[go: up one dir, main page]

WO1999007720A3 - Process for the purification of acarbose, pharmaceutical composition containing same and its use for the treatment of diabetes - Google Patents

Process for the purification of acarbose, pharmaceutical composition containing same and its use for the treatment of diabetes Download PDF

Info

Publication number
WO1999007720A3
WO1999007720A3 PCT/IB1998/001188 IB9801188W WO9907720A3 WO 1999007720 A3 WO1999007720 A3 WO 1999007720A3 IB 9801188 W IB9801188 W IB 9801188W WO 9907720 A3 WO9907720 A3 WO 9907720A3
Authority
WO
WIPO (PCT)
Prior art keywords
acarbose
purification
diabetes
treatment
pharmaceutical composition
Prior art date
Application number
PCT/IB1998/001188
Other languages
French (fr)
Other versions
WO1999007720A2 (en
Inventor
Carl William Lawton
Randall Wolfe Swartz
Original Assignee
Univ Massachusetts Lowell
Carl William Lawton
Randall Wolfe Swartz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Massachusetts Lowell, Carl William Lawton, Randall Wolfe Swartz filed Critical Univ Massachusetts Lowell
Priority to AU83542/98A priority Critical patent/AU8354298A/en
Priority to JP2000506222A priority patent/JP2001512738A/en
Priority to EP98933857A priority patent/EP1003761A2/en
Publication of WO1999007720A2 publication Critical patent/WO1999007720A2/en
Publication of WO1999007720A3 publication Critical patent/WO1999007720A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Quinoline Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

The present invention discloses a process for the purification of acarbose comprising loading a prepurified acarbose solution on a chromatography column packed with a non-aromatic strong acid cation exchanger which is hydrophilic and has high mass transfer and subsequent elution.
PCT/IB1998/001188 1997-08-05 1998-08-03 Process for the purification of acarbose, pharmaceutical composition containing same and its use for the treatment of diabetes WO1999007720A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU83542/98A AU8354298A (en) 1997-08-05 1998-08-03 A process for the purification of acarbose
JP2000506222A JP2001512738A (en) 1997-08-05 1998-08-03 Purification method of acabose, pharmaceutical composition containing the same, and use thereof for diabetes
EP98933857A EP1003761A2 (en) 1997-08-05 1998-08-03 A process for the purification of acarbose

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI97A001880 1997-08-05
IT97MI001880A IT1293819B1 (en) 1997-08-05 1997-08-05 PROCEDURE FOR THE PREPARATION OF ACARBOSE

Publications (2)

Publication Number Publication Date
WO1999007720A2 WO1999007720A2 (en) 1999-02-18
WO1999007720A3 true WO1999007720A3 (en) 1999-04-15

Family

ID=11377722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1998/001188 WO1999007720A2 (en) 1997-08-05 1998-08-03 Process for the purification of acarbose, pharmaceutical composition containing same and its use for the treatment of diabetes

Country Status (5)

Country Link
EP (1) EP1003761A2 (en)
JP (1) JP2001512738A (en)
AU (1) AU8354298A (en)
IT (1) IT1293819B1 (en)
WO (1) WO1999007720A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3992497B2 (en) * 1999-10-28 2007-10-17 チョン・クン・ダン・ファーマシューティカル・コーポレーション High purity acarbose manufacturing method
US20020111320A1 (en) * 2000-08-07 2002-08-15 Vilmos Keri Method for purification of acarbose
HRP20010792A2 (en) * 2001-10-26 2003-04-30 Pliva D D Acarbose purification process
TWI280281B (en) * 2003-12-02 2007-05-01 Cpc Corp Taiwan A novel process to recover and purify acarbose from fermentation broth
CN102030786A (en) * 2010-11-12 2011-04-27 丽珠集团新北江制药股份有限公司 Preparation method of acarbose
CN102603822B (en) * 2012-02-21 2013-07-03 河北华荣制药有限公司 Method for improving purity of acarbose

