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WO1999045119A3 - Fabrication de polypeptides mycobacteriens par une bacterie d'acide lactique - Google Patents

Fabrication de polypeptides mycobacteriens par une bacterie d'acide lactique Download PDF

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Publication number
WO1999045119A3
WO1999045119A3 PCT/DK1999/000109 DK9900109W WO9945119A3 WO 1999045119 A3 WO1999045119 A3 WO 1999045119A3 DK 9900109 W DK9900109 W DK 9900109W WO 9945119 A3 WO9945119 A3 WO 9945119A3
Authority
WO
WIPO (PCT)
Prior art keywords
lactic acid
polypeptide
production
acid bacteria
mycobacterium
Prior art date
Application number
PCT/DK1999/000109
Other languages
English (en)
Other versions
WO1999045119A2 (fr
Inventor
Carsten Loevstrup Jensen
Joergen Folkersen
Original Assignee
Statens Seruminstitut
Carsten Loevstrup Jensen
Joergen Folkersen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Statens Seruminstitut, Carsten Loevstrup Jensen, Joergen Folkersen filed Critical Statens Seruminstitut
Priority to CA002322505A priority Critical patent/CA2322505A1/fr
Priority to JP2000534650A priority patent/JP2002505106A/ja
Priority to EP99906089A priority patent/EP1058731A2/fr
Priority to NZ507278A priority patent/NZ507278A/en
Priority to AU26119/99A priority patent/AU749672B2/en
Publication of WO1999045119A2 publication Critical patent/WO1999045119A2/fr
Publication of WO1999045119A3 publication Critical patent/WO1999045119A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne un procédé de fabrication, chez une bactérie recombinante d'acide lactique telle que Lactococcus lactis, d'un polypeptide bioréactif dérivé de la mycobactérie appartenant au complexe M. tuberculosis (Mycobacterium tuberculosis, Mycobacterium africanum et Mycobacterium bovis) ou à n'importe quelle autre espèce mycobactérienne. Le polypeptide produit à partir de bactéries d'acide lactique se présente sous la forme d'un monomère ou de polymères d'un ou de plusieurs polypeptides et peut être utile en tant qu'agent diagnostique lors des tests de sensibilité cutanée à réaction d'hypersensibilité du type retardé chez les animaux, chez les humains et dans des vaccins. L'invention décrit un polypeptide d'homodimère ESAT-6 bioréactif.
PCT/DK1999/000109 1998-03-06 1999-03-05 Fabrication de polypeptides mycobacteriens par une bacterie d'acide lactique WO1999045119A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002322505A CA2322505A1 (fr) 1998-03-06 1999-03-05 Fabrication de polypeptides mycobacteriens par une bacterie d'acide lactique
JP2000534650A JP2002505106A (ja) 1998-03-06 1999-03-05 乳酸菌によるマイコバクテリアのポリペプチドの製造
EP99906089A EP1058731A2 (fr) 1998-03-06 1999-03-05 Fabrication de polypeptides mycobacteriens par une bacterie d'acide lactique
NZ507278A NZ507278A (en) 1998-03-06 1999-03-05 Production of mycobacterial polypeptides by lactic acid bacteria
AU26119/99A AU749672B2 (en) 1998-03-06 1999-03-05 Production of mycobacterial polypeptides by lactic acid bacteria

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7710598P 1998-03-06 1998-03-06
DK0306/98 1998-03-06
DK30698 1998-03-06
US60/077,105 1998-03-06

Publications (2)

Publication Number Publication Date
WO1999045119A2 WO1999045119A2 (fr) 1999-09-10
WO1999045119A3 true WO1999045119A3 (fr) 1999-10-21

Family

ID=26063737

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1999/000109 WO1999045119A2 (fr) 1998-03-06 1999-03-05 Fabrication de polypeptides mycobacteriens par une bacterie d'acide lactique

Country Status (6)

Country Link
EP (1) EP1058731A2 (fr)
JP (1) JP2002505106A (fr)
AU (1) AU749672B2 (fr)
CA (1) CA2322505A1 (fr)
NZ (1) NZ507278A (fr)
WO (1) WO1999045119A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000026248A2 (fr) * 1998-11-04 2000-05-11 Isis Innovation Limited Test de diagnostic de la tuberculose
ATE469963T1 (de) * 2002-04-05 2010-06-15 Pasteur Institut Identifizierung der virulenz-assoziierten regionen rd1 und rd5, die die entwicklung von verbesserten impfstoffen mit m. bovis bcg und m. microti ermöglicht
WO2004067702A2 (fr) * 2003-01-30 2004-08-12 The University Of Warwick Crible
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019093A1 (fr) * 1992-03-19 1993-09-30 Institut Pasteur Sequence peptidique apte a induire une reaction d'hypersensibilite de type retarde en presence de bacteries vivantes du complexe mycobacterium tuberculosis et ses applications
WO1995001441A1 (fr) * 1993-07-02 1995-01-12 Statens Serumsinstitut Vaccin contre la tuberculose
WO1995001440A1 (fr) * 1993-07-02 1995-01-12 Statens Seruminstitut Test cutane de diagnostic de la tuberculose
WO1998044119A1 (fr) * 1997-04-02 1998-10-08 Statens Serum Institut FRAGMENTS D'ACIDE NUCLEIQUE ET FRAGMENTS POLYPEPTIDIQUES DERIVES DE $i(M. TUBERCULOSIS)
WO1999024577A1 (fr) * 1997-11-10 1999-05-20 Statens Serum Institut Fragments d'acides nucleiques et fragments polypeptidiques derives de m. tuberculosis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019093A1 (fr) * 1992-03-19 1993-09-30 Institut Pasteur Sequence peptidique apte a induire une reaction d'hypersensibilite de type retarde en presence de bacteries vivantes du complexe mycobacterium tuberculosis et ses applications
WO1995001441A1 (fr) * 1993-07-02 1995-01-12 Statens Serumsinstitut Vaccin contre la tuberculose
WO1995001440A1 (fr) * 1993-07-02 1995-01-12 Statens Seruminstitut Test cutane de diagnostic de la tuberculose
WO1998044119A1 (fr) * 1997-04-02 1998-10-08 Statens Serum Institut FRAGMENTS D'ACIDE NUCLEIQUE ET FRAGMENTS POLYPEPTIDIQUES DERIVES DE $i(M. TUBERCULOSIS)
WO1999024577A1 (fr) * 1997-11-10 1999-05-20 Statens Serum Institut Fragments d'acides nucleiques et fragments polypeptidiques derives de m. tuberculosis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARBOE, M. ET AL.: "Evidence for occurence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG", INFECTION AND IMMUNITY., vol. 64, no. 1, January 1996 (1996-01-01), WASHINGTON US, pages 16 - 22, XP002105205 *
MALIN, A.S. ET AL.: "Vaccinia expression of M. tuberculosis antigens is enhanced by a eukaryotic leader sequence", IMMUNOLOGY., vol. 89, no. suppl 1, 1996, L SCIENTIFIC PUBLICATIONS GB, XP002105206 *
SORENSEN, A.L. ET AL.: "Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis", INFECTION AND IMMUNITY., vol. 63, no. 5, May 1995 (1995-05-01), WASHINGTON US, pages 1710 - 1717, XP002105204 *

Also Published As

Publication number Publication date
AU749672B2 (en) 2002-07-04
CA2322505A1 (fr) 1999-09-10
EP1058731A2 (fr) 2000-12-13
JP2002505106A (ja) 2002-02-19
AU2611999A (en) 1999-09-20
NZ507278A (en) 2003-10-31
WO1999045119A2 (fr) 1999-09-10

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