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WO1999000150A3 - Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor - Google Patents

Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor Download PDF

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Publication number
WO1999000150A3
WO1999000150A3 PCT/US1998/013398 US9813398W WO9900150A3 WO 1999000150 A3 WO1999000150 A3 WO 1999000150A3 US 9813398 W US9813398 W US 9813398W WO 9900150 A3 WO9900150 A3 WO 9900150A3
Authority
WO
WIPO (PCT)
Prior art keywords
monoclonal antibody
human insulin
insulin receptor
brain barrier
vivo
Prior art date
Application number
PCT/US1998/013398
Other languages
French (fr)
Other versions
WO1999000150A9 (en
WO1999000150A2 (en
Inventor
William M Pardridge
Original Assignee
Univ California
William M Pardridge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, William M Pardridge filed Critical Univ California
Priority to AU82698/98A priority Critical patent/AU8269898A/en
Publication of WO1999000150A2 publication Critical patent/WO1999000150A2/en
Publication of WO1999000150A3 publication Critical patent/WO1999000150A3/en
Publication of WO1999000150A9 publication Critical patent/WO1999000150A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

[125I]-Aβ1-40 was mono-biotinylated and conjugated to a blood-brain barrier drug delivery and brain targeting system comprised of a complex of the 83-14 monoclonal antibody (MAb) to the human insulin receptor, which is tagged with streptavidin (SA) to produce a marked increase in rhesus monkey brain uptake of the [125I]-bio-Aβ1-40 at 3 hours following intravenous injection compared to no measurable brain uptake of [125I]-bio-Aβ1-40 in the absence of a BBB drug.
PCT/US1998/013398 1997-06-27 1998-06-26 Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor WO1999000150A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU82698/98A AU8269898A (en) 1997-06-27 1998-06-26 Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5106597P 1997-06-27 1997-06-27
US60/051,065 1997-06-27

Publications (3)

Publication Number Publication Date
WO1999000150A2 WO1999000150A2 (en) 1999-01-07
WO1999000150A3 true WO1999000150A3 (en) 1999-04-01
WO1999000150A9 WO1999000150A9 (en) 1999-05-14

Family

ID=21969115

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/013398 WO1999000150A2 (en) 1997-06-27 1998-06-26 Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor

Country Status (2)

Country Link
AU (1) AU8269898A (en)
WO (1) WO1999000150A2 (en)

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US8497246B2 (en) 2006-08-18 2013-07-30 Armagen Technologies, Inc. Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions
US8741260B2 (en) 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
US8834874B2 (en) 2009-10-09 2014-09-16 Armagen Technologies, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS
US8974791B2 (en) 2007-07-27 2015-03-10 Armagen Technologies, Inc. Methods and compositions for increasing α-L-iduronidase activity in the CNS
US9533055B2 (en) 2009-03-18 2017-01-03 Armagen Technologies, Inc. Compositions and methods for blood-brain barrier delivery of IgG-decoy receptor fusion proteins
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU

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US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
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US7388079B2 (en) 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
MXPA05009726A (en) 2003-03-14 2005-11-04 Neose Technologies Inc Branched water-soluble polymers and their conjugates.
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US8741260B2 (en) 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
US8759297B2 (en) 2006-08-18 2014-06-24 Armagen Technologies, Inc. Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns
US8497246B2 (en) 2006-08-18 2013-07-30 Armagen Technologies, Inc. Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions
US10144783B2 (en) 2006-08-18 2018-12-04 Armagen, Inc. Macromolecular compositions that cross the blood-brain barrier and methods of use thereof
US8753610B2 (en) 2006-08-18 2014-06-17 Armagen Technologies, Inc. Methods for diagnosing CNS disorders with fusion antibodies that cross the blood-brain barrier in both directions
US8974791B2 (en) 2007-07-27 2015-03-10 Armagen Technologies, Inc. Methods and compositions for increasing α-L-iduronidase activity in the CNS
US9567400B2 (en) 2007-07-27 2017-02-14 Armagen Technologies, Inc. Methods and compositions for increasing α-L-iduronidase activity in the CNS
US11512145B2 (en) 2007-07-27 2022-11-29 Armagen, Inc. Methods and compositions for increasing alpha-L-iduronidase activity in the CNS
US10202467B2 (en) 2007-07-27 2019-02-12 Armagen, Inc. Methods and compositions for increasing α-L-iduronidase activity in the CNS
US9533055B2 (en) 2009-03-18 2017-01-03 Armagen Technologies, Inc. Compositions and methods for blood-brain barrier delivery of IgG-decoy receptor fusion proteins
US10011651B2 (en) 2009-10-09 2018-07-03 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS
US8834874B2 (en) 2009-10-09 2014-09-16 Armagen Technologies, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS
US11028156B2 (en) 2009-10-09 2021-06-08 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS
US12043661B2 (en) 2009-10-09 2024-07-23 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS
US9975955B2 (en) 2011-12-02 2018-05-22 Armagen, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
US8715661B2 (en) 2011-12-02 2014-05-06 Armagen Technologies, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
US8486399B2 (en) 2011-12-02 2013-07-16 Armagen Technologies, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
US8920801B2 (en) 2011-12-02 2014-12-30 Armagen Technologies, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU

Also Published As

Publication number Publication date
WO1999000150A9 (en) 1999-05-14
AU8269898A (en) 1999-01-19
WO1999000150A2 (en) 1999-01-07

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