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WO1999039006A3 - Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions - Google Patents

Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions Download PDF

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Publication number
WO1999039006A3
WO1999039006A3 PCT/US1999/001964 US9901964W WO9939006A3 WO 1999039006 A3 WO1999039006 A3 WO 1999039006A3 US 9901964 W US9901964 W US 9901964W WO 9939006 A3 WO9939006 A3 WO 9939006A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
human
polypeptide sequences
physiological
medical conditions
Prior art date
Application number
PCT/US1999/001964
Other languages
French (fr)
Other versions
WO1999039006A2 (en
Inventor
James M Sikela
Walter Messier
Original Assignee
Genoplex Inc
James M Sikela
Walter Messier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genoplex Inc, James M Sikela, Walter Messier filed Critical Genoplex Inc
Priority to JP2000529463A priority Critical patent/JP2002501761A/en
Priority to AU24841/99A priority patent/AU769931B2/en
Priority to EP99904442A priority patent/EP1051519A2/en
Priority to CA002318772A priority patent/CA2318772A1/en
Publication of WO1999039006A2 publication Critical patent/WO1999039006A2/en
Priority to AU58058/99A priority patent/AU5805899A/en
Priority to PCT/US1999/020209 priority patent/WO2000012764A1/en
Publication of WO1999039006A3 publication Critical patent/WO1999039006A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1072—Differential gene expression library synthesis, e.g. subtracted libraries, differential screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides methods for identifying polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as disease (including susceptibility (human) or resistance (chimpanzee) to development of AIDS). The methods employ comparison of human and non-human primate sequences using statistical methods. Sequences thus identified may be useful as host therapeutic targets and/or in screening assays.
PCT/US1999/001964 1998-01-30 1999-01-29 Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions WO1999039006A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2000529463A JP2002501761A (en) 1998-01-30 1999-01-29 Methods for identifying polynucleotide and polypeptide sequences for physiological and medical conditions
AU24841/99A AU769931B2 (en) 1998-01-30 1999-01-29 Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
EP99904442A EP1051519A2 (en) 1998-01-30 1999-01-29 Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
CA002318772A CA2318772A1 (en) 1998-01-30 1999-01-29 Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
AU58058/99A AU5805899A (en) 1998-09-02 1999-09-01 Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
PCT/US1999/020209 WO2000012764A1 (en) 1998-09-02 1999-09-01 Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7326398P 1998-01-30 1998-01-30
US60/073,263 1998-01-30

Publications (2)

Publication Number Publication Date
WO1999039006A2 WO1999039006A2 (en) 1999-08-05
WO1999039006A3 true WO1999039006A3 (en) 1999-11-04

Family

ID=22112723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/001964 WO1999039006A2 (en) 1998-01-30 1999-01-29 Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions

Country Status (4)

Country Link
EP (1) EP1051519A2 (en)
JP (1) JP2002501761A (en)
CA (1) CA2318772A1 (en)
WO (1) WO1999039006A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7247425B2 (en) 1998-01-30 2007-07-24 Evolutionary Genomics, Llc Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
US6280953B1 (en) * 1998-01-30 2001-08-28 Evolutionary Genomics, L.L.C. Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
US6866996B1 (en) 1998-01-30 2005-03-15 Evolutionary Genomics, Llc Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
EP1649067A4 (en) * 2003-06-30 2007-01-03 Evolutionary Genomics Llc Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BURGER H. ET AL.,: "Molecular evolution of interleukin-3", J. MOL. EVOL., vol. 39, no. 3, - September 1994 (1994-09-01), pages 255 - 267, XP002114680 *
HERBERT G. & EASTEAL S.: "Relative rates of nuclear DNA evolution in human and old world monkey lineages", MOL. BIOL. EVOL., vol. 13, no. 7, - September 1996 (1996-09-01), pages 1054 - 1057, XP002114698 *
JAEGER E. ET AL.,: "Structure, diversity, and evolution of the T-cell receptor VB gene repertoire in primates", IMMUNOGENETICS, vol. 40, no. 3, - 1994, pages 184 - 191, XP002114681 *
LEE M.E. ET AL.,: "Molecular cloning and expression of rhesus macaque and sooty mangabey interleukin 16: biologic activity and effect on simian immunodeficiency virus infection and/or replication", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 14, no. 15, - 15 October 1998 (1998-10-15), pages 1323 - 1328, XP002114679 *
LYN D. ET AL.,: "Conservation of sequences between human and gorilla lineages: ADP-ribosyltransferase(NAD+) pseudogene 1 and neighboring retroposons", GENE, vol. 155, - 1995, pages 241 - 245, XP002114678 *
MESSIER W. & STEWART C.-B.: "Episodic adaptive evolution of primate lysozymes", NATURE, vol. 385, - 9 January 1997 (1997-01-09), pages 151 - 154, XP002114682 *

Also Published As

Publication number Publication date
EP1051519A2 (en) 2000-11-15
CA2318772A1 (en) 1999-08-05
JP2002501761A (en) 2002-01-22
WO1999039006A2 (en) 1999-08-05

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