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WO1999006105A1 - Modele perfectionne de stimulateur cardiaque - Google Patents

Modele perfectionne de stimulateur cardiaque Download PDF

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Publication number
WO1999006105A1
WO1999006105A1 PCT/AU1998/000609 AU9800609W WO9906105A1 WO 1999006105 A1 WO1999006105 A1 WO 1999006105A1 AU 9800609 W AU9800609 W AU 9800609W WO 9906105 A1 WO9906105 A1 WO 9906105A1
Authority
WO
WIPO (PCT)
Prior art keywords
heart
electrodes
pacemaker
base member
electrode
Prior art date
Application number
PCT/AU1998/000609
Other languages
English (en)
Inventor
Noel Desmond Gray
Original Assignee
Noel Desmond Gray
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noel Desmond Gray filed Critical Noel Desmond Gray
Priority to AU86174/98A priority Critical patent/AU8617498A/en
Publication of WO1999006105A1 publication Critical patent/WO1999006105A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems

Definitions

  • the present invention relates to a method of pacing the heart and to a heart pacemaker apparatus.
  • Conventional existing cardiac pacemakers usually constitute a pulse generator housed within a hermetically sealed metal capsule.
  • the partly insulated metal capsule is arranged to be inserted within a patients body, normally near one of the pectoral muscles.
  • One or two insulated leads having their proximal ends connected into a receiving port of the metal capsule so as to provide a direct connection with the pulse generator, have their distal ends connected to one or more bare metal electrodes which are located inside the patients heart.
  • transvenous electrodes are positioned in the right ventricle and/or the right atrium and deliver stimulating impulses to the endocardium to pace the heart.
  • PCT/AU93/00541 discloses a pacemaker which comprises a base member arranged to be positioned about the apical area of the heart.
  • the base member mounts a number of electrodes which are arranged to abut the surface of the heart and provide electrical stimulation thereto, and also to provide a cardiac sensing function.
  • Stimulation of the heart using a plurality of apically positioned electrodes acts to stimulate the heart in a more natural way and substantially avoids pacemaker induced left branch block type conduction disturbance.
  • the construction of the pacemaker also enables reduction in polarisation and impedance between the pulse generator and the electrode. Using a plurality of electrodes also means that electrodes can be selected for the most convenient and optimum pacing and also to deal with polarisation. Disclosure of PCT/AU93/00541 is incorporated herein by reference.
  • the present invention concerns further improvements in methods and apparatus for pacing the heart.
  • the improvements of the present invention can be utilised with an apical-type pacemaker, such as disclosed in PCT/AU93/00541, or could, although less preferably, be utilised with a pacemaker of conventional type.
  • Prior art pacemakers pace the heart by applying a single electrical pulse for each heart beat required. If a heart beat of sixty beats per minute is required (60bpm) then a single electrical pulse is generated by the pacemaker 60 times per minute and applied to the pacemaker electrode for each required beat.
  • the basic pulse repetition rate of most pacemakers varies between approximately 60 and 120 bp , depending upon physiological requirements.
  • the present invention provides a method of pacing a heart, comprising the steps of, for each required paced heart beat, applying an electrical stimulus to the heart by applying a group of a plurality of electrical pulses, the time of occurrence of each group in a sequence of such groups being arranged to provide the required paced heart rate.
  • Each single electrical pulse in a group of pulses preferably has a width which is relatively short.
  • relatively short we mean it is shorter than the conventional pulse applied by conventional pacemakers.
  • each group comprises a sequential burst or wave train of pulses.
  • the total period or width of the burst may extend to substantially the width of a conventional pulse, 0.5ms, for example.
  • the amplitude of the pulses may be the same as the amplitude of a conventional pulse.
  • a lighter and cheaper battery could be utilised for the same pacemaker lifetime which would facilitate a smaller and lighter pulse generator.
  • the method of this aspect of the invention can be used with conventional pacemakers as well as with the pacemaker of the above referenced PCT application. Note that one problem with conventional pacemakers is the build up of fibrous tissue due to stimulation by the electrode. It is possible that this relatively low energy stimulation as proposed by this aspect of the present invention may also lead to less build up of fibrous tissue in conventional pacemakers, further obviating the need to use a large amount of energy from the pacemaker battery.
  • the present invention may also be utilised in a "demand" type pacemaker.
  • pacemakers which are already implanted may be adapted to provide pacing in accordance with this aspect of the invention. Adaptation would be required to the circuitry of the pulse generator, but the electrode may remain implanted.
