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WO1999046368A3 - Carbohydrate-modifying enzymes for burn and wound debridement and methods for treatment - Google Patents

Carbohydrate-modifying enzymes for burn and wound debridement and methods for treatment Download PDF

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Publication number
WO1999046368A3
WO1999046368A3 PCT/US1999/005722 US9905722W WO9946368A3 WO 1999046368 A3 WO1999046368 A3 WO 1999046368A3 US 9905722 W US9905722 W US 9905722W WO 9946368 A3 WO9946368 A3 WO 9946368A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbohydrate
active
present
active enzymes
cdna
Prior art date
Application number
PCT/US1999/005722
Other languages
French (fr)
Other versions
WO1999046368A2 (en
Inventor
John C Klock
Original Assignee
Biomarin Pharmaceuticals
John C Klock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharmaceuticals, John C Klock filed Critical Biomarin Pharmaceuticals
Priority to AU30068/99A priority Critical patent/AU3006899A/en
Publication of WO1999046368A2 publication Critical patent/WO1999046368A2/en
Publication of WO1999046368A3 publication Critical patent/WO1999046368A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention features a method for treating wounds comprising the step of administering an effective amount of a carbohydrate-active enzyme. In another aspect, the present invention features pharmaceutical compositions for treating wounds. The invention also features cDNA sequences for carbohydrate-active enzymes and cDNA expression systems for using various DNA sequences to produce mammalian carbohydrate-active enzymes for a variety of uses. The invention further includes recombinant plasmids comprising the cDNA of mammalian carbohydrate-active enzymes. The invention also includes transformed cells comprising a heterologous DNA sequence that encodes for a carbohydrate-active enzyme or a biologically active fragment or mutant thereof. Preferred carbohydrate-active enzymes according to the present invention include chondroitinases and hyaluronidases.
PCT/US1999/005722 1998-03-13 1999-03-12 Carbohydrate-modifying enzymes for burn and wound debridement and methods for treatment WO1999046368A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU30068/99A AU3006899A (en) 1998-03-13 1999-03-12 Carbohydrate-modifying enzymes for burn and wound debridement and methods for treatment

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3906698A 1998-03-13 1998-03-13
US09/039,066 1998-03-13

Publications (2)

Publication Number Publication Date
WO1999046368A2 WO1999046368A2 (en) 1999-09-16
WO1999046368A3 true WO1999046368A3 (en) 2000-08-31

Family

ID=21903486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/005722 WO1999046368A2 (en) 1998-03-13 1999-03-12 Carbohydrate-modifying enzymes for burn and wound debridement and methods for treatment

Country Status (2)

Country Link
AU (1) AU3006899A (en)
WO (1) WO1999046368A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1575548B1 (en) 2002-05-04 2011-03-09 Acorda Therapeutics, Inc. Compositions and methods for promoting neuronal outgrowth
US6762836B2 (en) 2002-05-22 2004-07-13 General Electric Company Portable laser plasma spectroscopy apparatus and method for in situ identification of deposits
JP2006523461A (en) * 2003-04-15 2006-10-19 イスタ・ファーマスーティカルズ・インコーポレイテッド Method for isolating and purifying sheep hyaluronidase
CA2525784C (en) 2003-05-16 2019-04-09 Acorda Therapeutics, Inc. Proteoglycan degrading mutants for treatment of cns
JP4754492B2 (en) * 2003-05-16 2011-08-24 アコーダ セラピューティクス、インク． Compositions and methods for treating central nervous system disorders
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
EP1750757B1 (en) 2004-05-18 2013-03-13 Acorda Therapeutics, Inc. Methods of purifying chondroitinase and stable formulations thereof
US7485295B2 (en) 2005-09-26 2009-02-03 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase ABCI mutants
JP5391069B2 (en) 2006-10-10 2014-01-15 アコーダ セラピューティクス、インク． Compositions and methods using chondroitinase ABCI variants
US20160101166A1 (en) 2014-10-10 2016-04-14 Rochal Industries, Llp Compositions and kits for treating pruritus and methods of using the same
US10238719B2 (en) 2014-10-10 2019-03-26 Rochal Industries, Llc Compositions and kits for enzymatic debridement and methods of using the same
US9592280B2 (en) 2014-10-10 2017-03-14 Rochal Industries Llc Compositions and kits for enzymatic debridement and methods of using the same
WO2018157011A1 (en) * 2017-02-24 2018-08-30 Xenotherapeutics, Inc. Products and methods for treating burn wounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1067253A (en) * 1965-02-15 1967-05-03 Biorex Laboratories Ltd Process for the preparation of enzymes
RO102703A2 (en) * 1988-10-05 1991-09-09 Intreprinderea De Medicamente "Biofarm", Bucuresti, Ro Producing method of a composition with hyaluronidase activity
WO1996001648A1 (en) * 1994-07-08 1996-01-25 Ibex Technologies R And D, Inc. Attenuation of wound healing processes
US5578480A (en) * 1993-04-23 1996-11-26 American Cyanamid Company Methods for the isolation and purification of the recombinantly expressed chondroitinase I and II enzymes from P. vulgaris

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1067253A (en) * 1965-02-15 1967-05-03 Biorex Laboratories Ltd Process for the preparation of enzymes
RO102703A2 (en) * 1988-10-05 1991-09-09 Intreprinderea De Medicamente "Biofarm", Bucuresti, Ro Producing method of a composition with hyaluronidase activity
US5578480A (en) * 1993-04-23 1996-11-26 American Cyanamid Company Methods for the isolation and purification of the recombinantly expressed chondroitinase I and II enzymes from P. vulgaris
WO1996001648A1 (en) * 1994-07-08 1996-01-25 Ibex Technologies R And D, Inc. Attenuation of wound healing processes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 9319, Derwent World Patents Index; Class B04, AN 1993-157093, XP002116910 *

Also Published As

Publication number Publication date
WO1999046368A2 (en) 1999-09-16
AU3006899A (en) 1999-09-27

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