[go: up one dir, main page]

WO1999036553A3 - Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres - Google Patents

Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres Download PDF

Info

Publication number
WO1999036553A3
WO1999036553A3 PCT/US1999/000178 US9900178W WO9936553A3 WO 1999036553 A3 WO1999036553 A3 WO 1999036553A3 US 9900178 W US9900178 W US 9900178W WO 9936553 A3 WO9936553 A3 WO 9936553A3
Authority
WO
WIPO (PCT)
Prior art keywords
regulation
biological events
chimeric proteins
multimeric chimeric
multimeric
Prior art date
Application number
PCT/US1999/000178
Other languages
English (en)
Other versions
WO1999036553A2 (fr
Inventor
Timothy P Clackson
Michael Z Gilman
Dennis A Holt
Terence P Keenan
Leonard Rozamus
Wu Yang
Original Assignee
Ariad Gene Therapeutics Inc
Timothy P Clackson
Michael Z Gilman
Dennis A Holt
Terence P Keenan
Leonard Rozamus
Wu Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/012,097 external-priority patent/US6187757B1/en
Application filed by Ariad Gene Therapeutics Inc, Timothy P Clackson, Michael Z Gilman, Dennis A Holt, Terence P Keenan, Leonard Rozamus, Wu Yang filed Critical Ariad Gene Therapeutics Inc
Priority to AU22132/99A priority Critical patent/AU755784B2/en
Priority to EP99902059A priority patent/EP1045915A2/fr
Priority to JP2000540254A priority patent/JP2002508971A/ja
Priority to CA002318402A priority patent/CA2318402A1/fr
Publication of WO1999036553A2 publication Critical patent/WO1999036553A2/fr
Publication of WO1999036553A3 publication Critical patent/WO1999036553A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des matières et des procédés servant à réguler des phénomènes biologiques tels que la transcription et la croissance d'un gène cible, la prolifération ou la différenciation de cellules mises au point génétiquement.
PCT/US1999/000178 1998-01-15 1999-01-15 Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres WO1999036553A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU22132/99A AU755784B2 (en) 1998-01-15 1999-01-15 Regulation of biological events using multimeric chimeric proteins
EP99902059A EP1045915A2 (fr) 1998-01-15 1999-01-15 Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres
JP2000540254A JP2002508971A (ja) 1998-01-15 1999-01-15 多量体キメラ蛋白質を使用する生物学的イベントの調節
CA002318402A CA2318402A1 (fr) 1998-01-15 1999-01-15 Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US7159198P 1998-01-15 1998-01-15
US60/071,591 1998-01-15
US7201698P 1998-01-21 1998-01-21
US60/072,016 1998-01-21
US7221998P 1998-01-22 1998-01-22
US09/012,097 1998-01-22
US60/072,219 1998-01-22
US09/012,097 US6187757B1 (en) 1995-06-07 1998-01-22 Regulation of biological events using novel compounds

Publications (2)

Publication Number Publication Date
WO1999036553A2 WO1999036553A2 (fr) 1999-07-22
WO1999036553A3 true WO1999036553A3 (fr) 1999-10-21

Family

ID=27486136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/000178 WO1999036553A2 (fr) 1998-01-15 1999-01-15 Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres

Country Status (5)

Country Link
EP (1) EP1045915A2 (fr)
JP (1) JP2002508971A (fr)
AU (1) AU755784B2 (fr)
CA (1) CA2318402A1 (fr)
WO (1) WO1999036553A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8426167B2 (en) 2001-06-22 2013-04-23 Roche Diagnostics Operations, Inc. Methods for producing fusion polypeptides or enhancing expression of fusion polypeptides

