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WO1999046371A3 - Induction of apoptotic or cytotoxic gene expression by adenoviral mediated gene codelivery - Google Patents

Induction of apoptotic or cytotoxic gene expression by adenoviral mediated gene codelivery Download PDF

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Publication number
WO1999046371A3
WO1999046371A3 PCT/US1999/005359 US9905359W WO9946371A3 WO 1999046371 A3 WO1999046371 A3 WO 1999046371A3 US 9905359 W US9905359 W US 9905359W WO 9946371 A3 WO9946371 A3 WO 9946371A3
Authority
WO
WIPO (PCT)
Prior art keywords
apoptotic
induction
codelivery
cytotoxic
gene expression
Prior art date
Application number
PCT/US1999/005359
Other languages
French (fr)
Other versions
WO1999046371A9 (en
WO1999046371A2 (en
Inventor
Timothy J Mcdonnell
Stephen G Swisher
Bingliang Fang
Elizabeth M Bruckheimer
Mona G Sarkiss
Li Ji
Jack A Roth
Original Assignee
Univ Texas
Timothy J Mcdonnell
Stephen G Swisher
Bingliang Fang
Elizabeth M Bruckheimer
Mona G Sarkiss
Li Ji
Jack A Roth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Timothy J Mcdonnell, Stephen G Swisher, Bingliang Fang, Elizabeth M Bruckheimer, Mona G Sarkiss, Li Ji, Jack A Roth filed Critical Univ Texas
Priority to EP99913854A priority Critical patent/EP1070122A4/en
Priority to AU31837/99A priority patent/AU762493B2/en
Priority to CA002322663A priority patent/CA2322663A1/en
Publication of WO1999046371A2 publication Critical patent/WO1999046371A2/en
Publication of WO1999046371A9 publication Critical patent/WO1999046371A9/en
Publication of WO1999046371A3 publication Critical patent/WO1999046371A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention generally relates to viral vectors and their use as expression vectors for transforming human cells, both in vitro and in vivo. More particularly, the present invention relates to adenoviral vectors containing propapoptotic genes and their use in cancer therapy.
PCT/US1999/005359 1998-03-11 1999-03-11 Induction of apoptotic or cytotoxic gene expression by adenoviral mediated gene codelivery WO1999046371A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99913854A EP1070122A4 (en) 1998-03-11 1999-03-11 INDUCTION OF THE EXPRESSION OF APOPTOTIC OR CYTOTOXIC GENES BY CO-SUPPORT OF ADENOVIRAL MEDIATED GENES
AU31837/99A AU762493B2 (en) 1998-03-11 1999-03-11 Induction of apoptic or cytotoxic gene expression by adenoviral mediated gene codelivery
CA002322663A CA2322663A1 (en) 1998-03-11 1999-03-11 Induction of apoptotic or cytotoxic gene expression by adenoviral mediated gene codelivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7754198P 1998-03-11 1998-03-11
US60/077,541 1998-03-11

Publications (3)

Publication Number Publication Date
WO1999046371A2 WO1999046371A2 (en) 1999-09-16
WO1999046371A9 WO1999046371A9 (en) 2000-02-17
WO1999046371A3 true WO1999046371A3 (en) 2000-08-24

Family

ID=22138678

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/005359 WO1999046371A2 (en) 1998-03-11 1999-03-11 Induction of apoptotic or cytotoxic gene expression by adenoviral mediated gene codelivery

Country Status (4)

Country Link
EP (1) EP1070122A4 (en)
AU (1) AU762493B2 (en)
CA (1) CA2322663A1 (en)
WO (1) WO1999046371A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110174456B (en) * 2019-06-11 2021-09-21 华润双鹤药业股份有限公司 Method for measuring lung surfactant protein and application thereof