  • the present invention further provides a method of adapting a pacemaker, comprising the steps of adapting the pacemaker circuitry in order to enable the pacemaker to provide pacing by applying a group of a plurality of electrical pulses for each required paced heart beat, the occurrence of each group of pulses in a sequence of such groups being arranged to provide the required paced heart rate.
  • the present invention yet further provides a heart pacemaker, comprising a pulse generator means for causing an electrode to provide cardiac stimulating pulses to the heart, the pulse generator means being arranged to provide a sequence of groups of electrical pulses, a group of a plurality of electrical pulses being applied for each required paced heart beat.
  • the pacemaker disclosed in the applicants earlier patent application includes an array of disk-like electrodes on a surface of a base member and arranged to be applied to the apical area of the heart.
  • the provision of a plurality of electrodes allows the use of different electrodes for pacing and sensing functions and preferably alleviates polarisation problems.
  • the inventors have also developed an improved electrode arrangement.
  • the present invention provides a heart pacemaker comprising a base member mounting at least one electrode for pacing the heart and/or sensing electrical activity in the heart, and a pulse generator means for causing the electrodes to provide heart stimulating pulses, wherein at least one electrode is formed as a ring on the surface of the base member.
  • a heart pacemaker comprising a base member mounting at least one electrode for pacing the heart and/or sensing electrical activity in the heart, and a pulse generator means for causing the electrodes to provide heart stimulating pulses, wherein at least one electrode is formed as a ring on the surface of the base member.
  • there are a plurality of electrodes available for pacing and/or sensing and more preferably there are a plurality of electrodes formed as rings on the surface of the base member.
  • Ring includes a circular ring, a square ring or generally a ring of any shape, rectangular, polygonal, irregular etc.
  • each ring electrode is equal in area and more preferably the ring electrodes are capacitive electrodes each electrode having equal capacitance.
  • a "indifferent" electrode is also provided on the base member.
  • the surface area of the electrode substantially covers the surface area of the base member (apart from the insulting gaps obviously required between adjacent electrodes) .
  • ring electrodes provides an increase in area of each electrode compared with prior art electrodes resulting in a lower impedance and preferably potentially increased electrical sensitivity when the electrode is in a sensing mode. Further, the increased capacitance of each electrode preferably provides for higher peak stimulating impulse in the pulse generator stimulating mode.
  • a further advantage of the increase in area of each electrode compared with the prior art is improved contact stability. Yet a further advantage is that the positioning of the base member (which is preferably positionable around the apical area of the heart) is less critical due to the increased electrode heart contact area.
  • any one, two, more or all of the electrodes may be chosen for pacing/sensing functions, thus providing improved directivity and the opportunity for the cardiologist to select the most appropriate electrodes, preferably covering virtually the entire surface of the apical area of the heart, to provide the most appropriate stimulation for the patients heart. Cardiologists can select electrodes in an attempt to mimic the natural pacing of the heart.
  • the pacing may be by means of the "burst" type stimulation discussed above in relation to the first aspect of this invention.
  • the provision of a plurality of electrodes for covering much of the apical area of the heart preferably allows cardiologists more "directivity" (by which we mean they can select any one or all of the electrodes as appropriate to pace various areas of the heart) and versatility. Electrodes may all be connected together to provide a sensing function and a pacing function, i.e., connected in parallel, or selective ones of the electrodes may be connected in parallel. All the electrodes may be connected in parallel to provide a defibrillation function, if required.
  • the or each ring electrode is segmented to provide a plurality of segments, each one of which can operate as a separate electrode separated by insulating material of the base member.
  • This provides yet more directivity and choice for pacing and/or sensing operations.
  • This type of electrode array is totally new to pacemaking technology.
  • the provision of a base member with a plurality of electrodes in the form of segments of a plurality of band or ring electrodes is totally novel, and allows the cardiologist versatility in selection of electrodes to be used in pacing and/or sensing so that the cardiologist can select the electrodes to as far as possible mimic the natural operation of the heart.
  • Electrodes may be formed on the base member in a series of "strips" extending substantially from the centre or bottom of the base member towards the periphery of the base member.
  • the strips preferably extend in a direction such that they will come into contact with vital areas of the heart required for pacing when the base member is fitted to the heart.