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9824544D0 (en) 1998-11-09 1999-01-06 Medical Res Council Screening system
USRE45795E1 (en) 1994-08-20 2015-11-10 Gendaq, Ltd. Binding proteins for recognition of DNA
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US6352842B1 (en) 1995-12-07 2002-03-05 Diversa Corporation Exonucease-mediated gene assembly in directed evolution
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6361974B1 (en) 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US7018793B1 (en) 1995-12-07 2006-03-28 Diversa Corporation Combinatorial screening of mixed populations of organisms
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6562594B1 (en) 1999-09-29 2003-05-13 Diversa Corporation Saturation mutagenesis in directed evolution
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
AU746454B2 (en) 1998-03-02 2002-05-02 Massachusetts Institute Of Technology Poly zinc finger proteins with improved linkers
US6977154B1 (en) 1998-03-17 2005-12-20 Gendaq Limited Nucleic acid binding proteins
US7070934B2 (en) 1999-01-12 2006-07-04 Sangamo Biosciences, Inc. Ligand-controlled regulation of endogenous gene expression
US7013219B2 (en) 1999-01-12 2006-03-14 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6599692B1 (en) 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US7030215B2 (en) 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
US20030104526A1 (en) 1999-03-24 2003-06-05 Qiang Liu Position dependent recognition of GNN nucleotide triplets by zinc fingers
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
ATE264863T1 (de) 1999-08-24 2004-05-15 Ariad Gene Therapeutics Inc 28-epirapaloge
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
HK1049515B (en) 1999-12-06 2006-01-13 Sangamo Biosciences Inc. Methods of using randomized libraries of zinc finger proteins for the identification of gene function
AU2693501A (en) 2000-01-24 2001-07-31 Gendaq Ltd Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
JP2004537260A (ja) 2000-12-07 2004-12-16 サンガモ バイオサイエンシーズ， インコーポレイテッド ジンクフィンガータンパク質による血管新生の調節
AU2002241946B2 (en) 2001-01-22 2007-04-26 Sangamo Therapeutics, Inc. Modified zinc finger binding proteins
US7262054B2 (en) 2002-01-22 2007-08-28 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
EA008379B1 (ru) 2002-02-01 2007-04-27 Ариад Джин Терапьютикс, Инк. Фосфорсодержащие соединения и их применения
US7361635B2 (en) 2002-08-29 2008-04-22 Sangamo Biosciences, Inc. Simultaneous modulation of multiple genes
US20080287675A1 (en) * 2007-05-18 2008-11-20 Abbott Laboratories Cascade system
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
KR20130040844A (ko) 2010-03-29 2013-04-24 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 약학적으로 유발된 전이유전자 제거 시스템
WO2012145572A1 (fr) 2011-04-20 2012-10-26 The Trustees Of The University Of Pennsylvania Régimes et compositions pour l'immunisation passive médiée par aav contre des agents pathogènes en suspension dans l'air
EP4303232A3 (fr) 2013-02-15 2024-04-17 The Regents of The University of California Récepteur d'antigène chimère et procédés d'utilisation de celui-ci
WO2015012924A2 (fr) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Cassettes d'expression préférentielle pour tissus modifiées par un codon, vecteurs les contenant, et utilisation
AU2014296626B2 (en) 2013-07-29 2019-03-07 Regeneron Pharmaceuticals, Inc. Multipartite signaling proteins and uses thereof
AU2016275909A1 (en) 2015-05-13 2017-11-09 The Trustees Of The University Of Pennsylvania AAV-mediated expression of anti-influenza antibodies and methods of use thereof
US10392607B2 (en) 2015-06-03 2019-08-27 The Regents Of The University Of California Cas9 variants and methods of use thereof
EP3368054A4 (fr) 2015-10-28 2019-07-03 Voyager Therapeutics, Inc. Expression régulable au moyen d'un virus adéno-associé (vaa)
EP3377523A4 (fr) 2015-11-19 2019-06-19 The Regents of The University of California Récepteurs de cellules immunitaires répressibles sous conditions et leurs procédés d'utilisation
