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WO1999033431A3 - Procedes de preparation et de selection de composes a noyaux biaromatiques et triaromatiques pontes a partir d'une bibliotheque universelle a diversite structurelle - Google Patents

Procedes de preparation et de selection de composes a noyaux biaromatiques et triaromatiques pontes a partir d'une bibliotheque universelle a diversite structurelle Download PDF

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Publication number
WO1999033431A3
WO1999033431A3 PCT/US1998/027695 US9827695W WO9933431A3 WO 1999033431 A3 WO1999033431 A3 WO 1999033431A3 US 9827695 W US9827695 W US 9827695W WO 9933431 A3 WO9933431 A3 WO 9933431A3
Authority
WO
WIPO (PCT)
Prior art keywords
selection
preparation
pharmaceutically useful
useful compounds
universal library
Prior art date
Application number
PCT/US1998/027695
Other languages
English (en)
Other versions
WO1999033431A2 (fr
Inventor
Michael R Pavia
Harold V Meyers
Guy Milot
Mark E Hediger
Original Assignee
Michael R Pavia
Harold V Meyers
Guy Milot
Mark E Hediger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael R Pavia, Harold V Meyers, Guy Milot, Mark E Hediger filed Critical Michael R Pavia
Priority to AU20175/99A priority Critical patent/AU2017599A/en
Publication of WO1999033431A2 publication Critical patent/WO1999033431A2/fr
Publication of WO1999033431A3 publication Critical patent/WO1999033431A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur de nouvelles bibliothèques combinatoires de composés à noyaux biaromatiques et triaromatiques pontés, sur des procédés de préparation de ces bibliothèques, et sur un appareil de stockage de ces bibliothèques destiné à être utilisé comme composant de systèmes de dosage pour identifier des composés dans le développement de médicaments.
PCT/US1998/027695 1997-12-30 1998-12-29 Procedes de preparation et de selection de composes a noyaux biaromatiques et triaromatiques pontes a partir d'une bibliotheque universelle a diversite structurelle WO1999033431A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU20175/99A AU2017599A (en) 1997-12-30 1998-12-29 Methods for preparing and selecting pharmaceutically useful bridged biaromatic and triaromatic ring compounds from structurally diverse universal library

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7002197P 1997-12-30 1997-12-30
US60/070,021 1997-12-30

Publications (2)

Publication Number Publication Date
WO1999033431A2 WO1999033431A2 (fr) 1999-07-08
WO1999033431A3 true WO1999033431A3 (fr) 1999-09-16

Family

ID=22092628

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027695 WO1999033431A2 (fr) 1997-12-30 1998-12-29 Procedes de preparation et de selection de composes a noyaux biaromatiques et triaromatiques pontes a partir d'une bibliotheque universelle a diversite structurelle

Country Status (2)

Country Link
AU (1) AU2017599A (fr)
WO (1) WO1999033431A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003932A (en) * 1972-03-07 1977-01-18 Gist-Brocades N.V. Aminoalkylethers
EP0331073A2 (fr) * 1988-02-29 1989-09-06 Chugai Seiyaku Kabushiki Kaisha Dérivés de benzhydrylamine
US4964893A (en) * 1986-04-17 1990-10-23 Monsanto Company Benzhydryl compounds as herbicide antidotes
US5324483A (en) * 1992-10-08 1994-06-28 Warner-Lambert Company Apparatus for multiple simultaneous synthesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003932A (en) * 1972-03-07 1977-01-18 Gist-Brocades N.V. Aminoalkylethers
US4964893A (en) * 1986-04-17 1990-10-23 Monsanto Company Benzhydryl compounds as herbicide antidotes
EP0331073A2 (fr) * 1988-02-29 1989-09-06 Chugai Seiyaku Kabushiki Kaisha Dérivés de benzhydrylamine
US5324483A (en) * 1992-10-08 1994-06-28 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
US5324483B1 (en) * 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GORDON E. M., ET AL.: "APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY. Ö2. COMBINATORIAL ORGANIC SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE DIRECTIONS1.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 37., no. 10., 13 May 1994 (1994-05-13), US, pages 1385 - 1401., XP000605162, ISSN: 0022-2623, DOI: 10.1021/jm00036a001 *
JANDA K. D.: "TAGGED VERSUS UNTAGGED LIBRARIES: METHODS FOR THE GENERATION AND SCREENING OF COMBINATORIAL CHEMICAL LIBRARIES.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 91., 1 November 1994 (1994-11-01), US, pages 10779 - 10785., XP002912829, ISSN: 0027-8424, DOI: 10.1073/pnas.91.23.10779 *

Also Published As

Publication number Publication date
WO1999033431A2 (fr) 1999-07-08
AU2017599A (en) 1999-07-19

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