  • strips of segmented electrodes are available for contacting the apical area of the right and left ventricle and other strips are provided for contacting the appropriate area to cause the septum to stiffen.
  • a cardiac muscle stimulation wavefront may be directed first to stimulate and stiffen the septum, then substantially simultaneously to the right and the left ventricle, or biased right or left as is clinically determined by the operator and/or by the physiological requirements of the patient (where physiological control is applied over the pacemaker - see applicants earlier application referenced above) .
  • the present invention provides a heart pacemaker comprising a base member mounting a plurality of electrodes and being arranged to fit to the apical area of the heart, the plurality of electrodes extending across the surface of the base member such that electrodes are available to contact substantially the entire surface of the apical area of the heart, whereby to provide means for pacing and/or sensing electrical activity for the entire apical area of the heart.
  • Electrodes may be band or ring type electrodes as discussed above or segmented electrodes as discussed above.
  • the electrodes extend over substantially the entire surface of the base member.
  • a heart pacemaker comprising a base member mounting a plurality of electrodes and being arranged to fit to the apical area of the heart, the plurality of electrodes being arranged in a plurality of strips, each strip being arranged on the base member so as to extend and contact a portion of the apical area of the heart, each contacted portion may be paced or sensed separately.
  • At least one strip contacts an area of the heart the electrical stimulation of which causes stimulation of the right ventricle, at least another strip contacts an area of the heart stimulation of which causes stimulation of the left ventricle and at least another strip contacts an area of the heart the stimulation of which causes stimulation of the septum.
  • the strips extend from substantially the centre of the base member out towards its periphery.
  • An indifferent electrode is preferably provided on the base member, preferably at its centre.
  • the heart pacemaker of the present invention is preferably an epicardial extra-cardiac device, the electrodes contacting the surface of the heart tissue and not being implanted therein.
  • FIG. 1 is a bottom view of a pacemaker device in accordance with an embodiment of the present invention.
  • FIG. 2 is a side view of the pacemaker of figure 1;
  • Figure 3 is a top view of the pacemaker of figure 1;
  • Figure 4 is a sectional view of a base member of the pacemaker of figure 1, illustrating the electrode structure
  • Figure 5 is a diagram of the heart
  • Figure 6 is a block diagram of the pacemaker circuitry for the pacemaker of figure 1;
  • FIGS 7 and 7A are diagrams illustrating a pulsing sequence for a pacemaker in accordance with an embodiment of the present invention.
  • Figure 8 is a top view of an alternative embodiment of a pacemaker in accordance with the present invention.
  • Figures 9A and 9B are cross sections through a base member of a pacemaker in accordance with further embodiments of the present invention showing alternative electrode structures.
  • the pacemaker shown in figures 1 to 4 is a self contained hermetically sealed unit which may be made of a resilient plastics material or a ceramic material (or any other material or materials compatible with mounting in the human body for extended periods) .
  • the pacemaker according to this first embodiment is part hemispherical in shape or dish-like and comprises a base member 10 having a concave surface 11 which forms the upper part of the pacemaker.
  • a housing member 9 has a convex surface 12 which forms the lower part of the base member.
  • the two members 9 and 10 form a sealed container which contains electronic circuitry (figure 6) , comprising at least a pulse generator means, required to operate the pacemaker.
  • the base member 11 is arranged to be positioned about the apical area of the heart. Electrodes 20 mounted on the surface of the base member 11 contact the apical surface of the heart and are arranged to provide stimulating pulses to the apical area and/or sense electrical activity of the apical area.
  • the housing member 9 mounts sensing electrodes 15 arranged to contact the diaphragm and in operation to sense physiological activity of the patient. This is described in the applicants earlier PCT application referenced above, and the diaphragm/physiological sensing function will not be described any further in the present application.
  • the pacemaker is arranged to be positioned in the chest in the sternal region approximately below the sixth rib proximate the junction between the underlying intercostal muscles and the diaphragm. With the pacemaker located in this position, the amount of relative movement between the heart and the diaphragm is minimised.
  • the electrodes 15 can then be used to sense variations in the physical activity of the patient by detecting changes in depth, rate, etc., of breathing.
  • Figure 5 is a diagram illustrating major features of the heart. The reference letters on the diagram indicate the following features:
  • the pacemaker in accordance with this embodiment is arranged to be positioned at site K, at the apical area of the heart where the free walls of the left and right ventricles meet the ventricular septum.
  • the pacemaker is therefore positioned so that the electrodes contact the apical surface of the heart and the electrodes 15, 8 contact the diaphragm.
  • the surface of the base member 11 (figure 3) also mounts an indifferent electrode 21.
  • Electrodes 20 are in the form of concentric rings. The arrangement is such that electrodes 20, 21 substantially contact the entire surface of the apical area of the heart.
  • the pacemaker circuitry preferably includes telemetry circuitry so that, after insertion of the pacemaker, the cardiologist may select the most appropriate electrodes for pacing the heart and the most appropriate electrodes 20 for sensing electrical activity of the heart.
  • pacing and sensing electrodes will be separate to avoid problems with polarisation.
  • the cardiologist can change which electrodes are used for pacing and/or sensing, to provide the most clinically appropriate stimulation.
  • the electrodes 20 used sequentially, i.e., one pulse applied to one electrode, the next pulse being applied to another electrode, etc. In some circumstances this may be advantageous.
  • Electrodes 21 and 20 are capacitive electrodes, and comprise capacitors Cl through C7. Capacitive electrodes were described in the applicants earlier application. A pulse applied to a plate on the underside of the base member 11 will be transmitted capacitively to the electrode 20 on the surface of the base member 11. It is believed that the provision of concentric ring capacitive electrodes gives the following advantages:
  • E An increase in the mechanical strength of the base member, because of the capacitive structure and the ring structure of the electrodes.
  • Several electrodes may be connected in parallel for the sensing function as well as in parallel for a stimulating function.
  • FIG 8 shows a top view of an alternative embodiment of the pacemaker.
  • the base member 11 of this alternative embodiment mounts a plurality of electrodes 30 which are arranged in "strips" 31 which extend from the central indifferent electrode 32 to the periphery of the base member 11. It can in fact be seen that the electrodes 30 in each strip 31 can be considered as being segments of the concentric electrodes 20 of the embodiment of figure 3, the strips 31 being spaced from each other by insulating areas 33 of the base member 11.
  • This arrangement provides many electrodes, each or any of which may be selected by the cardiologist for sensing and/or pacing functions.
  • the arrangement is such that the strips 31 extend about the apical area of the heart, so that electrodes can be selected to mimic the hearts "natural" pacing.
  • strips 31 are arranged to contact the apical area of the right ventricle (R) , the apical area of the left ventricle (L) and the apical area closest to the septum (S) . Electrodes in these strips can be selected for providing the most clinically appropriate pacing of the left and right ventricles and the septum. Some or all of the electrodes may be connected in parallel.
  • Electrodes may be used for sensing only, although, as discussed above, the arrangement is not limited to this operation.
  • the strips or segments lie on axes which are separated from each other by fifteen degree angles, making a total of 72 active electrodes, any combination of which may be used for pacing a heart or detecting the electrical activity of a heart.
  • a cardiac muscle stimulation wave front may be directed first to stimulate and stiffen the septum, thereby improving pump function or cardiac output then substantially simultaneously to the right and left ventricles, or biased right and left as is clinically determined by the cardiologist and/or by the physiological requirements of the patient (fed back via in built physiological control of the pacemaker) .
  • Stimulation may be by the electrodes connected in parallel or sequentially and the actual selection of the electrodes is dependent upon the patients clinical condition and the treatment selected by his or her clinician.
  • the electrodes could be of different shapes, i.e., disk shape, square triangular, etc., and could be of different numbers. The numbers and shape are not critical.
  • strips of electrodes are distributed evenly about the surface of the base member.
  • the strips may be distributed unevenly e.g., strips for the right ventricular area, the left ventricular area (in the apical area) and the septum. No other strips would be provided in such an embodiment.
  • a single 0.5ms stimulating impulse is generally applied to an electrode, recurring at a pulse repetition rate (PRR) of usually between 60 to 120 beats per minute, depending upon the clinical and physiological requirements of the patient.
  • PRR pulse repetition rate
  • this conventional single pulse method uses a significant amount of energy, and leads to a shorter pacemaker life and/or the requirement for a larger pacemaker.
  • FIGS 7 and 7A illustrate a pacing method in accordance with an embodiment of the present invention.
  • the present applicants have found that it is not necessary to provide a single, 0.5ms width pulse to cause the heart to beat. Instead, it is possible to effectively stimulate the heart by providing a group of pulses of relatively short width (shorter than the conventional pulse applied by conventional pacemakers) in a sequential burst or wave train of pulses.