EP3390434A2 (fr) * 2015-12-14 2018-10-24 Bellicum Pharmaceuticals, Inc. Doubles commandes pour l'activation ou l'élimination de cellules thérapeutiques
WO2020047527A2 (fr) 2018-09-02 2020-03-05 F1 Bioventures, Llc Procédés et compositions pour modifier génétiquement des lymphocytes dans le sang ou dans des pbmc enrichies
KR20230130765A (ko) 2016-04-15 2023-09-12 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 습성 연령 관련 황반 변성의 치료를 위한 조성물
EP3555296A4 (fr) 2016-12-13 2020-07-29 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Méthodes d'activation de médicament exogène de complexes de signalisation induits par agents chimiques exprimés dans des cellules modifiées in vitro et in vivo
JOP20190200A1 (ar) 2017-02-28 2019-08-27 Univ Pennsylvania تركيبات نافعة في معالجة ضمور العضل النخاعي
US10786568B2 (en) 2017-02-28 2020-09-29 The Trustees Of The University Of Pennsylvania AAV mediated influenza vaccines
MD3589730T2 (ro) 2017-02-28 2024-04-30 Univ Pennsylvania Vector de virus adeno-asociat (AAV) de cladă F și utilizările acestuia
IL268739B2 (en) 2017-03-03 2024-11-01 F1 Oncology Inc Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof
UY37900A (es) 2017-09-26 2019-04-30 Novartis Ag Nuevos derivados de rapamicina
CA3079568A1 (fr) 2017-10-18 2019-04-25 Regenxbio Inc. Agents therapeutiques a base d'anticorps entierement humains a modification post-traductionnelle
JP2021500071A (ja) 2017-10-18 2021-01-07 リジェネックスバイオ インコーポレイテッド ヒト翻訳後修飾ｖｅｇｆ−ｔｒａｐによる眼疾患および転移性大腸がんの処置
US11952413B2 (en) 2017-12-14 2024-04-09 2Seventy Bio, Inc. Dimerizing agent regulated immunoreceptor complexes comprising interleukin receptor signaling domains
WO2019210057A1 (fr) 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Cellules résistantes à la rapamycine
CN118894869A (zh) 2018-05-01 2024-11-05 锐新医药公司 作为mTOR抑制剂的C40-、C28-及C-32连接的雷帕霉素类似物
JP7381492B2 (ja) 2018-05-01 2023-11-15 レヴォリューション・メディスンズ，インコーポレイテッド Ｍｔｏｒ阻害剤としてのｃ２６－連結ラパマイシン類似体
KR20210075117A (ko) 2018-10-05 2021-06-22 세인트 안나 킨더크렙스포르슝 키메라 항원 수용체(car) 그룹
EP3632461A1 (fr) 2018-10-05 2020-04-08 St. Anna Kinderkrebsforschung Groupe de récepteurs d'antigène chimérique (cars)
EP3632460A1 (fr) 2018-10-05 2020-04-08 St. Anna Kinderkrebsforschung Groupe de récepteurs d'antigènes chimériques (cars)
WO2020070289A1 (fr) 2018-10-05 2020-04-09 St. Anna Kinderkrebsforschung Groupe de récepteurs d'antigènes chimériques (car)
US12291560B2 (en) 2018-12-14 2025-05-06 Regeneron Pharmaceuticals, Inc. Dimerizing agent regulated immunoreceptor complexes
FI3898637T3 (fi) * 2018-12-18 2025-02-24 Novartis Ag Rapamysiinijohdannaisia
US20220143221A1 (en) 2019-04-03 2022-05-12 Regenxbio, Inc. Gene Therapy For Eye Pathologies
EP3959323A1 (fr) 2019-04-24 2022-03-02 REGENXBIO Inc. Agents thérapeutiques à base d'anticorps entièrement humains à modification post-traductionnelle
MX2021013417A (es) 2019-05-04 2021-12-10 Inhibrx Inc Polipeptidos de union a la proteina del miembro a de la familia 12 del dominio de lectina tipo c (clec12a) y sus usos.
SG11202111927QA (en) 2019-05-08 2021-11-29 2Seventy Bio Inc Cll-1 targeted immunotherapies
CN114502197A (zh) 2019-08-26 2022-05-13 再生生物股份有限公司 用全人经翻译后修饰的抗VEGF Fab治疗糖尿病性视网膜病变
IL291930A (en) 2019-10-07 2022-06-01 Regenxbio Inc Adeno-associated virus vector pharmaceutical composition and methods
MX2022006807A (es) * 2019-12-05 2022-09-12 Anakuria Therapeutics Inc Análogos de rapamicina y usos de estos.
EP4126229A4 (fr) * 2020-03-27 2024-04-17 Aeovian Pharmaceuticals, Inc. Modulateurs de mtorc1 et leurs utilisations
EP4214242A1 (fr) 2020-09-15 2023-07-26 RegenxBio Inc. Anticorps vectorisés pour thérapie antivirale
WO2022060915A1 (fr) 2020-09-15 2022-03-24 Regenxbio Inc. Lanadelumab vectorisé et administration de celui-ci
WO2022076582A1 (fr) 2020-10-07 2022-04-14 Regenxbio Inc. Thérapie génique pour manifestations oculaires de maladie cln2
