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WO1999027997A1 - Procede et appareil depilatoires ameliores - Google Patents

Procede et appareil depilatoires ameliores Download PDF

Info

Publication number
WO1999027997A1
WO1999027997A1 PCT/US1998/025412 US9825412W WO9927997A1 WO 1999027997 A1 WO1999027997 A1 WO 1999027997A1 US 9825412 W US9825412 W US 9825412W WO 9927997 A1 WO9927997 A1 WO 9927997A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
irradiating
skin region
spots
target
Prior art date
Application number
PCT/US1998/025412
Other languages
English (en)
Inventor
Michael Kreindel
Shimon Eckhouse
Original Assignee
Esc Medical Systems Ltd.
Friedman, Mark, M.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esc Medical Systems Ltd., Friedman, Mark, M. filed Critical Esc Medical Systems Ltd.
Priority to AU16137/99A priority Critical patent/AU1613799A/en
Publication of WO1999027997A1 publication Critical patent/WO1999027997A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/00476—Hair follicles

Definitions

  • the present invention relates to hair removal and, more particularly, to an improved method and device for permanently removing hair using pulses of light.
  • both Tankovich and Anderson et al. direct a light beam at least on the order of 1 cm wide at each area of skin to be treated.
  • the width of the light beam preferably is at least as great as the depth of the follicles to be destroyed.
  • follicles may be between 0J mm and 0.5 mm deep.
  • the energy density of the light beam taught by Anderson et al. is between 10 J/cm 2 and 200 J/cm 2 , most preferably between 30 j/cm 2 and 50 J/cm 2 .
  • Figure 1 is a plot of the penetration depth of light in skin tissue, as a function of wavelength.
  • a larger volume of skin tissue is heated than is strictly necessary when destroying follicles shallower than 2 mm, and there is a risk of overheating the surrounding skin tissue.
  • an improved method for removing hairs from a skin region of a patient including the step of irradiating the skin region with light of a first wavelength shorter than about 680 nm.
  • an improved method for removing multiple hairs from a skin region of a patient, each of the hairs being in a corresponding follicle at a certain depth in the skin region including the step of irradiating a plurality of spots in a portion of the skin region having a lateral extent at least as great as the depth of the follicles, so as to deposit at least about 30 J/cm of energy in the portion of the skin region within a time shorter than about 200 ms.
  • a device for sequentially irradiating a plurality of substantially contiguous spots in a two-dimensional pattern on a target including: (a) a source of light; and (b) a mechanism for sequentially directing the light at each of the spots in the pattern.
  • a device for simultaneously irradiating a plurality of substantially contiguous spots in a two-dimensional pattern on a target including: (a) an array of apertures congruent with the pattern; (b) at least one light source; and (c) a mechanism for optically coupling the at least one light source with the apertures.
  • Figure 2 shows experimentally measured absorption coefficients of hair of four different colors, as a function of wavelength. In the especially preferred wavelength range of
  • the absorption coefficient of dark (black, red or brown) hair is between about 50 cm “1 and about 70 cm “1 , but the absorption coefficient of blond hair is only about 25 cm “1 .
  • the wavelength range of the present invention 550 nm to 680 nm.
  • the wavelength range of the present invention is preferred over the prior art wavelength range, both for shallow hair and for blond hair.
  • Light in the wavelength range of the present invention may be supplemented by light in the prior art wavelength range for removing shallow dark hair.
  • the preferred energy density and pulse length are similar to those of the prior art: an energy density between about 30 J/cm 2 and about 100 J/cm 2 , and a pulse length between about 1 ms and about 100 ms.
  • the upper end of this time span is the maximum expected thermal relaxation time of a hair follicle enclosed in
  • the therapeutic beams of light are created by diode lasers, or similar sources, that produce collimated beams of light that are narrower than the desired depth of penetration.
  • the beam or beams are directed at multiple spots within a region of skin whose lateral extent is as great as the desired depth of penetration.
  • One beam may be directed sequentially at several spots within the region, or several beams may be directed simultaneously at the several spots within the region, as long as the desired energy density of at least about 30 J/cm 2 is deposited within the desired time of no more than about 200 ms.
  • the preferred range of spot diameters within the scope of the present invention is between about 0.5 mm and about 5 mm.
  • a spot as small as 0.5 mm in diameter may require an energy density as high as about 1000 J/cm 2 .
  • the scope of the present invention also includes devices for effecting this irradiation with an effective beamwidth wider than the collimated beam produced by the light source.