  • a total period or width of the burst may extend to substantially the width of a conventional pulse, e.g., 0.5ms.
  • the amplitude of the pulses may be the same as the amplitude of a conventional pulse.
  • each "conventional pulse” there is in this embodiment of the present invention provided a group of six narrower pulses, each having a sequential pulse width (SPW) of t 4 .
  • the period of each wave train pulse is ti.
  • the width of the entire wave train (SWW) t 3 and will generally be set at the same level as a conventional pulse (which may or may not be 0.5ms, but will probably be there or there about - although not limited to) .
  • Each burst of pulses will be separated by a period t 5 , which may vary depending upon the physiological requirements of the paced heart.
  • t 5 is known as the "quiescent” or “listening period” (QP) .
  • the pulse repetition period PRP is given by t 2 , which again may vary depending upon the physiological requirements and clinical requirements of the patient. Burst or wave-train pulsing as illustrated can be applied to a conventional pacemaker or generally to any pacemaker, including the pacemaker described in relation to figures 1 to 4, 6 and 8.
  • each of the t 4 narrow pulses is lO ⁇ s, and six pulses are provided per burst, over the same t 3 time period of 0.5ms (500 ⁇ s) six pulses will be provided.
  • the applicants believe that a sequential wave train of six pulses will be able to effectively stimulate a heart. It will be appreciated that different numbers of pulses and different pulse and burst width parameters may be employed. Pulsing in this way would save considerable energy.
  • the battery life would be extended eight times, all other things being equal.
  • the same pacemaker implant life could be attained by using a smaller lighter and cheaper battery or the pacemaker would last longer using its present battery.
  • a smaller battery would enable a smaller and lighter pulse generator to be assembled.
  • Clinical analysis of various pulse times and intervals may be of value in a detailed study of a patients cardiac condition and useful as an aid to diagnosis .
  • Figure 6 is a block diagram showing the components of a pulse generator mounted in a pacemaker in accordance with figure 1 through 4 or figure 8, and being arranged to provide a pulsing sequence in accordance with figure 7.
  • the relatively narrow pulses are generated by a fixed frequency clock (or asymmetric multivibrator) 100.
  • the frequency chosen in the figure 7 example is 6kc but if it were 12kc then there would be 12 pulses in each 0.5ms burst.
  • the frequency may also be variable within pre-determined limits so as to provide more or less t 4 sequential pulses in each t 3 burst.
  • the pulses are fed to a burst control gate 200 where the PRR (pulse repetition rate) is set to time period t 2 and wherein the pulses are counted into predetermined burst lengths and then amplified in the adjustable burst pulse amplifier 300.
  • the output EP of the adjustable burst pulse amplifier is set by the cardiologist at implant via the central processing unit (CPU 600) .
  • An output controller 800 and an electrode multiplexer 900 provide the pulses to selected electrodes el through en (equivalent to electrodes 20 in figure 3 and electrodes 30 in figure 8) .
  • the CPU 600 controls the output controller 800 in accordance with clinical requirements and/or physiological inputs to select the electrodes to be used for pacing and sensing.
  • the CPU600 and clock 100 are desirably fully year 2000 compliant.
  • a telemetry system 700 enables a cardiologist to vary the operating parameters via the CPU 600 and output controller 800.
  • the transducer 400 may be connected to electrodes 15 of figure 1, which detect variations in the rate of movement of the diaphragm.
  • the telemetry system 700 includes an antenna 750 for communicating with a telemetry controller 760 (outside the patients body) operated by the cardiologist via a keyboard 770.
  • Electrodes which have been described in relation to previous embodiments are capacitive electrodes, which are preferred.
  • Figs. 9A and 9B illustrate alternative electrode structures.
  • Figs. 9A and 9B illustrate alternative "plated through" electrodes which could be used instead of the capacitive electrodes. Lead through electrodes would enable an increase in current flow, for defibrillation for example.
  • reference numeral 1 discloses a lead through electrode of conductive material
  • reference numeral 2 is an insulated base member such as the base member 11 of Figs. 8 and 4.
  • Reference numeral 4 indicates a non-corrosive joining material, such as silver, gold or platinum.
  • reference numeral 1 is again a lead through electrode.
  • Reference numeral 3, however, indicates a conductive base member.
  • Reference numeral 6 indicates an inert insulating membrane such as silicone. A plurality of electrodes could therefore be formed from the conductive base member together with “windows” in the silicone and a plurality of conductive lead through electrodes 1.
  • Many of the features of the pacemaker described above can be used for a "demand" type pacemaker, as well as for a conventional pacemaker.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

