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WO1999003993A3 - Suppressors of cytokine signaling; related reagents - Google Patents

Suppressors of cytokine signaling; related reagents Download PDF

Info

Publication number
WO1999003993A3
WO1999003993A3 PCT/US1998/014544 US9814544W WO9903993A3 WO 1999003993 A3 WO1999003993 A3 WO 1999003993A3 US 9814544 W US9814544 W US 9814544W WO 9903993 A3 WO9903993 A3 WO 9903993A3
Authority
WO
WIPO (PCT)
Prior art keywords
suppressors
cytokine signaling
related reagents
reagents
molecules
Prior art date
Application number
PCT/US1998/014544
Other languages
French (fr)
Other versions
WO1999003993A2 (en
Inventor
James A Johnson
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU84845/98A priority Critical patent/AU8484598A/en
Publication of WO1999003993A2 publication Critical patent/WO1999003993A2/en
Publication of WO1999003993A3 publication Critical patent/WO1999003993A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Purified genes encoding intracellular regulatory molecules from a human, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
PCT/US1998/014544 1997-07-18 1998-07-17 Suppressors of cytokine signaling; related reagents WO1999003993A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU84845/98A AU8484598A (en) 1997-07-18 1998-07-17 Suppressors of cytokine signaling; related reagents

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US5324497P 1997-07-18 1997-07-18
US5315397P 1997-07-18 1997-07-18
US60/053,244 1997-07-18
US60/053,153 1997-07-18
US5580497P 1997-08-15 1997-08-15
US5585397P 1997-08-15 1997-08-15
US60/055,853 1997-08-15
US60/055,804 1997-08-15

Publications (2)

Publication Number Publication Date
WO1999003993A2 WO1999003993A2 (en) 1999-01-28
WO1999003993A3 true WO1999003993A3 (en) 1999-06-03

Family

ID=27489542

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1998/014545 WO1999003994A1 (en) 1997-07-18 1998-07-16 Suppressors of cytokine signaling socs16; related reagents
PCT/US1998/014544 WO1999003993A2 (en) 1997-07-18 1998-07-17 Suppressors of cytokine signaling; related reagents

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US1998/014545 WO1999003994A1 (en) 1997-07-18 1998-07-16 Suppressors of cytokine signaling socs16; related reagents

Country Status (2)

Country Link
AU (2) AU8484698A (en)
WO (2) WO1999003994A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905842B1 (en) 1996-11-01 2005-06-14 The Walter And Eliza Hall Institute Of Medical Research Therapeutic and diagnostic agents
JP2001502183A (en) * 1996-11-01 2001-02-20 ザ ウォルター アンド イライザ ホール インスティチュート オブ メディカル リサーチ Therapeutic and diagnostic agents that can modulate cellular responsiveness to cytokines
US6323317B1 (en) 1996-11-01 2001-11-27 The Walter And Eliza Hall Institute Of Medical Research Therapeutic and diagnostics proteins comprising a SOCS box
JPH11103867A (en) * 1997-05-07 1999-04-20 Smithkline Beecham Corp Epo primary response gene1, eprg1
AU1205599A (en) * 1997-11-03 1999-05-24 Incyte Pharmaceuticals, Inc. Suppressor of cytokine signaling
EP0953636A3 (en) * 1998-03-23 2000-03-29 Smithkline Beecham Plc Cytokine signal regulators
US7078174B1 (en) 1998-12-21 2006-07-18 The Walter & Eliza Hall Institute Of Medical Research Screening methods using SOCS box-containing peptides
GB9918680D0 (en) * 1999-08-09 1999-10-13 Medical Res Council Polypeptide
WO2001029178A2 (en) * 1999-10-21 2001-04-26 Smithkline Beecham Corporation Epo primary response gene 1, eprg1
GB2373502A (en) * 2000-11-08 2002-09-25 Smithkline Beecham Corp Suppressor of cytokine signalling 4 (SOCS4)
EP1341913A2 (en) * 2000-12-14 2003-09-10 PHARMACIA & UPJOHN COMPANY Socs (suppressor of cytokine signaling)
US20060194275A1 (en) * 2001-04-13 2006-08-31 Incyte Corporation Transporter and ion channels
US7348139B1 (en) 2001-04-13 2008-03-25 The Johns Hopkins University School Of Medicine SOCS-1 gene methylation in cancer
US8420096B2 (en) 2004-03-04 2013-04-16 Vanderbilt University Cell-penetrating SOCS polypeptides that inhibit cytokine-induced signaling

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020023A1 (en) * 1996-11-01 1998-05-14 The Walter And Eliza Hall Institute Of Medical Research Therapeutic and diagnostic agents capable of modulating cellular responsiveness to cytokines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020023A1 (en) * 1996-11-01 1998-05-14 The Walter And Eliza Hall Institute Of Medical Research Therapeutic and diagnostic agents capable of modulating cellular responsiveness to cytokines

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A. YOSHIMURA ET AL: "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to Tyrosine-phosphorylated interleukin-3 and erythropoietin", EMBO JOURNAL., vol. 14, no. 12, 1995, EYNSHAM, OXFORD GB, pages 2816 - 2826, XP002088456 *
D.J. HILTON ET AL: "Twenty proteins containing a C-terminal SOCS box form five structural classes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 95, January 1998 (1998-01-01), WASHINGTON US, pages 114 - 119, XP002085497 *
M. MASUHARA ET AL: "Cloning and characterization of novel CIS family genes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 239, October 1997 (1997-10-01), ORLANDO, FL US, pages 439 - 446, XP002088457 *
R. STARR ET AL: "A family of cytokine-inducible inhibitors of signalling", NATURE., vol. 387, no. 6636, 26 June 1997 (1997-06-26), LONDON GB, pages 917 - 921, XP002085491 *
T. NAKA ET AL: "Structure and function of a new STAT-induced STAT inhibitor", NATURE., vol. 387, no. 6636, 26 June 1997 (1997-06-26), LONDON GB, pages 924 - 929, XP002088455 *
T.A ENDO ET AL: "A new protein containing an SH2 domain that inhibits JAK kinases", NATURE., vol. 387, no. 6636, 26 June 1997 (1997-06-26), LONDON GB, pages 921 - 924, XP002085492 *

Also Published As

Publication number Publication date
WO1999003993A2 (en) 1999-01-28
WO1999003994A1 (en) 1999-01-28
AU8484598A (en) 1999-02-10
AU8484698A (en) 1999-02-10

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