  • a diode laser is optically coupled to a proximal end of an optical waveguide that is about as wide as the collimated beam produced by the laser, and the other, distal end of the waveguide is scanned across the target region.
  • several diode lasers are optically coupled to the proximal ends of several optical waveguides, and the distal ends of the waveguides are bundled in a two dimensional pattern that is as wide as the desired effective beamwidth.
  • the distal ends of the waveguides are inserted in a spacer which, w en held against the target, holds the distal ends of the waveguide stationary with respect to the target and at a fixed distance from the
  • FIG. 1 is a graph showing the penetration depth of light of various wavelengths in
  • FIG. 2 is a graph showing the absorption coefficient of hair of various colors as a function of wavelength
  • FIG. 3 shows an irradiation pattern of the present invention superposed on a prior art irradiation pattern
  • FIG. 4 is a schematic depiction, partly in perspective, of a first device of the present invention.
  • FIG. 5 is a schematic depiction, partly in perspective, of a second device of the present invention. DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • the present invention is of a method and device which can be used to remove
  • Figure 3 shows a square 10 that is 3 mm on a side. Superimposed thereon is a pattern of 16 partly overlapping circles 12, each 1 mm in diameter, for the equivalent irradiation of a skin region according to the present invention.
  • To deposit 30 J/cm 2 of light energy in the area of square 10 within 75 msec requires a 36W laser.
  • To deposit the same 30 J/cm 2 sequentially in circles 12 within 75 msec (4.1 msec per circle) requires a 50W laser.
  • To deposit the same 30 J/cm 2 simultaneously in circles 12 within 75 msec requires 16 3W lasers.
  • Figure 4 shows, schematically, a device 20 for effecting the sequential irradiation of circles 12.
  • the mechanical portion of device 20 is based on a rigid hollow rectangular frame 22. Rising from three of the corners of frame 22 are three towers 24, 26 and 28.
  • Tower 24 supports a stepping motor 36 which rotates a mirror 30 about a vertical rotation axis. From tower 26 projects an arm 34 which supports a second stepping motor 38. Stepping motor 38 rotates a mirror 32 about a horizontal rotation axis.
  • Tower 28 supports a clamp 40 which secures a distal end 46 of an optical waveguide 44 to tower 28 so that distal end 46 of optical waveguide 44 points at mirror 30.
  • Waveguide 44 is circular in cross section and 1 mm in diameter.
  • the combined rotations of mirror 30 in a horizontal plane and mirror 32 in a vertical plane directs light emerging from distal end 46 of optical waveguide 44 to any desired lateral position within the inte ⁇ or of frame 22.
  • a proximal end 48 of waveguide 44 is optically coupled to a laser 50 having an output power of 50W.
  • Laser 50 is energized and controlled by a microprocessor-based control system 52 via a power/control line 54.
  • Stepping motors 36 and 38 are energized and controlled by control system 52 via a power/control line 56.
  • frame 22 is positioned to enclose the targeted skin region.
  • Control system 52 then sequentially rotates mirrors 30 and 32 to direct the light emerging from distal end 46 to each of circles 12 in the pattern of Figure 3, spending 4.1 msec at each circle 12 while firing laser 50.
  • Distal end 46 functions in combination with mirrors 30 and 32 as an optical aperture, wherefrom light from laser 50 emerges to irradiate the target.
  • Laser 50 may be pulsed, with the pulses thereof synchronized with the rotations of mirrors 30 and 32 so that the pulses are directed at each of circles 12.
  • laser 50 may operate continuously, with mirrors 30 and 32 providing a dwell time of 4.1 msec at each of circles
  • Figure 5 is a partial schematic depiction of a device 60 for effecting the simultaneous irradiation of circles 12.
  • 16 fiber optic waveguides 64 are arranged in a bundle 62 so that distal ends 66 of waveguides 64 are deployed in the pattern of circles 12 of Figure 3.
  • Distal ends 66 of waveguides 64 are inserted together in a proximal end 74 of a hollow rectangular sleeve 70.
  • a distal end 76 of sleeve 70 is placed adjacent to a targeted skin region, sleeve 70 keeps distal ends 66 of waveguides 64 at the desired distance from the target.
  • a proximal end 68 of each waveguide 64 is optically coupled to a separate 3W diode laser 72.
  • lasers 72 With sleeve 70 in place above the target, lasers 72 are fired simultaneously for 75 msec.
  • Distal ends 66 serve as apertures, wherefrom light from lasers 72 emerges to irradiate the target.
  • Diode lasers suitable for implementing the various aspects of the present invention are manufactured by a variety of manufacturers, for example Applied Optronics Corporation. While the invention has been described with respect to a limited number of embodiments, it will be appreciated that many variations, modifications and other applications of the invention may be made.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Electromagnetism (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
  • Laser Surgery Devices (AREA)