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1266022B1 (en) * 2000-03-24 2008-10-22 Cell Genesys, Inc. Cell-specific adenovirus vectors comprising an internal ribosome entry site
DE60140052D1 (en) 2000-05-31 2009-11-12 Human Gene Therapy Res Inst METHOD AND COMPOSITIONS FOR EFFICIENT GENETIC TRANSFER THROUGH TRANSCOMPLEMENTING VECTORS
DE60142050D1 (en) * 2000-06-02 2010-06-17 Takeda Pharmaceutical PROMOTER OF PROLIFERATION AND INHIBITOR OF APOPTOSIS OF PANCREATIC LANGERHANS BETA CELLS AND SCREENING OF PROTECTIVE COMPOUNDS FOR MEDICAMENTS
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
EP1207205A1 (en) * 2000-11-20 2002-05-22 Crucell Holland B.V. Adenoviral replicons
US20030086903A1 (en) 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
WO2003057158A2 (en) 2001-12-31 2003-07-17 Dana-Farber Cancer Institute, Inc. Method of treating apoptosis and compositions thereof
JP4511108B2 (en) 2002-05-31 2010-07-28 オンコリクス インコーポレイテッド Human prolactin antagonist-angiogenesis inhibitor fusion protein
CN100361710C (en) 2004-06-07 2008-01-16 成都康弘生物科技有限公司 Construction and application of oncolytic adenovirus recombinant of tumor cell specifically expressing immunoregulation factor GM-CSF
US20080081354A1 (en) * 2006-10-02 2008-04-03 Cardiac Pacemakers, Inc. Devices, vectors and methods for inducible ischemia cardioprotection
EP3541803B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
US11149040B2 (en) 2017-11-03 2021-10-19 Amgen Inc. Fused triazole agonists of the APJ receptor
WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor
CN117731804A (en) * 2023-11-10 2024-03-22 南开大学 Multi-gene nano-carrier, preparation method and application thereof, and anticancer drug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996025507A2 (en) * 1995-02-17 1996-08-22 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods of preparation and use of recombinant adenoviral vectors
DE19615803A1 (en) * 1996-04-20 1997-10-23 Boehringer Ingelheim Int CELO virus
AU5817299A (en) * 1998-09-10 2000-04-03 Uab Research Foundation, The Adenoviral vector encoding pro-apoptotic bax gene and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"ONE WAY TO KILL CANCER: GIVE IT A COLD", XP002917479, Retrieved from the Internet <URL:HTTP://WWW.CNN.COM> [retrieved on 19970522] *
COLL J.L. ET AL: "Antitumor Activity of Bax and p53 Naked Gene Transfer in Lung Cancer: In Vitro and in Vivo Analysis", HUMAN GENE THERAPY, vol. 9, no. 14, 20 September 1998 (1998-09-20), pages 2063 - 2074, XP002917478 *
SAKAKURA C. ET AL: "Overexpression of Bax Sensitizes Human Breast Cancer MCF-7 Cells to Radiation-Incuced Apoptosis", INT. J. CANCER, vol. 67, 3 July 1996 (1996-07-03), pages 101 - 105, XP002917476 *
See also references of EP1070122A4 *
VOGELBAUM M.A. ET AL: "Transfection of C6 Glioma Cells with the Bax Gene and Increased Sensitivity to Treatment with Cytosine Arabinoside", JOURNAL OF NEUROSURGERY, vol. 88, no. 1, January 1998 (1998-01-01), pages 99 - 105, XP002917477 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110174456B (en) * 2019-06-11 2021-09-21 华润双鹤药业股份有限公司 Method for measuring lung surfactant protein and application thereof

Also Published As

Publication number Publication date
EP1070122A2 (en) 2001-01-24
EP1070122A4 (en) 2004-11-10
CA2322663A1 (en) 1999-09-16
WO1999046371A9 (en) 2000-02-17
WO1999046371A2 (en) 1999-09-16
AU762493B2 (en) 2003-06-26
AU3183799A (en) 1999-09-27

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