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WO1999061640A3 - Aav derived vector - Google Patents

Aav derived vector Download PDF

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Publication number
WO1999061640A3
WO1999061640A3 PCT/GB1999/001633 GB9901633W WO9961640A3 WO 1999061640 A3 WO1999061640 A3 WO 1999061640A3 GB 9901633 W GB9901633 W GB 9901633W WO 9961640 A3 WO9961640 A3 WO 9961640A3
Authority
WO
WIPO (PCT)
Prior art keywords
derived vector
aav derived
aav
vector
encapsidating
Prior art date
Application number
PCT/GB1999/001633
Other languages
French (fr)
Other versions
WO1999061640A2 (en
Inventor
Robert James Anderson
Hugh Grant Prentice
Ian Duncan Macdonald
Original Assignee
Univ London
Robert James Anderson
Hugh Grant Prentice
Ian Duncan Macdonald
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ London, Robert James Anderson, Hugh Grant Prentice, Ian Duncan Macdonald filed Critical Univ London
Publication of WO1999061640A2 publication Critical patent/WO1999061640A2/en
Publication of WO1999061640A3 publication Critical patent/WO1999061640A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

An adeno-associated viral vector containing a transgene and encapsidating a protein with adenovirus E4 ORF6 activity.
PCT/GB1999/001633 1998-05-22 1999-05-21 Aav derived vector WO1999061640A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9811171.9 1998-05-22
GBGB9811171.9A GB9811171D0 (en) 1998-05-22 1998-05-22 Viral vector

Publications (2)

Publication Number Publication Date
WO1999061640A2 WO1999061640A2 (en) 1999-12-02
WO1999061640A3 true WO1999061640A3 (en) 2000-01-27

Family

ID=10832634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/001633 WO1999061640A2 (en) 1998-05-22 1999-05-21 Aav derived vector

Country Status (2)

Country Link
GB (1) GB9811171D0 (en)
WO (1) WO1999061640A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468181B2 (en) 2002-04-25 2008-12-23 Crucell Holland B.V. Means and methods for the production of adenovirus vectors

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10056210A1 (en) * 2000-11-13 2002-05-29 Arimedes Biotechnology Gmbh Viral expression system
US8912142B2 (en) 2009-04-01 2014-12-16 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Method of regulating proliferation and differentiation of keratinocyes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000587A1 (en) * 1994-06-30 1996-01-11 University Of Pittsburgh Aav capsid vehicles for molecular transfer
WO1996022378A1 (en) * 1995-01-20 1996-07-25 Rhone-Poulenc Rorer S.A. Cells for the production of recombinant adenoviruses
WO1996039530A2 (en) * 1995-06-05 1996-12-12 The Trustees Of The University Of Pennsylvania Recombinant adenovirus and adeno-associated virus, cell lines, and methods of production and use thereof
WO1997009441A2 (en) * 1995-09-08 1997-03-13 Genzyme Corporation Improved aav vectors for gene therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000587A1 (en) * 1994-06-30 1996-01-11 University Of Pittsburgh Aav capsid vehicles for molecular transfer
WO1996022378A1 (en) * 1995-01-20 1996-07-25 Rhone-Poulenc Rorer S.A. Cells for the production of recombinant adenoviruses
WO1996039530A2 (en) * 1995-06-05 1996-12-12 The Trustees Of The University Of Pennsylvania Recombinant adenovirus and adeno-associated virus, cell lines, and methods of production and use thereof
WO1997009441A2 (en) * 1995-09-08 1997-03-13 Genzyme Corporation Improved aav vectors for gene therapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FERRARI F. K. ET AL.: "SECOND-STRAND SYNTHESIS IS A RATE-LIMITING STEP FOR EFFICIENT TRANSDUCTION BY RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS", JOURNAL OF VIROLOGY,US,THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 70, no. 5, pages 3227-3234, XP000570467, ISSN: 0022-538X *
FISHER K. J. ET AL.: "TRANSDUCTION WITH RECOMBINANT ADENO-ASSOCIATED VIRUS FOR GENE THERAPY IS LIMITED BY LEADING-STRAND SYNTHESIS", JOURNAL OF VIROLOGY,US,THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 70, no. 1, pages 520-532, XP000570468, ISSN: 0022-538X *
LEPPARD K. N.: "E4 gene function in adenovirus, adenovirus vector and adenovirus infections", JOURNAL OF GENERAL VIROLOGY,GB,SOCIETY FOR GENERAL MICROBIOLOGY, READING, vol. 78, pages 2131-2138, XP002086863, ISSN: 0022-1317 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468181B2 (en) 2002-04-25 2008-12-23 Crucell Holland B.V. Means and methods for the production of adenovirus vectors

Also Published As

Publication number Publication date
WO1999061640A2 (en) 1999-12-02
GB9811171D0 (en) 1998-07-22

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