Abstract

L'invention concerne un procédé amélioré d'élimination de poils et des appareils associés. Pour éliminer des poils superficiels et/ou clairs, on irradie la zone cutanée cible avec une lumière possédant une longueur d'onde comprise entre 550 nm et 680 nm et une densité d'énergie comprise entre 30 J/cm2 et 100 J/cm2, pendant une durée comprise entre 1 ms et 100 ms. On irradie une zone cible environ aussi large que la profondeur des follicules pileux à détruire en utilisant une ou plusieurs sources, telles que des lasers, produisant des faisceaux considérablement plus étroits, soit en balayant la cible avec un faisceau, soit en irradiant la cible simultanément au moyen de plusieurs faisceaux.
PCT/US1998/025412 1997-12-01 1998-12-01 Procede et appareil depilatoires ameliores WO1999027997A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16137/99A AU1613799A (en) 1997-12-01 1998-12-01 Improved depilatory method and device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98062597A 1997-12-01 1997-12-01
US08/980,625 1997-12-01

Publications (1)

Publication Number Publication Date
WO1999027997A1 true WO1999027997A1 (fr) 1999-06-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/025412 WO1999027997A1 (fr) 1997-12-01 1998-12-01 Procede et appareil depilatoires ameliores

Country Status (2)

Country Link
AU (1) AU1613799A (fr)
WO (1) WO1999027997A1 (fr)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2167252A1 (es) * 2000-07-13 2002-05-01 Villacampa Francisco J Arcusa Procedimiento para el tratamiento de un tejido por laser
US6607523B1 (en) 1999-03-19 2003-08-19 Asah Medico A/S Apparatus for tissue treatment
US6723090B2 (en) 2001-07-02 2004-04-20 Palomar Medical Technologies, Inc. Fiber laser device for medical/cosmetic procedures
WO2005007003A1 (fr) * 2003-07-11 2005-01-27 Reliant Technologies, Inc. Procede et appareil pour phototherapie fractionnelle de la peau
US6878144B2 (en) 1996-12-02 2005-04-12 Palomar Medical Technologies, Inc. System for electromagnetic radiation dermatology and head for use therewith
US6974451B2 (en) 1997-05-15 2005-12-13 Palomar Medical Technologies, Inc. Light energy delivery head
US6997923B2 (en) 2000-12-28 2006-02-14 Palomar Medical Technologies, Inc. Method and apparatus for EMR treatment
US7029469B2 (en) 1998-12-03 2006-04-18 Palomar Medical Technologies, Inc. Method and apparatus for laser removal of hair
US7044959B2 (en) 2002-03-12 2006-05-16 Palomar Medical Technologies, Inc. Method and apparatus for hair growth management
DE102004058263A1 (de) * 2004-12-03 2006-06-08 Rehau Ag + Co Einrichtung zur Führung eines Strahles, insbesondere eines Laserstrahles, Vorrichtung zur optischen Bearbeitung, insbesondere zur Laserbearbeitung, und Verfahren zum Führen eines Strahles, insbesondere eines Laserstrahles
US7060061B2 (en) 1998-03-27 2006-06-13 Palomar Medical Technologies, Inc. Method and apparatus for the selective targeting of lipid-rich tissues
US7077840B2 (en) 1997-05-15 2006-07-18 Palomar Medical Technologies, Inc. Heads for dermatology treatment
US7135033B2 (en) 2002-05-23 2006-11-14 Palomar Medical Technologies, Inc. Phototreatment device for use with coolants and topical substances
US7204832B2 (en) 1996-12-02 2007-04-17 Pálomar Medical Technologies, Inc. Cooling system for a photo cosmetic device
US7220254B2 (en) 2003-12-31 2007-05-22 Palomar Medical Technologies, Inc. Dermatological treatment with visualization
US7274155B2 (en) 2001-03-01 2007-09-25 Palomar Medical Technologies, Inc. Flash lamp drive circuit
US7282060B2 (en) 2003-12-23 2007-10-16 Reliant Technologies, Inc. Method and apparatus for monitoring and controlling laser-induced tissue treatment
US7351252B2 (en) 2002-06-19 2008-04-01 Palomar Medical Technologies, Inc. Method and apparatus for photothermal treatment of tissue at depth
US7540869B2 (en) 2001-12-27 2009-06-02 Palomar Medical Technologies, Inc. Method and apparatus for improved vascular related treatment
EP1585432A4 (fr) * 2002-10-22 2010-06-02 Reliant Technologies Llc Appareil dermatologique et procede associe
USRE42594E1 (en) 1998-10-16 2011-08-02 Reliant Technologies, Inc. Tissue cooling rod for laser surgery
US8291913B2 (en) 2004-06-14 2012-10-23 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
US8915948B2 (en) 2002-06-19 2014-12-23 Palomar Medical Technologies, Llc Method and apparatus for photothermal treatment of tissue at depth
US9028536B2 (en) 2006-08-02 2015-05-12 Cynosure, Inc. Picosecond laser apparatus and methods for its operation and use
US9351792B2 (en) 2003-03-27 2016-05-31 The General Hospital Corporation Method and apparatus for dermatological treatment and fractional skin resurfacing
US9780518B2 (en) 2012-04-18 2017-10-03 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US10245107B2 (en) 2013-03-15 2019-04-02 Cynosure, Inc. Picosecond optical radiation systems and methods of use
US10434324B2 (en) 2005-04-22 2019-10-08 Cynosure, Llc Methods and systems for laser treatment using non-uniform output beam
US11418000B2 (en) 2018-02-26 2022-08-16 Cynosure, Llc Q-switched cavity dumped sub-nanosecond laser

