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WO1999030157A3 - Neuropilines et leur utilisation a des fins de diagnostic et de pronostic du cancer - Google Patents

Neuropilines et leur utilisation a des fins de diagnostic et de pronostic du cancer Download PDF

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Publication number
WO1999030157A3
WO1999030157A3 PCT/US1998/026127 US9826127W WO9930157A3 WO 1999030157 A3 WO1999030157 A3 WO 1999030157A3 US 9826127 W US9826127 W US 9826127W WO 9930157 A3 WO9930157 A3 WO 9930157A3
Authority
WO
WIPO (PCT)
Prior art keywords
neuropilins
prognosis
diagnosis
cancer
methods
Prior art date
Application number
PCT/US1998/026127
Other languages
English (en)
Other versions
WO1999030157A2 (fr
WO1999030157A9 (fr
Inventor
Michael Klagsbrun
Shay Soker
Hua-Quan Miao
Seiji Takashima
Original Assignee
Childrens Medical Center
Michael Klagsbrun
Shay Soker
Miao Hua Quan
Seiji Takashima
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center, Michael Klagsbrun, Shay Soker, Miao Hua Quan, Seiji Takashima filed Critical Childrens Medical Center
Priority to AU18108/99A priority Critical patent/AU1810899A/en
Publication of WO1999030157A2 publication Critical patent/WO1999030157A2/fr
Publication of WO1999030157A3 publication Critical patent/WO1999030157A3/fr
Publication of WO1999030157A9 publication Critical patent/WO1999030157A9/fr
Priority to US09/583,638 priority patent/US6635421B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des récepteurs du facteur de croissance de l'endothélium vasculaire (VEGFR), et des neuropilines telles que les VEGF165R/NP-1 et NP-2 qui sont associées au potentiel métastatique des cellules malignes, et sur leur utilisation pour diagnostiquer ou pronostiquer le cancer. Les neuropilines VEGF165R/NP-1 et NP-2 sont préférées, mais toute neuropiline ou tout VEGFR dont les constituants présentent 85 % d'homologie avec lesdites VEGF165R/NP-1 et NP-2, ou mieux 90 %, ou mieux encore 95 %, peut être utilisé.
PCT/US1998/026127 1997-12-09 1998-12-09 Neuropilines et leur utilisation a des fins de diagnostic et de pronostic du cancer WO1999030157A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU18108/99A AU1810899A (en) 1997-12-09 1998-12-09 Neuropilins and use thereof in methods for diagnosis and prognosis of cancer
US09/583,638 US6635421B1 (en) 1997-12-09 2000-05-30 Neuropilins and use thereof in methods for diagnosis and prognosis of cancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6915597P 1997-12-09 1997-12-09
US60/069,155 1997-12-09
US6968797P 1997-12-12 1997-12-12
US60/069,687 1997-12-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/583,638 Continuation US6635421B1 (en) 1997-12-09 2000-05-30 Neuropilins and use thereof in methods for diagnosis and prognosis of cancer

Publications (3)

Publication Number Publication Date
WO1999030157A2 WO1999030157A2 (fr) 1999-06-17
WO1999030157A3 true WO1999030157A3 (fr) 1999-07-22
WO1999030157A9 WO1999030157A9 (fr) 1999-10-21

Family

ID=26749747

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1998/026127 WO1999030157A2 (fr) 1997-12-09 1998-12-09 Neuropilines et leur utilisation a des fins de diagnostic et de pronostic du cancer
PCT/US1998/026103 WO1999029861A1 (fr) 1997-12-09 1998-12-09 Peptides antagonistes du facteur de croissance de l'endothelium vasculaire

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US1998/026103 WO1999029861A1 (fr) 1997-12-09 1998-12-09 Peptides antagonistes du facteur de croissance de l'endothelium vasculaire

Country Status (5)