La présente invention concerne, d'une part un procédé permettant de stimuler le coeur, et d'autre part un stimulateur cardiaque. De façon conventionnelle, pour stimuler le coeur, les stimulateurs cardiaques fournissent une impulsion électrique unique pour chaque pulsation cardiaque requise. Dans le cas d'un rythme cardiaque de 60 pulsations par minute, on délivre 60 fois une impulsion d'une durée de 0,5 ms. Cela requiert une quantité importante d'énergie. Selon la présente invention, on stimule le coeur en fournissant une rafale d'une pluralité d'impulsions à montée rapide pour chacune des pulsations cardiaques. Cette utilisation de l'énergie est plus rationnelle. L'invention concerne également des faisceaux d'électrodes pour un stimulateur cardiaque à implantation apicale.
PCT/AU1998/000609 1997-07-31 1998-07-31 Modele perfectionne de stimulateur cardiaque WO1999006105A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU86174/98A AU8617498A (en) 1997-07-31 1998-07-31 Improved heart pacemaker

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO8334 1997-07-31
AUPO8334A AUPO833497A0 (en) 1997-07-31 1997-07-31 Improved heart pacemaker

Publications (1)

Publication Number Publication Date
WO1999006105A1 true WO1999006105A1 (fr) 1999-02-11

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Cited By (17)

