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WO1999038185A3 - Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use - Google Patents

Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use Download PDF

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Publication number
WO1999038185A3
WO1999038185A3 PCT/CA1999/000034 CA9900034W WO9938185A3 WO 1999038185 A3 WO1999038185 A3 WO 1999038185A3 CA 9900034 W CA9900034 W CA 9900034W WO 9938185 A3 WO9938185 A3 WO 9938185A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion
ions
transmission device
source
spectrometer
Prior art date
Application number
PCT/CA1999/000034
Other languages
French (fr)
Other versions
WO1999038185A2 (en
Inventor
Andrew N Krutchinsky
Alexandre V Loboda
Victor L Spicer
Erich W Ens
Kenneth G Standing
Original Assignee
Univ Manitoba
Andrew N Krutchinsky
Alexandre V Loboda
Victor L Spicer
Erich W Ens
Kenneth G Standing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4162020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999038185(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Manitoba, Andrew N Krutchinsky, Alexandre V Loboda, Victor L Spicer, Erich W Ens, Kenneth G Standing filed Critical Univ Manitoba
Priority to DE1050061T priority Critical patent/DE1050061T1/en
Priority to DK99900849.3T priority patent/DK1050061T4/en
Priority to AU20428/99A priority patent/AU745866B2/en
Priority to DE69919325.7T priority patent/DE69919325T3/en
Priority to EP99900849.3A priority patent/EP1050061B2/en
Priority to JP2000528992A priority patent/JP4331398B2/en
Priority to AT99900849T priority patent/ATE273561T2/en
Publication of WO1999038185A2 publication Critical patent/WO1999038185A2/en
Publication of WO1999038185A3 publication Critical patent/WO1999038185A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Electron Sources, Ion Sources (AREA)

Abstract

A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and includes a damping gas, to damp spatial and energy spreads of ions generated by a pulsed ion source. The multipole rod set has the effect of guiding the ions along an ion path, so that they can be directed into the inlet of a mass spectrometer. The invention has particular application to MALDI (matrix-assisted laser desorption/ionization) ion sources, which produce a small supersonic jet of matrix molecules and ions, which is substantially non-directional, and can have ions travelling in all available directions from the source and having a wide range of energy spreads. The ion transmission device can have a number of effects, including: substantially spreading out the generated ions along an ion axis to generate a quasi-continuous beam; reducing the energy spread of ions emitted from the source; and at least partially suppressing unwanted fragmentation of analyte ions. Consequently, a number of pulses of ions can be delivered to the time-of-flight or other spectrometer, for each cycle of the ion generation.
PCT/CA1999/000034 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use WO1999038185A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE1050061T DE1050061T1 (en) 1998-01-23 1999-01-25 SPECTROMETER WITH PULSED ION SOURCE, COUPLING DEVICE FOR DAMPING ION MOVEMENT, AND METHOD FOR USE THEREOF
DK99900849.3T DK1050061T4 (en) 1998-01-23 1999-01-25 Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereof
AU20428/99A AU745866B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
DE69919325.7T DE69919325T3 (en) 1998-01-23 1999-01-25 Pulsed ion source spectrometer, coupling device for damping ion motion, and method of using same
EP99900849.3A EP1050061B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
JP2000528992A JP4331398B2 (en) 1998-01-23 1999-01-25 An analyzer with a pulsed ion source and a transport device for damping ion motion and method of use thereof
AT99900849T ATE273561T2 (en) 1998-01-23 1999-01-25 PULSE ION SOURCE SPECTROMETER, COUPLING DEVICE FOR DAMPING ION MOVEMENT, AND METHOD OF USING THE SAME

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002227806A CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
CA2,227,806 1998-01-23

Publications (2)

Publication Number Publication Date
WO1999038185A2 WO1999038185A2 (en) 1999-07-29
WO1999038185A3 true WO1999038185A3 (en) 1999-10-21

Family

ID=4162020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000034 WO1999038185A2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Country Status (8)

Country Link
EP (1) EP1050061B2 (en)
JP (1) JP4331398B2 (en)
AT (1) ATE273561T2 (en)
AU (1) AU745866B2 (en)
CA (1) CA2227806C (en)
DE (2) DE69919325T3 (en)
DK (1) DK1050061T4 (en)
WO (1) WO1999038185A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
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US8097425B2 (en) 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
US9196466B2 (en) 2002-07-24 2015-11-24 Micromass Uk Limited Mass spectrometer with bypass of a fragmentation device

