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WO1999046581A1 - Procede de detection de substances diffusees dans un echantillon et appareil permettant de realiser ce procede - Google Patents

Procede de detection de substances diffusees dans un echantillon et appareil permettant de realiser ce procede Download PDF

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Publication number
WO1999046581A1
WO1999046581A1 PCT/IB1999/000391 IB9900391W WO9946581A1 WO 1999046581 A1 WO1999046581 A1 WO 1999046581A1 IB 9900391 W IB9900391 W IB 9900391W WO 9946581 A1 WO9946581 A1 WO 9946581A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
radiation
diffused
detecting
substance
Prior art date
Application number
PCT/IB1999/000391
Other languages
English (en)
Inventor
Wolmer Lupi
Original Assignee
Wolmer Lupi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wolmer Lupi filed Critical Wolmer Lupi
Publication of WO1999046581A1 publication Critical patent/WO1999046581A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474—Details of optical heads therefor, e.g. using optical fibres

Definitions

  • the present invention relates to identification and quantitative analysis of particular substances.
  • the present invention relates to a method for detecting one or more substances, which is/are present in a sample to be analyzed, even only in traces, and which cannot be detected immediately by a direct observation.
  • the invention relates alsq to an apparatus that carries out this method.
  • the presence of blood in faeces can derive either from benign diseases or gastrointestinal apparatus, such as ulcer of strong irritations, or from neoplasia, specially of colon.
  • This invention was evolved with the general object of providing a method for detection of substances diffused in a sample, which is simple to apply and can be performed immediately also by non-specialized staff.
  • Another object of the present invention is to propose a method which allows to detect these diffused substances without using chemical reagents, or anyway, without application of any foreign substance to the sample.
  • a further object of the present invention is to propose an apparatus which carries out the above mentioned method and whose production cost is low and which is very reliable and manageable.
  • a detection sector connected to this box-like body and featuring inside a chamber which is to be set in contact with the sample, said detection sector having also housings made thereinside, respectively a central housing and peripheral housings; a sensor, situated in the small housing and aimed at detecting electromagnetic radiations diffused by the sample; a plurality of emitters of electromagnetic radiations, situated in the housings and aimed at sending electromagnetic radiations of at least one predetermined frequency, * which are to reach the sample;
  • processing and control means connected to the sensor and the emitting means and aimed at operating these emitting means according to predetermined sequences and timing, and at obtaining corresponding information detected by the sensor and processing it; means for displaying the processing result, connected to the processing and control means; a feeder, which supplies energy to the processing and control means, emitting means and display means .
  • FIG. 1 is a schematic partially sectional lateral view of the apparatus proposed by the present invention.
  • FIG. 2 is a schematic enlarged section view of a detection sector of the apparatus of Figure 1;
  • reference numeral 1 generally designates a sample, e.g. human faeces, to be analyzed, so as to detect possible presence of a substance diffused therein, e.g. blood.
  • the apparatus for detection of the above mentioned diffused substance is indicated by reference numeral 100 and includes a box-like body 3 of an oblong and approximately tubular shape, which allows its easy gripping like a pen.
  • a detection sector 4 substantially of a truncated cone form and hollow inside, is made in the lower part of the box-like body 3 (see Figure 4) .
  • a chamber 5 communicating with outside through a mouth 6 is made inside the detection sector 4.
  • the chamber 5 is set in contact with the sample 1 through this mouth 6.
  • central housing 7 there is one central housing 7 and four peripheral housings 8, arranged symmetrically in the regions of the corners of a quadrilateral made around the central housing 7. - 6 -
  • a sensor 9 for detecting an electromagnetic radiation diffused by the sample 1 inside the chamber 5 is situated in the central housing 7.
  • the sensor 9 can be accessed from the chamber 5 through a channel 7a made in the lower part of the central housing 7.
  • a plurality of electromagnetic radiation emitters 10, facing directly the shaped chamber 5, are fastened to the peripheral housings 8.
  • These emitters 10 are preferably light emitting diodes, commonly known by acronym LED, which emit a radiation having different frequency bands corresponding to different colors.
  • This emission of radiation can be considered, for the invention objects, approximately monochromatic, or anyway composed of a limited and definite number of frequencies .
  • the apparatus has four LEDs 11, 12, 13, 14 which are situated in the respective housings 8 and which are preferably red, green, yellow and orange.
