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WO1999040113A3 - Lipopeptides contenant un fragment de l'interferon et leur utilisation dans des compositions pharmaceutiques - Google Patents

Lipopeptides contenant un fragment de l'interferon et leur utilisation dans des compositions pharmaceutiques Download PDF

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Publication number
WO1999040113A3
WO1999040113A3 PCT/FR1999/000259 FR9900259W WO9940113A3 WO 1999040113 A3 WO1999040113 A3 WO 1999040113A3 FR 9900259 W FR9900259 W FR 9900259W WO 9940113 A3 WO9940113 A3 WO 9940113A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
concerns
lipopeptide
amino acids
defined above
Prior art date
Application number
PCT/FR1999/000259
Other languages
English (en)
Other versions
WO1999040113A9 (fr
WO1999040113A2 (fr
Inventor
Kader Thiam
Claude Auriault
Helene Gras-Masse
Estelle Loing
Claudie Verwaerde
Jean Gerard Guillet
Original Assignee
Inst Nat Sante Rech Med
Pasteur Institut
Centre Nat Rech Scient
Kader Thiam
Claude Auriault
Gras Masse Helene
Estelle Loing
Claudie Verwaerde
Jean Gerard Guillet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9522697&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999040113(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inst Nat Sante Rech Med, Pasteur Institut, Centre Nat Rech Scient, Kader Thiam, Claude Auriault, Gras Masse Helene, Estelle Loing, Claudie Verwaerde, Jean Gerard Guillet filed Critical Inst Nat Sante Rech Med
Priority to EP99902607A priority Critical patent/EP1054901A2/fr
Priority to US09/601,729 priority patent/US6683052B1/en
Priority to JP2000530541A priority patent/JP2002506003A/ja
Priority to AU22842/99A priority patent/AU2284299A/en
Publication of WO1999040113A2 publication Critical patent/WO1999040113A2/fr
Publication of WO1999040113A9 publication Critical patent/WO1999040113A9/fr
Publication of WO1999040113A3 publication Critical patent/WO1999040113A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne tout lipopeptide caractérisé en ce qu'il comprend: une partie peptidique comprenant la séquence peptidique constituée par environ 30 à environ 50 des derniers acides aminés contigus de l'extrémité C-terminale de l'interféron-η (IFN-η) des mammifères, dont, le cas échéant, les 3 à 20 derniers acides aminés ont été supprimés; et une ou plusieurs parties lipophiles comprenant une chaîne hydrocarbonée en C4 à C20, saturée ou insaturée, linéaire ou ramifiée, ou un groupe stéroïde. L'invention concerne également tout lipopeptide tel que défini ci-dessus, contenant un ou plusieurs épitopes CD8, et/ou CD4, et/ou B. L'invention a également pour objet les médicaments ou vaccins contenant tout lipopeptide tel que défini ci-dessus.
PCT/FR1999/000259 1998-02-06 1999-02-05 Lipopeptides contenant un fragment de l'interferon et leur utilisation dans des compositions pharmaceutiques WO1999040113A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99902607A EP1054901A2 (fr) 1998-02-06 1999-02-05 Lipopeptides contenant un fragment de l'interferon et leur utilisation dans des compositions pharmaceutiques
US09/601,729 US6683052B1 (en) 1998-02-06 1999-02-05 Lipopeptides containing an interferon-γ fragment, and uses thereof in pharmaceutical compositions
JP2000530541A JP2002506003A (ja) 1998-02-06 1999-02-05 インターフェロン−γフラグメントを含むリポペプチド、及び薬学的組成物におけるその使用
AU22842/99A AU2284299A (en) 1998-02-06 1999-02-05 Lipopeptides containing an interferon fragment and uses thereof in pharmaceutical compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR98/01439 1998-02-06
FR9801439A FR2774687B1 (fr) 1998-02-06 1998-02-06 Lipopeptides contenant un fragment de l'interferon gamma, et leur utilisation dans des compositions pharmaceutiques

Publications (3)

Publication Number Publication Date
WO1999040113A2 WO1999040113A2 (fr) 1999-08-12
WO1999040113A9 WO1999040113A9 (fr) 1999-10-21
WO1999040113A3 true WO1999040113A3 (fr) 2000-04-06

Family

ID=9522697

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1999/000259 WO1999040113A2 (fr) 1998-02-06 1999-02-05 Lipopeptides contenant un fragment de l'interferon et leur utilisation dans des compositions pharmaceutiques

Country Status (6)

