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WO1999032066A2 - Utilisation d'un ciment osteocompatible pour la fixation et la stabilisation de dents naturelles et/ou d'implants dentaires - Google Patents

Utilisation d'un ciment osteocompatible pour la fixation et la stabilisation de dents naturelles et/ou d'implants dentaires Download PDF

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Publication number
WO1999032066A2
WO1999032066A2 PCT/IT1998/000375 IT9800375W WO9932066A2 WO 1999032066 A2 WO1999032066 A2 WO 1999032066A2 IT 9800375 W IT9800375 W IT 9800375W WO 9932066 A2 WO9932066 A2 WO 9932066A2
Authority
WO
WIPO (PCT)
Prior art keywords
bone
implant
cement
mixture
use according
Prior art date
Application number
PCT/IT1998/000375
Other languages
English (en)
Other versions
WO1999032066A3 (fr
Inventor
Ernesto D'aloja
Original Assignee
Aloja Ernesto D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aloja Ernesto D filed Critical Aloja Ernesto D
Priority to AU17837/99A priority Critical patent/AU1783799A/en
Publication of WO1999032066A2 publication Critical patent/WO1999032066A2/fr
Publication of WO1999032066A3 publication Critical patent/WO1999032066A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the present invention relates to a new use in the field of parodontology and of dental implantology of a bone cement of known composition and specifically and uniquely used in orthopaedic surgery until now.
  • the new use according to the present invention concerns the rebuilding and/or substitution of a part of maxillo-facial tissue with which it results therefore to be possible to stabilize a natural tooth and/or a titanium implant with its relative dental prothesis.
  • implants all normally made of titanium, in the field of implantology is known in the art .
  • said implants are provided with suitable means for the support of one or more dental protheses, according to the specific case dealt with.
  • suitable equipment such as cutters or other tools.
  • Said boring is made to have such a size that it allows a precise and calibrated insertion of the implant which is generally made of titanium, which is also threaded inside according to a suitable pitch so as to subsequently receive the actual dental prothesis .
  • Said prothesis is in fact provided with a screw whose threading has a pitch which is the same as that of the above mentioned implant which is suitable for receiving the above mentioned prothesis which has been duly screwed.
  • the main drawback of an operation of this type is given by the long waiting times which are necessary for the titanium implant to acquire solidity and firmness inside the bone, said times being in the range of months, generally between six and nine, or even more.
  • the implant which plays the role of being a support for the future capsule, becomes an integrating part of the bone which it was introduced into, for example of the mandibular bone, said osseointegration process being made possible by treating the outside surface of the titanium used, with a hydroxylapathite .
  • hydroxylapathite is a biological material in itself as it is the mineral part of a bone, even if bone hydroxylapathite is structurally different as it has a laminar structure surrounded by bone cells, by collagen fibrils and submerged in protein mucus fluid, whereas implantary hydroxylapathite is a synthesis material, which has been sintered and compressed so as to increase its resistance.
  • This rebuilding is carried out by filling the- volume of the bone which is involved in the implant, with a suitable material which generally consists of human bone (autologous transplant) , for example excised from the chin or from the hip, or with hydroxylapathite or else with bovine or demineralised human bone.
  • a suitable material which generally consists of human bone (autologous transplant) , for example excised from the chin or from the hip, or with hydroxylapathite or else with bovine or demineralised human bone.
  • autologous transplant autologous transplant
  • the implant is therefore inserted and the superficial part of the whole volume can then be covered with resorbable membranes or not, such as for example a Goretex® film, said membranes having the specific task of isolating the above mentioned filling material from the surrounding mucose.
  • a considerable drawback of such a type of operation is that once again, a very long waiting time for the patient is necessary before finding his new tooth available.
  • a further disadvantage is furthermore relative to the fact that said operation is not always successful as there is a very high risk that the implant does not have enough stability because of its unsatisfactory tightness of the material employed for the rebuilding and/or substitution of the bone, once the new capsule has been screwed in.
  • the polymer phase consists of poly ethylmethacrylate, whereas the remaining 3% by weight consists of a catalyst, such as benzoyl peroxide; instead, 99.1% of the monomer phase consists of monomethyl methacrylate, whereas 0.89% consists of an accelerator, such as N-N-dimethyl-p-toluidine, and the remaining percentage by weight consists of a stabilizer such as hydroquinone .
  • Such mixtures can furthermore comprise the employment of fluoride salts that are additioned to the solid phase on account of the fact that fluorine brings about an advantageous increase in size of the hydroxylapathite crystals present in the bone tissue as a mineral component, fact that causes a remarkable improvement of the mechanical properties of the bone straucture.
  • fluoride ions favours osteoblast stimulation, these being the cells that are directly responsible for the formation of the bone tissue.
  • the cement mixtures dealt with above exhibit several advantageous properties related to their biocompatibility with the bone tissue with which they have to matched, not causing disadvantageous reject-related phenomena, and eliminating at source those implant detachment problems that arise in case acrylic resin based cements are used as it happens for example in the orthopaedic field.
  • the Applicant is aware of the fact that mixtures of the above described type are used in orthopaedics, particularly for the application of a prosthetic hip.
  • the dental surgeon in case for the dental surgeon the need arises to have to set out for an operation of the surgical parodontal type in order to stabilise and/or insert an implant into a volume of bone which has a sufficient thickness to host it, he is faced with having to dig an undercut cavity which is suitable for receiving the bone cement and is capable of making it possible for the bone to remain integral with the bone itself .
  • the cavity is filled up with the bone cement of which above, in case an implant or a totally extracted tooth is being dealt with, and these are inserted into the cement before its polymerisation phase has gone to completion.
  • the bone cement used as a filling and adhesion material for the implant allows a very good and rapid setting, eliminating the risk of rejection, whose occurrence would unavoidably determine the detachment of the device fixed by the dental surgeon.
  • canals or holes can be dug on the side surfaces of the portion of bone that must be filled up and reconstructed with the bone cement object of the present invention, said canals or holes working as anchoring means for blocking the material once it has been positioned in its location which is suitable for hosting it.

