Download PDF

Info

Publication number
WO1998036260A1
WO1998036260A1 PCT/GB1998/000128 GB9800128W WO9836260A1 WO 1998036260 A1 WO1998036260 A1 WO 1998036260A1 GB 9800128 W GB9800128 W GB 9800128W WO 9836260 A1 WO9836260 A1 WO 9836260A1
Authority
WO
WIPO (PCT)
Prior art keywords
microtube
closure
hollow needle
sample
needle
Prior art date
Application number
PCT/GB1998/000128
Other languages
English (en)
Inventor
Graham Clough
Original Assignee
Rts Thurnall Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rts Thurnall Plc filed Critical Rts Thurnall Plc
Priority to EP98900612A priority Critical patent/EP0960326A1/fr
Publication of WO1998036260A1 publication Critical patent/WO1998036260A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403—Sample carriers with closing or sealing means
    • G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Definitions

  • the present invention relates to the preparation and storage of
  • the compounds may also be mixed and matched in an attempt to identify
  • microtubes which, in turn, are mounted in blocks.
  • microtubes on a 9mm pitch It is desirable to make microtubes as small as
  • Microtubes may either be stored open ended or sealed. At present
  • microtubes are sealed using plastic mats or strips of joined plastic caps that can
  • microtubes be pressed into the open end of microtubes.
  • the existing method of sealing microtubes has a number of disadvantages. To allow for the individual handling of microtubes it is
  • microtube having an opening therein; providing a self sealing pierceable closure for said microtube;
  • closure member to seal said microtube.
  • the microtube is preferably a standard microtube suitable for handling
  • the above method is particularly suited for the preparation of a liquid
  • the closure may be fitted to the microtube manually, or preferably by
  • the cap is preferably produced from a self-sealing material which is pierceable
  • the closure preferably provides a sufficient seal after being pierced at least 50 and
  • the closure may be produced from a
  • the closure preferably provides sufficient integrity for the long term
  • the liquid sample may be a solution, the solvent of which may comprise
  • the hollow needle preferably includes two unconnected conduits for fluid
  • the needle is preferably of coaxial construction .
  • closure member may be pierced by more than one
  • the method of preparing a sample may include the further step of
  • the needle may then be withdrawn leaving a sample stored
  • an inert gas may be injected before the liquid
  • the microtube is preferably stored in a block.
  • the method is preferably the method
  • the method preferably includes the further step of marking the microtube
  • the marking is preferably machine readable and is
  • the method may also include the step of using a hollow needle to remove
  • the method of the present invention is particularly suitable for use with
  • the method includes additional steps for the
  • preparation of a liquid for injection into the microtube including any or all of the
  • the solvent preferably comprises DMSO (Dimethyl Sulfoxide) .
  • the vial is preferably of greater internal volume than a microtube.
  • the liquid prepared in the vial may then be injected into microtubes.
  • the pierceable closure member preferably comprises a septum cap.
  • microtube with a sample and subsequently removing the sample may be carried
  • septum caps are separate, each microtube remains individually removable from
  • microtubes may be conveniently prefilled with suitable materials
  • the tubes may be
  • a microtube assembly comprising a microtube and a self-sealing pierceable
  • the microtube is preferably a conventional microtube and may, for
  • the closure is preferably inserted into the open end of the microtube.
  • the assembly enables a microtube to be filled with a desired liquid compound using automated laboratory equipment, preferably by the use of a coaxial hollow needle. Subsequently various analysis and mixing of the
  • samples may also be performed by automated laboratory equipment, gaining
  • Figure 1 shows an exploded view of one embodiment of a microtube
  • Figure 2 shows a side elevation of the microtube and closure illustrated
  • Figure 3 shows a side elevation of the microtube of Figure 2 with the
  • Figure 4 shows an exploded perspective view of a second embodiment
  • Figure 5 shows a side elevation of the microtube and closure of Figure 4.
  • Figure 6 shows an elevational view of the microtube and closure of Figure 5 with the closure partially inserted into the microtube;
  • Figure 7 shows the microtube and closure of Figure 6 with the closure
  • Figure 8 shows a perspective view of a partially filled block of
  • Figure 9 shows a cross-sectional view of a partially filled microtube of the
  • microtube 1 is formed from a plastics material, resistant to the compounds to
  • DMSO Dimethyl Sulfoxide
  • a septum bung or cap 2 having a substantially cylindrical portion 3 and
  • the bung 2 is produced from a
  • silicone based material arranged to re-seal itself following being pierced with a
  • the material is resilient and the bung 2 is of appropriate dimensions to
  • the microtube 6 is formed from a plastics material and includes a
  • the open end of the tube is of reduced external diameter compared
  • the bung 7 is produced from a silicone based material
  • the bung 7 includes a cylindrical portion 9 and an integrally formed flexible skirt portion 10.
  • the bung 7 is inserted into the microtube 6 and the skirt 10 rolled over
  • Microtubes with pierceable septum bungs are particularly suited to use
  • microtubes 1 1 1
  • septum bungs 1 2 may be stored in blocks 1 3 for ease of handling in bulk.
  • microtubes are stored
  • the bung 1 2 is inserted into the microtube 1 1 , this may be
  • microtubes may then be filled
  • a hollow needle preferably a coaxial
  • a coaxial needle allows air or an inert gas to flow in and out of the microtube in response to the injection or withdrawal of a liquid.
  • a coaxial needle comprises
  • the inner needle extends further than the
  • the needle 1 6 After injection the needle 1 6 may be withdrawn from the bung
  • the bung is
  • Liquid for injection into a microtube may be prepared in a vial, of larger
  • the product is placed in the vial along with a solvent and the bung inserted.
  • the solvent may be injected through the bung.
  • the vial is then
  • Microtubes fitted with septum bungs allow liquid products to be