Citations (1)

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Publication number Priority date Publication date Assignee Title
US5182857A (en) * 1989-11-02 1993-02-02 U.S. Philips Corp. Shaving apparatus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182857A (en) * 1989-11-02 1993-02-02 U.S. Philips Corp. Shaving apparatus

Cited By (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431719B2 (en) 1996-12-02 2008-10-07 Palomar Medical Technologies, Inc. System for electromagnetic radiation dermatology and head for use therewith
US7204832B2 (en) 1996-12-02 2007-04-17 Pálomar Medical Technologies, Inc. Cooling system for a photo cosmetic device
US6878144B2 (en) 1996-12-02 2005-04-12 Palomar Medical Technologies, Inc. System for electromagnetic radiation dermatology and head for use therewith
US7077840B2 (en) 1997-05-15 2006-07-18 Palomar Medical Technologies, Inc. Heads for dermatology treatment
US6974451B2 (en) 1997-05-15 2005-12-13 Palomar Medical Technologies, Inc. Light energy delivery head
US7060061B2 (en) 1998-03-27 2006-06-13 Palomar Medical Technologies, Inc. Method and apparatus for the selective targeting of lipid-rich tissues
USRE43881E1 (en) 1998-10-16 2012-12-25 Reliant Technologies, Inc. Tissue cooling rod for laser surgery
USRE46208E1 (en) 1998-10-16 2016-11-22 Reliant Technologies, Llc Method for cryogenically treating tissue below the skin surface
USRE42594E1 (en) 1998-10-16 2011-08-02 Reliant Technologies, Inc. Tissue cooling rod for laser surgery
US7029469B2 (en) 1998-12-03 2006-04-18 Palomar Medical Technologies, Inc. Method and apparatus for laser removal of hair
US6607523B1 (en) 1999-03-19 2003-08-19 Asah Medico A/S Apparatus for tissue treatment
ES2167252A1 (es) * 2000-07-13 2002-05-01 Villacampa Francisco J Arcusa Procedimiento para el tratamiento de un tejido por laser
US6997923B2 (en) 2000-12-28 2006-02-14 Palomar Medical Technologies, Inc. Method and apparatus for EMR treatment
US7274155B2 (en) 2001-03-01 2007-09-25 Palomar Medical Technologies, Inc. Flash lamp drive circuit
US7531967B2 (en) 2001-03-01 2009-05-12 Palomar Medical Technologies, Inc. Flashlamp drive circuit
US6723090B2 (en) 2001-07-02 2004-04-20 Palomar Medical Technologies, Inc. Fiber laser device for medical/cosmetic procedures
US7540869B2 (en) 2001-12-27 2009-06-02 Palomar Medical Technologies, Inc. Method and apparatus for improved vascular related treatment
US7044959B2 (en) 2002-03-12 2006-05-16 Palomar Medical Technologies, Inc. Method and apparatus for hair growth management
US7135033B2 (en) 2002-05-23 2006-11-14 Palomar Medical Technologies, Inc. Phototreatment device for use with coolants and topical substances
US7351252B2 (en) 2002-06-19 2008-04-01 Palomar Medical Technologies, Inc. Method and apparatus for photothermal treatment of tissue at depth
US8915948B2 (en) 2002-06-19 2014-12-23 Palomar Medical Technologies, Llc Method and apparatus for photothermal treatment of tissue at depth
US10556123B2 (en) 2002-06-19 2020-02-11 Palomar Medical Technologies, Llc Method and apparatus for treatment of cutaneous and subcutaneous conditions
US10500413B2 (en) 2002-06-19 2019-12-10 Palomar Medical Technologies, Llc Method and apparatus for treatment of cutaneous and subcutaneous conditions
