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WO1999038524A3 - Therapeutic administration of low density lipoprotein receptor for viral infections and immune regulation - Google Patents

Therapeutic administration of low density lipoprotein receptor for viral infections and immune regulation Download PDF

Info

Publication number
WO1999038524A3
WO1999038524A3 PCT/IB1999/000149 IB9900149W WO9938524A3 WO 1999038524 A3 WO1999038524 A3 WO 1999038524A3 IB 9900149 W IB9900149 W IB 9900149W WO 9938524 A3 WO9938524 A3 WO 9938524A3
Authority
WO
WIPO (PCT)
Prior art keywords
low density
density lipoprotein
lipoprotein receptor
immune regulation
ldl
Prior art date
Application number
PCT/IB1999/000149
Other languages
French (fr)
Other versions
WO1999038524A2 (en
Inventor
Patrick Thomas Prendergast
Original Assignee
Patrick Thomas Prendergast
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Patrick Thomas Prendergast filed Critical Patrick Thomas Prendergast
Priority to AU20697/99A priority Critical patent/AU2069799A/en
Publication of WO1999038524A2 publication Critical patent/WO1999038524A2/en
Publication of WO1999038524A3 publication Critical patent/WO1999038524A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Human and animal low density lipoprotein receptor ('LDL-R' is used herein to refer to low density lipoprotein receptor; 'LDL' is used herein to refer to low density lipoprotein) are administered to provide valuable anti-HIV activity together with anti-Hepatitis viral action. In a preferred aspect, this invention relates to anti-viral and immune regulation activity of the cysteine-rich domain of human low density lipoprotein receptor (LDL-R). As disclosed herein these substances (LDL-R [Human/Animal]) are administered for the treatment of viral infections and as immune regulation agents, and/or these substances are used in the manufacture of a medicament for any such treatment.
PCT/IB1999/000149 1998-01-29 1999-01-28 Therapeutic administration of low density lipoprotein receptor for viral infections and immune regulation WO1999038524A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU20697/99A AU2069799A (en) 1998-01-29 1999-01-28 Therapeutic administration of low density lipoprotein receptor for viral infections and immune regulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7298098P 1998-01-29 1998-01-29
US60/072,980 1998-01-29

Publications (2)

Publication Number Publication Date
WO1999038524A2 WO1999038524A2 (en) 1999-08-05
WO1999038524A3 true WO1999038524A3 (en) 1999-09-23

Family

ID=22110978

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000149 WO1999038524A2 (en) 1998-01-29 1999-01-28 Therapeutic administration of low density lipoprotein receptor for viral infections and immune regulation

Country Status (3)

Country Link
AU (1) AU2069799A (en)
WO (1) WO1999038524A2 (en)
ZA (1) ZA99719B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1111040A1 (en) * 1999-12-10 2001-06-27 Daniel Favre Infection of eukaryotic cells with viruses in vitro
WO2001047545A1 (en) * 1999-12-28 2001-07-05 Sumitomo Pharmaceuticals Company, Limited Preventives and remedies for chronic hepatitis
JP2004529080A (en) * 2000-10-25 2004-09-24 アグネッロ，ヴィンセント Method of preventing infection by HCV, other Flaviviridae viruses, and any other virus that forms a complex with low-density or very-low-density lipoprotein in the blood by suppressing virus entry into cells
IL188628A0 (en) * 2008-01-07 2008-12-29 Yeda Res & Dev Use of soluble ldl-r for viral hepatitis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02157229A (en) * 1988-12-07 1990-06-18 Nitto Denko Corp immunosuppressant
EP0553667A1 (en) * 1992-01-19 1993-08-04 Yeda Research And Development Company Limited Soluble LDL receptor, its production and use
DE4222385A1 (en) * 1992-07-08 1994-01-13 Boehringer Ingelheim Int Isolating substances which inhibit binding of ligands to low-density lipoprotein receptors - comprises incubating LDL receptors with labelled form of ligand in presence of test substance and measuring deg. of binding

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02157229A (en) * 1988-12-07 1990-06-18 Nitto Denko Corp immunosuppressant
EP0553667A1 (en) * 1992-01-19 1993-08-04 Yeda Research And Development Company Limited Soluble LDL receptor, its production and use
DE4222385A1 (en) * 1992-07-08 1994-01-13 Boehringer Ingelheim Int Isolating substances which inhibit binding of ligands to low-density lipoprotein receptors - comprises incubating LDL receptors with labelled form of ligand in presence of test substance and measuring deg. of binding

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FISCHER D G ET AL: "Isolation and characterization of a soluble form of the LDL receptor, an interferon-induced antiviral protein.", PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, (1994 JUL) 206 (3) 228-32., XP002110889 *
PATENT ABSTRACTS OF JAPAN vol. 014, no. 417 (C - 0756) 10 September 1990 (1990-09-10) *

Also Published As

Publication number Publication date
ZA99719B (en) 1999-10-22
WO1999038524A2 (en) 1999-08-05
AU2069799A (en) 1999-08-16

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