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hydrology & Water Resources (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Procédé de préparation d'un échantillon caractérisé en ce qu'il comprend un microtube (1), en ce qu'un bouchon de fermeture (2) à cloison permet de fermer le microtube (1) et en ce qu'un échantillon liquide est injecté à travers le bouchon à cloison au moyen d'une aiguille creuse. Le procédé peut être mis en oeuvre au moyen de matériel de laboratoire automatisé ou robotique.
PCT/GB1998/000128 1997-02-15 1998-01-15 Microtube individuel avec bouchon a cloison et procede WO1998036260A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP98900612A EP0960326A1 (fr) 1997-02-15 1998-01-15 Microtube individuel avec bouchon a cloison et procede

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9703185.0 1997-02-15
GBGB9703185.0A GB9703185D0 (en) 1997-02-15 1997-02-15 Individual septum capped microtubes

Publications (1)

Publication Number Publication Date
WO1998036260A1 true WO1998036260A1 (fr) 1998-08-20

Family

ID=10807748

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/000128 WO1998036260A1 (fr) 1997-02-15 1998-01-15 Microtube individuel avec bouchon a cloison et procede

Country Status (3)

Country Link
EP (1) EP0960326A1 (fr)
GB (1) GB9703185D0 (fr)
WO (1) WO1998036260A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1155742A3 (fr) * 2000-05-19 2002-01-16 Genetix Limited Procédé et dispositif de distribution de liquide
EP1516669A1 (fr) * 2003-09-19 2005-03-23 The Automation Partnership (Cambridge) Limited Appareil pour cachetage d'éprouvettes
EP2080555A1 (fr) * 2008-01-17 2009-07-22 Ortho-Clinical Diagnostics, Inc. Puits de dilution fabriqués au format carte pour les essais d'immunodiagnostic
EP2145685A1 (fr) * 2008-07-18 2010-01-20 Ortho Clinical Diagnostics Inc. Eléments d'analyse immunologique à colonne unique
JP2015161528A (ja) * 2014-02-26 2015-09-07 株式会社日立ハイテクノロジーズ 分析用試料前処理装置
EP3460482A1 (fr) * 2017-09-25 2019-03-27 Roche Diagnostics GmbH Procédé de manipulation d'un récipient d'échantillons de laboratoire, appareil de laboratoire et système d'automatisation de laboratoire