EP1585432A4 (fr) * 2002-10-22 2010-06-02 Reliant Technologies Llc Appareil dermatologique et procede associe
US9351792B2 (en) 2003-03-27 2016-05-31 The General Hospital Corporation Method and apparatus for dermatological treatment and fractional skin resurfacing
WO2005007003A1 (fr) * 2003-07-11 2005-01-27 Reliant Technologies, Inc. Procede et appareil pour phototherapie fractionnelle de la peau
US7282060B2 (en) 2003-12-23 2007-10-16 Reliant Technologies, Inc. Method and apparatus for monitoring and controlling laser-induced tissue treatment
US7220254B2 (en) 2003-12-31 2007-05-22 Palomar Medical Technologies, Inc. Dermatological treatment with visualization
US7309335B2 (en) 2003-12-31 2007-12-18 Palomar Medical Technologies, Inc. Dermatological treatment with visualization
US8291913B2 (en) 2004-06-14 2012-10-23 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
DE102004058263A1 (de) * 2004-12-03 2006-06-08 Rehau Ag + Co Einrichtung zur Führung eines Strahles, insbesondere eines Laserstrahles, Vorrichtung zur optischen Bearbeitung, insbesondere zur Laserbearbeitung, und Verfahren zum Führen eines Strahles, insbesondere eines Laserstrahles
US10434324B2 (en) 2005-04-22 2019-10-08 Cynosure, Llc Methods and systems for laser treatment using non-uniform output beam
US10966785B2 (en) 2006-08-02 2021-04-06 Cynosure, Llc Picosecond laser apparatus and methods for its operation and use
US10849687B2 (en) 2006-08-02 2020-12-01 Cynosure, Llc Picosecond laser apparatus and methods for its operation and use
US11712299B2 (en) 2006-08-02 2023-08-01 Cynosure, LLC. Picosecond laser apparatus and methods for its operation and use
US9028536B2 (en) 2006-08-02 2015-05-12 Cynosure, Inc. Picosecond laser apparatus and methods for its operation and use
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US9780518B2 (en) 2012-04-18 2017-10-03 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
US10581217B2 (en) 2012-04-18 2020-03-03 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US12431683B2 (en) 2012-04-18 2025-09-30 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US12068571B2 (en) 2012-04-18 2024-08-20 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US10305244B2 (en) 2012-04-18 2019-05-28 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US11095087B2 (en) 2012-04-18 2021-08-17 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US11664637B2 (en) 2012-04-18 2023-05-30 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US11446086B2 (en) 2013-03-15 2022-09-20 Cynosure, Llc Picosecond optical radiation systems and methods of use
US10245107B2 (en) 2013-03-15 2019-04-02 Cynosure, Inc. Picosecond optical radiation systems and methods of use
US10285757B2 (en) 2013-03-15 2019-05-14 Cynosure, Llc Picosecond optical radiation systems and methods of use
US12193734B2 (en) 2013-03-15 2025-01-14 Cynosure, Llc Picosecond optical radiation systems and methods of use
US10765478B2 (en) 2013-03-15 2020-09-08 Cynosurce, Llc Picosecond optical radiation systems and methods of use
US11418000B2 (en) 2018-02-26 2022-08-16 Cynosure, Llc Q-switched cavity dumped sub-nanosecond laser
US11791603B2 (en) 2018-02-26 2023-10-17 Cynosure, LLC. Q-switched cavity dumped sub-nanosecond laser

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