  • the radiation beam emitted by the LEDs 11, 12, 13, 14 reach the surface of the sample 1, so as to be diffused inside the chamber 5.
  • the inner wall 5a of the chamber 5 is curvilinear and progressively convergent toward the mouth 6, so as to facilitate directing of the radiation emitted by the LEDs toward the mouth 6 and to avoid direct reflection by the wall 5a toward the sensor 9.
  • Processing and control unit 20, situated inside the boxlike body 3, is electrically connected to the sensor 9 and emitters 10.
  • This processing and control unit includes a microprocessor electronic circuit, which contains a program suitable prepared for cooperating in carrying out the method of the present invention.
  • the processing and control unit 20 activates the emitters 10, according to timing and sequences described later, so that the latter receive corresponding information about the diffusion by the sample 1, detected by the sensor 9, and process this information by the above mentioned program for obtaining a result indicating the presence of the substance diffused in the sample 1.
  • Display means 30 for displaying this result are fastened outside the box-like body 3.
  • These display means 30 are electrically connected to the processing and control means 20 and include substantially a group of display elements 31 of alphanumeric type.
  • these display elements 31 could also include light segments, of the light emitting diodes or liquid crystals, which give less precise indications of the above mentioned result.
  • Feeding means 35 situated in the upper part of the box ⁇ like body 4, include e.g. a re-chargeable accumulator of a suitable type available on the market, which supply energy to the above mentioned processing and control unit 20, emitters 10 and display means 30.
  • the method for detecting a substance diffused in the sample 1 includes a sequence of working steps performed automatically by the apparatus 100.
  • the working steps are started manually by a user, who pushes a starting button 40, after having set the mouth 6 of the apparatus 100 in communication with the surface of the sample 1.
  • the sequence of working steps is suitably set by the program stored in the processing and control unit 20.
  • a first step is emission rating, which consists in preparing the sensor 8 to detecting, reading, and storing a normalization value N of the light radiation intensity diffused by a sample 1 in particular conditions of environmental light present in that moment. Then a plurality of detecting steps follow, each of which including various sub-steps.
  • a LED 11, 12, 13, 14 is activated to emit a beam of radiation on its characteristic frequency for a predetermined period of time.
  • the radiation is conveyed, partly also by the wall 5a of the chamber 5, toward the sample 1.
  • a part of the radiation beam is diffused by the sample toward the sensor 8, which therefore can measure the intensity of the diffusion; then the program operating in - 9 -
  • the processing and control unit 20 defines a working parameter L, which is the value of this intensity.
  • the subsequent sub-step is comparison of the characteristic value C with a stored reference value R, which is typical for the substance to be detected, and which indicates the diffusion of the particular radiation frequency emitted by this substance.
  • Each of the characteristic values Cl, C2, C3, C4 is preferably calculated also in relation to the other three, by formulas which change in relation to the substance to detect.
  • the valuation of the convergence degree of the characteristic values Cl, C2, C3, C4 toward the reference values Rl, R2, R3, R4 gives the information about quantity of the substance to detect.
  • this quantity information is displayed in a numeric form in the display means 31.
  • the present method can have different embodiments, all carried out by the same described apparatus 100, - 10 -
  • the number of detection steps can be different from four, thus a corresponding number of LEDs is used, even of color different from the above specified ones.
  • ⁇ the rating and detection steps can be repeated by a predetermined number of times.
  • an average characteristic value CM is calculated for different detection steps relating to each color, which is defined by an average of the characteristic values C obtained subsequently.
  • each average characteristic value CM is compared, according to the present method, to the corresponding reference value R.
  • the present invention proposes a method which advantageously allows to detect substances diffused in a sample, in particular substances which cannot be seen in a direct observation, in an extremely simple way and can be performed immediately also by non-specialized staff, in particular by the apparatus user.
  • Another advantage of the present invention derives from the fact that the production costs of the proposed apparatus carrying out the method are very low, therefore a large number of users can afford it and thus they can control constantly diagnostic parameters particularly important for the public health.
  • a further advantage of the present invention lies in the fact that the proposed apparatus allows to perform this control without using chemical reagents, and therefore, without any risk for the user's health and safety.