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4682703A (en) * 1985-04-25 1987-07-28 Terumo Kabushiki Kaisha Stopper for medical container
EP0332732A2 (fr) * 1988-03-15 1989-09-20 FINBIOMEDICA S.r.l. Dispositif pour effectuer des déterminations photométriques et spectrophotométriques et des réactions chimiques microscopiques, procédé apparenté
EP0399151A1 (fr) * 1989-05-24 1990-11-28 Robert Aaron Levine Mesures de couche de matériel centrifugées prises dans un tube vide
EP0617920A1 (fr) * 1993-03-31 1994-10-05 Becton, Dickinson and Company Bouchon pour tube de prélèvement du sang de petit diamètre
WO1996001693A1 (fr) * 1994-07-11 1996-01-25 Akzo Nobel N.V. Tube de micro-echantillon avec volume perdu reduit et systeme de code barre
US5522518A (en) * 1988-04-15 1996-06-04 C.A. Greiner & Sohne Gesellschaft M.B.H Closure device for a cylindrical housing

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4682703A (en) * 1985-04-25 1987-07-28 Terumo Kabushiki Kaisha Stopper for medical container
EP0332732A2 (fr) * 1988-03-15 1989-09-20 FINBIOMEDICA S.r.l. Dispositif pour effectuer des déterminations photométriques et spectrophotométriques et des réactions chimiques microscopiques, procédé apparenté
US5522518A (en) * 1988-04-15 1996-06-04 C.A. Greiner & Sohne Gesellschaft M.B.H Closure device for a cylindrical housing
EP0399151A1 (fr) * 1989-05-24 1990-11-28 Robert Aaron Levine Mesures de couche de matériel centrifugées prises dans un tube vide
EP0617920A1 (fr) * 1993-03-31 1994-10-05 Becton, Dickinson and Company Bouchon pour tube de prélèvement du sang de petit diamètre
WO1996001693A1 (fr) * 1994-07-11 1996-01-25 Akzo Nobel N.V. Tube de micro-echantillon avec volume perdu reduit et systeme de code barre

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1155742A3 (fr) * 2000-05-19 2002-01-16 Genetix Limited Procédé et dispositif de distribution de liquide
US6943035B1 (en) 2000-05-19 2005-09-13 Genetix Limited Liquid dispensing apparatus and method
EP1516669A1 (fr) * 2003-09-19 2005-03-23 The Automation Partnership (Cambridge) Limited Appareil pour cachetage d'éprouvettes
EP2080555A1 (fr) * 2008-01-17 2009-07-22 Ortho-Clinical Diagnostics, Inc. Puits de dilution fabriqués au format carte pour les essais d'immunodiagnostic
US8496878B2 (en) 2008-01-17 2013-07-30 Ortho-Clinical Diagnostics, Inc. Diluent wells produced in card format for immunodiagnostic testing
US8187538B2 (en) 2008-01-17 2012-05-29 Ortho-Clinical Diagnostics, Inc. Diluent wells produced in card format for immunodiagnostic testing
US8076126B2 (en) 2008-07-18 2011-12-13 Ortho-Clinical Diagnostics, Inc. Single column immunological test elements
CN101629952A (zh) * 2008-07-18 2010-01-20 奥索临床诊断有限公司 单柱免疫学测试元件
EP2145685A1 (fr) * 2008-07-18 2010-01-20 Ortho Clinical Diagnostics Inc. Eléments d'analyse immunologique à colonne unique
CN101629952B (zh) * 2008-07-18 2015-05-20 奥索临床诊断有限公司 单柱免疫学测试元件
US9052297B2 (en) 2008-07-18 2015-06-09 Ortho-Clinical Diagnostics, Inc. Single column immunological test elements
EP3290115A1 (fr) * 2008-07-18 2018-03-07 Ortho-Clinical Diagnostics, Inc. Éléments d'essais immunologiques en colonne unique
JP2015161528A (ja) * 2014-02-26 2015-09-07 株式会社日立ハイテクノロジーズ 分析用試料前処理装置
EP3460482A1 (fr) * 2017-09-25 2019-03-27 Roche Diagnostics GmbH Procédé de manipulation d'un récipient d'échantillons de laboratoire, appareil de laboratoire et système d'automatisation de laboratoire

Also Published As

Publication number Publication date
GB9703185D0 (en) 1997-04-02
EP0960326A1 (fr) 1999-12-01

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