EP4236999A1 (fr) 2020-10-28 2023-09-06 RegenxBio Inc. Anticorps anti-tnf-alfa vectorisés pour indications oculaires
WO2022094157A1 (fr) 2020-10-28 2022-05-05 Regenxbio Inc. Anticorps vectorisés anti-cgrp et anti-récepteur de cgrp et leur administration
WO2022094295A1 (fr) 2020-10-29 2022-05-05 Regenxbio Inc. Antagonistes de tnf-alpha vectorisés pour des indications oculaires
WO2022094255A2 (fr) 2020-10-29 2022-05-05 Regenxbio Inc. Anticorps de facteur xii vectorisés et leur administration
KR20230117157A (ko) 2020-12-01 2023-08-07 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 조직 특이적 표적화 모티프를 갖는 신규 조성물 및 이를 포함하는 조성물
WO2022187289A1 (fr) 2021-03-01 2022-09-09 Exuma Biotech Corp. Procédés et compositions pour l'administration de particules rétrovirales
TW202305124A (zh) 2021-04-23 2023-02-01 賓州大學委員會 具有腦特異性靶向模體的新穎構成物及含有其之組成物
US20240384298A1 (en) 2021-10-02 2024-11-21 The Trustees Of The University Of Pennsylvania Novel aav capsids and compositions containing same
MX2024009186A (es) 2022-01-25 2024-09-30 Univ Pennsylvania Cápsides de aav para mejorar la transducción cardiaca y desdireccionamiento del hígado.
WO2023168305A1 (fr) 2022-03-01 2023-09-07 Exuma Biotech Corp. Particules virales comprenant de l'hyaluronidase liée à une membrane
EP4507741A1 (fr) 2022-04-14 2025-02-19 RegenxBio Inc. Thérapie génique pour le traitement d'une maladie oculaire
US20250277004A1 (en) 2022-04-18 2025-09-04 Regenxbio Inc. Hybrid aav capsids
EP4518972A2 (fr) 2022-05-03 2025-03-12 RegenxBio Inc. Anticorps anti-complément vectorisés et agents de complément et leur administration
TW202417633A (zh) 2022-05-03 2024-05-01 美商銳進科斯生物股份有限公司 用於眼適應症之載體化抗TNF-α抑制劑
US20240082249A1 (en) 2022-05-25 2024-03-14 Revolution Medicines, Inc. Methods of treating cancer with an mtor inhibitor
IL319873A (en) 2022-09-30 2025-05-01 Regenxbio Inc Treatment of eye diseases with recombinant viral vectors containing anti-VEGF FAB
AU2023398931A1 (en) 2022-12-17 2025-07-10 The Trustees Of The University Of Pennsylvania Recombinant aav mutant vectors with cardiac and skeletal muscle-specific targeting motifs and compositions containing same
WO2024130070A2 (fr) 2022-12-17 2024-06-20 The Trustees Of The University Of Pennsylvania Capsides aav recombinantes avec motifs de ciblage spécifiques du muscle cardiaque et squelettique et leurs utilisations
WO2024238859A1 (fr) 2023-05-16 2024-11-21 Regenxbio Inc. Agents inhibiteurs de c5 vectorisés et leur administration
WO2024238867A1 (fr) 2023-05-16 2024-11-21 Regenxbio Inc. Anticorps anti-complément vectorisés et leur administration
TW202516019A (zh) 2023-06-29 2025-04-16 賓州大學委員會 具中樞神經系統靶向模體的突變aav及含有其之組成物
WO2025102034A1 (fr) 2023-11-10 2025-05-15 The Trustees Of The University Of Pennsylvania Thérapie génique pour le syndrome de barth
WO2025106661A1 (fr) 2023-11-14 2025-05-22 The Trustees Of The University Of Pennsylvania Compositions ayant des motifs de ciblage spécifiques des muscles cardiaques et squelettiques et leurs utilisations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
WO1996041865A1 (fr) * 1995-06-07 1996-12-27 Ariad Gene Therapeutics, Inc. Regulation d'evenements biologiques fondee sur la rapamycine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
WO1996041865A1 (fr) * 1995-06-07 1996-12-27 Ariad Gene Therapeutics, Inc. Regulation d'evenements biologiques fondee sur la rapamycine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JUAN I LUENGO ET AL.: "Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domainand positioned at the FKBP12-FRAP interface", CURRENT BIOLOGY, vol. 2, 1995, pages 471 - 481, XP002045681 *
VICTOR M. RIVERA ET AL.: "A humanized system for phamacologic control of gene expression", NATURE MEDICINE, vol. 2, no. 9, September 1996 (1996-09-01), pages 1028 - 1032, XP002018162 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8426167B2 (en) 2001-06-22 2013-04-23 Roche Diagnostics Operations, Inc. Methods for producing fusion polypeptides or enhancing expression of fusion polypeptides

