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WO1998039654A3 - Complexes de ligands-ions de neodymium (iii), ytterbium (iii) ou erbium (iii) - Google Patents

Complexes de ligands-ions de neodymium (iii), ytterbium (iii) ou erbium (iii) Download PDF

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Publication number
WO1998039654A3
WO1998039654A3 PCT/EP1998/001287 EP9801287W WO9839654A3 WO 1998039654 A3 WO1998039654 A3 WO 1998039654A3 EP 9801287 W EP9801287 W EP 9801287W WO 9839654 A3 WO9839654 A3 WO 9839654A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion
iii
analyte
lanthanide
region
Prior art date
Application number
PCT/EP1998/001287
Other languages
English (en)
Other versions
WO1998039654A2 (fr
Inventor
Johannes Willem Hofstraat
Original Assignee
Akzo Nobel Nv
Johannes Willem Hofstraat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv, Johannes Willem Hofstraat filed Critical Akzo Nobel Nv
Priority to AU68284/98A priority Critical patent/AU6828498A/en
Priority to EP98913667A priority patent/EP0968424A1/fr
Publication of WO1998039654A2 publication Critical patent/WO1998039654A2/fr
Publication of WO1998039654A3 publication Critical patent/WO1998039654A3/fr
Priority to US09/380,336 priority patent/US6951760B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/969—Multiple layering of reactants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/971—Capture of complex after antigen-antibody reaction

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé pour la détection d'un analyte dans un échantillon d'essai par une réaction de liaison spécifique dans l'analyte, un partenaire de liaison spécifique pour l'analyte, et un (immuno)réactif pourvu d'un marqueur. Ce procédé se caractérise en ce que le marqueur est un complexe ligand-ion de lanthanide où l'ion de lanthanide est un ion (Nd3+) de neodymium (III), un ion (Yb3+) d'ytterbium (III) ou un ion (Er3+) d'erbium et le ligand comprend, ou est en contact avec une fraction de sensibilisation dont l'absorption se situe dans la zone de 400 à 1000 nm, et de préférence, dans la zone de 400 à 800 nm. En outre, un kit de diagnostique est décrit ainsi qu'un procédé pour détecter un analyte dans une matrice présentant un intérêt biomédical à l'aide d'un oligonucléotide, un antigène, ou un anticorps fixé à un matériau, de préférence, un latex de coeur-coquille ou à des sites de liaison spécifiques où l'antigène ou l'anticorps est marqué avec le complexe ligand-ion de lanthanide et amené en contact avec l'analyte, après quoi l'analyte avec le complexe d'ions de lanthanide est retiré. L'échantillon obtenu est ainsi irradié à la lumière dans la zone de 400 à 1000 nm, et la lumière émise par cet échantillon est détectée lorsque cet analyte est présent dans la matrice présentant un intérêt biomédical.
PCT/EP1998/001287 1997-03-03 1998-02-28 Complexes de ligands-ions de neodymium (iii), ytterbium (iii) ou erbium (iii) WO1998039654A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU68284/98A AU6828498A (en) 1997-03-24 1998-02-28 Diagnostic neodymium(iii), ytterbium(iii), or erbium(iii) ion-ligand complexes
EP98913667A EP0968424A1 (fr) 1997-03-03 1998-02-28 Complexes de ligands-ions de neodymium (iii), ytterbium (iii) ou erbium (iii)
US09/380,336 US6951760B2 (en) 1997-03-03 2000-02-04 Diagnostic neodymium(III), ytterbium(III), or erbium(III) ion-ligand complexes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP97200615.9 1997-03-03
EP97200615 1997-03-03
US4235497P 1997-03-24 1997-03-24
US60/042,354 1997-03-24

Publications (2)

Publication Number Publication Date
WO1998039654A2 WO1998039654A2 (fr) 1998-09-11
WO1998039654A3 true WO1998039654A3 (fr) 2000-01-06

Family

ID=56289828

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001287 WO1998039654A2 (fr) 1997-03-03 1998-02-28 Complexes de ligands-ions de neodymium (iii), ytterbium (iii) ou erbium (iii)

Country Status (2)

Country Link
EP (1) EP0968424A1 (fr)
WO (1) WO1998039654A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004562A2 (fr) * 2000-07-07 2002-01-17 Massachussets Institute Of Technology Capteurs de metal a base de fluoresceine et procedes de fabrication et utilisation des memes
US6902904B2 (en) * 2001-08-27 2005-06-07 Pharmanetics Incorporated Coagulation assay reagents containing lanthanides

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
JPH0454455A (ja) * 1990-06-22 1992-02-21 Mochida Pharmaceut Co Ltd 多座配位蛍光キレートで標識した生物物質
US5312922A (en) * 1992-04-06 1994-05-17 Nordion International Inc. Europium and terbium chelators for time-resolved fluorometric assays
WO1996000901A1 (fr) * 1994-06-29 1996-01-11 The Regents Of The University Of California Chelates au lanthanide luminescents et leurs procedes d'utilisation
US5587394A (en) * 1991-03-28 1996-12-24 The University Of Toledo Production and use of diels alder adducts of vinyl porphyrins, of metal complexes thereof, and of compositions containing such adducts and complexes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
JPH0454455A (ja) * 1990-06-22 1992-02-21 Mochida Pharmaceut Co Ltd 多座配位蛍光キレートで標識した生物物質
US5587394A (en) * 1991-03-28 1996-12-24 The University Of Toledo Production and use of diels alder adducts of vinyl porphyrins, of metal complexes thereof, and of compositions containing such adducts and complexes
US5312922A (en) * 1992-04-06 1994-05-17 Nordion International Inc. Europium and terbium chelators for time-resolved fluorometric assays
WO1996000901A1 (fr) * 1994-06-29 1996-01-11 The Regents Of The University Of California Chelates au lanthanide luminescents et leurs procedes d'utilisation

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BEIJING DAXUE XUEBAO, ZIRAN KEXUEBAN, vol. 24, no. 4, 1988, pages 441 - 446 *
CHEMICAL ABSTRACTS, vol. 105, no. 18, 3 November 1986, Columbus, Ohio, US; abstract no. 164071, S. SUSHENG & W. DONGMEI: "Color reaction of ternary complexes of rare earths with salicylfluorone and cetyltrimethylammonium bromide" XP002036704 *
CHEMICAL ABSTRACTS, vol. 110, no. 22, 29 May 1989, Columbus, Ohio, US; abstract no. 204714, S. SUSHENG & L. TANGGING: "Color reactions of rare earths with p-aminophenylfluorone and cetyltrimethylammonium bromide system." XP002036705 *
DATABASE WPI Section Ch Week 9214, Derwent World Patents Index; Class B04, AN 92-110885, XP002036706 *
DATABASE WPI Section Ch Week 9609, Derwent World Patents Index; Class B02, AN 96-085967, XP002036707 *
DATABASE WPI Section Ch Week 9609, Derwent World Patents Index; Class B02, AN 96-086153, XP002036708 *
ZHONGGUO XITU XUEBAO, vol. 4, no. 1, 1986, pages 67 - 70 *

Also Published As

Publication number Publication date
EP0968424A1 (fr) 2000-01-05
WO1998039654A2 (fr) 1998-09-11

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