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WO1999033973A3 - Cloned octapamine-receptor-producing cells - Google Patents

Cloned octapamine-receptor-producing cells Download PDF

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Publication number
WO1999033973A3
WO1999033973A3 PCT/EP1998/008411 EP9808411W WO9933973A3 WO 1999033973 A3 WO1999033973 A3 WO 1999033973A3 EP 9808411 W EP9808411 W EP 9808411W WO 9933973 A3 WO9933973 A3 WO 9933973A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
neurotransmitter
cells
producing cells
octapamine
Prior art date
Application number
PCT/EP1998/008411
Other languages
German (de)
French (fr)
Other versions
WO1999033973A2 (en
Inventor
Arnd Baumann
Stephan Frings
Original Assignee
Forschungszentrum Juelich Gmbh
Arnd Baumann
Stephan Frings
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich Gmbh, Arnd Baumann, Stephan Frings filed Critical Forschungszentrum Juelich Gmbh
Publication of WO1999033973A2 publication Critical patent/WO1999033973A2/en
Publication of WO1999033973A3 publication Critical patent/WO1999033973A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a method for producing octopamine receptor-producing cells. To this end, at least one gene with coding for an octopamine receptor is transformed into a host cell. The cloning of neurotransmitter receptor genes and their stable expression makes it possible to investigate individual neurotransmitter receptor subtypes with precisely defined structures, for the first time. The cells transformed by the neurotransmitter receptor gene can be used in a simple method for investigating the characteristics of neurotransmitter receptors. According to said method, a ligand to be investigated is allowed to act on these cells and the effect is determined by analysing intracellular messenger substances.
PCT/EP1998/008411 1997-12-23 1998-12-22 Cloned octapamine-receptor-producing cells WO1999033973A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19757695.8 1997-12-23
DE1997157695 DE19757695A1 (en) 1997-12-23 1997-12-23 Cloned neurotransmitter receptor producing cells

Publications (2)

Publication Number Publication Date
WO1999033973A2 WO1999033973A2 (en) 1999-07-08
WO1999033973A3 true WO1999033973A3 (en) 1999-09-16

Family

ID=7853269

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/008411 WO1999033973A2 (en) 1997-12-23 1998-12-22 Cloned octapamine-receptor-producing cells

Country Status (2)

Country Link
DE (2) DE19758545A1 (en)
WO (1) WO1999033973A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7541155B2 (en) 2003-04-24 2009-06-02 Tyratech, Inc. Methods of screening compositions for potential insect control activity
US7622269B2 (en) 2004-03-19 2009-11-24 Tyratech, Inc. Methods of screening tyramine- and octopamine-expressing cells for compounds and compositions having potential insect control activity
US8685471B2 (en) 2006-07-17 2014-04-01 Tyratech, Inc. Compositions and methods for controlling insects
US8865230B2 (en) 2006-06-27 2014-10-21 Tyratech, Inc. Compositions and methods for treating parasitic infections

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10150971B8 (en) * 2001-10-05 2006-11-09 Technische Universität Dresden Method and device for measuring receptor activity on transfected cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5344776A (en) * 1991-03-28 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding an insect octopamine receptor
WO1999021891A1 (en) * 1997-10-27 1999-05-06 Baylor College Of Medicine Invertebrate octopamine receptor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5344776A (en) * 1991-03-28 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding an insect octopamine receptor
WO1999021891A1 (en) * 1997-10-27 1999-05-06 Baylor College Of Medicine Invertebrate octopamine receptor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EVANS P.D. , ROBB S.: "Octopamine Receptor Subtypes and Their Modes of Action", NEUROCHEMICAL RESEARCH, vol. 18, no. 8, August 1993 (1993-08-01), pages 869 - 874, XP002109582 *
GERHARDT C.C. ET AL.: "Cloning and Expression of a Complementary DNA Encoding a Molluscan Octopamine Receptor That Couples to Chloride Channels in HEK293 Cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 10, 7 March 1997 (1997-03-07), pages 6201 - 6207, XP002109580 *
HAN K.A. ET AL.: "Novel biogenic amine receptors preferentially expressed in mushroom bodies of Drosophila melanogaster", SOCIETY FOR NEUROSCIENCE ABSTRACTS; 27TH ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE NEW ORLEANS, LOUISIANA, USA, 25-30 OF OCTOBER, 1997, vol. 23, no. 1-2, pages 1417, XP002109581 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7541155B2 (en) 2003-04-24 2009-06-02 Tyratech, Inc. Methods of screening compositions for potential insect control activity
US8507013B2 (en) 2003-04-24 2013-08-13 Tyratech, Inc. Compositions for controlling insects
US7622269B2 (en) 2004-03-19 2009-11-24 Tyratech, Inc. Methods of screening tyramine- and octopamine-expressing cells for compounds and compositions having potential insect control activity
US8865230B2 (en) 2006-06-27 2014-10-21 Tyratech, Inc. Compositions and methods for treating parasitic infections
US8685471B2 (en) 2006-07-17 2014-04-01 Tyratech, Inc. Compositions and methods for controlling insects

Also Published As

Publication number Publication date
WO1999033973A2 (en) 1999-07-08
DE19757695A1 (en) 1999-07-01
DE19758545A1 (en) 1999-09-23

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