Country Link
EP (1) EP1037994A1 (fr)
JP (2) JP4312955B2 (fr)
AU (2) AU1906099A (fr)
CA (1) CA2313390A1 (fr)
WO (2) WO1999030157A2 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7423125B2 (en) 1995-08-01 2008-09-09 Vegenics Limited Antibodies to VEGF-C
US6635421B1 (en) * 1997-12-09 2003-10-21 Children's Medical Center Corporation Neuropilins and use thereof in methods for diagnosis and prognosis of cancer
EP1248642A4 (fr) * 2000-01-18 2005-05-18 Ludwig Inst Cancer Res Inhibiteur peptidomimetique de vegf-d/vegf-c/vegf
ATE377081T1 (de) 2000-02-25 2007-11-15 Ludwig Inst Cancer Res Material und verfahren die hybridvaskularendothelwachstumfaktoren dns und proteine enthalten und screeningverfahren für modulatoren
US8263739B2 (en) 2000-06-02 2012-09-11 Bracco Suisse Sa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
WO2001091805A2 (fr) 2000-06-02 2001-12-06 Bracco Research Usa Composes pour le ciblage des cellules endotheliales, compositions les contenant et leurs procedes d'utilisation
WO2002020813A2 (fr) * 2000-09-05 2002-03-14 Karolinska Innovations Ab Materiaux et procedes concernant des inhibiteurs de croissance cellulaire endotheliale
GB0029015D0 (en) 2000-11-28 2001-01-10 Univ London Medical device
US7611711B2 (en) 2001-01-17 2009-11-03 Vegenics Limited VEGFR-3 inhibitor materials and methods
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (fr) 2002-03-01 2007-03-21 Dyax Corp Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
GB0207644D0 (en) * 2002-04-02 2002-05-15 Ark Therapeutics Ltd Peptides and their use
CA2517939C (fr) 2003-03-03 2015-11-24 Dyax Corp. Peptides presentant une fixation specifique avec le recepteur de hgf (cmet) et ses utilisations
JP2009504679A (ja) * 2005-08-12 2009-02-05 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｖｅｇｆアンタゴニストを用いて疾患を処置する方法
ATE502956T1 (de) 2005-08-15 2011-04-15 Vegenics Pty Ltd Modifizierte vegf und pdgf mit verbesserten angiogenen eigenschaften
RU2395090C2 (ru) * 2005-10-21 2010-07-20 БАЙЕР ХелсКер ЛЛСи Способы прогнозирования и предсказания рака и мониторинг терапии раковых заболеваний
UA96139C2 (uk) 2005-11-08 2011-10-10 Дженентек, Інк. Антитіло до нейропіліну-1 (nrp1)
WO2011087066A1 (fr) * 2010-01-14 2011-07-21 株式会社三和化学研究所 Produit pharmaceutique destiné au traitement prophylactique ou thérapeutique de troubles accompagnés d'une angiogenèse oculaire et/ou d'une perméabilité vasculaire oculaire supérieure à la normale
MX2013000083A (es) 2010-07-09 2013-02-26 Genentech Inc Anticuerpos de anti-neuropilina y metodos de uso.
CN113226367B (zh) 2018-04-06 2025-05-06 Atyr医药公司 包括抗nrp2抗体的组合物和方法
CA3156803A1 (fr) 2019-10-03 2021-04-08 Atyr Pharma, Inc. Compositions et methodes comprenant des anticorps anti-nrp2

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011499A1 (fr) * 1992-11-13 1994-05-26 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Flk-1 UTILISE COMME RECEPTEUR POUR FACTEUR DE CROISSANCE ENDOTHELIAL VASCULAIRE
WO1997008313A1 (fr) * 1995-08-25 1997-03-06 Genentech, Inc. Variants du facteur de croissance des cellules de l'endothelium vasculaire, leurs utilisations et leurs procedes de fabrication

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011499A1 (fr) * 1992-11-13 1994-05-26 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Flk-1 UTILISE COMME RECEPTEUR POUR FACTEUR DE CROISSANCE ENDOTHELIAL VASCULAIRE
WO1997008313A1 (fr) * 1995-08-25 1997-03-06 Genentech, Inc. Variants du facteur de croissance des cellules de l'endothelium vasculaire, leurs utilisations et leurs procedes de fabrication

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. L. KOLODKIN ET AL.: "Neuropilin is a semaphorin III receptor.", CELL, vol. 90, 22 August 1997 (1997-08-22), pages 753 - 762, XP002084496 *
H. CHEN ET AL.: "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins sema E and sema IV but not sema III.", NEURON, vol. 19, September 1997 (1997-09-01), pages 547 - 559, XP002084494 *
S. SOKER ET AL.: "Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 10, 8 March 1996 (1996-03-08), pages 5761 - 5767, XP002097905 *
S. SOKER ET AL.: "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.", CELL, vol. 92, 20 March 1998 (1998-03-20), pages 735 - 745, XP002097906 *
T. OMURA ET AL.: "Identification of a 190-kDa vascular endothelial growth factor 165 cell surface binding protein on a human glioma cell line.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 37, 12 September 1997 (1997-09-12), pages 23317 - 23322, XP002097907 *

Also Published As

Publication number Publication date
EP1037994A1 (fr) 2000-09-27
CA2313390A1 (fr) 1999-06-17
WO1999030157A2 (fr) 1999-06-17
JP2001526032A (ja) 2001-12-18
AU1906099A (en) 1999-06-28
WO1999030157A9 (fr) 1999-10-21
JP4312955B2 (ja) 2009-08-12
WO1999029861A1 (fr) 1999-06-17
JP2009148293A (ja) 2009-07-09
AU1810899A (en) 1999-06-28

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