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)

Abstract

L'invention concerne l'utilisation, dans les domaines de la médecine dentaire et maxillo-faciale, notamment de la parodontologie et de l'implantologie, d'un mélange de ciment ostéocompatible pour des opérations telles que les reconstructions osseuses, ou comme matériau d'obturation radiculaire de cavités formées naturellement ou suite à des opérations réalisées sur les maxillaires.
PCT/IT1998/000375 1997-12-23 1998-12-22 Utilisation d'un ciment osteocompatible pour la fixation et la stabilisation de dents naturelles et/ou d'implants dentaires WO1999032066A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU17837/99A AU1783799A (en) 1997-12-23 1998-12-22 Use of a bone cement for the fixing and stabilisation of natural teeth and/or dental implants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITVR97A000121 1997-12-23
IT97VR000121A IT1297509B1 (it) 1997-12-23 1997-12-23 Uso di cementi ossei per fissaggio e stabilizzazione di denti naturali e/o impianti dentari

Publications (2)

Publication Number Publication Date
WO1999032066A2 true WO1999032066A2 (fr) 1999-07-01
WO1999032066A3 WO1999032066A3 (fr) 1999-09-02

Family

ID=11428465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT1998/000375 WO1999032066A2 (fr) 1997-12-23 1998-12-22 Utilisation d'un ciment osteocompatible pour la fixation et la stabilisation de dents naturelles et/ou d'implants dentaires

Country Status (3)

Country Link
AU (1) AU1783799A (fr)
IT (1) IT1297509B1 (fr)
WO (1) WO1999032066A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8845801B2 (en) 2009-12-30 2014-09-30 Regents Of The University Of Minnesota Bone cement and method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141864A (en) * 1974-03-15 1979-02-27 University Of Virginia Alumni Patents Foundation Osseous cement composition
DE2752297C2 (de) * 1977-11-23 1991-06-20 Dobrivoje Dr. 8000 München Tomic Material als Spongiosazement mit schäumendem und resorbierbarem Effekt und dessen Verwendung
IT1234978B (it) * 1988-06-01 1992-06-09 Tecres Spa Miscela cementifera a due fasi, particolarmente adatta per usi ortopedici.
CA2027921C (fr) * 1989-10-19 1997-12-09 Nobuo Nakabayashi Composition de ciment pour les os, produit polymerise a base de cette composition, materiau d'implant et procede de preparation de cette composition
EP0884984B1 (fr) * 1996-03-08 2000-05-24 AO-Forschungsinstitut Davos Implant destine a etre cimente dans un os

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8845801B2 (en) 2009-12-30 2014-09-30 Regents Of The University Of Minnesota Bone cement and method

Also Published As

Publication number Publication date
ITVR970121A1 (it) 1999-06-23
IT1297509B1 (it) 1999-12-17
WO1999032066A3 (fr) 1999-09-02
ITVR970121A0 (it) 1997-12-23
AU1783799A (en) 1999-07-12

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