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FR2796562A1 (fr) * 1996-04-04 2001-01-26 Medtronic Inc Techniques de stimulation d'un tissu vivant et d'enregistrement avec commande locale de sites actifs
WO2002034332A1 (fr) * 2000-10-25 2002-05-02 Medtronic, Inc. Electrodes de ceramique multicouches permettant de detecter les signaux de depolarisation cardiaque
WO2003041795A1 (fr) * 2001-11-09 2003-05-22 Medtronic, Inc. Extension d'un reseau d'electrodes multiplexees
EP1284781A4 (fr) * 2000-05-04 2006-10-04 Impulse Dynamics Nv Acheminement de signaux a travers la cloison interventriculaire droite
US7236834B2 (en) 2003-12-19 2007-06-26 Medtronic, Inc. Electrical lead body including an in-line hermetic electronic package and implantable medical device using the same
US7254443B2 (en) 2003-06-06 2007-08-07 Medtronic, Inc. Implantable medical device including a hermetic connector block extension
US7310555B2 (en) 1998-11-06 2007-12-18 Impulse Dynamics N.V. Regulation of excitable tissue control of the heart based on physiological input
US8489196B2 (en) 2003-10-03 2013-07-16 Medtronic, Inc. System, apparatus and method for interacting with a targeted tissue of a patient
US8934975B2 (en) 2010-02-01 2015-01-13 Metacure Limited Gastrointestinal electrical therapy
US8958872B2 (en) 1996-01-08 2015-02-17 Impulse Dynamics, N.V. Electrical muscle controller
US8977353B2 (en) 2004-03-10 2015-03-10 Impulse Dynamics Nv Protein activity modification
US9101765B2 (en) 1999-03-05 2015-08-11 Metacure Limited Non-immediate effects of therapy
US9289618B1 (en) 1996-01-08 2016-03-22 Impulse Dynamics Nv Electrical muscle controller
US9713723B2 (en) 1996-01-11 2017-07-25 Impulse Dynamics Nv Signal delivery through the right ventricular septum
US9931503B2 (en) 2003-03-10 2018-04-03 Impulse Dynamics Nv Protein activity modification
US11439815B2 (en) 2003-03-10 2022-09-13 Impulse Dynamics Nv Protein activity modification
US11779768B2 (en) 2004-03-10 2023-10-10 Impulse Dynamics Nv Protein activity modification

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US4289134A (en) * 1979-07-23 1981-09-15 Electro-Catheter Corporation Tripolar catheter apparatus
US4313442A (en) * 1980-07-21 1982-02-02 Cardiac Pacemakers, Inc. Atrial rate sensitive cardiac pacer apparatus
US4686987A (en) * 1981-06-18 1987-08-18 Cardiac Pacemakers, Inc. Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiologic demand
WO1994008657A1 (fr) * 1992-10-20 1994-04-28 Noel Desmond Gray Stimulateur cardiaque
US5772689A (en) * 1996-06-28 1998-06-30 Pacesetter, Inc. Implantable cardioverter-defibrillator with apical shock delivery

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289134A (en) * 1979-07-23 1981-09-15 Electro-Catheter Corporation Tripolar catheter apparatus
US4313442A (en) * 1980-07-21 1982-02-02 Cardiac Pacemakers, Inc. Atrial rate sensitive cardiac pacer apparatus
US4686987A (en) * 1981-06-18 1987-08-18 Cardiac Pacemakers, Inc. Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiologic demand
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US5772689A (en) * 1996-06-28 1998-06-30 Pacesetter, Inc. Implantable cardioverter-defibrillator with apical shock delivery

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8958872B2 (en) 1996-01-08 2015-02-17 Impulse Dynamics, N.V. Electrical muscle controller
US9289618B1 (en) 1996-01-08 2016-03-22 Impulse Dynamics Nv Electrical muscle controller
US9186514B2 (en) 1996-01-08 2015-11-17 Impulse Dynamics Nv Electrical muscle controller
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