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WO1999006577A3 - Agent for expressing and detecting a fusion polypeptide with an hpol-epitope and a polypeptide - Google Patents

Agent for expressing and detecting a fusion polypeptide with an hpol-epitope and a polypeptide Download PDF

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Publication number
WO1999006577A3
WO1999006577A3 PCT/DE1998/002221 DE9802221W WO9906577A3 WO 1999006577 A3 WO1999006577 A3 WO 1999006577A3 DE 9802221 W DE9802221 W DE 9802221W WO 9906577 A3 WO9906577 A3 WO 9906577A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
hpol
epitope
expressing
detecting
Prior art date
Application number
PCT/DE1998/002221
Other languages
German (de)
French (fr)
Other versions
WO1999006577A2 (en
Inventor
Karl-Werner Knopf
Uwe Schreiner
Reiner Strick
Jutta Hansen
Original Assignee
Deutsches Krebsforsch
Bayer Ag
Knopf Karl Werner
Uwe Schreiner
Reiner Strick
Jutta Hansen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Bayer Ag, Knopf Karl Werner, Uwe Schreiner, Reiner Strick, Jutta Hansen filed Critical Deutsches Krebsforsch
Priority to EP98948711A priority Critical patent/EP1002112A1/en
Priority to JP2000505317A priority patent/JP2001512026A/en
Publication of WO1999006577A2 publication Critical patent/WO1999006577A2/en
Publication of WO1999006577A3 publication Critical patent/WO1999006577A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

An expression vector is disclosed that codes for a fusion polypeptide with an HPOL-epitope and a polypeptide. Also disclosed is an antibody directed against such a fusion polypeptide, its use and a kit suitable for expressing and detecting the fusion polypeptide.
PCT/DE1998/002221 1997-08-01 1998-07-29 Agent for expressing and detecting a fusion polypeptide with an hpol-epitope and a polypeptide WO1999006577A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98948711A EP1002112A1 (en) 1997-08-01 1998-07-29 Agent for expressing and detecting a fusion polypeptide with an hpol-epitope and a polypeptide
JP2000505317A JP2001512026A (en) 1997-08-01 1998-07-29 Agent for expression and detection of fusion polypeptide of HPOL epitope and polypeptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19733389A DE19733389C2 (en) 1997-08-01 1997-08-01 Means for the expression and detection of a fusion polypeptide containing an HPOL epitope and a polypeptide
DE19733389.3 1997-08-01

Publications (2)

Publication Number Publication Date
WO1999006577A2 WO1999006577A2 (en) 1999-02-11
WO1999006577A3 true WO1999006577A3 (en) 1999-04-22

Family

ID=7837751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1998/002221 WO1999006577A2 (en) 1997-08-01 1998-07-29 Agent for expressing and detecting a fusion polypeptide with an hpol-epitope and a polypeptide

Country Status (5)

Country Link
EP (1) EP1002112A1 (en)
JP (1) JP2001512026A (en)
DE (1) DE19733389C2 (en)
IT (1) ITMI981685A1 (en)
WO (1) WO1999006577A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002546A1 (en) 1997-07-08 1999-01-21 Human Genome Sciences, Inc. 123 human secreted proteins

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120639A (en) * 1989-04-03 1992-06-09 E. R. Squibb & Sons, Inc. Selective inhibition of dna polymerase
WO1997007132A1 (en) * 1995-08-15 1997-02-27 Commonwealth Scientific And Industrial Research Organisation Epitope tagging system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120639A (en) * 1989-04-03 1992-06-09 E. R. Squibb & Sons, Inc. Selective inhibition of dna polymerase
WO1997007132A1 (en) * 1995-08-15 1997-02-27 Commonwealth Scientific And Industrial Research Organisation Epitope tagging system

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KNOPF C.W.: "Nucleotide sequence of the DNA polymerase gene of herpes simplex virus type 1 strain Angelotti", NUCLEIC ACIDS RESEARCH, vol. 14, no. 20, 1986, pages 8225 - 826, XP002093668 *
STRICK R. ET AL.: "Epitope mapping and functional characterization of monoclonal antibodies specific for Herpes simplex virus type I DNA polymerase", INTERVIROLOGY, vol. 40, no. 1, July 1997 (1997-07-01), pages 41 - 49, XP002093667 *

Also Published As

Publication number Publication date
JP2001512026A (en) 2001-08-21
DE19733389A1 (en) 1999-02-11
DE19733389C2 (en) 1999-08-19
EP1002112A1 (en) 2000-05-24
ITMI981685A1 (en) 2000-01-21
WO1999006577A2 (en) 1999-02-11
ITMI981685A0 (en) 1998-07-21

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