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WO1999030695A8 - Substituted amidino compounds in the treatment of chronic obstructive pulmonary disease - Google Patents

Substituted amidino compounds in the treatment of chronic obstructive pulmonary disease

Info

Publication number
WO1999030695A8
WO1999030695A8 PCT/EP1998/008066 EP9808066W WO9930695A8 WO 1999030695 A8 WO1999030695 A8 WO 1999030695A8 EP 9808066 W EP9808066 W EP 9808066W WO 9930695 A8 WO9930695 A8 WO 9930695A8
Authority
WO
WIPO (PCT)
Prior art keywords
aliphatic
hydrocarbon radical
radical
hydroxy
araliphatic
Prior art date
Application number
PCT/EP1998/008066
Other languages
French (fr)
Other versions
WO1999030695A1 (en
Inventor
Paul James Marshall
Roger Aki Fujimoto
Original Assignee
Novartis Ag
Novartis Erfind Verwalt Gmbh
Paul James Marshall
Roger Aki Fujimoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR9813538-4A priority Critical patent/BR9813538A/en
Priority to AU22703/99A priority patent/AU2270399A/en
Priority to PL98340910A priority patent/PL340910A1/en
Priority to JP2000538678A priority patent/JP2002508313A/en
Priority to IL13666398A priority patent/IL136663A0/en
Priority to KR1020007006371A priority patent/KR20010033018A/en
Priority to CA002314395A priority patent/CA2314395A1/en
Priority to SK881-2000A priority patent/SK8812000A3/en
Priority to HU0100733A priority patent/HUP0100733A3/en
Priority to EP98966292A priority patent/EP1037617A1/en
Application filed by Novartis Ag, Novartis Erfind Verwalt Gmbh, Paul James Marshall, Roger Aki Fujimoto filed Critical Novartis Ag
Publication of WO1999030695A1 publication Critical patent/WO1999030695A1/en
Publication of WO1999030695A8 publication Critical patent/WO1999030695A8/en
Priority to NO20002943A priority patent/NO20002943D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Use in medicaments for the treatment of chronic obstructive pulmonary disease of compounds of formula (I) wherein the C(=NH)-NHR3 group may be in tautomeric or isomeric form, or a pharmaceutically acceptable salt thereof, in which: R1 is amino which is mono- or disubstituted by a substitutent selected from an aliphatic hydrocarbon radical, an araliphatic hydrocarbon radical, an aromatic radical, and a cycloaliphatic hydrocarbon radical or is amino which is disubstituted by a divalent aliphatic hydrocarbon radical or a said radical interrupted by oxygen; R2 is hydrogen, halogen, trifluoromethyl, an aliphatic hydrocarbon radical, hydroxy or is hydroxy which is etherified by an aliphatic, araliphatic or aromatic alcohol or by an aliphatic alcohol which is substituted by carboxy, by esterified carboxy or by amidated carboxy or which is esterified by an aliphatic or araliphatic carboxylic acid; R3 is hydrogen or an acyl radical which is derived from an organic carbonic acid, an organic carboxylic acid, a sulfonic acid, or a carbamic acid; X1 and X3, independently or one another, are oxygen (-O-) or sulphur (-S-); and X2 is a divalent aliphatic hydrocarbon radical which may be interrupted by an aromatic radical; wherein the phenyl rings of formula (I) may be, independently or one another, further substituted by one or more substituents selected from halogen, trifluoromethyl, an aliphatic hydrocarbon radical, hydroxy, and hydroxy which is etherified by an aliphatic alcohol or which is esterified by an aliphatic or araliphatic carboxylic acid; wherein aryl in the above definitions may be, independently of one another, further substituted by one or more substitutents selected from halogen, trifluoromethyl, an aliphatic hydrocarbon radical, hydroxy, and hydroxy which is ethereified by an aliphatic alcohol or which is esterified by an aliphatic or araliphatic carboxylic acid; wherein a cycloaliphatic hydrocarbon radical may be substituted by an aliphatic radical.
PCT/EP1998/008066 1997-12-12 1998-12-10 Substituted amidino compounds in the treatment of chronic obstructive pulmonary disease WO1999030695A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
HU0100733A HUP0100733A3 (en) 1997-12-12 1998-12-10 Amidino compounds for use in the treatment of chronic obstructive pulmonary
PL98340910A PL340910A1 (en) 1997-12-12 1998-12-10 Substituted amidine compounds useful in treating chronic bronchitis with accompanying ephysema
JP2000538678A JP2002508313A (en) 1997-12-12 1998-12-10 Substituted amidino compounds in the treatment of chronic obstructive pulmonary disease
IL13666398A IL136663A0 (en) 1997-12-12 1998-12-10 Use of substituted amino compounds in the treatment of chronic obstructive pulmonary disease
KR1020007006371A KR20010033018A (en) 1997-12-12 1998-12-10 Use of Substituted Amidino Compounds in The Treatment of Chronic Obstructive Pulmonary Disease
BR9813538-4A BR9813538A (en) 1997-12-12 1998-12-10 Substituted amidino compounds in the treatment of chronic obstructive pulmonary disease
SK881-2000A SK8812000A3 (en) 1997-12-12 1998-12-10 Substituted amidino compounds in the treatment of chronic obstructive pulmonary disease
CA002314395A CA2314395A1 (en) 1997-12-12 1998-12-10 Use of substituted amidino compounds in the treatment of chronic obstructive pulmonary disease
EP98966292A EP1037617A1 (en) 1997-12-12 1998-12-10 Substituted amidino compounds in the treatment of chronic obstructive pulmonary disease
AU22703/99A AU2270399A (en) 1997-12-12 1998-12-10 Use of substituted amidino compounds in the treatment of chronic obstructive pulmonary disease
NO20002943A NO20002943D0 (en) 1997-12-12 2000-06-08 Use of substituted amidino compounds in the treatment of chronic obstructive pulmonary disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11200297P 1997-12-12 1997-12-12
US60/112,002 1997-12-12