Landscapes

  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un procédé de détection de substances diffusées dans un échantillon (1). Ce procédé, réalisé à l'aide d'un appareil (100), consiste d'abord à lire, à l'aide d'un détecteur (8), une valeur de normalisation (N) de l'intensité de rayonnement de la lumière diffusée dans la lumière ambiante par un échantillon (1). Ce procédé comporte ensuite une pluralité d'étapes de détection, lesquelles consistent chacune à mesurer un faisceau de rayonnement d'une fréquence prédéterminée envoyé par un dispositif d'émission (10) et diffusé dans l'échantillon (1), de manière à définir un paramètre de travail (L). Ces étapes consistent alors à traiter ledit paramètre de travail (L) en fonction de la valeur de normalisation (N) et à définir une valeur caractéristique (C) de la diffusion de la substance. Ces étapes consistent enfin à comparer à une valeur de référence mémorisée (R) la valeur caractéristique (C) de la diffusion de la substance. Enfin, ce procédé consiste à visualiser le résultat de cette comparaison.
PCT/IB1999/000391 1998-03-10 1999-03-10 Procede de detection de substances diffusees dans un echantillon et appareil permettant de realiser ce procede WO1999046581A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98BO000141A IT1299889B1 (it) 1998-03-10 1998-03-10 Metodo per la rilevazione di sostanze diffuse in un campione, ed apparecchiatura che realizza tale metodo.
ITBO98A000141 1998-03-10

Publications (1)

Publication Number Publication Date
WO1999046581A1 true WO1999046581A1 (fr) 1999-09-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000391 WO1999046581A1 (fr) 1998-03-10 1999-03-10 Procede de detection de substances diffusees dans un echantillon et appareil permettant de realiser ce procede

Country Status (2)

Country Link
IT (1) IT1299889B1 (fr)
WO (1) WO1999046581A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008111055A1 (fr) * 2007-03-12 2008-09-18 In-Dot Ltd. Détection de couleur pour un dispositif de lecture et similaire
US8556732B2 (en) 2008-02-13 2013-10-15 In-Dot Ltd. Method and an apparatus for managing games and a learning plaything
US8591302B2 (en) 2008-03-11 2013-11-26 In-Dot Ltd. Systems and methods for communication
US8787672B2 (en) 2007-03-12 2014-07-22 In-Dot Ltd. Reader device having various functionalities

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755048A (en) * 1986-10-23 1988-07-05 Amoco Corporation Optical analysis of impurity absorptions
EP0394909A1 (fr) * 1989-04-28 1990-10-31 Roche Diagnostics GmbH Procédé d'illumination diffuse d'une aire de mesure dans un analyseur pour support d'essai
EP0655221A1 (fr) * 1993-11-26 1995-05-31 L'oreal Tête de mesure colorimétrique, et procédé pour déterminer la couleur interne d'un matériau non opaque
EP0764843A2 (fr) * 1995-09-25 1997-03-26 SOLVAY (Société Anonyme) Procédé et dispositif de contrôle de la qualité de latex de polyméres vinyliques halogénés
WO1998038494A1 (fr) * 1997-02-28 1998-09-03 Slagteriernes Forskningsinstitut Dispositif de mesure de reflexion et procede de determination de la qualite des articles, notamment des articles contenant de la graisse

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755048A (en) * 1986-10-23 1988-07-05 Amoco Corporation Optical analysis of impurity absorptions
EP0394909A1 (fr) * 1989-04-28 1990-10-31 Roche Diagnostics GmbH Procédé d'illumination diffuse d'une aire de mesure dans un analyseur pour support d'essai
EP0655221A1 (fr) * 1993-11-26 1995-05-31 L'oreal Tête de mesure colorimétrique, et procédé pour déterminer la couleur interne d'un matériau non opaque
EP0764843A2 (fr) * 1995-09-25 1997-03-26 SOLVAY (Société Anonyme) Procédé et dispositif de contrôle de la qualité de latex de polyméres vinyliques halogénés
WO1998038494A1 (fr) * 1997-02-28 1998-09-03 Slagteriernes Forskningsinstitut Dispositif de mesure de reflexion et procede de determination de la qualite des articles, notamment des articles contenant de la graisse

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008111055A1 (fr) * 2007-03-12 2008-09-18 In-Dot Ltd. Détection de couleur pour un dispositif de lecture et similaire
US8787672B2 (en) 2007-03-12 2014-07-22 In-Dot Ltd. Reader device having various functionalities
US8556732B2 (en) 2008-02-13 2013-10-15 In-Dot Ltd. Method and an apparatus for managing games and a learning plaything
US8591302B2 (en) 2008-03-11 2013-11-26 In-Dot Ltd. Systems and methods for communication

Also Published As

Publication number Publication date
IT1299889B1 (it) 2000-04-04
ITBO980141A1 (it) 1999-09-10
ITBO980141A0 (it) 1998-03-10

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