Country Link
US (1) US6683052B1 (fr)
EP (1) EP1054901A2 (fr)
JP (1) JP2002506003A (fr)
AU (1) AU2284299A (fr)
FR (1) FR2774687B1 (fr)
WO (1) WO1999040113A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9915074D0 (en) * 1999-06-28 1999-08-25 Cortecs Plc Ligand-binding composition
GB9930591D0 (en) * 1999-12-23 2000-02-16 Univ London Component for vaccine
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
AU2002309141B2 (en) * 2001-03-27 2007-08-09 Oncothyreon Inc. Vaccine for modulating between T1 and T2 immune responses
JP4527407B2 (ja) * 2002-04-15 2010-08-18 オンコサイレオン インコーポレーテッド ワクチンとしての合成グリコリポペプチド
US20080081045A1 (en) * 2003-10-14 2008-04-03 Biomira, Inc. Combination Therapy for Cancer
TWI395591B (zh) * 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白（ｍｕｃ-１）疫苗
WO2006120580A2 (fr) * 2005-05-04 2006-11-16 Nautilus Biotech Polypeptides d'interferon-gamma modifies et procedes d'utilisation de polypeptides d'interferon-gamma modifies
ES2526344T3 (es) * 2005-06-28 2015-01-09 Oncothyreon Inc. Método para el tratamiento de pacientes con una vacuna de glicoproteína mucinosa (MUC-1)
WO2008042421A2 (fr) * 2006-10-02 2008-04-10 The Board Of Trustees Of The Leland Stanford Junior University PEPTIDES DÉRIVÉS DU DOMAINE C2 DE εPKC ET LEURS PROCÉDÉS D'UTILISATION
WO2010151495A2 (fr) * 2009-06-26 2010-12-29 University Of Florida Research Foundation Inc. Matériaux et procédés pour traiter et prévenir des infections virales
EP2504353B2 (fr) 2009-11-23 2023-09-13 Cubist Pharmaceuticals LLC Compositions de lipopeptides et procédés apparentés
CN103014015B (zh) * 2010-03-26 2014-09-10 华南农业大学 编码猪γ干扰素的基因片段及其应用
WO2011143280A2 (fr) 2010-05-11 2011-11-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibiteur peptidique de la signalisation de l'interleukine-10 ou de l'interféron-gamma
BR112013021779A2 (pt) 2011-02-24 2017-09-19 Oncothyreon Inc vacina de glicolipopeptídeo baseada em muc1 com adjuvante.
WO2013173676A1 (fr) * 2012-05-18 2013-11-21 Tufts Medical Center, Inc Polypeptide et compositions de conjugué à fraction lipophile, leurs formulations et utilisations associées
FR3008099B1 (fr) 2013-07-05 2020-08-07 Commissariat Energie Atomique Peptides immunogenes de l'antigene tumoral cycline b1
FR3090319A1 (fr) 2018-12-21 2020-06-26 Commissariat A L'energie Atomique Et Aux Energies Alternatives Melanges d’epitopes t cd8+ immunogenes de la cycline b1
FR3091651A1 (fr) 2019-01-11 2020-07-17 Commissariat A L'energie Atomique Et Aux Energies Alternatives Peptides immunogènes issus de la nucléoprotéine du virus ebola zaïre
FR3096894A1 (fr) 2019-06-06 2020-12-11 Commissariat A L'energie Atomique Et Aux Energies Alternatives Melanges d’epitopes t cd8 immunogènes du virus ebola
CN117024563B (zh) * 2023-06-16 2024-04-19 苏州西山生物技术有限公司 分泌实验猴γ-干扰素单克隆抗体的杂交瘤细胞及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236987A2 (fr) * 1986-03-10 1987-09-16 F. Hoffmann-La Roche Ag Protéines chimiquement modifiées et leur production
EP0510356A1 (fr) * 1991-03-25 1992-10-28 F. Hoffmann-La Roche Ag Conjugués polyéthylène glycol-protéine
US5270038A (en) * 1992-01-23 1993-12-14 Board Of Regents, The University Of Texas System Tumor necrosis factor receptors on microorganisms
EP0593868A1 (fr) * 1992-08-26 1994-04-27 F. Hoffmann-La Roche Ag Conjugués PEG-interféron
WO1997018832A1 (fr) * 1995-11-21 1997-05-29 Enzon, Inc. Conjugues de polymere et d'interferon et processus de preparation de ces conjugues

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236987A2 (fr) * 1986-03-10 1987-09-16 F. Hoffmann-La Roche Ag Protéines chimiquement modifiées et leur production
EP0510356A1 (fr) * 1991-03-25 1992-10-28 F. Hoffmann-La Roche Ag Conjugués polyéthylène glycol-protéine
US5270038A (en) * 1992-01-23 1993-12-14 Board Of Regents, The University Of Texas System Tumor necrosis factor receptors on microorganisms
EP0593868A1 (fr) * 1992-08-26 1994-04-27 F. Hoffmann-La Roche Ag Conjugués PEG-interféron
WO1997018832A1 (fr) * 1995-11-21 1997-05-29 Enzon, Inc. Conjugues de polymere et d'interferon et processus de preparation de ces conjugues

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DEPREZ B. ET AL.: "Comparative efficiency of simple lipopeptide constructs for in vivo induction of virus specific CTL", VACCINE, vol. 14, no. 5, 1996, UK, pages 375 - 382, XP004057291 *
ROUAIX F. ET AL.: "Effect of a lipopeptidic formulation on macrophage activation and peptide presentation to T cells", VACCINE, vol. 12/13, 1994, GB, pages 1209 - 1214, XP002082968 *
THIAM K. ET AL.: "Unrestricted agonist activity on murine and human cells of a lipopeptide derived from IFN-gamma", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 253, no. 3, 30 December 1998 (1998-12-30), pages 639 - 647, XP002102358 *

Also Published As

Publication number Publication date
FR2774687B1 (fr) 2002-03-22
FR2774687A1 (fr) 1999-08-13
EP1054901A2 (fr) 2000-11-29
WO1999040113A9 (fr) 1999-10-21
JP2002506003A (ja) 2002-02-26
AU2284299A (en) 1999-08-23
WO1999040113A2 (fr) 1999-08-12
US6683052B1 (en) 2004-01-27

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