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US5965884A (en) * 1998-06-04 1999-10-12 The Regents Of The University Of California Atmospheric pressure matrix assisted laser desorption
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
GB9820210D0 (en) 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
EP1181707B8 (en) 1999-06-11 2011-04-27 DH Technologies Development Pte. Ltd. Maldi ion source with a pulse of gas, apparatus and method for determining molecular weight of labile molecules
DE10010204A1 (en) 2000-03-02 2001-09-13 Bruker Daltonik Gmbh Conditioning ion beam for flight time mass spectrometer involves damping ion movements in conducting system with gas pules, feeding ions to system end and extracting ions via lens system
DE10010902A1 (en) 2000-03-07 2001-09-20 Bruker Daltonik Gmbh Tandem mass spectrometer consisting of two quadrupole filters
US6586727B2 (en) * 2000-06-09 2003-07-01 Micromass Limited Methods and apparatus for mass spectrometry
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
GB2370685B (en) 2000-11-29 2003-01-22 Micromass Ltd Mass spectrometers and methods of mass spectrometry
CA2364158C (en) 2000-11-29 2003-12-23 Micromass Limited Mass spectrometers and methods of mass spectrometry
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6617577B2 (en) 2001-04-16 2003-09-09 The Rockefeller University Method and system for mass spectroscopy
US6849848B2 (en) 2001-09-17 2005-02-01 Mds, Inc. Method and apparatus for cooling and focusing ions
WO2003052399A2 (en) * 2001-12-14 2003-06-26 Mds Inc., D.B.A. Mds Sciex Method of chemical of ionization at reduced pressures
EP1492613A4 (en) 2002-03-21 2009-12-16 Thermo Finnigan Llc Ionization apparatus and method for mass spectrometer system
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
US7388194B2 (en) 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
JP2005521874A (en) * 2002-03-28 2005-07-21 エムディーエス シエックス Methods and systems for high-throughput quantification of small molecules using laser desorption and multiple reaction monitoring
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
CA2431603C (en) 2003-06-10 2012-03-27 Micromass Uk Limited Mass spectrometer
DE102004025841B4 (en) * 2004-05-24 2015-07-09 Bruker Daltonik Gmbh Method and apparatus for mass spectroscopic analysis of analytes
GB0420408D0 (en) * 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
DE102004051785B4 (en) * 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Protein profiles with air MALDI
US8304206B2 (en) 2005-12-02 2012-11-06 Sirtris Pharmaceuticals, Inc. Mass spectrometry assays for identifying compounds that activate deacetylases
DE102007043456B4 (en) 2007-07-31 2012-02-09 Bruker Daltonik Gmbh Matrix-assisted laser desorption with high ionization efficiency
KR102744729B1 (en) * 2018-02-13 2024-12-18 바이오메리욱스, 인코포레이티드. Methods and related devices for detecting generation of charged particles in devices
US12205807B2 (en) 2020-04-01 2025-01-21 Mstm, Llc Multi-mode ionization apparatus and uses thereof

Citations (3)

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DE19511333C1 (en) * 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
WO1999030350A1 (en) * 1997-12-05 1999-06-17 University Of British Columbia Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap

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US4535235A (en) † 1983-05-06 1985-08-13 Finnigan Corporation Apparatus and method for injection of ions into an ion cyclotron resonance cell
EP0202943B2 (en) † 1985-05-24 2004-11-24 Thermo Finnigan LLC Method of operating an ion trap
WO1989006044A1 (en) † 1987-12-24 1989-06-29 Unisearch Limited Mass spectrometer
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Patent Citations (3)

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DE19511333C1 (en) * 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
WO1999030350A1 (en) * 1997-12-05 1999-06-17 University Of British Columbia Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KRUTCHINSKY A N ET AL: "Collisional Damping Interface for an Electrospray Ionization Time -of-Flight Mass Spectrometer", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 9, no. 6, 1 June 1998 (1998-06-01), pages 569-579, XP004122896, ISSN: 1044-0305 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9196466B2 (en) 2002-07-24 2015-11-24 Micromass Uk Limited Mass spectrometer with bypass of a fragmentation device
US9384951B2 (en) 2002-07-24 2016-07-05 Micromass Uk Limited Mass analysis using alternating fragmentation modes
US8097425B2 (en) 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation

Also Published As

Publication number Publication date
DE69919325T3 (en) 2017-03-02
DK1050061T3 (en) 2004-11-22
ATE273561T2 (en) 2004-08-15
EP1050061B2 (en) 2016-10-19
WO1999038185A2 (en) 1999-07-29
EP1050061B1 (en) 2004-08-11
DE69919325T2 (en) 2005-02-17
AU745866B2 (en) 2002-04-11
DE1050061T1 (en) 2001-06-07
DE69919325D1 (en) 2004-09-16
JP4331398B2 (en) 2009-09-16
DK1050061T4 (en) 2017-01-23
CA2227806A1 (en) 1999-07-23
CA2227806C (en) 2006-07-18
JP2002502084A (en) 2002-01-22
EP1050061A2 (en) 2000-11-08
AU2042899A (en) 1999-08-09

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