Also Published As

Publication number Publication date
AU755784B2 (en) 2002-12-19
AU2213299A (en) 1999-08-02
JP2002508971A (ja) 2002-03-26
EP1045915A2 (fr) 2000-10-25
WO1999036553A2 (fr) 1999-07-22
CA2318402A1 (fr) 1999-07-22

Similar Documents

Publication Publication Date Title
WO1999036553A3 (fr) Regulation de phenomenes biologiques au moyen de proteines chimeres multimeres
IL193758A0 (en) Genetically engineered duckweed
CA2383926A1 (fr) Genomique fonctionnelle utilisant des proteines a doigts de zinc
WO2002059277A3 (fr) Materiaux electroactifs destines a la stimulation de l'activite biologique de cellules souches
AU560340B2 (en) Rennin from recombinant dna
AU2002235994A1 (en) Method for producing proteins by fermentation of microorganisms from the thermus family, the protein mixture thus obtained and cosmetic compositions containing same
AU3462899A (en) Sequence and method for genetic engineering of proteins with cell membrane translocating activity
AU6724194A (en) Nucleotide sequences for the control of the expression of dna sequences in a cellular host
TW200718784A (en) Method of extended culture for antigen-specific cytotoxic T lumphocytes
CA2290776A1 (fr) Proteines presentant une activite insecticide et leur procede d'utilisation
WO2004044183A3 (fr) Nouveaux procedes d'alimentation pour la fermentation
AU2028601A (en) Arginine-enriched medium composition used for mass-producing recombinant proteinin animal cell culture
DE69830066D1 (en) Lunasin peptide
WO2004010925A3 (fr) Genes de mammifere impliques dans la suppression des infections virales et des tumeurs
WO2000029551A3 (fr) Cellules, procedes de culture et leurs utilisations
WO2000004051A3 (fr) Promoteur de facteur de differenciation de croissance et ses utilisations
WO2002002591A3 (fr) Peptides a utiliser dans des milieux de culture
GB9901499D0 (en) Biological control
AU2001278700A1 (en) Method of culturing human chondrocytes
WO2000006713A8 (fr) Techniques et produits de recombinaison relatifs a une expression de proteine
AU2342899A (en) Method of screening for neuropharmaceuticals using the (drosophila) gene (volado) and its mutants
CA2375549A1 (fr) Systeme d'apport de materiel biologique
AU3189899A (en) Gene therapy vector with osteocalcin promoter and genes for bone morphogenic proteins or growth factors
EP1728859A4 (fr) Sequence capable d'accelerer l'expression genique a une temperature moderement faible
WO2001040443A3 (fr) Methode de production de cellules animales adherentes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2318402

Country of ref document: CA

Ref country code: CA

Ref document number: 2318402

Kind code of ref document: A

Format of ref document f/p: F

NENP Non-entry into the national phase

Ref country code: KR

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 540254

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 22132/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1999902059

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09600241

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1999902059

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 22132/99

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 1999902059

Country of ref document: EP