Publications (2)

Publication Number Publication Date
WO1999030695A1 WO1999030695A1 (en) 1999-06-24
WO1999030695A8 true WO1999030695A8 (en) 1999-07-29

Family

ID=22341609

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/008066 WO1999030695A1 (en) 1997-12-12 1998-12-10 Substituted amidino compounds in the treatment of chronic obstructive pulmonary disease

Country Status (15)

Country Link
US (1) US6380259B2 (en)
EP (1) EP1037617A1 (en)
JP (1) JP2002508313A (en)
KR (1) KR20010033018A (en)
CN (1) CN1281360A (en)
AU (1) AU2270399A (en)
BR (1) BR9813538A (en)
CA (1) CA2314395A1 (en)
HU (1) HUP0100733A3 (en)
ID (1) ID24720A (en)
IL (1) IL136663A0 (en)
NO (1) NO20002943D0 (en)
PL (1) PL340910A1 (en)
SK (1) SK8812000A3 (en)
WO (1) WO1999030695A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002352726A1 (en) 2001-11-15 2003-06-10 Galileo Laboratories, Inc. Formulations and methods for treatment or amelioration of inflammatory conditions
GB2445920A (en) * 2007-01-25 2008-07-30 Mucokinetica Ltd Amidino compounds for treatment of respiratory disease
WO2016040570A2 (en) 2014-09-12 2016-03-17 Children's Medical Center Corporation Dietary emulsion formulations and methods for using the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488160A (en) * 1991-06-11 1996-01-30 Ciba-Geigy Corporation Amidino compounds, their manufacture and method of treatment
US5246965A (en) 1991-06-11 1993-09-21 Ciba-Geigy Arylethers, their manufacture and methods of treatment
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
NZ246593A (en) 1992-02-05 1997-07-27 Boehringer Ingelheim Int Amidine derivatives; their preparation and medicaments containing them
US5455274A (en) * 1992-12-09 1995-10-03 Ciba-Geigy Corporation Hydroxyamidine derivatives
US5846963A (en) * 1995-06-07 1998-12-08 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
DE4309285A1 (en) 1993-03-23 1994-09-29 Boehringer Ingelheim Kg Heterocyclic-containing amidine derivatives, their preparation and use
DE4424714A1 (en) 1994-07-13 1996-01-18 Boehringer Ingelheim Kg New chemical compound, its production and its use as an arsenic
DE4424713A1 (en) 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Substituted benzamidines, their preparation and their use as pharmaceutical substances
DE19546452A1 (en) 1995-12-13 1997-06-19 Boehringer Ingelheim Kg New phenylamidine derivatives, process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
EP1037617A1 (en) 2000-09-27
HUP0100733A2 (en) 2001-08-28
HUP0100733A3 (en) 2003-07-28
IL136663A0 (en) 2001-06-14
SK8812000A3 (en) 2000-12-11
CN1281360A (en) 2001-01-24
US20010000341A1 (en) 2001-04-19
US6380259B2 (en) 2002-04-30
WO1999030695A1 (en) 1999-06-24
PL340910A1 (en) 2001-03-12
KR20010033018A (en) 2001-04-25
NO20002943L (en) 2000-06-08
BR9813538A (en) 2000-10-10
ID24720A (en) 2000-08-03
JP2002508313A (en) 2002-03-19
NO20002943D0 (en) 2000-06-08
AU2270399A (en) 1999-07-05
CA2314395A1 (en) 1999-06-24

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