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2347782A1 (en) * 1973-09-22 1975-04-10 Bayer Ag AMINO SUGAR DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
DE2719912A1 (en) * 1977-05-04 1978-11-16 Bayer Ag METHOD OF INSULATION FROM 0 CURVED CLAMP ON -4,6-DIDEOXY-4 ANGULAR CLAMP ON ANGULAR CLAMP ON 1 S- (1,4,6 / 5) -4,5,6-TRIHYDROXY-3-HYDROXYMETHYL-2-CYCLOHEXEN -1-YL SQUARE CLIP CLOSE -AMINO SQUARE CLIP CLOSE -ALPHA-D-GLUCOPYRANOSYL CURVED CLIP CLOSE - (1- RIGHT ARROW 4) -0- ALPHA-D-GLUCOPYRANOSYL- (1- RIGHT ARROW 4) -D- GLUCOPYRANOSE FROM BRUSH
EP0226121A2 (en) * 1985-12-13 1987-06-24 Bayer Ag Composition containing very pure acarbose
US4767850A (en) * 1984-10-25 1988-08-30 Bayer Aktiengesellschaft Process for the purification of acarbose with polymers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2347782A1 (en) * 1973-09-22 1975-04-10 Bayer Ag AMINO SUGAR DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
DE2719912A1 (en) * 1977-05-04 1978-11-16 Bayer Ag METHOD OF INSULATION FROM 0 CURVED CLAMP ON -4,6-DIDEOXY-4 ANGULAR CLAMP ON ANGULAR CLAMP ON 1 S- (1,4,6 / 5) -4,5,6-TRIHYDROXY-3-HYDROXYMETHYL-2-CYCLOHEXEN -1-YL SQUARE CLIP CLOSE -AMINO SQUARE CLIP CLOSE -ALPHA-D-GLUCOPYRANOSYL CURVED CLIP CLOSE - (1- RIGHT ARROW 4) -0- ALPHA-D-GLUCOPYRANOSYL- (1- RIGHT ARROW 4) -D- GLUCOPYRANOSE FROM BRUSH
US4767850A (en) * 1984-10-25 1988-08-30 Bayer Aktiengesellschaft Process for the purification of acarbose with polymers
EP0226121A2 (en) * 1985-12-13 1987-06-24 Bayer Ag Composition containing very pure acarbose

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHIBATA, YASUSHI ET AL: "Synthesis of pseudo-oligosaccharide glycosidase inhibitors. Part VII. Total synthesis of acarbose and adiposin-2", CARBOHYDR. RES. (1989), 189, 309-22, XP002091224 *

Also Published As

Publication number Publication date
EP1003761A2 (en) 2000-05-31
AU8354298A (en) 1999-03-01
ITMI971880A1 (en) 1999-02-05
WO1999007720A2 (en) 1999-02-18
JP2001512738A (en) 2001-08-28
IT1293819B1 (en) 1999-03-10

Similar Documents

Publication Publication Date Title
IL109579A0 (en) Bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
AU1819088A (en) New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
ZA975866B (en) Novel heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases.
UA29450C2 (en) Derivatives of hydroxamic acid, a PROCESS for PREPARATION thereof, a method for influence on diseases and pharmaceutical composition containing them
FI942075L (en) Tetrazole derivatives of bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals
AU8163394A (en) Treatment of diabetes by administration of myo-inositol
CA2192418A1 (en) New crystal modification of cdch, a process for its preparation and pharmaceutical formulations comprising this modification
AU2705588A (en) New ciclosporin crystal form, processes for its production, pharmaceutical compositions containing it and its use.
GR3000472T3 (en) Azacyclic compounds, processes for their preparation, and their use as pharmaceuticals
WO1999007720A3 (en) Process for the purification of acarbose, pharmaceutical composition containing same and its use for the treatment of diabetes
AU5100685A (en) New pyrrolobenzimidazoles, processes for the preparation thereof and pharmaceutical compositions containing them
GR3033416T3 (en) Fluorophenyl substituted alkenyl carboxylic acid guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agent as well as a medicament containing them
PT95212A (en) A process for the preparation of a composition for topical use in the treatment of capillary fragility comprising defibrotide
GR3032363T3 (en) Substituted cinnamic acid guanidides, process for their preparation, their use as cardiovascualr medicament or diagnostic agent, as well as medicament containing them
SI0748795T1 (en) Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them
FR2704773B1 (en) Process for the preparation of catalysts which can be used in dehydrogenation.
AU2869489A (en) Novel amino acid glycerides, processes for their preparation, medicaments containing them and their use
CA2175201A1 (en) Human activated protein c and process for preparing same
CA2344686A1 (en) High purity composition comprising (7.alpha.,17.alpha.)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one
SI0754680T1 (en) 4-Fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as medicament as well as medicaments containing them
CA2053604A1 (en) Improved method for the purification of acetaminophen
AU1630188A (en) Substituted compounds, processes for their preparation and their use as medicaments
EP0220653A3 (en) 3-aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds, process for preparation and use thereof, and pharmaceutical composition containing the same
FR2709753B1 (en) Organic nitrates, process for their preparation and their use as medicaments.
AU6797987A (en) A column for mass transfer and/or heat exchange and for the performance of cocurrent and counter-current chemical reactions

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: KR

WWE Wipo information: entry into national phase

Ref document number: 1998933857

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09720919

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1998933857

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA

WWW Wipo information: withdrawn in national office

Ref document number: 1998933857

Country of ref document: EP