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WO1999031256A3 - Proteines cathepsine dc, adn codant pour ces proteines et utilisation de ces proteines dans l'etablissement de pronostics pour les cancers chez l'homme - Google Patents

Proteines cathepsine dc, adn codant pour ces proteines et utilisation de ces proteines dans l'etablissement de pronostics pour les cancers chez l'homme Download PDF

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Publication number
WO1999031256A3
WO1999031256A3 PCT/US1998/026920 US9826920W WO9931256A3 WO 1999031256 A3 WO1999031256 A3 WO 1999031256A3 US 9826920 W US9826920 W US 9826920W WO 9931256 A3 WO9931256 A3 WO 9931256A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
polypeptides
cathepsin
dna encoding
human cancer
Prior art date
Application number
PCT/US1998/026920
Other languages
English (en)
Other versions
WO1999031256A2 (fr
Inventor
Dirk Michael Anderson
Terry Y Nakagawa
Original Assignee
Immunex Corp
Dirk Michael Anderson
Terry Y Nakagawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp, Dirk Michael Anderson, Terry Y Nakagawa filed Critical Immunex Corp
Priority to AU19266/99A priority Critical patent/AU1926699A/en
Publication of WO1999031256A2 publication Critical patent/WO1999031256A2/fr
Publication of WO1999031256A3 publication Critical patent/WO1999031256A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne de nouveaux polypeptides cathepsine DC isolés et purifiés, les acide nucléiques codant pour ces polypeptides, les protéinases ainsi codées, des techniques permettant de produire des formes recombinantes de ces polypeptides, les anticorps produits contre ces polypeptides, des peptides fragmentés dérivés de ces polypeptides, ainsi que les utilisations de ces diverses formes.
PCT/US1998/026920 1997-12-18 1998-12-18 Proteines cathepsine dc, adn codant pour ces proteines et utilisation de ces proteines dans l'etablissement de pronostics pour les cancers chez l'homme WO1999031256A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19266/99A AU1926699A (en) 1997-12-18 1998-12-18 Cathepsin dc proteins, dna encoding the proteins, and their use in human cancer prognosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6940997P 1997-12-18 1997-12-18
US60/069,409 1997-12-18

Publications (2)

Publication Number Publication Date
WO1999031256A2 WO1999031256A2 (fr) 1999-06-24
WO1999031256A3 true WO1999031256A3 (fr) 1999-11-04

Family

ID=22088795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/026920 WO1999031256A2 (fr) 1997-12-18 1998-12-18 Proteines cathepsine dc, adn codant pour ces proteines et utilisation de ces proteines dans l'etablissement de pronostics pour les cancers chez l'homme

Country Status (2)

Country Link
AU (1) AU1926699A (fr)
WO (1) WO1999031256A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60224002T2 (de) * 2002-02-14 2008-11-06 Biofrontera Pharmaceuticals Ag Kathepsin Y Inhibitoren für die Entwicklung von Medikamenten zur Schmerzbehandlung
US6974672B2 (en) 2002-03-19 2005-12-13 Amgen Inc. Gene amplification in cancer
AU2003210347A1 (en) * 2003-02-25 2004-09-17 Biofrontera Pharmaceuticals Gmbh Cathepsin y for the treatment of pain
JP2007516725A (ja) * 2003-12-30 2007-06-28 アベンティス・ファーマスーティカルズ・インコーポレイテツド 関節リウマチ及び他の自己免疫疾患の治療のためのカテプシンｚ阻害剤の使用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039194A1 (fr) * 1995-06-06 1996-12-12 Athena Neurosciences, Inc. Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039194A1 (fr) * 1995-06-06 1996-12-12 Athena Neurosciences, Inc. Nouvelle cathepsine et procedes et compositions d'inhibition de cathepsine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NÄGLER D AND MÉNARD R: "Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions", FEBS LETTERS., vol. 434, 1998, AMSTERDAM NL, pages 135 - 139, XP002101279 *
SANTAMARIA I ET AL: "Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 273, no. 27, 3 July 1998 (1998-07-03), MD US, pages 16816 - 16823, XP002101278 *

Also Published As

Publication number Publication date
WO1999031256A2 (fr) 1999-06-24
AU1926699A (en) 1999-07-05

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